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Molecular signaling of 5-HT1Aand presence of serotonergic cells in the fetal cerebral cortex

World Journal of Neuroscience 2013年第2期3卷 76-82页

作者： Alfonso B. M. de Oca Gabriel M. Gutiérrez jorge H. Rodríguez Laboratorio de Neurontogenia Departamento de Fisiología Biofísica y Neurociencias Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Ciudad de México México Unidad de Investigación Biomolecular Hospital de Cardiología Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México

Early appearance of the serotonergic system in the fetal brain and the various effects of serotonin (5-HT) on brain morphogenesis, have given support to a neurotrophic role of serotonin. This function of serotonin is accomplished through a system of serotonin nerve terminals in the target regions that involves various 5-HT receptors. In visual, auditory and somatosensory cortex an early and intense serotonergic innervation is particularly important. The neuronal somata of these terminals are normally located in the mesencephalon and they have not been observed in the maturing cerebral cortex, neither in the adult brain. By using immunolabeling techniques, fluorescence and confocal microscopy, we observe the presence of both, 5-HT terminals and 5-HT cells in mesencephalon (Me, E17) and in the neopallium (Np, E13-E16) cocultures. Cells immunopositive to 5-HT and to tryptophan-5-hydroxilase are also observed in the Np on day 12 of culture. These results concerning the unexpected presence of serotonergic cells in the fetal cerebral cortex are interesting and may be of importance in corticogenesis. As it happens with other elements of the serotonergic system, the presence of these phenotypically serotonergic cells in the early cerebral cortex may be transitory and probably supporting cortex maturation processes. The molecular signaling path of the 5-HT1A receptor has also been identified.

关键词： Serotonergic System Serotonin Receptor 5-HT1A Molecular Signaling Paths

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GOECP/SEOR clinical recommendations for lung cancer radiotherapy during the COVID-19 pandemic

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World Journal of Clinical Oncology 2020年第8期11卷 510-527页

作者： Felipe Couñago Arturo Navarro-Martin Javier Luna Nuria Rodríguez de Dios Aurora Rodríguez Francesc Casas Rafael García Antonio Gómez-Caamaño jorge Contreras Javier Serrano Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Clinical Department Hospital La LuzMadridFaculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Institut Catalád’OncologiaL’Hospitalet de LlobregatBarcelona 08908Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Thoracic UnitHospital ClínicBarcelona 08036Spain Department of Radiaiton Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaA Coruña 15706Spain Department of Radiation Oncology Hospital Regional Universitario de Málaga29010Spain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain

The coronavirus disease 2019 crisis has had a major and highly complex impact on the clinical practice of radiation oncology *** is one of the countries hardest hit by the virus,with devastating *** is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung *** the present article,the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic.

关键词： Lung cancer COVID-19 Pandemic Radiotherapy Recommendations

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Optimization of Extrusion Process for Producing High Antioxidant Instant Amaranth (Amaranthus hypochondriacusL.) Flour Using Response Surface Methodology

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Applied Mathematics 2012年第10期3卷 1516-1525页

作者： jorge Milán-Carrillo Alvaro Montoya-Rodríguez Roberto Gutiérrez-Dorado Xiomara Perales-Sánchez Cuauhtémoc Reyes-Moreno Maestria en Ciencia y Tecnología de Alimentos Facultad de Ciencias Químico-Biológicas Universidad Autónoma de Sinaloa Sinaloa México Programa Regional del Noroeste para el Doctorado en Biotecnología Universidad Autónoma de Sinaloa Sinaloa México

The objective of this research was to determine the best combination of extrusion process variables for the production of a high antioxidant extruded amaranth flour (EAF) suitable to elaborate a nutraceutical beverage. Extrusion operation conditions were obtained from a factorial combination of process variables: Extrusion temperature (ET, 70℃ - 130?℃) and screw speed (SS, 100 - 220 rpm). Response surface methodology was employed as optimization technique;both the numeric and graphical methods were applied to obtain maximum values for response variables [Antioxidant capacity (AoxC) and water solubility index (WSI)]. The best combination of extrusion process variables was: Extrusion tem- perature (ET) = 130℃/Screw speed (SS) = 124 rpm. The raw amaranth flour (RAF) and optimized extruded amaranth flour (EAF) had an antioxidant activity of 3475 and 3903 μmol Trolox equivalents/100 g sample (dw), respectively. A 200 mL portion of the beverage prepared with 22 g of optimized EAF contained 3.16 g proteins, 1.09 g lipids, 17.39 g carbohydrates and 92 kcal. This portion covers 25.3% and 16.9% of the daily protein requirements for children 1-3 and 4 - 8 years old, respectively. A 200 mL portion of the beverage from optimized EAF contributes with 15.5% - 25.5% of the recommended daily intake for antioxidants, respectively. The nutraceutical beverage was evaluated with an average acceptability of 8.4 (level of satisfaction between “I like it” and “I like it extremely”) and could be used for health promotion and disease prevention as an alternative to beverages with low nutritional/nutraceutical value.

关键词： Optimization Amaranth Flour Antioxidant Activity Extrusion Nutraceutical Beverage

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The Thermal Decomposition of Ammonium Perchlorate-Aluminum Propellants in Presence of Metallic Zinc Particles

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Materials Sciences and Applications 2017年第6期8卷 436-447页

作者： Mónica Rodríguez-Pesina jorge García-Domínguez Felipe García-Hernández Luisa Maria Flores-Vélez Octavio Domínguez Institute of Metallurgy UASLP San Luis Potosi México INIDETAM Polígono Naval Antón Lizardo Veracruz México Faculty of Chemistry UASLP San Luis Potosi México

The thermal decomposition of ammonium perchlorate (AP) with Al and Zn metallic particles was studied at different heating rates in dry air atmosphere and the combustion behavior of AP/Al/Zn propellant was evaluated. The exothermic reaction kinetics was studied by differential thermal analysis (DTA) in non-isothermal conditions and compare with the thermal decomposition of pure AP and AP/aluminum particles analyzed in the same experimental conditions. The Arrhenius parameters were estimated according to the Ozawa and Kissinger methods. The calculated activation energies for the low and high temperature exothermic reactions were 91 and 229 kJ/mol for pure AP, 90 and 112 kJ/mol for 80 wt% AP/20 wt% Al particles. When zinc was incorporated, activation energy of 56 kJ/mol was determined for the only exothermic peak observed for 90 wt% AP/10 wt% Zn and 44 kJ/mol for 78.4 wt% AP/19.6 wt% Al/2 wt% Zn propellant composition.

关键词： Thermal Analysis Ozawa Method Kissinger Method Thermal Decomposition Ammonium Perchlorate Propellants

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Genotoxic Potential of the Insecticide Imidacloprid in a Non-Target Organism (Oreochromis niloticus-Pisces)

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Journal of Environmental Protection 2015年第12期6卷 1360-1367页

作者： Yadira Ansoar-Rodríguez Cintya A. Christofoletti Ana Claudia Marcato jorge Evangelista Correia Odair Correa Bueno Osmar Malaspina Carmem S. Fontanetti 1UNESP—Sã o Paulo State University Rio Claro Brazil UNESP—Sã o Paulo State University Rio Claro Brazil Department of Pharmacology and Toxicology Pharmacy and Food Institute University of Havana Havana Cuba UNIARARAS—Hermínio Ometto Foundation Araras Brazil UNESP/CEIS—Center of Study of Social Insects Rio Claro Brazil

The indiscriminate use of pesticides has become a serious environmental concern. Insecticide imidacloprid (IMI) is the second most widely used pesticides worldwide. In 2010, 1.934 tons of IMI were sold in Brazil, mostly to be used in sugarcane crops. Several studies have detected its presence in the aquatic environment constituting a risk to non-target organisms. The aquatic animals are organisms used for environmental biomonitoring worldwide. They are considered excellent genetic models to detect environmental mutagens. Among animal species, the fish Oreochromis niloticus, commonly known as Nile tilapia, has been used to evaluate DNA damage. The present study therefore evaluated the effect of IMI on the genetic material of Oreochromis niloticus (Pisces) erythrocytes exposed to different concentration (250;125 and 62.5 μg/L) of IMI used in growing sugarcane. The effect of the IMI was measured using the comet assay and the micronucleus (MN) test, assays that detected genotoxic damage. The results in the comet assay demonstrated that the concentrations tested induced primary damage to DNA. They also proved the occurrence of MN and nuclear abnormalities at the higher concentration used in the micronuclei and other nuclear abnormalities test. The insecticide IMI induced primary DNA damage at all concentrations and damage at the chromosomal level at the highest concentration tested. The results of this study show the potential risk of IMI in a non-target organism.

关键词： DNA damage pesticide comet assay genotoxicity micronucleus test.

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Environmental Impact Assessment for an Absorption Heat Transformer

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Open Journal of Applied Sciences 2016年第7期6卷 409-415页

作者： jorge Avelino Domínguez Patiño Antonio Rodríguez Martínez Rosenberg Javier Romero Jonathan Ibarra-Bahena Martha Lilia Domínguez Patiño FCQeI (Facultad de Ciencias Químicas e Ingeniería) Universidad Autónoma del Estado de Morelos Cuernavaca México CIICAp (Centro de Investigación en Ingeniería y Ciencias Aplicadas) Universidad Autónoma del Estado de Morelos Cuernavaca México

This study presents the environmental impact assessment of an absorption heat transformer designed to recover 1 kW of thermal energy from each 2 kW of waste heat supplies. The net contribution of the heat transformer is a load avoided of 0.665 kg CO2 equivalents;the recovery process avoids 0.729 kg CO2 equivalents and the major contribution to the environment impacts is the pumping process with 0.0437 kg CO2 equivalents for each 1 kWh recovered. The study results show that absorption heat transformer is a good environmental option because it produces useful energy from waste heat and the final result is an environmental impact diminution.

关键词： Environmental Impact Life Cycle Assessment LCA Absorption Heat Transformer Waste Heat Recovery

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抗原性生物标志物在结核分枝杆菌中的应用

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 856-870页

作者： Elba RODRIguez-HERNANDEZ Laura Itzel QUINTAS-GRANADOS Susana FLORES-VILLALVA jorge Germinal CANTO-ALARCON Feliciano MILIAN-SUAZO Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias(INIFAP)Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento AnimalKm.1 Carretera a ColonAjuchitlan Colon76280ColonQueretaroMexico Universidad Mexiquense del Bicentenario Unidad de Estudios Superiores de TultitlanAvenida Ex-Hacienda de Portales s/nVilla EsmeraldaTultitlan Estado de Mexico54910TultitlanMexico Universidad Autonoma de Queretaro Facultadde Ciencias NaturalesAvenida de las Ciencias s/nJuriquillaDelegacion Santa Rosa Jauregui76230QueretaroMexico

研究和鉴定分枝杆菌与其宿主间相互作用的生物分子,对于确定分枝杆菌在入侵过程中的作用至关重要,并为相关疾病生物学和发病机制提供基础知识。分枝杆菌是一种古老的病原体,它为自己在宿主和环境中生存发展了复杂的策略,这可能与其参与... 详细信息

研究和鉴定分枝杆菌与其宿主间相互作用的生物分子,对于确定分枝杆菌在入侵过程中的作用至关重要,并为相关疾病生物学和发病机制提供基础知识。分枝杆菌是一种古老的病原体,它为自己在宿主和环境中生存发展了复杂的策略,这可能与其参与感染分子之间相互作用网络的复杂性有关。在结核病检测技术的发展过程中,一些生物标记物已经开始受到关注。研究最广泛的抗原有CFP-10、ESAT-6、Ag85A、Ag85B、CFP-7和PPE18。其中一些抗原已被作为生物标记来评估病原体和宿主感染反应。设计新颖而准确的诊断方法对控制全世界的结核病至关重要。目前,诊断方法是基于对感染个体体液反应分子的识别。因此,这些测试依赖于宿主产生免疫反应的能力,而免疫反应通常是异质的。在过去的20年里,人们特别重视多抗原诊断方法的设计,以提高敏感性和特异性水平。本文综述了结核分枝杆菌生物分子的研究和应用现状,以期为结核控制提供新的支持。

关键词：结核分枝杆菌重组抗原诊断生物标志物

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Evaluation Regarding the Efficacy and Safety of a Probiotic Mixture in Healthy Volunteers with Evacuation Disorders

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Food and Nutrition Sciences 2012年第1期3卷 117-122页

作者： Lourdes Rodríguez-Fragoso Adriana Sandoval-Ocampo Martha Corbalá-Nava Carlos A. Arjona-Canul Diana Lizbeth Gomez-Galicia Guillermo Tellez Billy Hargis jorge Reyes-Esparza 不详

Probiotics have been used in humans for almost a century and are widely recommended because they play an important role in gastrointestinal physiological and pathophysiological processes. The aim of this study was to evaluate the effi- cacy and safety of a probiotic mixture in healthy volunteers with evacuation disorders. We undertook a prospective study with historical control. We used the number of evacuations, effort and stool consistency 10 days before, 10 days during and 10 days after treatment with the probiotic as primary outcome measures. Eligible par-ticipants comprised 25 patients with an average age of 25.12 years (range: 18 - 55) who suffered from evacuation disorders. BIO L6 is a func- tional food consisting of a probiotic preparation that contains 1 mg (108 CFUs) of lyophilized strains of Lactic Acid Bacteria resuspended in 250 mL of drinking water. The probiotic preparation was prescribed daily for two weeks, five days a week. A significant increase in the number of evacuations was observed in 23 patients during BIO L6 consump- tion and continued in 20 after consumption. The degree of effort spent defecating decreased in 17 patients during treat- ment and in 7 after treatment. A significant improvement (P < 0.001) in stool consistency was also observed in all pa- tients receiving BIO L6. Fourteen patients had at least one adverse event (AE) for one or two days during treatment;most treatment-related AEs were considered minor or mild in terms of severity and were consistent with AEs reported for probiotic consumption. The results of this study suggest that the use of probiotic mixture BIO L6 is effective, safe and tolerable and provides beneficial effects for subjects with evacuations disorders.

关键词： Chronic Constipation Probiotic Lactic Acid Bacteria

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Nylon/Porphyrin/Graphene Oxide Fiber Ternary Composite, Synthesis and Characterization

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Open Journal of Composite Materials 2017年第3期7卷 146-165页

作者： César García-Pérez Carmina Menchaca-Campos Miguel A. García-Sánchez Elsa Pereyra-Laguna Ociel Rodríguez-Pérez jorge Uruchurtu-Chavarín Centro de Investigación en Ingeniería y Ciencias Aplicadas-IICBA Universidad Autónoma del Estado de Morelos Cuernavaca México Departamento de Química UAM Iztapalapa Vicentina México

This research was based on the manufacture of new composite materials that offer technological possibilities in the development of new devices with greater efficiency. Electrospinning was used to form nylon 66/-tetra-(para-aminophenyl) porphyrin (H2T(p-NH2)PP)/graphene oxide (GO) composite film. Graphene oxide coatings were obtained from graphite, through mechanical exfoliation followed by calcination and ultrasonic agitation in an oxidant solution. These samples were characterized under SEM, FTIR, Raman spectroscopy, UV-vis and R-X techniques. On the other hand, H2T(p-NH2)PP was synthesized in two steps?process by the Rothemun reaction and the Adler Method and it was integrated within nylon polyamide fibers by direct addition of a hexamethylenediamine/adipoyl chloride reactant mixture. The polymerization of the nylon/H2T(p-NH2)PP species occurs in such a way that it starts or ends on the four peripherals-NH2 groups, connected and located in the same molecular plane of H2T(p-NH2)PP, forming nylon chains at the periphery of the macrocycle. The association of GO with nylon/H2T(p-NH2)PP fibers is performed by dipole-dipole interaction and hydrogen bonding. To take advantage of the properties of these materials, they were combined as a ternary composite.

关键词： Electrospinning Composite Nylon Porphyrin Graphene Oxide

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Effect of Carica papayaLeaf Extract on Serum Lipids and Liver Metabolic Parameters of Rats Fed a High Cholesterol Diet

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Health 2015年第9期7卷 1196-1205页

作者： Alma M. Zetina-Esquivel Carlos A. Tovilla-Zárate Crystell Guzmán-Garcia Arturo Rodríguez-Hernández Andrés E. Castell-Rodríguez jorge L. Ble-Castillo Angela Avila-Fernandez Isela E. Juárez-Rojop Juan C. Díaz-Zagoya Centro de Investigación División Académica de Ciencias de la Salud Universidad Juárez Autónoma de Tabasco Villahermosa México División Académica Multidisciplinaria de Comalcalco Universidad Juárez Autónoma de Tabasco Comalcalco México Unidad de Medicina Familiar 10 Instituto Mexicano del Seguro Social Xalapa México División de Investigación Facultad de Medicina Universidad Nacional Autónoma de México México D. F. México

Hyperlipidemia plays an important role in the development of atherosclerosis, the main cause of death in the world. In this study, the lipid-lowering effect of Carica papaya leaf in rats fed with a high cholesterol diet was evaluated. Daily doses of C. papaya extract 0, 31, 62 or 125 mg/kg body weight were orally administered in 300 μl polyethylene glycol to hypercholesterolemic rats;it was also administered 62 mg/kg body weight of the extract to rats with normal diet. After a 20-day treatment, the animals were sacrificed;blood and liver were analyzed. Hypercholesterolemic rats showed an increased serum and liver cholesterol, triacylglycerols, and atherogenic index. The C. papaya extract produced a significant decrease of serum and liver cholesterol concentrations in hypercholesterolemic rats, but did not modify serum or liver triacylglycerols;however, the extract reduced the atherogenic index in a dose-dependent manner. C. papaya treatment decreased LDL-C and increased HDL-C in serum significantly. When the oxygen consumption was evaluated in phosphorylating and resting states, the respiratory control in hypercholesterolemic rats mitochondria was lower than in normal diet rats. However, a higher respiratory control in hypercholesterolemic rats mitochondria was observed after C papaya treatment. The liver morphological data are in accordance with serum and liver biochemical values. Our data support that C. papaya has a significant hypocholesterolemic action and HDL-C raising effect on rats fed with a cholesterol-rich diet, however, the precise metabolites responsible of this effect remain unknown.

关键词： Serum Lipids Carica papaya Cholesterol Mitochondria

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