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Iodized oil uptake assessment with cone-beam CT in chemoembolization of small hepatocellular carcinomas

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World Journal of Gastroenterology 2009年第46期15卷 5833-5837页

作者： Ung Bae Jeon Jun Woo Lee Ki Seok Choo Chang Won Kim Suk Kim Tae Hong Lee yeon joo Jeong Dae Hwan Kang Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Pusan National University Hospital Department of Internal Medicine Pusan National University Yangsan Hospital

AIM:To evaluate the utility of assessing iodized oil uptake with cone-beam computed tomography(CT)in transarterial chemoembolization(TACE)for small he-patocellular carcinoma(HCC).METHODS:Cone-beam CT provided by a biplane flat-panel detector angiography suite was performed on eighteen patients(sixteen men and two women;41-76 years;mean age,58.9 years)directly after TACE for small HCC(26 nodules under 30 mm;mean diam-eter,11.9 mm;range,5-28 mm).The pre-procedural locations of the tumors were evaluated using tripha-sic multi-detector row helical computed tomography(MDCT).The tumor locations on MDCT and the iodized oil uptake by the tumors were analyzed on cone-beam CT and on spot image directly after the ***:All lesions on preprocedural MDCT were de-tected using iodized oil uptake in the lesions on cone-beam CT(sensitivity 100%,26/26).Spot image depictediodized oil uptake in 22 of the lesions(sensitivity 85%).The degree of iodized oil uptake was overestimated(9%,2/22)or underestimated(14%,3/22)on spot image in f ive nodules compared with that of cone-beam ***:Cone-beam CT is a useful and conve-nient tool for assessing the iodized oil uptake of small hepatic tumors(< 3 cm)directly after TACE.

关键词： Chemoembolization Computed tomography Hepatocellular carcinoma Liver

Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： Jeong Suk Koh Yoon joo Kim Da Hyun Kang Jeong Eun Lee song-I Lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

Fabrication and Gas Response Characteristics of Metal Semiconductor Nanostructures Grown by Ambient Pressure

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稀有金属材料与工程 2006年第A3期35卷 182-184页

作者： Sang-Rok Lee Kap-Duk song Yang-Rye Lim Byung-Su joo Myoung-Ho Sohn Duk-Dong Lee School of Electronic Engineering & Computer Science Sankyuk-Dong 1370Bukgu Daegu 702-701Korea Department of Sensor and Display engineering Sankyuk-Dong 1370Bukgu Daegu 702-701Korea

SnO_2 nanowires and ZnO nanorods were grown on the surface of thin film by heat treatment of mental Sn and Zn under Ar gas flow and O_2 atmospheric *** sensitivity of the SnO_2 thin film device on which grown nanowires to CO gas(concentration of 5000μg/g)was 50% at the operating temperature of 200℃.In case of using Pt as catalysts,the sensitivity was enhanced and operating temperature was reduced(sensitivity of 70% at the operating temperature of 150℃). The sensitivity of the ZnO nanorods device using Cu as catalysts to NO_x gas was 90% at the operating temperature of 200℃.It was found that the sensitivity to CO and NO_x gases for the device on which grown nanostructures was much higher than those for general thin films devices.

关键词： SnO2 nanowires ZnO nanorods CO NO_x

A New Efficient Synthetic Method for 3-1odothyronamine and Its Potent Hypothermic Efficacy

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Chinese Journal of Chemistry 2011年第10期29卷 2205-2208页

作者： Kim, joong-Gon song, Young-Kyu Jeon, Su-yeon Lim, Ye-Ji Ju, Hyunwo Choi, Inho Chung, Chan-Moon Biotechnology Division Hanwha Chemical R＆D Center Daejeon 305-345 Korea Department of Chemistry and Medical Chemistry Yonsei University Wonju Gangwon-do 220- 710 Korea Department of Biological Science and Technology Yonsei University Wonju Gangwon-do 220-710 Korea

We developed a new efficient synthetic method for a 3-iodothyronamine （TjAM） that has advantages of less synthetic steps and much higher overall yield compared to those in the conventional method. Our animal study s... 详细信息

关键词： 3-iodothyronamine hibernation-like state ICR mouse

Intra and extra pelvic multidisciplinary surgical approach of retroperitoneal sarcoma:Case series report

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World Journal of Clinical Cases 2022年第27期10卷 9693-9702页

作者： Heekyoung song Jung Hwan Ahn Yuyeon Jung Jae yeon Woo Jimin Cha Yang-Guk Chung Keun Ho Lee Department of Obstetrics and Gynecology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Obstetrics and Gynecology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Orthopaedic Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Retroperitoneal sarcoma(RPS) is a rare malignancy arising from mesenchymal cells that most commonly presents as an abdominal mass and is associated with poor *** several studies have assessed the survival benefits of wide excision,few have reported detailed methods for achieving wide excision in patients with *** To describe our experience with multidisciplinary surgical resection of RPS using intra-and extra-pelvic *** Multidisciplinary surgery is an anatomical approach that combines intra-and extra-peritoneal access within the same surgery to achieve complete RPS *** retrospective review of the records of patients who underwent multidisciplinary surgery for RPS analyzed surgical and survival *** Eight patients underwent 10 intra-and extra-pelvic surgical resections,and their median mass size was 12.75 cm(range,6-45.5 cm).Using an intrapelvic approach,laparoscopy-assisted surgery was performed in four cases and laparotomy surgery in *** an extrapelvic approach,ilioinguinal and posterior approaches were used in four cases each,and the prone position and midline skin incision were shared in *** patients’ RPS masses were removed completely,and four achieved R0 resection through intra-and extra-pelvic *** median estimated blood loss was 2000 m L(range,300-20000 m L) and the median hospitalization was 12.6 d(range,9-69 d).Reoperation was needed in two patients(one for wound necrosis and the other for bowel perforation and wound necrosis).The median overall survival rate and median progression-free survival were 64.6 and 13.7 mo,*** RPS is therapeutically challenging because of its location and high risk of ***,intra-and extra-pelvic surgical approaches can improve the macroscopic security of the surgical margin.

关键词： Margins of excision Retroperitoneal neoplasms Sarcoma

Male metaplastic breast cancer with poor prognosis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4964-4970页

作者： Hyun Yul Kim Seungju Lee Dong-il Kim Chang Shin Jung Jee yeon Kim Kyung Jin Nam Ki Seok Choo Youn joo Jung Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Pathology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Radiology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast *** constitute less than 1%of breast cancer cases and are much rarer in *** are few reports of MBC because of its ***,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor *** SUMMARY We report a case of MBC in a 78-year-old *** visited our clinic with a palpable mass on the left breast with no masses in the axillary *** had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of *** breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower *** patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung *** mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was ***,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial *** MBC is an aggressive and extremely rare breast cancer *** case reports are needed to determine the optimal treatment.

关键词： Breast neoplasm Male Triple-negative breast cancer Metaplastic breast cancer Adjuvant treatment Case report

Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia

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Neural Regeneration Research 2014年第9期9卷 912-918页

作者： Seung song Jong-Tae Park joo Young Na Man-Seok Park Jeong-Kil Lee Min-Cheol Lee Hyung-Seok Kim Department of Forensic Medicine Chonnam National University Medical School Department of Neurology Chonnam National University Medical School Department of Neurosurgery Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Endogenous neural stem cells become ＂activated＂ after neuronal injury, but the activation sequence and fate of endogenous neural stem cells in focal cerebral ischemia model are little known. We evaluated the relationships between neural stem cells and hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a photothromobotic rat stroke model using immunohistochemistry and western blot analysis. We also evaluated the chronological changes of neural stem cells by 5-bromo-2′-deoxyuridine（BrdU） incorporation. Hypoxia-inducible factor-1α expression was initially increased from 1 hour after ischemic injury, followed by vascular endothelial growth factor expression. Hypoxia-inducible factor-1α immunoreactivity was detected in the ipsilateral cortical neurons of the infarct core and peri-infarct area. Vascular endothelial growth factor immunoreactivity was detected in bilateral cortex, but ipsilateral cortex staining intensity and numbers were greater than the contralateral cortex. Vascular endothelial growth factor immunoreactive cells were easily found along the peri-infarct area 12 hours after focal cerebral ischemia. The expression of nestin increased throughout the microvasculature in the ischemic core and the peri-infarct area in all experimental rats after 24 hours of ischemic injury. Nestin immunoreactivity increased in the subventricular zone during 12 hours to 3 days, and prominently increased in the ipsilateral cortex between 3–7 days. Nestin-labeled cells showed dual differentiation with microvessels near the infarct core and reactive astrocytes in the peri-infarct area. BrdU-labeled cells were increased gradually from day 1 in the ipsilateral subventricular zone and cortex, and numerous BrdU-labeled cells were observed in the peri-infarct area and non-lesioned cortex at 3 days. BrdU-labeled cells rather than neurons, were mainly co-labeled with nestin and GFAP. Early expressions of hypoxia-inducible factor-1α and vascular endothelial gr

关键词： nerve regeneration brain ischemia neural stem cell neural precursor cell hypoxia-inducible factor 1α vascular endothelial growth factor microenvironment photothrombosis neural regeneration

Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 2032-2041页

作者： Ji Hyeong song Tae Jeong Oh Sungwhan An Kyung Ha Lee Ji yeon Kim Jin Soo Kim Department of Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Genomictree Inc.Daejeon 34027South Korea Department of Surgery College of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Early detection of colorectal cancer(CRC)is essential to reduce cancer-related morbidity and *** DNA(sDNA)testing is an emerging method for early CRC ***-2(SDC2)methylation is a potential biomarker for the sDNA *** DNA methylation is an early epigenetic event during tumorigenesis and can occur in the normal colonic mucosa during aging,which can compromise the sDNA test *** In this prospective study,we enrolled 151 patients with CRC who underwent curative surgical resection between September 2016 and May *** stool samples were collected from 123 patients and postoperative samples were collected from 122 patients.A total of 104 samples were collected from both preoperative and postoperative *** promoter methylation of SDC2 in sDNA was assessed using linear target enrichment quantitative methylation-specific real-time polymerase chain *** parameters were analyzed using the results of SDC2 *** Detection rates of SDC2 methylation in the preoperative and postoperative stool samples were 88.6%and 19.7%,*** tumor size(3 cm,P=0.019)and advanced T stage(T3–T4,P=0.033)were positively associated with the detection rate of SDC2 methylation before *** sex was associated with false positives after surgery(P=0.030).Cycle threshold(CT)values were significantly decreased postoperatively compared with preoperative values(P<0.001).The postoperative negative conversion rate for preoperatively methylated SDC2 was 79.3%(73/92).CONCLUSION Our results suggested that the SDC2 methylation test for sDNA has acceptable sensitivity and ***,small size and early T stage tumors are associated with a low detection rate of SDC2 *** the cycle threshold values significantly decreased after surgery,SDC2 methylation test for sDNA might have a diagnostic value for CRC.

关键词： Biomarkers DNA methylation Syndecan-2 Colorectal cancer

Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis

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World Journal of Gastroenterology 2012年第22期18卷 2837-2843页

作者： Seung joo Kang Ji Won Kim Jee Hyun Baek Se Hyung Kim Byeong Gwan Kim Kook Lae Lee Ji Bong Jeong Yong Jin Jung joo Sung Kim Hyun Chae Jung In Sung song Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Boramae Hospital Department of Radiology Seoul National University College of Medicine

AIM： To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis （TBP） and peritoneal carcinoma- tosis （PC）. METHODS： A retrospective analysis of data was per- formed on consecutive patients who underwent perito- neoscopic and abdominal computed tomography （CT） evaluations. Among 75 patients at the Seoul National University Hospital from January 2000 to June 2010 who underwent both tests, 27 patients （36.0%） and 25 patients （33.3%） were diagnosed with TBP and PC, re- spectively. Diagnosis was confirmed by peritoneoscopic biopsy. RESULTS： Serum c-reactive protein （7.88：1：6.62 mg/ dL vs 3.12 ＋ 2.69 mg/dL, P = 0.01）, ascites adenos- ine deaminase （66.76：1：32.09 IU/L vs 13.89 ：l： 8.95 IU/L, P 〈 0.01）, ascites lymphocyte proportion （67.77 ：1： 23.41% vs 48.36 ＋ 18.78%, P 〈 0.01）, and serum- ascites albumin gradient （0.72 ＋ 0.49 g/dL vs 1.05 ＋ 0.50 g/dL, P = 0.03） were significantly different be- tween the two groups. Among tumor markers, serum and ascites carcinoembryonic antigen, serum carbohy- drate antigen 19-9 showed significant difference be- tween two groups. Abdominal CT examinations showed that smooth involvement of the parietal peritoneum was more common in the TBP group （77.8% vs 40.7%） whereas nodular involvement was more common in the PC group （14.8% vs 40.7%, P = 0.04）. From receiver operating characteristic （ROC） curves ascites adeno- sines deaminase （ADA） showed better discriminative capability than tumor markers. An ADA cut-off level of 21 IU/L was found to yield the best results of differ- ential diagnosis; sensitivity, specificity, positive predic- tive value, and negative predictive value were 92.0%, 85.0%, 88.5% and 89.5%, respectively. CONCLUSION： Besides clinical and radiologic findings, ascitic fluid ADA measurement is helpful in the differen- tial diagnosis of TBP and PC.

关键词： Tuberculous peritonitis Peritoneal carcino-matosis, Adenosine deaminase, Peritoneoscopy