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Ecological evaluation of marine macroalgal communities on five islands of Korea in the Yellow Sea

Acta Oceanologica Sinica 2023年第6期42卷 49-56页

作者： Su Jin Han Jae-Gil Jang Hyun-Jung Kim Tae-Ho Seo joo Myun park Marine Eco-Technology Institute Co. Ltd.Busan 48520R.O.Korea Coastal Production Institute Yeosu 59699R.O.Korea Dokdo Research Center Korea Institute of Ocean Science&TechnologyUljin 36315R.O.Korea

Macroalgae have long been used as biological indicators of marine ecosystem health worldwide due to their ecological importance and sensitivity to environmental stress.A number of previous studies have utilized macroalgal communities in monitoring surveys of environmental *** study examined the characteristics and patterns of marine macroalgal communities in the Yellow Sea off the western coast of *** were analyzed for the number of species,biomass,and coverage ratio by macroalgal *** the study period,82 macroalgal species(10 green algae,17 brown algae,and 55 red algae)were identified at the five study sites,with the highest number of species found at Gwanrido and Uido(both containing 41 species)and the lowest at Daeijakdo(27 species).The average biomass(via dry weight)was 98.63 g/m^(2),consisting of green algae(8.39 g/m^(2)),brown algae(35.08 g/m^(2)),and red algae(55.16 g/m^(2)).The dominant macroalgae species in terms of biomass were Corallina pilulifera,Sargassum thunbergii,and Ulva australis in the intertidal zones,and Botryocladia wrightii and Gelidium elegans in the subtidal ***,evenness,and diversity indices based on the biomass of abundant species were 5.08,0.65,and 2.30,respectively,over the entire study *** on the evaluation of the environmental states by the community indices,overall,the Ecological Evaluation Index of macroalgae communities in the study area was marked as“Good-Moderate”,but was determined as“ModerateLow”at several sites during *** results can be a direct approach in the assessment of coastal habitats in which anthropogenic as well as climate change influences persist.

关键词： macroalgae Yellow Sea ecological state groups ecological index Ecological Evaluation Index(EEI) community variable

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Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J

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Journal of Animal Science and Biotechnology 2019年第2期10卷 410-423页

作者： Hong Jo Lee Kyung Je park Kyung youn Lee Yongxiu Yao Venugopal Nair Jae Yong Han Sciences and Research Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea The Pirbright Institute WokingSurrey GU24 0NFUK.

Background: Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus(ALV)subgroups using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9))-based genome editing confers resistance to ALV subgroups B and J. Here, we used the same strategy to target the receptor expressed by ALV subgroup A(TVA) and generate chicken cells resistant to infection by this ***: CRISPR/Cas9-based disruption of exon 2 within the tva gene of DF-1 fibroblasts conferred resistance to infection by ALV subgroup A regardless of whether frameshift mutations were introduced during editing. Conversely,overexpression of the wild-type TVA receptor(wtTVA) by tva-modified DF-1 clones restored susceptibility to ALV subgroup A. The results confirm that exon 2, which contains the low-density lipoprotein receptor class A domain of TVA, is critical for virus entry. Furthermore, we sequentially modified DF-1 cells by editing the tva, tvb, and Na^+/H^+ exchange 1(chNHE1) genes, which are the specific receptors for ALV subgroups A, B, and J, ***: Simultaneous editing of multiple receptors to block infection by different subgroups of ALV confirmed that ALV subgroups A, B, and J do not share host receptors. This strategy could be used to generate cells resistant to multiple viral pathogens that use distinct receptors for cell entry.

关键词： Avian leukosis virus CRISPR/Cas9 Genome editing Host receptor TVA

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Effects of Chairside Polishing and Brushing on SurfaceRoughness of Acrylic Denture Base Resins

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Journal of Wuhan University of Technology(Materials Science) 2009年第1期24卷 100-105页

作者： Seung-Kyun Kim Ju-Mi park Min-Ho Lee Jae-youn Jung Shipu Li Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The effects of 3 chairside polishing kits and mechanical brushing on the surface roughness of 3 different acrylic denture base resins were compared. Acrylic denture base resins （auto-polymerizing, heat-polymerizing, injected heat-polymerizing resins） were examined after a tungsten carbide bur, and after chairside polishing using 3 polishing kits and pumice. The specimens were subjected to mechanical brushing using a wear tester to simulate 30 000 strokes of brushing. The surface roughness of the acrylic denture base resin specimens was measured using a contact pro-filometer. After the test, the random polished acrylic resins were evaluated by scanning electron mi-croscopy （SEM） and atomic force microscopy （AFM）. Acrylic denture base resins polished using the 3 types of polishing kits had a smoother surface than those finished with the tungsten carbide bur （p〈0.05）. The surface of the resin polished by a TC cutter exceeded the Ra of 0.2 μm （p〈0.05）. The auto-polymerizing resin showed a significantly higher surface roughness than the heat-polymerizing resin and injected heat-polymerizing resin （p〉0.05）. In the case of polishing step wise, there was almost no change in surface roughness after brushing （p〉0.05）.

关键词： acrylic denture base resin polishing brushing surface roughness

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Comparative studies on the binding site of anesthetics to GABA a receptors using in silico docking methods

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BIOCELL 2023年第7期47卷 1661-1673页

作者： SEUNGHYUN AHN JUNG-YEON LEE JIHA SUNG HYUN joo KIM SEYEON park Department of Applied Chemistry Dongduk Women’s UniversitySeoul02748Korea Division of Applied Chemistry and Cosmetic Science Dongduk Women’s UniversitySeoul02748Korea Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research InstituteYonsei University College of MedicineSeoul03722Korea

Although the GABAA receptor(GABAAR)has been proposed as the main action site for sevoflurane,isoflurane,halothane,enflurane,propofol,and benzodiazepines(BZDs),binding of these anesthetics with high-resolution structures of the GABAAR have been rarely examined by comparative docking ***,various combinations of ligands on more GABAARs with various subtypes need to be analyzed to understand the elaborate action mechanism of GABAARs better because some GABAA ligands showed specificity toward the distinct subtypes of the ***:We performed in silico docking analysis to compare the binding modes of sevoflurane,isoflurane,halothane,enflurane,propofol,and BZDs to the GABAAR based on one of the most recently provided 3D *** performed the docking analysis and the affinity-based ranking of the binding ***:Our docking studies revealed that isoflurane,halothane,and enflurane docked in an extracellular domain(ECD)on GABAARs,in contrast to ***:Our results supported a multi-site mechanism for the allosteric modulation of *** was bound to the pore or favored various subsites in the transmembrane domain(TMD).Our result confirmed that different chemically related BZD ligands interact via distinct binding modes rather than by using a common binding mode,as previously suggested.

关键词： GABAAR In silico docking Multi-binding site Anesthetics

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Simple colonoscopy reporting system checking the detection rate of colon polyps

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World Journal of Gastroenterology 2015年第31期21卷 9380-9386页

作者： Jae Hyun Kim youn Jung Choi Hye Jung Kwon Seun Ja park Moo In park Won Moon Sung Eun Kim Department of Internal Medicine Kosin University College of Medicine

AIM: To present a simple colonoscopy reporting system that can be checked easily the detection rate of colon ***: A simple colonoscopy reporting system Kosin Gastroenterology(KG quality reporting system) was developed. The polyp detection rate(PDR),adenoma detection rate(ADR),serrated polyp detection rate(SDR),and advanced adenoma detection rate(AADR) are easily calculated to use this ***: In our gastroenterology center,the PDR,ADR,SDR,and AADR test results from each gastroenterologist were updated,every month. Between June 2014,when the program was started,and December 2014,the overall PDR and ADR in our center were 62.5% and 41.4%,respectively. And the overall SDR and AADR were 7.5% and 12.1%,***: We envision that KG quality reporting system can be applied to develop a comprehensive system to check colon polyp detection rates in other gastroenterology centers.

关键词： Colon polyp Detection rate Reporting system

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Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia

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Neural Regeneration Research 2014年第9期9卷 912-918页

作者： Seung Song Jong-Tae park joo young Na Man-Seok park Jeong-Kil Lee Min-Cheol Lee Hyung-Seok Kim Department of Forensic Medicine Chonnam National University Medical School Department of Neurology Chonnam National University Medical School Department of Neurosurgery Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Endogenous neural stem cells become ＂activated＂ after neuronal injury, but the activation sequence and fate of endogenous neural stem cells in focal cerebral ischemia model are little known. We evaluated the relationships between neural stem cells and hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a photothromobotic rat stroke model using immunohistochemistry and western blot analysis. We also evaluated the chronological changes of neural stem cells by 5-bromo-2′-deoxyuridine（BrdU） incorporation. Hypoxia-inducible factor-1α expression was initially increased from 1 hour after ischemic injury, followed by vascular endothelial growth factor expression. Hypoxia-inducible factor-1α immunoreactivity was detected in the ipsilateral cortical neurons of the infarct core and peri-infarct area. Vascular endothelial growth factor immunoreactivity was detected in bilateral cortex, but ipsilateral cortex staining intensity and numbers were greater than the contralateral cortex. Vascular endothelial growth factor immunoreactive cells were easily found along the peri-infarct area 12 hours after focal cerebral ischemia. The expression of nestin increased throughout the microvasculature in the ischemic core and the peri-infarct area in all experimental rats after 24 hours of ischemic injury. Nestin immunoreactivity increased in the subventricular zone during 12 hours to 3 days, and prominently increased in the ipsilateral cortex between 3–7 days. Nestin-labeled cells showed dual differentiation with microvessels near the infarct core and reactive astrocytes in the peri-infarct area. BrdU-labeled cells were increased gradually from day 1 in the ipsilateral subventricular zone and cortex, and numerous BrdU-labeled cells were observed in the peri-infarct area and non-lesioned cortex at 3 days. BrdU-labeled cells rather than neurons, were mainly co-labeled with nestin and GFAP. Early expressions of hypoxia-inducible factor-1α and vascular endothelial gr

关键词： nerve regeneration brain ischemia neural stem cell neural precursor cell hypoxia-inducible factor 1α vascular endothelial growth factor microenvironment photothrombosis neural regeneration

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Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： In Tae Moon Si-Hyuck Kang Wonjae Lee youngjin Cho Jin joo park Yeonyee EYoon Il-young Oh Chang-Hwan Yoon Jung-Won Suh Tae-Jin youn In-Ho Chae Dong-Ju Choi young-Seok Cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang Hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

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Flux Optimization During Tapping in BOF Process

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Journal of Iron and Steel Research International 2011年第S2期18卷 148-152页

作者： Hyun-Seo park Sung-Mo SEO Ji-Tae KWON joo CHOI Steelmaking Research Group POSCO Technical Research Laboratories 699 Gumho-dong Gwangyang-si Jeonnam 545-090 Korea Technology development team plate rolling department Gwangyang Steelworks POSCO Gumho-dong Gwangyang-si Jeonnam 545-711 Korea

An integrated Plate Mill has started it’s operation on July 7, 2010 in Gwangyang Steelworks, POSCO. The production capability is about 2.5 million tons per year and the main stream consists of Blast Furnace, Hot metal pretreatment (KR), Converter, Bubbling Station, RH/VTD and Continuous Casting. Particularly, it is possible to control sulfur concentration at excellent level in BOF without any further treatment in LF or VTD, which is attained by unique KR process and scrap usage strategy in BOF. In this paper, desulfurization efficiency and steel cleanliness was introduced by optimizing flux amount during tapping in BOF process. In addition, the effect of the flux addition on the refractory of ladle was investigated based on EPMA analyses with the viewpoint of phase diagram. The cleanliness of each sample was examined using optical emission spectrometry and oxygen nitrogen determinator.

关键词： plate mill steel cleanliness flux tapping

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Colonoscopy procedural skills and training for new beginners

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World Journal of Gastroenterology 2014年第45期20卷 16984-16995页

作者： Seung-Hwa Lee young-Kyu park Duck-joo Lee Kwang-Min Kim Center for Health Promotion Ajou University School of Medicine Center for Health Promotion Bundang Jesaeng Hospital

The incidence of colorectal cancer has been increasing in the developed world including South Korea and *** allows for greater diagnostic specificity and sensitivity compared with other types of examinations,such as the stool occult blood test,barium enema,and computed tomography ***,in recent years,the demand for colonoscopies has grown *** beginners including primary care physicians may help meet the increasing demand by performing ***,it is a challenge to learn the procedure due to the long learning-curve and the high rate of complications,such as perforation and bleeding,as compared to ***,considerable training and experience are required for optimal performance of *** order to perform a complete colonoscopic examination,there were a few important thingsto learn and remember,such as the position of examinee(e.g.,left and right decubitus,supine,and prone)and examiner(two-man method vs one-man standing method vs one-man sitting method),basic skills(e.g.,tip deflection,push forward and pull back,torque,air suction and insufflation),advanced skills(e.g.,jiggling and shaking,right and left turn shortening,hooking,and slide-by technique),assisting skills(e.g.,position change of examinee,abdominal compression,breathing-holding,and liquid-infusion technique),and intubation techniques along the lower gastrointestinal *** this article,we attempt to describe the methods of insertion and advancement of the colonoscope to the new beginners including primary care *** believe that this article may be helpful to the new beginners who wish to learn the procedure.

关键词： Colonoscopy Beginner Training Proce-dural skills

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An Efficient and Spam-Robust Proximity Measure Between Communication Entities

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Journal of Computer Science & Technology 2013年第2期28卷 394-400页

作者： joo Hyuk Jeon Jihwan Song Jeong Eun Kwon Yoon joon Lee Man Ho park Myoung Ho Kim Department of Computer Science Korea Advanced Institute of Science and Technology Biz Solution Team SK Telecom Information Technology R&D Center Mobile Communication Convergence Research Team Electronics and Telecommunications Research Institute

Electronic communication service providers are obliged to retain communication data for a certain amount of time by their local laws. The retained communication data or the communication logs are used in various applications such as crime detection, viral marketing, analytical study, and so on. Many of these applications rely on effective techniques for analyzing communication logs. In this paper, we focus on measuring the proximity between two communication entities, which is a fundamental and important step toward further analysis of communication logs, and propose a new proximity measure called ESP （Efficient and Spam-Robust Proximity measure）. Our proposed measure considers only the （graph- theoretically） shortest paths between two entities and gives small values to those between spam-like entities and others. Thus, it is not only computationally efficient but also spam-robust. By conducting several experiments on real and synthetic datasets, we show that our proposed proximity measure is more accurate, computationally efficient and spam-robust than the existing measures in most cases.

关键词： proximity closeness spam electronic communication

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