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Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists

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World Journal of Gastrointestinal Endoscopy 2015年第9期7卷 895-911页

作者： Rok Orel Jernej Brecelj jorge Amil dias Claudio Romano Fernanda Barros Mike Thomson Yvan Vandenplas Children’s Hospital University Medical Centre Ljubljana Medical Faculty University of Ljubljana Department of Pediatrics Hospital S.Joo Pediatric Department University of Messina the Paediatric Section of the Portuguese Society of Anaesthesiology Department of AnesthesiologyHospital S.Joo Centre for Paediatric Gastroenterology International Academy of Paediatric Endoscopy TrainingSheffield Children’s Hospital Department of Pediatrics UZ BrusselVrije Universiteit Brussel1090 BrusselsBelgium

AIM: To present evidence and formulate recommendations for sedation in pediatric gastrointestinal(GI) endoscopy by ***: The databases MEDLINE, Cochrane and EMBASE were searched for the following keywords "endoscopy, GI", "endoscopy, digestive system" AND "sedation", "conscious sedation", "moderate sedation", "deep sedation" and "hypnotics and sedatives" for publications in English restricted to the pediatric age. We searched additional information published between January 2011 and January 2014. Searches for(upper) GI endoscopy sedation in pediatrics and sedation guidelines by non-anesthesiologists for the adult population were performed. RESULTS: From the available studies three sedation protocols are highlighted. Propofol, which seems to offer the best balance between efficacy and safety is rarely used by non-anesthesiologists mainly because of legal restrictions. Ketamine and a combination of a benzodiazepine and an opioid are more frequently used. Data regarding other sedatives, anesthetics and adjuvant medications used for pediatric GI endoscopy are also ***: General anesthesia by a multidisciplinary team led by an anesthesiologist is preferred. The creation of sedation teams led by non-anesthesiologists and a careful selection of anesthetic drugs may offer an alternative, but should be in line with national legislation and institutional regulations.

关键词： Gastro-intestinal endoscopy Gastroscopy Colonoscopy Sedatives Pediatric ages Anesthetics Analgesics

SACI Protocol: Preliminary Guidelines for the Development of Digital Health Technologies for Clinical Trials in Brazil

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E-Health Telecommunication Systems and Networks 2022年第3期11卷 85-100页

作者： Lídia Maria Lourençön Rodrigues Agia jorge Luiz dias Agia Rui Pedro Charters Lopes Rijo Valdes Roberto Bollela Domingos Alves Department of Social Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Postgraduate Program in Production Engineering UNIP S&#227 o Paulo Brazil Polytechnic Institute of Leiria Leiria Portugal Department of Internal Medicine Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil

In the last decade, evidence-based medical practice has been supported on a large scale by computerized decision support tools, aiming to reduce diagnostic and therapeutic uncertainty, complementing the actions of the health professional. With technological developments, it is now possible to consider these systems as part of clinical intervention, both for the diagnosis and treatment of diseases. The literature has described the implementation of e-health tools, that is, technological innovations in the health area such as software, applications, serious games, among others, as a strategy to improve the process and adherence to treatment. However, there is still no standardized instrument in Brazil that can be used to guide the development, from the research phase, and the implementation of these tools as a health intervention, also impacting patient outcomes. With the objective of investigating a new therapeutic and preventive form, based on intervention with a computerized system, this work proposes the creation of guidelines for the registration and implementation of e-health tools as a clinical intervention. The proposal aims to be able to assist in the reporting standardization from the development stage to the application of the e-health tool helping in the treatment of diseases, registering all the experience lived in the research and applying it in different contexts of health.

关键词： Reporting Guidelines Clinical Trials Digital Health E-Health

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鱼肌肉蛋白质组学分级过程的重现性研究

生命科学仪器 2010年第4期8卷 24-27页

作者： ToméS.SILVA Odete CORDEIRO Flemming JESSEN jorge dias Pedro M.RODRIGUES CCMAR-Centro de Ci(e) ncias do Mar do Algarve Universidade do AlgarveCampus de Gambelas 8005-139 Faro Portugal DTU Aqua-Institut for Akvatiske Ressourcer Danmark Tekniske Universitet CopenhagenDenmark CCMAR-Centro de Ci(e) ncias do Mar do Algarve Universidade do AlgarveCampus de Gambelas 8005-139 Faro Portugal DTU Aqua-Institut for Akvatiske Ressourcer Danmark Tekniske Universitet CopenhagenDenmark

在比较蛋白质组学中,分级过程经常被用于去除高丰度蛋白质,从而提高低丰度蛋白质的浓度至检出限以上。作者为了证实在二维凝胶电泳分离流程中增加额外的分级过程将会减小对金头鲷宰前应激响应时间依赖检测中所引入的噪声和批次间的偏差... 详细信息

在比较蛋白质组学中,分级过程经常被用于去除高丰度蛋白质,从而提高低丰度蛋白质的浓度至检出限以上。作者为了证实在二维凝胶电泳分离流程中增加额外的分级过程将会减小对金头鲷宰前应激响应时间依赖检测中所引入的噪声和批次间的偏差,采用多维标度对结果数据进行了多参数分析。结果表明生物响应比分级引入的误差高出几个数量级,而批次间误差不小于不同IEF/SDS-PAGE运行所引入的偏差。

关键词：比较蛋白质组学分级过程重现性鱼肌肉二维凝胶电泳多参数分析时间依赖宰前应激

Magnetic-gateable valley exciton emission

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npj Computational Materials 2020年第1期6卷 915-923页

作者： Helena Bragança Hao Zeng Alexandre Cavalheiro dias jorge Huamani Correa Fanyao Qu Instituto de Física Universidade de BrasíliaBrasília-DF 70919-970Brazil Departamento de Física Universidade Federal de Ouro PretoOuro PretoMinas Gerais 35400-000Brazil Department of Physics University at Buffalothe State University of New YorkBuffaloNY 14260USA

The use of valley excitonic states of transition metal dichalcogenides to store and manipulate information is hampered by fast carrier recombination and short valley *** propose theoretically a scheme to overcome such an obstacle,by applying a tilted exchange field through the magnetic proximity effect on monolayer MoS_(2).While the in-plane component of the exchange field brightens the dark exciton by spin mixing,the out-of-plane field can effectively gate the emission with an ON/OFF ratio of ***,the brightening is valley selective,leading to nearly 100% valley and spin polarization at room *** resulting strongly gateable dark-exciton emission with long lifetime and near unity valley polarization makes it convenient to manipulate the valley degree of freedom,which may offer new paradigm for information processing and transmission.

关键词： temperature overcome applying

Metal-organic frameworks of lanthanide iminodiacetates and tartrates:Synthesis,structural characterization and luminescence properties——Commemorating the 100th anniversary of the birth of Academician Guangxian Xu

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Journal of Rare Earths 2021年第5期39卷 487-494页

作者： Melissa Fairley M.M.Varuni S.Livera Wanmin Chen jorge H.S.K.Monteiro Adam Schmitt Ana de Bettencourt-dias Sue Roberts Zhiping Zheng Department of Chemistry and Biochemistry University of ArizonaTucsonAZ 85721USA Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry University of NevadaRenoNV 89557USA

Two series of lanthanide-containing metal-organic frameworks(Ln-MOFs)of the general formula{[Ln(HIDA)_(2)H_(2)O]ClO_(4)·H_(2)O}_n(Ln=La(1),Nd(2),Eu(3),Gd(4),Tb(5),Eu:Tb(6);H_(2)IDA=iminodiacetic acid)and[Ln(TT)(HTT)(H_(2)O)_3]_n(Ln=Eu(7),Gd(8),Tb(9),Dy(10),and Eu:Tb(11);H_(2)TT=tartaric acid)were synthesized by reacting Ln(ClO_(4))_3 with iminodiacetic acid and L-tartaric acid,*** compounds were structurally characterized by single-crystal X-ray *** analyses are co nsistent with the corre sponding crystallographically generated *** reover,the luminescence properties of both the single and mixed-lanthanide complexes were *** infrared,red,and green emissions that are characteristic of Nd(Ⅲ),Eu(Ⅲ),and Tb(Ⅲ)are observed for 2,3/7,and 5/9,*** the two mixed-lanthanide complex systems 6 and 11,depending on the relative amount of Eu(Ⅲ)and Tb(Ⅲ),the color of emission can be *** is found that a small amount of Eu(Ⅲ)is adequate for the observation of the most intense transition of Eu(Ⅲ).This is believed to be a result of energy transfer from Tb(Ⅲ)to Eu(Ⅲ)within the same complex-a conclusion supported by the significantly shortened lifetime of Tb(Ⅲ)and the accompanying enhanced lifetime of Eu(Ⅲ)in the mixedlanthanide complex with respect to the corresponding values for the pure Tb(Ⅲ)and Eu(Ⅲ)complexes with the same ligand.

关键词： Lanthanides Metal-organic frameworks Luminescence Rare earths

Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEJIA Gustavo Lima URBIETA Bruna da Silva XAVIER Isaíjorge de CASTRO JoséJúlio DE TOLEDO Gustavo GRACIOLLI Lucio AndréVIANA dias William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

Web-based system for training and dissemination of a magnification chromoendoscopy classification

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World Journal of Gastroenterology 2008年第46期14卷 7086-7092页

作者： Mário jorge Dinis-Ribeiro Ricardo Cruz Correia Cristina Santos Sónia Fernandes Ernesto Palhares Rui Almeida Silva Pedro Amaro Miguel Areia Altamiro Costa-Pereira Luis Moreira-dias Gastroenterology Department Portuguese Oncology Institute Center for Research in Information Systems and Health Technologies (CINTESIS)/Department of Biostatistics and Medical Informatics Porto Faculty of Medicine Gastroenterology Department Coimbra University Hospital

AIM： To evaluate the use of web-based technologies to assess the learning curve and reassess reproducibility of a simplified version of a classification for gastric magnification chromoendoscopy （MC）. METHODS： As part of a multicenter trial, a hybrid approach was taken using a CD-ROM, with 20 films of MC lasting 5 s each and an ＂autorun＂ file triggering a local HTML frameset referenced to a remote questionnaire through an Internet connection. Three endoscopists were asked to prospectively and independently classify 10 of these films randomly selected with at least 3 d apart. The answers were centrally stored and returned to participants together with adequate feedback with the right answer. RESULTS： For classification in 3 groups, both intra- [Cohen＇s kappa （K） = 0.79-1.00 to 0.89-1.00] and inter-observer agreement increased from 1st （moderate） to 6th observation （k = 0.94）. Also, agreement with reference increased in the last observations （0.90, 1.00 and 1.00, for observers A, B and C, respectively）. Validity of 100% was obtained by all observers at their 4th observation. When a 4th （sub）group was considered, inter-observer agreement was almost perfect （K = 0.92） at 6th observation. The relation with reference clearly improved into K （0.93-1.00） and sensitivity （75%-100%） at their 6th observations. CONCLUSION： This MC classification seems to be easily explainable and learnable as shown by excellent intra- and inter-observer agreement, and improved agreement with reference. A web system such as the one used in this study may be useful for endoscopic or other image based diagnostic procedures with respect to definition, education and dissemination.

关键词： Magnification Chromoendoscopy Reproducibility Learning curve

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中国碳排放影响因素研究

中国碳排放影响因素研究

作者： dias DE BARROS jorge ALBERTO 北京交通大学

学位级别：硕士

经济发展、人口结构变化和城市人口增长导致了能源消耗的大幅增加和各种交通方式的密集使用。这些因素对环境产生了不利影响,碳排放的比例也越来越大。2006年中国超越美国成为碳排放第一大国,2010年中国超过日本成为世界第二经济大国。... 详细信息

经济发展、人口结构变化和城市人口增长导致了能源消耗的大幅增加和各种交通方式的密集使用。这些因素对环境产生了不利影响,碳排放的比例也越来越大。2006年中国超越美国成为碳排放第一大国,2010年中国超过日本成为世界第二经济大国。尽管中国人均二氧化碳排放量比美国的低。2013-2017年统计数据也显示中国环境政策高效控制排放强度,但是国际初步核算显示自2018年中国碳排放量重新增长,因此“中国绿色发展”面临着巨大压力。本文综合STIRPAT模型理论基础、岭回归以及可行广义最小二乘方法的框架,研究影响对中国碳排放的因素。本文首先利用1978-2018年度时间序列数据,以中国为研究对象,基于扩展的STIRPAT模型,应用岭回归分析中国碳排放影响因素;其次选取1995-2018年中国30个省(除西藏外)的面板数据,运用修正的碳排放因子对中国各省市的八类能源消费碳排放进行测算。在此基础上,对比了全国与东、中、西部三个区域的碳排放发展趋势;运用面板数据回归模型与STIRPAT模型相结合的方法,从地区的角度对中国碳排放的影响因素进行了分析。在不同时间段,碳排放影响因素的实证分析结果表明,人口规模、城镇化率、人口年龄结构、城镇居民家庭人均可支配收入、铁路营业里程以及铁路客运量对碳排放都有显著的不同影响。近年来,尤其铁路发展与客运使用对中国碳排放的有显著抑制作用。在不同地区,碳排放的影响因素具有一定差异性。根据实证结果,本文提出了控制中国省市的碳排放的结论与建议。

关键词：碳排放 STIRPAT模型岭回归面板数据回归模影响因素

Genetic Parameters and Correlation between Tomato Late Blight Field Resistance and Fruit Quality

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American Journal of Plant Sciences 2014年第15期5卷 2418-2425页

作者： Carlos Nick jorge Gonzalez Aguilera Bruno Soares Laurindo Victor de Souza Almeida Renata dias de Freitas Cosme Damiao Cruz Derly Jose Henriques da Silva Departamento de Fitotecnia Universidade Federal de VicosaVicosaBrazil Embrapa Trigo Passo FundoBrazil Departamento de Biologia Geral Universidade Federal de VicosaVicosaBrazil

The objective of this study was to estimate genetic parameters and quantify the correlations between late blight (LB) resistance and fruit quality traits in 220 families F2:3, under tropical field conditions. The families were arranged in randomized blocks in field trials, with six resistant inbred lines used as control, in plots of five plants. It evaluated the severity in the middle of the epidemy, final severity, area under the curve of progress of late blight, pH, total soluble solids, titratable acidity and flavor. There is genetic variability for epidemiological variables and total soluble solids. Heritabilities, obtained by parent-offspring regression, were high and indicated the possibility of satisfactory genetics gains and success in the introgression of resistance alleles. The correlations were negative, of high to intermediate magnitude, among the variables area under the curve of progress of late blight, total soluble solids and total titratable acidity.

关键词： Pre-Breeding Alleles Introgression Genetic Resources Tomato Wild Species