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17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

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Acta Pharmaceutica Sinica B 2016年第5期6卷 504-509页

作者： Sung-joon Cho Miaoran Ning Yanyan Zhang Leah H.Rubin Hyunyoung jeong Department of Biopharmaceutical Sciences College of PharmacyUniversity of Illinois at Chicago Department of Pharmacy Practice College of PharmacyUniversity of Illinois at Chicago Department of Psychiatry University of Illinois at Chicago

UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous *** data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users,but the role of estrogen in the regulation of UGT1A9 expression remains *** this study,we investigated the effect of 17β-estradiol(E2) on UGT1A9 expression and the role of ERα in the transcriptional regulation of UGT1A9.E2 significantly increased UGT1A9 promoter activity in Hep G2 cells in the presence of ERα.UGT1A9 induction by E2 was abrogated by antiestrogen ICI182,780 in Hep G2 cells that constitutively express ERα.Results from transient transfection of ERα mutants into Hep G2 cells demonstrated that mutation at DNA-binding domain of ERα abrogates increased UGT1A9 promoter activity by *** and mutation assays of UGT1A9 promoter revealed a putative ERE located within -2262/-1987 *** of healthy human liver tissues revealed significantly higher UGT1A9 expression in women as compared to ***,these findings provide a mechanistic basis for the previous clinical reports and may shed a light on identifying sources for inter-individual variability in UGT1A9-mediated drug metabolism.

关键词： UGT1A9 17β-Estradiol Estrogen receptor Drug metabolism Sex difference

Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases

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Cellular & Molecular Immunology 2018年第12期15卷 1085-1087页

作者： Hyo jeong Kim Yeonsoo Joe Young-joon Surh Hun Taeg Chung Department of Biological Sciences University of UlsanUlsanSouth Korea Tumor Microenvironment Global Core Research Center Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoulSouth Korea

Immunometabolism is the intersection of immunology and *** heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory *** we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.

关键词： system monoxide oxidative

An Efficient and Spam-Robust Proximity Measure Between Communication Entities

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Journal of Computer Science & Technology 2013年第2期28卷 394-400页

作者： Joo Hyuk Jeon Jihwan Song jeong Eun Kwon Yoon joon Lee Man Ho Park Myoung Ho Kim Department of Computer Science Korea Advanced Institute of Science and Technology Biz Solution Team SK Telecom Information Technology R&D Center Mobile Communication Convergence Research Team Electronics and Telecommunications Research Institute

Electronic communication service providers are obliged to retain communication data for a certain amount of time by their local laws. The retained communication data or the communication logs are used in various applications such as crime detection, viral marketing, analytical study, and so on. Many of these applications rely on effective techniques for analyzing communication logs. In this paper, we focus on measuring the proximity between two communication entities, which is a fundamental and important step toward further analysis of communication logs, and propose a new proximity measure called ESP （Efficient and Spam-Robust Proximity measure）. Our proposed measure considers only the （graph- theoretically） shortest paths between two entities and gives small values to those between spam-like entities and others. Thus, it is not only computationally efficient but also spam-robust. By conducting several experiments on real and synthetic datasets, we show that our proposed proximity measure is more accurate, computationally efficient and spam-robust than the existing measures in most cases.

关键词： proximity closeness spam electronic communication

Precise control of surface oxygen vacancies in ZnO nanoparticles for extremely high acetone sensing response

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Journal of Advanced Ceramics 2022年第5期11卷 769-783页

作者： Jihyun LEE Youngmoon CHOI Byoung joon PARK jeong Woo HAN Hyun-Sook LEE Jong Hyeok PARK Wooyoung LEE Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biological Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea

ZnO has been studied intensely for chemical sensors due to its high sensitivity and fast ***,we present a simple approach to precisely control oxygen vacancy contents to provide significantly enhanced acetone sensing performance of commercial ZnO nanopowders.A combination of H_(2)O_(2)treatment and thermal annealing produces optimal surface defects with oxygen vacancies on the ZnO nanoparticles(NPs).The highest response of~27,562 was achieved for 10 ppm acetone in 0.125 MH_(2)O_(2)treated/annealed ZnO NPs at the optimal working temperature of 400℃,which is significantly higher than that of reported so far in various acetone sensors based on metal oxide semiconductors(MOSs).Furthermore,first-principles calculations indicate that pre-adsorbed O formed on the surface of H_(2)O_(2)treated ZnO NPs can provide favorable adsorption energy,especially for acetone detection,due to strong bidentate bonding between carbonyl C atom of acetone molecules and pre-adsorbed O on the ZnO *** study demonstrates that controlling surface oxygen vacancies by H_(2)O_(2)treatment and re-annealing at optimal temperature is an effective method to improve the sensing properties of commercial MOS materials.

关键词： gas sensors acetone metal oxide semiconductors(MOSs) ZnO nanoparticles(NPs) H_(2)O_(2)treatment

Relation between preoperative hyperopia and surgical outcome in infantile esotropia

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1963-1967页

作者： Haeng Jin Lee jeong-Ah Kim Seong-joon Kim Young Suk Yu Department of Ophthalmology Seoul National University College of Medicine Seoul Artificial Eye Center Seoul National University Hospital Clinical Research Institute

AIM: To evaluate the relation between preoperative hyperopia and surgical outcomes of infantile esotropia in patients younger than 24 months of ***: Medical records of patients who underwent bilateral medial rectus muscle recession for infantile esotropia between November 1, 2002 and December 1, 2011 were retrospectively reviewed. Patients were divided into two groups according to the degree of preoperative hyperopia. Group I had less than +3.0 diopter(D) of hyperopia and group II had between +3.0 and +5.0 D of hyperopia. Postoperative alignments were evaluated 1 wk, 3, 6 mo, and 1 y after surgery. Following the 1-year postoperative visit, patients were monitored yearly. Relationships between preoperative factors including hyperopia and postoperative outcomes were evaluated. RESULTS: Forty-six patients were included, with 33 patients in group I and 13 patients in group II. The preoperative mean refractive error was +0.88 D in group I and +3.45 D in group II. Surgical outcomes were not significantly different between groups at any postoperative time point examined. Cumulative probability of surgical success, prevalence of inferior oblique overaction, dissociated vertical deviation, and re-operation rate were not significantly different between ***: Preoperative moderate hyperopia(less than +5.0 D) did not affect the surgical outcome of infantile esotropia. Therefore, the surgical correction of esotropia should be considered when the angle of esodeviation is unchanged following hyperopia correction, even in children with moderate hyperopia.

关键词： infantile esotropia hyperopia medial rectus muscle recession

Improved formaldehyde gas sensing properties of well-controlled Au nanoparticle-decorated In2O3 nanofibers integrated on low power MEMS platform

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Journal of Materials Science & Technology 2020年第3期38卷 56-63页

作者： Dongha Im Donghyun Kim Dasol jeong Woon Ik Park Myoungpyo Chun joon-Shik Park Hyunjung Kim Hyunsung Jung Nano Materials&Nano Technology Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Department of Mineral Resources and Energy Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Smart Sensor Research Center Korea Electronic Technology InstituteSeongnam 13509Republic of Korea

Approaches for the fabrication of a low power-operable formaldehyde(HCHO)gas sensor with high sensitivity and selectivity were performed by the utilization of an effective micro-structured platform with a micro-heater to reach high temperature with low heating power as well as by the integration of indium oxide(In2O3)nanofibers decorated with well-dispersed Au nanoparticles as a sensing *** In2O3 nanofibers with the large specific surface area were prepared by the electrospinning following by calcination *** nanoparticles with the well-controlled size as a catalyst were synthesized on the surface of In2O3 *** Au-decorated In2O3 nanofibers were reliably integrated as sensing materials on the bridge-type micro-platform including micro-heaters and *** micro-platform designed to maintain high temperature with low power consumption was fabricated by a microelectromechanical system(MEMS)*** micro-platform gas sensor consisting with Au-In2O3 nanofibers were fabricated effectively to detect HCHO gases with high sensitivity and *** HCHO gas sensing behaviors were schematically studied as a function of the gas concentration,the size of the adsorbed Au nanoparticles,the applied power to raise the temperature of a sensing part and the kind of target gases.

关键词： Gold nanoparticle In2O3 nanofiber Formaldehyde Gas sensor Low power Micro-platform

Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B9期19卷 271-275页

作者： jeong-Soo LEE Young-Soo RYU Nam-In KIM Bong-joon KIM Yoo-Kyung KIM Myung-Hyun KIM Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

Management of the complications of endoscopic submucosal dissection

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World Journal of Gastroenterology 2011年第31期17卷 3575-3579页

作者： Seong Hwan Kim jeong Seop Moon Young Hoon Youn Ki Myung Lee Sung joon Lee Division of Gastroenterology Department of Internal MedicineEulji University Division of Gastroenterology Department of Internal MedicineInje UniversitySeoul Paik Hospital Division of Gastroenterology Department of Internal MedicineYonsei University-ang Nam Severance Hospital Division of Gastroenterology Department of Internal MedicineAjou University Hospital Division of Gastroenterology Department of Internal Medicineang-on University Hospital

Endoscopic submucosal dissection(ESD) is currently widely accepted as a standard treatment option for early gastrointestinal neoplasms in ***,ESD has technical difficulties and a longer procedure time than conventional endoscopic *** it may have a higher risk of complications than conventional endoscopic resection ***,the ESD study group of Korean Society of Gastrointestinal Endoscopy,have experienced many complications,mostly treated by endoscopic or conservative ***,we introduce and share our experiences for managementof post ESD complications and review published papers on the topic.

关键词： Endoscopic submucosal dissection Complication Management

Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation

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World Journal of Gastroenterology 2015年第47期21卷 13360-13367页

作者： Hong Kim Seok-Hyun Hong Seoung-Ae Lee jeong-Ryeol Gong Bum-joon Kim Department of Biomedical Sciences Microbiology and Immunology and Liver Research Institute Seoul National University College of Medicine

AIM: To develop a Fok-I nested polymerase chain reaction(PCR)-restriction fragment length polymorphism analysis(PRA) method for the detection of hepatitis B virus X region(HBx) V5 M ***: Nested PCR was applied into DNAs from 198 chronic patients at 2 different stages [121 patients with hepatocellular carcinoma(HCC) and 77 carrier patients]. To identify V5 M mutants, digestion of nested PCR amplicons by the restriction enzyme Fok-I(GGA TGN9↓) was done. For size comparison, the enzymetreated products were analyzed by electrophoresis on 2.5% agarose gels, stained with ethidium bromide, and visualized on a UV ***: The assay enabled the identification of 69 patients(sensitivity of 34.8%; 46 HCC patients and 23 carrier patients). Our data also showed that V5 M prevalence in HCC patients was significantly higher than in carrier patients(47.8%, 22/46 patients vs 0%, 0/23 patients, P < 0.001), suggesting that HBx Ag V5 M mutation may play a pivotal role in HCC generation in chronic patients with genotype C ***: The Fok-I nested PRA developed in this study is a reliable and cost-effective method to detect HBx Ag V5 M mutation in chronic patients with genotype C2 infection.

关键词： Hepatitis B virus X antigen Polymerasechain reaction-restriction fragment length polymorphismanalysis V5M mutation Hepatocellur carcinoma