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Nut.ient.Evaluat.on of Dining Cent.r Food Wast. and Comparison t. Monogast.ic and Ruminant.Feedst.ffs

Open Journal of Animal Sciences 2023年第3期13卷 323-335页

作者： Nelsa M. Beckman Phillip A. Lancast.r Haley K. Ot.t. Rachel N. Kort.Kat.erine M. Krauss Melissa A. Schrader jordan t. gebhardt Charles R. St.rk Chad B. Paulk Depart.ent.of Grain Science and Indust.y Kansas State University Manhattan USA Depart.ent.of Clinical Sciences Kansas State University Manhattan USA Depart.ent.of Housing and Dining Kansas State University Manhattan USA Depart.ent.of Diagnost.c Medicine Pat.obiology Kansas State University Manhattan USA

t.e object.ve of t.is st.dy was t. analyze t.e nut.ient.composit.on and variabilit. of universit. dining hall food wast. and compare it.wit. common feedst.ffs used in ruminant.and monogast.ic diet.. Food wast. was cat.gorized int. t.o init.al st.eams: mainst.eam (MS) from t.e serving line and veget.ble preparat.on (VP) from t.e kit.hen. Wast. was collect.d from t.e Kramer Dining Cent.r, Kansas St.t. Universit., result.ng in 30 daily samples. Wast. was weighed and ground t. homogenous part.cle size. Daily samples of MS and VP were analyzed for nut.ient.composit.on, where result. were combined t. calculat. t.e nut.ient.profile of a hypot.et.cal mixed food wast. st.eam (MX) composit.d by t.t.l weight. Dat. were analyzed using R st.t.st.cal soft.are (v 4.2.2). Moist.re and neut.al det.rgent.fiber (NDF) were great.r in VP (P , while et.er ext.act.(EE) was less compared t. MS and MX. Crude prot.in (CP) was great.r (P t.eams compared t. VP. t.e t.t.l digest.ble nut.ient. (t.N) and energy were great.r in MS food wast. t.an in MX, which was also great.r t.an VP (P cont.nt. measured by st.ndard deviat.on, was similar (P > 0.05) among st.eams for NDF, nit.ogen-correct.d neut.al det.rgent.fiber, acid det.rgent.insoluble crude prot.in, CP, ash, lignin, and digest.ble and met.bolizable energy. Dry mat.er and EE variat.on were great.r (P t. MX. St.ndard deviat.on increased (P t.al det.rgent.insoluble crude prot.in, t.N, and gross energy when compared t. VP. Despit. having 70% - 80% moist.re, dining hall food wast. does have nut.it.ve value and t.e pot.nt.al t. be included in ruminant.and monogast.ic diet.. Furt.er research needs t. be done t. underst.nd t.e value of including it.in animal diet..

关键词： Food Wast. Feedst.ffs Monogast.ic Ruminant Nut.ient.Variabilit.

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Aging impairs t.e ost.ocyt.c regulat.on of collagen int.grit. and bone qualit.

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Nat.lia Cast.llo Ryan Pot.er Jacob P.Rose Joanna Bons Christ.na D.King jordan B.Burt.n Birgit.Schilling Simon Melov Simon t.ng Eric Schaible t.mara Allist.n Depart.ent.of Ort.opaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduat. Program in Bioengineering San FranciscoCA 94143USA Buck Inst.t.t. for Research on Aging NovatoCA 94945USA Washingt.n Universit. in St.Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light.Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone qualit. is a major fact.r in skelet.l fragilit. in elderly individuals.t.e molecular mechanisms t.at.est.blish and maint.in bone qualit.,independent.of bone mass,are unknown but.are t.ought.t. be primarily det.rmined by ost.ocyt.s.We hypot.esize t.at.t.e age-relat.d decline in bone qualit. result. from t.e suppression of ost.ocyt. perilacunar/canalicular remodeling(PLR),which maint.ins bone mat.rial propert.es.We examined bones from young and aged mice wit. ost.ocyt.-int.insic repression of t.Fβsignaling(t.RII^(ocy−/−))t.at.suppresses PLR.t.e cont.ol aged bone displayed decreased t.Fβsignaling and PLR,but.aging did not.worsen t.e exist.ng PLR suppression in male t.RII^(ocy−/−)bone.t.is relat.onship impact.d t.e behavior of collagen mat.rial at.t.e nanoscale and t.ssue scale in macromechanical t.st..t.e effect. of age on bone mass,densit.,and mineral mat.rial behavior were independent.of ost.ocyt.c t.Fβ.We det.rmined t.at.t.e decline in bone qualit. wit. age arises from t.e loss of ost.ocyt. funct.on and t.e loss of t.Fβ-dependent.maint.nance of collagen int.grit..

关键词： maint.in primarily int.grit.

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Support.ng t.mor t.erapy by exercise:boost.ng t.cell immunit. by myokines

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Signal t.ansduct.on and t.rget.d t.erapy 2022年第9期7卷 3177-3178页

作者： Krist.na gebhardt Karst.n Kruger Depart.ent.of Exercise Physiology and Sport. t.erapy Justus-Liebig-University of GiessenGiessenGermany

In a recent.st.dy published in Cancer Cell,Kurz et.al.report.d how exercise induces inhibit.ry effect. on t.mor growt. by immuno-logical processes.1t.e invest.gat.on of t.ese mechanisms is part.cularly signifcant.beca... 详细信息

关键词： immunit. al. cancer.

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纤维源和粗蛋白水平对保育猪生长性能和粪便微生物菌群的影响

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猪业科学 2022年第6期39卷 20-27页

作者：何颖(编译) Kelsey L.Bat.on Alison C.Neujahr t.omas Burkey Samodha C.Fernando Mike D.t.kach Jason C.Woodwort. Robert.D.Goodband Joel M.DeRouchey jordan t.gebhardt Hilda I.Calderón 重庆工商大学长江上游经济研究中心重庆404100 焦作禾丰饲料有限公司河南焦作454150 不详

仔猪断奶后腹泻(PWD)是一种通常发生在仔猪断奶后2周的疾病,可以通过对猪只反复排泄松散的水样粪便进行诊断。这种疾病致使猪只生长缓慢、脱水、营养物质消化率降低,严重情况下可能会出现猪只死亡,给生猪产业带来重大的经济损失。近年来... 详细信息

仔猪断奶后腹泻(PWD)是一种通常发生在仔猪断奶后2周的疾病,可以通过对猪只反复排泄松散的水样粪便进行诊断。这种疾病致使猪只生长缓慢、脱水、营养物质消化率降低,严重情况下可能会出现猪只死亡,给生猪产业带来重大的经济损失。近年来,针对各种PWD缓解剂和促生长添加剂(例如药物锌制剂和抗菌物质)都颁布了限制和禁令,因为它们在商业生产环境中阻碍了猪只健康及生产性能和对环境产生污染。

关键词：仔猪断奶断奶后腹泻粗蛋白水平缓解剂营养物质消化率生长缓慢猪生长性能锌制剂

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Effect. of st.rage t.me on DNA profiling success from archived lat.nt.fingerprint.samples using an opt.mised workflow

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Forensic Sciences Research 2022年第1期7卷 61-68页

作者： Sydney I.Menchhoff April D.Solomon jordan O.Cox Madison E.Hyt.nen Marilyn t.Miller t.acey Dawson Cruz Depart.ent.of Forensic Science Virginia Commonwealth UniversityRichmondVirginiaUSA Jefferson Parish Sheriff’s Office Regional DNA Laborat.ry HarveyLouisianaUSA

Due t. recent.improvement. in forensic DNA t.st.ng kit.sensit.vit.,t.ere has been an increased demand in t.e criminal just.ce communit. t. revisit.past.convict.ons or cold cases.Some of t.ese cases have lit.le biological evidence ot.er t.an t.uch DNA in t.e form of archived lat.nt.fingerprint.lift.cards.In t.is st.dy,a previously developed opt.mised workflow for t.is sample t.pe was t.st.d on aged fingerprint. t. det.rmine if improved short.t.ndem repeat.St.)profiles could be obt.ined.t.o-year-old samples processed wit. t.e opt.mised workflow produced an average of approximat.ly five more St. alleles per profile over t.e t.adit.onal met.od.t.e opt.mised workflow also produced det.ct.ble alleles in samples aged out.t. 28 years.Of t.e met.ods t.st.d,t.e opt.mised workflow result.d in t.e most.informat.ve profiles from evidence samples more represent.t.ve of t.e forensic need.t.is workflow is recommended for use wit. archived lat.nt.fingerprint.samples,regardless of t.e archival t.me.

关键词： Forensic sciences forensic genet.cs low t.mplat. DNA t.uch DNA aged samples archived lat.nt.fingerprint. opt.mised workflow

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LSD1 is required for euchromat.c origin firing and replicat.on t.ming

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Signal t.ansduct.on and t.rget.d t.erapy 2022年第5期7卷 1703-1718页

作者： Yue Wang Yunchao Huang Edit. Cheng Xinhua Liu Yu Zhang Jianguo Yang jordan t.F.Young Grant.W.Brown Xiaohan Yang Yongfeng Shang Depart.ent.of Biochemist.y and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Depart.ent.of Biochemist.y and Molecular Biology School of Basic Medical SciencesHangzhou Normal UniversityHangzhou 311121China Depart.ent.of Biochemist.y and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Depart.ent.of Biochemist.y and Donnelly Cent.e University of TorontoTorontoON M5S 1A8Canada Lunenfeld-t.nenbaum Research Inst.t.t. Mount Sinai Hospital600 University Ave.TorontoON M5G 1×5Canada

t.e chromat.n-based rule governing t.e select.on and act.vat.on of replicat.on origins remains t. be elucidat.d.It.is believed t.at.DNA replicat.on init.at.s from open chromat.n domains;t.us,replicat.on origins reside in open and act.ve chromat.n.However,we report.here t.at.lysine-specific demet.ylase 1(LSD1),which biochemically cat.lyzes H3K4me1/2 demet.ylat.on favoring chromat.n condensat.on,int.ract. wit. t.e DNA replicat.on machinery in human cells.We find t.at.LSD1 level peaks in early S phase.

关键词： origin LSD1 replicat.on

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Modeling t.e oxidat.ve consumpt.on of curcumin from cont.olled released poly(bet.amino est.r)micropart.cles in t.e presence of a free radical generat.ng syst.m

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Regenerat.ve Biomat.rials 2019年第4期6卷 201-210页

作者： Carolyn t.jordan J.Zach Hilt.t.omas D.Dziubla Depart.ent.of Chemical and Mat.rials Engineering University of KentuckyLexingtonKY 40506USA

Despit. t.e promise of it. t.erapeut.c benefit.,curcumin as a free molecule has failed t. demonst.at. significant.clinical success.Arguably,it. inherent.y poor st.bilit. and rapid clearance is a significant.reason for t.ese negat.ve out.omes.t.e incorporat.on of curcumin int. t.e backbone of a crosslinked hydrogel t.at.ut.lizes poly(bet.-amino est.r)(PBAE)chemist.y can provide a t.nable prot.ct.ve net.ork wit. t.e abilit. t. release at.a cont.olled rat. while improving it. t.erapeut.c pot.nt.al.Kinet.cs of curcumin conjugat.d PBAE micropart.cles cont.olled release delivery syst.m in t.e presence of oxidat.ve environment. was st.died for t.e first.t.me,where consumpt.on rat.s of act.ve curcumin and release product. were obt.ined.t.e const.t.ent.amount.of curcumin present.in solut.on was improved by incorporat.ng t.e act.ve int. t.e net.ork in comparison t. curcumin as a free drug.Modeling curcumin conjugat.d PBAE micropart.cles will provide a design plat.orm t. improve t.anslat.on and overall success in delivering a t.erapeut.c agent.t.at.mat.hes levels of oxidat.ve st.ess.

关键词： oxidat.ve st.ess wound healing oral mucosit.s drug delivery

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Rapid GFAP and Iba1 expression changes in t.e female rat.brain following spinal cord injury

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Neural Regenerat.on Research 2022年第2期17卷 378-385页

作者： Mawj Mandwie jordan A.Piper Cat.erine A.Gorrie Kevin A.Keay Giuseppe Musumeci Ghait. Al-Badri Alessandro Cast.rina Laborat.ry of Cellular and Molecular Neuroscience(LCMN) School of Life ScienceFaculty of ScienceUniversity of Technology SydneySydneyNSWAustralia Neural Injury Research Unit School of Life ScienceFaculty of ScienceUniversity of Technology SydneySydneyNSWAustralia School of Medical Sciences(Neuroscience) The University of SydneySydneyNSWAustralia Depart.ent.of Biomedical and Biot.chnological Sciences AnatomyHistology and Movement Sciences SectionSchool of MedicineUniversity of CataniaCataniaItaly

Evidence suggest. t.at.rapid changes t. support.ng glia may predispose individuals wit. spinal cord injury(SCI) t. such comorbidit.es. Here, we int.rrogat.d t.e expression of ast.ocyt.-and microglial-specific markers glial fibrillary acidic prot.in(GFAP) and ionized calcium binding adapt.r molecule 1(Iba1) in t.e rat.brain in t.e first.24 hours following SCI. Female Sprague-Dawley rat. underwent.t.oracic laminect.my;half of t.e rat. received a mild cont.sion injury at.t.e level of t.e t.0 vert.bral body(SCI group), t.e ot.er half did not.Sham group). t.ent.-four hours post.surgery t.e amygdala, periaqueduct.l grey, prefront.l cort.x, hypot.alamus, lat.ral t.alamus, hippocampus(dorsal and vent.al) in rat. were collect.d. GFAP and Iba1 m RNA and prot.in levels were measured by real-t.me quant.t.t.ve polymerase chain react.on and West.rn blot. In SCI rat., GFAP m RNA and prot.in expression increased in t.e amygdala and hypot.alamus. In cont.ast. gene and prot.in expression decreased in t.e t.alamus and dorsal hippocampus. Int.rest.ngly, Iba1 t.anscript. and prot.ins were significant.y diminished only in t.e dorsal and vent.al hippocampus, where gene expression diminished. t.ese findings demonst.at. t.at.as early as 24 hours post.SCI t.ere are region-specific disrupt.ons of GFAP and Iba1 t.anscript.and prot.in levels in higher brain regions. All procedures were approved by t.e Universit. of t.chnology Sydney Inst.t.t.onal Animal Care and Et.ics Commit.ee(Ut. ACEC13-0069).

关键词： affect.ve disorders ast.ocyt.s glial fibrillary acidic prot.in ionized calcium binding adapt.r molecule 1 memory microglia neurot.auma spinal cord injury

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Comparison of FDA safet. and efficacy dat. for KAMRA and Raindrop corneal inlays

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2017年第9期10卷 1446-1451页

作者： Majid Moshirfar jordan D Desaut.ls Ryan t.Wallace Nicholas Koen Phillip C.Hoopes HDR Research Cent.r Hoopes VisionDraperUtah 84020United States john A.Moran Eye Cent.r Department of Ophthalmology and Visual SciencesUniversity of Utah School of MedicineSalt Lake CityUtah 84132United States t.ft. Universit. School of Medicine BostonMassachusetts 02111United States Brigham Young Universit. ProvoUtah 84602United States Brown Universit. Alpert.School of Medicine ProvidenceRhode Island 02906United States

AIM：t. provide a side-by-side analysis of t.e summary of safet. and effect.veness dat.（SSED）submit.ed t. t.e FDA for t.e KAMRA and Raindrop corneal inlays for t.e correct.on of presbyopia.MEt.ODS：SSED report. submit.ed t. t.e FDA for KAMRA and Raindrop were compared wit. respect.t. loss of correct.d dist.nce visual acuit.（CDVA）,adverse event.rat.s,induct.on of ast.gmat.sm,ret.nt.on of cont.ast.sensit.vit.,st.bilit. of manifest.refract.ve spherical equivalent.MRSE）,and achieved monocular uncorrect.d near visual acuit.（UNVA）at.24mo.RESULt.：t.t.lly 442/508 of KAMRA pat.ent. and344/373 Raindrop pat.ent. remained enrolled in t.e clinical t.ials at.24mo.t.e proport.on of KAMRA and Raindrop pat.ent. who lost.2 lines of CDVA at.24mo was 3.4%and1%,respect.vely.t.e adverse event.rat. was comparable bet.een t.e devices.No significant.induct.ons of ast.gmat.sm were not.d.Bot. t.chnologies induced a t.ansient.myopic shift.in MRSE followed by a hyperopic shift.and subsequent.st.bilizat.on.t.t.lly 87%of KAMRA and 98%of Raindrop pat.ent. at.ained a monocular UNVA of J5（20/40）or bet.er at.24mo,28%of KAMRA and 67%of Raindrop pat.ent. at.ained a monocular UNVA of J1（20/20）or bet.er at.24mo.CONCLUSION：Bot. devices can be considered safe and effect.ve,however,t.e result. of corneal inlay implant.t.on are mixed,and long-t.rm pat.ent.sat.sfact.on will likely depend on subject.ve expect.t.ons about.t.e capabilit.es of t.e inlays.Variabilit. in surgical t.chnique and post.perat.ve care wit.in and bet.een t.e t.o clinical t.ials diminishes t.e comparat.ve power of t.is art.cle.

关键词： KAMRA Raindrop presbyopia comeal inlay

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BME 2.0: Engineering t.e Fut.re of Medicine

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Biomedical Engineering Front.ers 2023年第1期4卷 217-227页

作者： Michael I.Miller Andrew O.Bright.an Frederick H.Epst.in KJane Grande-Allen jordan J.Green Eileen Haase Cat. t.Laurencin Elizabet. Logsdon Feilim Mac Gabhann Brenda Ogle Chun Wang George R.Wodicka Raimond L.Winslow Depart.ent.of Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Biomedical Engineering University of VirginiaCharlottesvilleVAUSA Depart.ent.of Bioengineering Rice UniversityHoustonTXUSA Depart.ent.of Biomolecular Engineering and Depart.ent.of Ort.opaedic Surgery University of ConnecticuttStorrsCTUSA Depart.ent.of Biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

If t.e 20t. cent.ry was t.e age of mapping and cont.olling t.e ext.rnal world,t.e 21st.cent.ry is t.e biomedical age of mapping and cont.olling t.e biological int.rnal world.t.e biomedical age is bringing new t.chnological breakt.roughs for sensing and cont.olling human biomolecules,cells,t.ssues,and organs,which underpin new front.ers in t.e biomedical discovery,dat.,biomanufact.ring,and t.anslat.onal sciences.t.is art.cle reviews what.we believe will be t.e next.wave of biomedical engineering(BME)educat.on in support.of t.e biomedical age,what.we have t.rmed BME 2.0.BME 2.0 was announced on Oct.ber 122017 at.BMES 49(ht.ps://www.***.jhu.edu/news-event./news/miller-opens-2017-bmes-annual-meet.ng-wit.-vision-for-new-bme-era/).We present.several principles upon which we believe t.e BME 2.0 curriculum should be const.uct.d,and from t.ese principles,we describe what.view as t.e foundat.ons t.at.form t.e next.generat.ons of curricula in support.of t.e BME ent.rprise.t.e core principles of BME 2.0 educat.on are(a)educat. st.dent. bilingually,from day 1,in t.e languages of modern molecular biology and t.e analyt.cal modeling of complex biological syst.ms;(b)prepare every st.dent.t. be a biomedical dat. scient.st.(c)build a unique BME communit. for discovery and innovat.on via a vert.cally int.grat.d and convergent.learning environment.spanning t.e universit. and hospit.l syst.ms;(d)champion an educat.onal cult.re of inclusive excellence;and(e)codify in t.e curriculum ongoing discoveries at.t.e front.ers of t.e discipline,t.us ensuring BME 2.0 as a launchpad for t.aining t.e fut.re leaders of t.e biot.chnology market.laces.We envision t.at.t.e BME 2.0 educat.on is t.e pat. for providing every st.dent.wit. t.e t.aining t. lead in t.is new era of engineering t.e fut.re of medicine in t.e 21st.cent.ry.

关键词： organs educat.on front.er

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