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New Insights into Aluminum Tolerance in Rice： The ASR5 Protein Binds the STAR1 Promoter and Other Aluminum-Responsive Genes

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Molecular Plant 2014年第4期7卷 709-721页

作者： Rafael Augusto Arenhart Yang Bai Luiz Felipe Valter de Oliveira Lauro Bucker Neto Mariana Schunemann Felipe dos Santos Maraschin jorge mariath Adriano Silverio Gilberto Sachetto-Martins Rogerio Margis Zhi-Yong Wang Marcia Margis-Pinheiro Programa de Pos-Graduacao em Genetica e Biologia Molecular Avenida Bento Goncalves 9500 Departamento de Genetica sala 207 predio 43312 Universidade Federal do Rio Grande do Sul 91501-970 Porto Alegre Brasil Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 USA School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Departamento de Botanica Universidade Federal do Rio Grande do Sul Porto Alegre Brasil Departamento de Genetica Universidade Federal do Rio de Janeiro Porto Alegre Brasil Centro de Biotecnologia Universidade Federal do Rio Grande do Sul Porto Alegre Brasil

Aluminum （AI） toxicity in plants is one of the primary constraints in crop production. Al3＋, the most toxic form of Al, is released into soil under acidic conditions and causes extensive damage to plants, especially in the roots. In rice, Al tolerance requires the ASR5 gene, but the molecular function of ASR5 has remained unknown. Here, we perform genome-wide analyses to identify ASR5-dependent Al-responsive genes in rice. Based on ASRS_RNAi silencing in plants, a global transcriptome analysis identified a total of 961 genes that were responsive to Al treatment in wildtype rice roots. Of these genes, 909 did not respond to Al in the ASR5_RNAi plants, indicating a central role for ASR5 in Al-responsive gene expression. Under normal conditions, without Al treatment, the ASR5 RNAi plants expressed 1.756 genes differentially compared to the wild-type plants, and 446 of these genes responded to AI treatment in the wild-type plants. Chromatin immunoprecipitation followed by deep sequencing identified 104 putative target genes that were directly regulated by ASR5 binding to their promoters, including the STAR1 gene, which encodes an ABC transporter required for AI tolerance. Motif analysis of the binding peak sequences revealed the binding motif for ASR5, which was confirmed via in vitro DNA-binding assays using the STAR1 promoter. These results demonstrate that ASR5 acts as a key transcription factor that is essential for AI-responsive gene expression and Al tolerance in rice.

关键词： Aluminum ChlP-Seq RNA-Seq rice ASR.

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Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta Gabriele Capurso Ivo Boskoski Cristiano Spada jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Biodiesel production from waste frying oil in sub- and supercritical methanol on a zeolite Y solid acid catalyst

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 401-407页

作者： jorge MEDINA-VALTIERRA jorge RAMIREZ-ORTIZ Department of Chemical & Biochemical Engineering Aguascalientes Institute of Technology Aguascalientes Ags. 20256 M6xico Academic Unit of Chemical Sciences Autonomous University of Zacatecas Zac. 98160 Mexico

Waste frying oil （WFO） is a very important feedstock for obtaining biodiesel at low cost and using WFO in transesterification reactions to produce biodiesel helps eliminate local environmental problems. In this study biodiesel was produced from WFO in sub- and super- critical methanol on a zeolite Y solid acid catalyst. The procedure was optimized using a design of experiments by varying the methanol to WFO molar ratio, the reaction temperature, and the amount of catalyst. Typical biodiesel yields varied from 83 to nearly 100% with methyl esters content ranging from 1.41-1.66mol.L-~ and typical dynamic viscosities of 22.1-8.2 cE Gas chromatography was used to determine the molecular composition of the biodiesel. The reaction products contained over 82 wt-% methyl esters, 4.2 wt-% free acids, 13.5 wt-% monoglycer- ides, and 0.3 wt-% diglycerides. The transesterification of WFO with methanol around its critical temperature combined with a zeolite Y as an acid catalyst is an efficient approach for the production of biodiesel with acceptable yields.

关键词： biodiesel methanol critical temperature,waste frying oil zeolite Y

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Core promoter: A critical region where the hepatitis B virus makes decisions

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World Journal of Gastroenterology 2014年第2期20卷 425-435页

作者： jorge Quarleri Instituto de Investigaciones Biomédicas en Retrovirus y Sida Universidad de Buenos AiresBuenos Aires C1121ABGArgentina

The core promoter(CP) of the viral genome plays an important role for hepatitis B virus(HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic(pg) RNAs. The CP consists of the upper regulatory region and the basa core promoter(BCP). The CP overlaps with the 3'-end of the X open reading frames and the 5'-end of the precore region,and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation,when variations appear,they may contribute to the persistence of HBV within the host,leading to chronic infection and cirrhosis,and eventually,hepatocellular carcinoma. Among CP sequence variations,those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen,and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated.

关键词： Hepatitis B virus Core promoter Variants Basal core promoter Transcription regulation

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Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： jorge CARAVANTES Laureano GONZALEZ-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词： Topology computation Real plane curves Sweeping method

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Stable Matchings in the Marriage Model with Indifferences

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Journal of the Operations Research Society of China 2021年第3期9卷 593-617页

作者： Noelia Juarez jorge Oviedo Instituto de Matemática Aplicada San Luis IMASLUniversidad Nacional de San Luis and CONICETEjército de los Andes 950D5700HHW San LuisArgentina

For the marriage model with indifferences,we define an equivalence relation over the stable matching *** identify a sufficient condition,the closing property,under which we can extend results of the classical model(without indifferences)to the equivalence classes of the stable matching *** condition allows us to extend the lattice structure over classes of equivalences and the rural hospital theorem.

关键词： Stability Indifferences Lattice structure

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Asymptomatic male currently not desiring fertility with bilateral subclinical varicocele found on ultrasound evaluation and borderline semen analysis results

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Asian Journal of Andrology 2016年第2期18卷 315-316页

作者： jorge Hallak Androscience High Complexity Andrology and Research Laboratory in MaleReproductive Health Section of Andrology Division of Urology Department of Surgery Hospital das Clinicas University of Sao Paulo Medical School Sao PauloBrazil Reproductive Toxicology Unit Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil.

Varicoceles are a fountain of inspiration for male health providers since times immemorial, and it has haunted men ever since with so many different and multifaceted aspects that even today, basic scientists and andrologists are finding new and exciting discoveries derived from its pathophysiology, clinical outcomes, and consequences. Varicocele is a perfect model to link basic science with technological innovation in diagnostic testing in semen analysis and surgical techniques improving medical practice and improving male reproductive and general health.

关键词： @@

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Architectural survey of historical buildings:The orders of classical architecture in the Baptistery of Florence

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Frontiers of Architectural Research 2021年第1期10卷 117-133页

作者： jorge Romero School of Architecture Pontifical Catholic University of Ecuador(Iborro Headquarters)IbarraEcuador School of Architecture UIDE Universidad Internacional Del Ecuador(Quito Headquarters)QuitoEcuador

The survey of historic buildings is very important for architectural *** integral survey allows perpetuating the building historical memory,deciphering it for future generations,and recovering it in case of accidental *** Baptistery of Florence survey was done with four measuring methods:the"direct"one,which employs traditional measuring tools;the"indirect"one,which expedites the dimension-gathering process with more preci-sion;and the"photogrammetric"one,which uses snapshots to facilitate the representation process with *** innova tive measuring concept,known here as the"recovery sur-vey",synthetizes graphical reality so that irregularities--due to the project materialization and deterioration over time-disappear;therefore,retrieving the building original ***-umns with their bases,shafts and capitals,as well as entablatures with their architraves,friezes and cornices were under *** three Greek orders(Doric,lonic and Corinthian)together with the two roman orders(Tuscan and Composite)unveiled the classical architecture *** constituents,which reoccur inside and outside the baptistery,were measured as part of these holistic survey and recovery process,to achieve the objective of this research study:the recording of this world historical building through an integral survey and rilievo to decode its significance and symbolism.

关键词： Architectural survey Recovery rilievo Photogrammetric survey Architectural conservation Classical architecture orders Architectural symbolism

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