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Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2311-2314页

作者： Yan-Hong Cui Jae-Hyeok Kang Yongjoon Suh yi Zhao joo mi yi In-Hwa Bae Hae-June Lee Dong Won Park min-Jung Kim Su-Jae Lee Department of Life Science Research Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Medicine Section of DermatologyUniversity of ChicagoChicagoILUSA Department of microbiology and Immunology Inje UniversityBusanSouth Korea Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical SciencesSeoulKorea Division of Radiation Effect Korea Institute of Radiological and Medical SciencesSeoulKorea Department of Internal Medicine College of MedicineHanyang UniversitySeoulKorea Laboratory of Radiation Exposure and Therapeutics National Radiation Emergency Medical CenterKorea Institute of Radiological and Medical SciencesSeoulKorea

Dear Editor,Lung cancer is the most common cause of cancer-related mortality worldwide,with non-small cell lung cancer(NSCLC)accounting for the largest number of cases.1 Ionizing radiation(IR)is widely used as an indispensable tool for treating lung cancer patients;however,the acquisition of resistance following radiation is the major obstacle for reducing the efficacy of radiotherapy.

关键词： lung cancer mortality

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中华文化生命体的特征探析

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 122-127页

作者：秘天一新疆大学马克思主义学院新疆乌鲁木齐830046

中华文化生命体呈现对环境刺激的反应、生长发育、新陈代谢、自我调节和超脱自然选择等特征,具有整体性、连贯性、创新性、开放性与和平性特质。整体性和连贯性确保中华文化在数千年发展中的赓承延续与稳定,通过“天人合一”“和而不同... 详细信息

中华文化生命体呈现对环境刺激的反应、生长发育、新陈代谢、自我调节和超脱自然选择等特征,具有整体性、连贯性、创新性、开放性与和平性特质。整体性和连贯性确保中华文化在数千年发展中的赓承延续与稳定,通过“天人合一”“和而不同”实现内在和谐统一;创新性使中华文化在历史长河中保持强大的生长力,推动中华优秀传统文化现代转型,实现马克思主义中国化的新飞跃;开放性增强了中华文化的适应性和生命力,通过吸收和融合外来优秀文化元素,使中华文化在全球化进程中保持独特性和竞争力,并以开放姿态积极借鉴吸收人类文明一切优秀成果,推动文化守正创新;和平性源于对和谐、和合文化的深刻理解,强调和谐共生、和合共在、和平发展,通过对话与合作解决争端。中华文化生命体在全球化背景下展现出独特的现代价值和全球视野,彰显了中华文化的强大生命力和国际影响力。

关键词：习近平文化思想中华文化生命体两个结合文化新使命中华优秀传统文化

Prostate only radiotherapy using external beam radiotherapy:A clinician’s perspective

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World Journal of Clinical Cases 2022年第29期10卷 10428-10434页

作者： Jeong Won Lee mi joo Chung Department of Radiation Oncology Daegu Catholic University School of MedicineDaegu 42472South Korea Department of Radiation Oncology Hanyang University Hanmaeum Changwon HospitalChangwon 51139South Korea

Prostate-only radiotherapy(PORT) is widely used as the definitive treatment for localized prostate *** cancer has an α/β ratio;therefore,radiotherapy(RT) with a large fraction size is biologically effective for tumor *** current external beam RT technique for PORT has been improved from threedimensional conformal RT to intensity-modulated,stereotactic body,and imageguided *** methods are associated with reduced radiation exposure to normal tissues,decreasing urinary and bowel *** trials have shown improved local control with dose escalation through the aforementioned methods,and the efficacy and safety of intensity-modulated and stereotactic body RTs have been ***,the management of RT in patients with prostate cancer has not been fully *** a clinician,there are several concerns regarding the RT volume and dose considering the patient’s age and ***,this review aimed to discuss the radiobiological basis and external beam technical advancements in PORT for localized prostate cancer from a clinician’s perspective.

关键词： Prostate cancer Radiotherapy Radiation dose Radiation technique Radiation volume

Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： mi-Young Kim Jun-Hyung Cho joo Young Cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

Diffusion Mode Transition between Gaussian and Non-Gaussian of Nanoparticles in Polymer Solutions

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Chinese Journal of Polymer Science 2019年第7期37卷 719-728页

作者： yi Ye Han Qin ming Tian Jian-Guo mi State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing 100029 China

The dynamic density functional theory is applied to study the diffusion of nanoparticles in polymer solutions, in which different diffusion modes have been identified by exploiting the density and free energy evolutions. Under the condition of low polymer concentration, diffusion is controlled by particle free motion with a normal Gaussian type. As the concentration increases, the non- Gaussian behavior can be observed when the particle size is comparable to the correlation length of polymer chain. Particles need to penetrate through a cage and overcome an entropic barrier, where the hopping and the model-coupling diffusion coexist. Further increase of polymer concentration can result in complete restriction of the particle by surrounding polymer segments. In this case, the non-Gaussian process fades away, and particle diffusion is controlled by Rouse dynamics of polymer chains with the generalized Gaussian characteristics.

关键词： Nanoparticle Polymer solution Diffusion modes Driving force Dynamic density functional theory

ER-Net:Efficient Recalibration Network for Multi-ViewMulti-Person 3D Pose Estimation

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 2093-2109页

作者： mi Zhou Rui Liu Pengfei yi Dongsheng Zhou National and Local Joint Engineering Laboratory of Computer Aided Design School of Software EngineeringDalian UniversityDalian116622China School of Computer Science and Technology Dalian University of TechnologyDalian116024China

Multi-view multi-person 3D human pose estimation is a hot topic in the field of human pose estimation due to its wide range of application *** the introduction of end-to-end direct regression methods,the field has entered a new stage of ***,the regression results of joints that are more heavily influenced by external factors are not accurate enough even for the optimal *** this paper,we propose an effective feature recalibration module based on the channel attention mechanism and a relative optimal calibration strategy,which is applied to themulti-viewmulti-person 3D human pose estimation task to achieve improved detection accuracy for joints that are more severely affected by external ***,it achieves relative optimal weight adjustment of joint feature information through the recalibration module and strategy,which enables the model to learn the dependencies between joints and the dependencies between people and their corresponding *** call this method as the Efficient Recalibration Network(ER-Net).Finally,experiments were conducted on two benchmark datasets for this task,Campus and Shelf,in which the PCP reached 97.3% and 98.3%,respectively.

关键词： Multi-view multi-person pose estimation attention mechanism computer vision

Strict Feasibility of Variational Inequalities in Reflexive Banach Spaces

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Acta Mathematica Sinica,English Series 2007年第3期23卷 563-570页

作者： yi Ran HE Xiu Zhen MAO mi ZHOU Department of Mathematics Sichuan Normal University Chengdu 610068 P. R. China

Strict feasibility is proved to be an equivalent characterization of （dual） variational inequalities having a nonempty bounded solution set, provided the mappings involved are stably properly quasimonotone. This generalizes an earlier result from finite-dimensional Euclidean spaces to infinitedimensional reflexive Banach spaces. Moreover, the monotonicity-type assumptions are also mildly relaxed.

关键词： variational inequalities well-positioned sets barrier cone strict feasibility stably properly quasimonotone

Distribution of α-, β-, and γ-Phases in a Multi-flow Injection-molded Hierarchical Structure

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Chinese Journal of Polymer Science 2018年第6期36卷 765-775页

作者： Da-Shan mi Feng-yi Hou Man Zhou Jie Zhang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

In the current work, a custom-made vibration injection molding device that can provide oscillatory pressure was utilized to create an injection-molded hierarchical structure. Growth competition among α, β, and γ phases in the injection-molded structure can be studied because of the presence of this hierarchical structure, wherein shish-kebab and spherulite layers were arranged alternately along the thickness direction. The γ crystals only existed in layers subjected to high pressure and shear stress, whereas β crystals formed between the shear layers. The change in trend of the γ fraction was similar to that of parent-to-daughter ratio. In addition, this hierarchical and alternating crystal structure can sharply increase the mechanical properties.

关键词： Shish-kebab Growth competition α Phase γ Phase β Phase

Annual Energy Production Estimation for Variable-speed Wind Turbine at High-altitude Site

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 684-687页

作者： Dongran Song Songyue Zheng Sheng Yang Jian Yang mi Dong Mei Su Young Hoon joo the School of Automation Central South UniversityChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 573701Korea

This letter presents a systematic approach to estimate the annual energy production(AEP) of variable-speed wind turbines erected at high-altitude sites. Compared with the existing empirical-model based approaches, the proposed approach models the influence of the air density on the power production while employing the theoretical power curve. Consequently, the proposed approach provides a precise estimation of AEP, which can serve as a foundation of the optimum turbinesite matching design at different-altitude sites.

关键词： Variable-speed wind turbine annual energy production high-altitude site turbine-site matching