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Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June Choi joo hye sim Younmin Shin Seung-joon Oh Ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon Eun-Jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

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On-skin and tele-haptic application of mechanically decoupled taxel array on dynamically moving and soft surfaces

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npj Flexible Electronics 2022年第1期6卷 964-972页

作者： Se Young Kwon Gyeongsuk Park Hanbit Jin Changyeon Gu Seung Jin Oh joo Yong sim Wooseup Youm Taek-Soo Kim hye Jin Kim Steve Park Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Electronics and Telecommunications Research Institute(ETRI) Daejeon 34129Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical Systems Engineering Sookmyung Women’s UniversityDaejeon 04313Republic of Korea

To accurately probe the tactile information on soft skin,it is critical for the pressure sensing array to be free of noise and inter-taxel crosstalk,irrespective of the measurement ***,on dynamically moving and soft surfaces,which are common conditions for on-skin and robotic applications,obtaining precise measurement without compromising the sensing performance is a significant challenge due to mechanical coupling between the sensors and with the moving *** this work,multi-level architectural design of micro-pyramids and trapezoid-shaped mechanical barrier array was implemented to enable accurate spatiotemporal tactile sensing on soft surfaces under dynamic ***-off relationship between limit of detection and bending insensitivity was discovered,which was overcome by employing micropores in barrier ***,in-situ pressure mapping on dynamically moving soft surfaces without signal distortion is demonstrated while human skin and/or soft robots are performing complicated tasks such as reading Braille and handling the artificial organs.

关键词： artificial moving dynamically

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Sperm hyaluronidase is critical to mammals'fertilization for its ability to disperse cumulus-oocyte complex layer

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Asian Journal of Andrology 2022年第4期24卷 411-415页

作者： Dong-Won Seol Sang Hoon joo Young-Hyun Kim Bong-Seok Song Bo-Woong sim Sun-Uk Kim Soojin Park Gabbine Wee Ekyune Kim Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)Daegu 41061Korea College of Pharmacy Catholic University of DaeguGyeongbuk 38430Korea National Primate Research Center(NPCR) Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Department of Biochemistry and Molecular Biology Melvin and Bren Simon Comprehensive Cancer CenterIndiana University School of MedicineIndianapolisIN 46202USA

Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains ***,we have shown that hyaluronidase 5(Hyal5)/Hyal7 double-knockout(dKO)mice produce significantly fewer offspring than their wild-type(WT)counterparts because of defective COC *** infertility is mainly caused by a low sperm *** can be further exacerbated by the deficiency of sperm hyaluronidase,which disperses the cumulus cells of the outer layer of the *** the current study,we evaluated the effects of a low count of Hyal-deficient sperm and conditions of ovulated oocytes on the fertilization rate using a mouse *** results demonstrated that a low sperm count further decreases the in vitro fertilization(IVF)rate of Hyal-deficient dKO *** addition,the dKO spermatozoa resulted in a fertilization rate of 12.5%upon fertilizing COCs with a thick cumulus layer,whereas the IVF rate was comparable to that of WT spermatozoa when oocytes with a thin or no cumulus layer were ***,we proved that the IVF rate of dKO spermatozoa could be recovered by adding rat spermatozoa as a source of sperm *** results suggest that a deficiency of proteins involved in fertilization,such as sperm hyal,has a vital role in fertilization.

关键词： HYAL5 HYAL7 cumulus-oocyte complex fertilization infertility sperm hyaluronidase

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A new technique of ganglion impar pulsed radiofrequency ablation

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Chinese Medical Journal 2021年第10期134卷 1221-1223页

作者： Ji Yeong Kim Sung Eun sim Subin Yoo Mina joo Hue Jung Park Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

The ganglion impar block was first introduced in 1990 by Plancarte et al.[1]Since then,several modified versions have been reported by Wemm and Saberski,[2]Nebab and Florence,[3]and Foye.[4]They tried to reduce pain effectively by considering the anatomy of the ganglion impar and *** were differences in the strengths of each individual’s ***,owing to the anatomical diversity of the structure itself,[5]it was difficult to determine which technique would be more *** ablation(RFA)developed in the ganglion impar block also faced this *** this clinical background,we present a new technique to implement ganglion impar *** informed consent was obtained from the patient before the initiation of the study.

关键词： anatomy technique. al.

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Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1395-1407页

作者： Ye Eun joo Pil-Soo Jeong Sanghoon Lee Se-Been Jeon Min-Ah Gwon Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong sim Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuSouth Korea Department of Animal Science College of Natural Resources and Life SciencePusan National UniversityMiryangSouth Korea Laboratory of Theriogenology College of Veterinary MedicineChungnam National UniversityDaejeonSouth Korea Department of Biotechnology College of EngineeringDaegu UniversityGyeongsanSouth Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeonSouth Korea Department of Functional Genomics University of Science and TechnologyDaejeonSouth Korea Department of Animal Science College of Natural Resources and Life ScienceLife and Industry Convergence Research InstitutePusan National UniversityMiryangSouth Korea

Background Anethole(AN)is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in ***,no study has examined the effect of AN on porcine embryonic ***,we investigated the effect of AN on the development of porcine embryos and the underlying *** We cultured porcine in vitro-fertilized embryos in medium with AN(0,0.3,0.5,and 1 mg/mL)for 6 *** at 0.5 mg/mL significantly increased the blastocyst formation rate,trophectoderm cell number,and cellular survival rate compared to the ***-supplemented embryos exhibited significantly lower reactive oxygen species levels and higher glutathione levels than the ***,AN significantly improved the quantity of mitochondria and mitochondrial membrane potential,and increased the lipid droplet,fatty acid,and ATP ***,the levels of proteins and genes related to the sonic hedgehog(SHH)signaling pathway were significantly increased by *** These results revealed that AN improved the developmental competence of porcine preimplantation embryos by activating SHH signaling against oxidative stress and could be used for large-scale production of high-quality porcine embryos.

关键词： Anethole Lipid metabolism Mitochondrial function Porcine embryo development Sonic hedgehog signaling pathway

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Effect of intermetallic compound thickness on anisotropy of Al/Cu honeycomb rods fabricated by hydrostatic extrusion process

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Transactions of Nonferrous Metals Society of China 2016年第2期26卷 456-463页

作者： Tae-hyuk LEE Moon-soo sim Sin-hyeong joo Kyoung-tae PARK Ha-guk JEONG Jong-hyeon LEE Graduate School of Department of Advanced Materials Engineering Chungnam National University Rapidly Solidified Materials Research Center Chungnam National University Graduate School of Energy Science & Technology Chungnam National University Rare Metal R&D Group Korea Institute of Industrial Technology Advanced Fusion Process R&D Group Korea Institute of Industrial Technology

The effect of intermetallic compound （IMC） thickness on the thermal and mechanical properties of Al/Cu honeycomb rods was investigated. The Al/Cu honeycomb rods were fabricated using repeated hydrostatic extrusions at 200 ℃. During the process, an IMC layer with 1μm in thickness was generated at the Al/Cu interface. Different IMC thicknesses were obtained by post-heat treatment at 420 ℃ for 0.5 to 2 h. The IMC thickness increased to 10.1μm. The IMC layers were identified as Al2Cu （θ）, AlCu （η2）, and Al4Cu9（γ1） phases. The thermal conductivities in the longitudinal direction and cross direction decreased by 11.9% （（268±4.8） to （236±4.4） W/（m·K）） and 10.4% （（210±3.2） to （188±2.8） W/（m＆#183;K））, respectively, with increasing IMC thickness. The ultimate tensile strength and elongation of the Al/Cu honeycomb rod are （103±8.4） MPa and （73±6.2）%, respectively. The ultimate tensile strength increased to （131±6.5） MPa until the IMC thickness reached 7.7μm. It subsequently decreased to （124±3.9） MPa until the IMC thickness reached 10.1μm. The elongation of the Al/Cu honeycomb rod then sharply decreased to （29±2.5）% with increasing IMC thickness.

关键词： intermetallic compound Al/Cu honeycomb rod anisotropy thermal conductivity tensile strength hydrostatic extrusion

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Phakomatosis pigmentokeratotica associated with multiple basal cell carcinomas

Phakomatosis pigmentokeratotica associated with multiple bas...

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The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Dong-Woo Suh Yoo-Jin Oh Eun-joo Lee Bark-Lynn Lew Woo-Young sim Department of Dermatology College of MedicineKyung Hee UniversitySeoulKorea

＜正＞Phacomatosis pigmentokeratotica（PPK） is a recently identified disease characterized by the coexistence of an organoid nevus with sebaceous differentiation arranged along Blaschko’s lines and a speckled lentiginous nevus showing a checkerboard pattern,mostly in association with various extra-cutaneous defects.A 52-year-old male presented with

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Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae Young Jang Sung Woo Ryu Ji hye Kim Eui Ju Park Woong Cheul Lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee Lee Sung Ran Jeon Jun Hyung Cho joo Young Cho So Young Jin Ji Sung Lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(sim).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had sim,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting sim were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had sim,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting sim were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting sim by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of sim.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis

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