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Plastic and Aesthetic Research 2018年第4期5卷 28-35页

作者： Alejandra garcía Botero jorge Ernesto Cantini Ardila luis David Devoz Borja Viviana Gómez-Ortega Plastic and Reconstructive Surgery Department Hospital de San JoséFundación Universitaria de Ciencias de la SaludBogotá110111Colombia Plastic and Reconstructive Surgery Department Fundación Santa Féde BogotáBogotá110111Colombia

Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or without growth factors. Methods: A systematic review of the literature was performed to evaluate the use of fibrin matrices with or without growth factors for the management of chronic venous ulcers in lower limbs. Article searches were performed in MEDLINE, EMBASE, COCHRANE, LILACS and ongoing clinical trials at ***. Results: The search in MEDLINE and EMBASE identified three articles;one was a pilot study evaluating the use of fibrin matrix and autologous growth factors that included patients with chronic ulcers of different etiology. The second article was a description of the product used in the previous study, and the third consisted of a series case reports of patient treated with cultured keratinocytes in a fibrin matrix. A COCHRANE searched resulted in one study assessing the cost effectiveness of using different fibrin matrices. The search in *** and LILACS did not result in any findings. Conclusion: The study did not provide a conclusive evidence for the use of fibrin matrices in patients with venous leg ulcers.

关键词： Venous ulcers legs fibrin matrix growth factors

A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility

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Asian Journal of Andrology 2021年第3期23卷 306-313页

作者： Julio Bunay Luz-Maria Gallardo jorge luis Torres-Fuentes M Veronica Aguirre-Arias Renan Orellana Nestor Sepulveda Ricardo D Moreno Physiology Department Faculty of Biological SciencesPontificia Universidad Cat6lica de Chile(PUC)Santiago 8331150Chile Department of Chemistry and Biological Sciences Health Sciences FacultyUniversidad Bernardo 0 HigginsSantiago 8370854Chile Center of Excellence in Biotechnology of Reproduction Universidad de la FronteraTemuco 4780000Chile.

Obesity is a major worldwide health problem that is related to most chronic diseases,including male *** to its wide impact on health,mechanisms underlying obesity-related infertility remain *** this study,we report that mice fed a high-fat diet(HFD)for over 2 months showed reduced fertility rates and increased germ cell apoptosis,seminiferous tubule degeneration,and decreased intratesticular estradiol(E2)and E2-to-testosterone ***,we also detected a decrease in testicular fatty acid levels,behenic acid(C22:0),and docosahexaenoic acid(DHA,22:6n-3),which may be related to the production of dysfunctional ***,we did not detect any changes in the frequency of seminiferous tubule stages,sperm count,or rate of in vitro ***,there was an increase in spontaneous and progesterone-induced acrosomal exocytosis(acrosome reaction)in spermatozoa from HFD-fed *** data suggest that a decrease in E2 and fatty acid levels influences spermatogenesis and some steps of acrosome biogenesis that will have consequences for ***,our results add new evidence about the adverse effect of obesity in male reproduction and suggest that the acrosomal reaction can also be affected under this condition.

关键词： cholesterol estradiol fat acid testis testosterone

A techno-economic and life cycle assessment for the production of green methanol from CO_(2): catalyst and process bottlenecks

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Journal of Energy Chemistry 2022年第5期31卷 255-266页

作者： Tomas Cordero-Lanzac Adrian Ramirez Alberto Navajas Lieven Gevers Sirio Brunialti luis MGandía Andrés T.Aguayo S.Mani Sarathy jorge Gascon Department of Chemical Engineering University of the Basque Country(UPV/EHU)PO Box 64448080 BilbaoSpain King Abdullah University of Science and Technology KAUST Catalysis Center(KCC)Advanced Catalytic MaterialsThuwal 23955Saudi Arabia Department of Science Public University of Navarre(UPNA)Arrosadía Campus s/n31006 PamplonaSpain Institute for Advanced Materials and Mathematics(InaMat2) Universidad Pública de Navarra(UPNA)Edificio Jerónimo de AyanzCampus de ArrosadiaPamplona-Iruña 31006Spain King Abdullah University of Science and Technology Clean Combustion Research Center(CCRC)Thuwal 23955Saudi Arabia

The success of catalytic schemes for the large-scale valorization of CO_(2) does not only depend on the development of active,selective and stable catalytic materials but also on the overall process *** we present a multidisciplinary study(from catalyst to plant and techno-economic/lifecycle analysis)for the production of green methanol from renewable H2 and CO_(2).We combine an in-depth kinetic analysis of one of the most promising recently reported methanol-synthesis catalysts(InCo)with a thorough process simulation and techno-economic *** then perform a life cycle assessment of the simulated process to gauge the real environmental impact of green methanol production from CO_(2).Our results indicate that up to 1.75 ton of CO_(2) can be abated per ton of produced methanol only if renewable energy is used to run the process,while the sensitivity analysis suggest that either rock-bottom H2 prices(1.5$kg1)or severe CO_(2) taxation(300$per ton)are needed for a profitable methanol ***,we herein highlight and analyze some critical bottlenecks of the *** attention has been paid to the contribution of H2 to the overall plant costs,CH4 trace formation,and purity and costs of raw *** addition to providing important information for policy makers and industrialists,directions for catalyst(and therefore process)improvements are outlined.

关键词： CO_(2) Methanol Kinetic modeling Process simulation Life cycle assessment

Experimental evaluation and simulation of volumetric shrinkage and warpage on polymeric composite reinforced with short natural fibers

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Frontiers of Mechanical Engineering 2015年第3期10卷 287-293页

作者： Jonnathan D. SANTOS jorge I. FAJARDO Alvaro R. CUJI Jaime A. garcIA luis E. GARZON luis M. LOPEZ Department of Mechanical Engineering Universidad Polit6cnicaSalesiana Elia Liut Ecuador Department of Mechanical Engineering Universidad PontificiaBolivariana Medellin Columbia

A polymeric natural fiber-reinforced composite is developed by extrusion and injection molding process. The shrinkage and warpage of high-density polyethylene reinforced with short natural fibers of Guadua angustifolia Kunth are analyzed by experimental measure- ments and computer simulations. Autodesk Moldflow and Solid Works are employed to simulate both volumetric shrinkage and warpage of injected parts at different configurations： 0wt.%, 20wt.%, 30wt.% and 40 wt.% reinforcing on shrinkage and warpage behavior of polymer composite. Become evident the restrictive effect of reinforcing on the volumetric shrinkage and warpage of injected parts. The results indicate that volumetric shrinkage of natural composite is reduced up to 58% with fiber increasing, whereas the warpage shows a reduction form 79% to 86% with major fiber content. These results suggest that it is a highly beneficial use of natural fibers to improve the assembly properties of polymeric natural fiber-reinforced composites.

关键词： biocomposite natural fiber shrinkage,simulation warpage

Evolution of sexual size dimorphism and its relationship with sex ratio in carabid beetles of Genus Ceroglossus Solier

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Current Zoology 2013年第6期59卷 769-777页

作者： Hugo A. BENITEZ jorge AVARIA-LLAUTUREO Cristian B.CANALES-AGUIRRE Viviane JEREZ luis E. PARRA Cristifin E.HERNANDEZ Faculty of Life Sciences University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT UK Instituto de Alta Investigaci6n Universidad de Tarapaca Casilla 7-D Arica Chile Departamento de Zoologia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepcion Casilla 160-C Concepcion Chile Departamento de Oceanografia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepci6n Casilla 160-C Concepcion Chile

Although the degree of mate competition, given extreme differences in sex ratio, explains much of the pattern of male-biased size dimorphism among diverse taxa, it fails for some species which have potential for intense male competition for mates and yet exhibit little or no sexual size dimorphism （SSD）. This fact suggest that species with low SSD should be express the effect of evolutionary pressure in non-obvious geometrical shape promoted by sex ratio in an evolutionary time scale. To evaluate this hypothesis we used phylogenetic comparative method in a Bayesian framework to investigate the evolution of SSD and the role of sex ratio at inter-specific level in the species of Ceroglossus （Coleoptera： Carabidae）. In our results the proportion farthest from 1：1 is associated with more disparate body shape, even though the entire group has minimum variation in sex ratio, which is an intrinsic life history character of this group considering its phylogenetic conservatism or phylogenetic signal. We suggest that the sex ratio has determined the dimorphism degree during evolution of this group, since both traits have increased or decreased together during the species divergence （i.e. positive phylogenetic correlation： r2=0.85）. We suggest that morphological studies of SSD will benefit from using comparative method with Bayesian approaches to assess the effect of phylogenetic history and its uncertainty. Finally, this will be allow to researchers to quantify the uncertainty of specific evolutionary hypotheses accounting for observed sexual dimorphism patterns.

关键词： Macroevolution Geometric Morphometrics Bayesian approach Sexual Dimorphism Sex Ratio Ceroglossus

Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第36期24卷 4104-4118页

作者： jorge-luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos Department of Internal Medicine University Hospital of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL Spanish Working Group on Alcohol and Alcoholism Spanish Society of Internal Medicine Department of Internal Medicine University Hospital of Santiago de Compostela Department of Internal Medicine HM Rosaleda HospitalSantiago de Compostela Department of Medicine Faculty of MedicineUniversity of Salamanca

MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease.

关键词： Alcohol use disorder Alcoholic liver disease Non-alcoholic fatty liver disease Steatosis Obesity miRNA Biomarkers

Infrared fluorescence imaging of infarcted hearts with A@S nanodots

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Nano Research 2019年第4期12卷 749-757页

作者： Dirk H. Ortgies Angel luis garcia-Villalon Miriam Granado Sara Amor Emma Martin Rodriguez Harrisson DA Santos Jingke Yao jorge Rubio-Retama Daniel Jaque Nanobiology Group Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 Spain Fluorescence Imaging Group Departamento de Fisica de Materiales - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Fluorescence Imaging Group Departamento de Fisiologia - Facultad de Medicina Avda. Arzobispo Morcillo 2 Universidad Autonoma de Madrid Madrid 28029 Spain Fluorescence Imaging Group Departamento de Fisica Aplicada - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Grupo de Nano-Fotonica e Imagens Instituto de Fisica Universidade Federal de Alagoas Maceio-AL 57072-900 Brazil Departamento de Quimica Fisica en Ciencias Farmaceuticas Facultad de Farmacia Plaza de Ramon y Cajal s/n Universidad Complutense de Madrid Madrid 28040 Spain

Ag2S nano dots have already bee n dem onstrated as promisi ng n ear-i nfrared (NIR-II, 1.0-1.45 pm) emitting nan oprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the pote ntial applicati on of function alized Ag2S nano dots for accurate imaging of damaged myocardium tissues after a myocardial in farction in duced by either partial or global ischemia. Ag2S nano dots surface-function alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an in direct evaluati on of the damage level. The pote ntial applicati on of Ag2S nano dots in the n ear future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.

关键词： infrared imaging myocardial infarct Ag2S nanodots biological windows Langendorff heart

Direct transmesenteric venous interventions in the acute post liver transplant setting

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Journal of Interventional Medicine 2021年第1期4卷 46-48页

作者： Keshav Anand luis Garza Glenn Halff Tarunjeet Klair Francisco Cigarroa Rajeev Suri jorge Lopera UT Health San Antonio Long School of Medicine 7703 Floyd Curl DrSan AntonioTX78229USA

Introduction: Portal venous thrombosis and stenosis are uncommon but serious causes of liver transplant graft *** surgical thrombectomy can be utilized for the treatment of portal steno-occlusive disease,venous interventions with IR have been performed with encouraging *** description:69-year-old female with non-alcoholic steatohepatitis cirrhosis who received a liver transplant complicated by portal vein *** between transplant surgery and IR allowed for successful thrombus removal via direct SMV ***:The advantages of direct SMV access with the surgery team include direct approach to accessing thrombus,sparing of liver parenchyma,and significant hemostatic control.

关键词： venous thrombus surgery

Identification and Characterization of Métiers in Multi-Species Artisanal Fisheries. A Case Study in Northwest Spain

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Natural Resources 2016年第6期7卷 295-314页

作者： Javier González-Álvarez Laura garcía-de-la-Fuente Lucía garcía-Flórez Mª del Pino Fernández-Rueda jorge luis Alcázar-Álvarez INDUROT (Instituto de Recursos Naturales y Ordenación del Territorio) University of Oviedo Mieres Spain CEP (Centro de Experimentación Pesquera) Regional Ministry of Rural Development and Natural Resources of the Principality of Asturias Gijón Spain

Artisanal fisheries are characterized by using a vast array of different fishing gears and target species. Such heterogeneity has traditionally complicated their management and the availability of accurate data on fishing effort and incomes. This study identifies and characterizes the métiers currently used by an artisanal fishing fleet based in a coastal Atlantic region in South-Europe (Asturias, Northwest Spain), by applying an integrated method of analysis which combines administrative data on fishing licenses, daily sales statistics and information from surveys. As a result, 21 artisanal fishing métiers have been identified, with special relevance of the trammel net (targeting Lophius spp.), the Merluccius longline and the Merluccius gillnet métiers. Spatio-temporal patterns of fishing effort have been also described, and outputs and inputs demands per métier have been quantified. It has been also found a high degree of alternation between different métiers during the fishing season and significant differences in terms of technical aspects and workforce. Finally, fishermen’s short- and long-term strategies (métier choice) are discussed, different comparisons are made on the basis of other South-European studies and main findings are linked to artisanal fisheries management.

关键词： Métier Artisanal Fisheries Multi-Species Fleet Management Bioeconomic Sustainability North West Spain

A minimally invasive midface suspension

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Plastic and Aesthetic Research 2020年第3期7卷 11-16页

作者： jorge I.de la Torre John Lindsey Jr. Dean Cerio luis O.Vasconez Division of Plastic Surgery University of Alabama at Birmingham and Birmingham V.A.Medical Center BirminghamBirminghamAL 35294USA

Aim:With the normal aging process,the malar fat pad descends vertically,causing a number of characteristic changes to the *** techniques have been used to correct ptosis of the malar fat ***:The authors describe a technique that is minimally invasive and can be used to correct malar fat pad *** technique uses a suspension suture to elevate the malar fat pad to a more youthful *** technique has been successfully used in 71 ***:All of the cases were performed in the office setting under local *** were no complications,and,by patient self-report and physician exam,results have been lasting and ***:The minimally invasive midface suspension is a safe and successful approach to midface rejuvenation in properly selected patients.

关键词： Midface rejuvenation midface suspension malar fat pad facial rejuvenation