检索结果-南通市图书馆

Recent updates of precision therapy for gastric cancer: Towards optimal tailored management

World Journal of Gastroenterology 2016年第19期22卷 4638-4650页

作者： moon Kyung Joo jong-Jae park Hoon Jai Chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) have been suggested as an important step in the formation of a microenvironment favorable for gastric cancer. Accomplishments in basic research have led to the development of novel agents targeting these signaling pathways. However, phase III studies of selective anti-HGF/c-MET antibodies and mTOR inhibitor failed to show significant benefits in terms of overall survival and progression-free survival. Few agents directly targeting STAT3 have been developed. However, this target is still critical issue in terms of chemoresistance, and SH2-containing protein tyrosine phosphatase 1 might be a significant link to effectively inhibit STAT3 activity. Inhibition of PD-1/PD-L1 showed durable efficacy in phase I studies, and phase III evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase II study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.

关键词： Gastric cancer Hepatocyte growth factor Mammalian target of rapamycin Signal transducer and activator of transcription 3 Programmed cell death ligand-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proton pump inhibitor: The dual role in gastric cancer

引用

World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： moon Kyung Joo jong-Jae park Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage

引用

World Journal of Gastroenterology 2007年第23期13卷 3265-3267页

作者： Kyu-jong Kim Won moon Moo In park Seun Ja park Seung Hyun Lee Bong Kwon Chun Department of Internal Medicine Kosin University College of Medicine Busan South Korea Department of General Surgery Kosin University College of Medicine Busan South Korea Department of Pathology Kosin University College of Medicine Busan South Korea

Gastrointestinal stromal tumor is rare, which arises from the mesenchymal tissues in the gastrointestinal tract, and it is extremely rare in the appendix. Only a few cases have been found in this location to date. Although the annual incidence of lower gastrointestinal bleeding has been increasing, bleeding related to the appendix is quite rare. We herein present a very rare case of gastrointestinal stromal tumor incidentally found by appendiceal hemorrhage.

关键词： Gastrointestinal stromal tumor Gastrointestinal tract Appendix Lower gastrointestinal bleeding Appendiceal hemorrhage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy

引用

World Journal of Gastroenterology 2009年第34期15卷 4298-4304页

作者： Hyun Gun Kim Young Koog Cheon Young Deok Cho jong Ho moon Do Hyun park Tae Hoon Lee Hyun jong Choi Sang-Heum park Joon Seong Lee moon Sung Lee Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medicine

AIM： To compare small sphincterotomy combined with endoscopic papillary large balloon dilation （SES ＋ ELBD） and endoscopic sphincterotomy （EST） for large bile duct stones. METHODS： We compared prospectively SES ＋ ELBD （group A, n = 27） with conventional EST （group B, n = 28） for the treatment of large bile duct stones （≥ 15 mm）. When the stone could not be removed with a normal basket, mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS： No significant differences were observed in the mean largest stone size （A： 20.8 mm, B： 21.3 mm）, bile duct diameter （A： 21.4 turn, B： 20.5 ram）, number of stones （A： 2.2, B： 2.3）, or procedure time （A： 18 min, B： 19 rain） between the two groups. The rates of complete stone removal with one session was 85% in group A and 86% in group B （P = 0.473）. Mechanical lithotripsy was required for stone removal in nine of 27 patients （33%） in group A and nine of 28 patients （32%, P = 0.527） in group ***： SES ＋ ELBD did not show significant benefits compared to conventional EST, especially for the removal of large （≥ 15 mm） bile duct stones.

关键词： Sphincterotomy Endoscopic Balloon dilatation Cholelithiasis Lithotripsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of dehydrating agents on the oxidative carbonylation of methanol for dimethyl carbonate synthesis over a Cu/Y-zeolite catalyst

引用

Chinese Journal of Chemical Engineering 2018年第5期26卷 1059-1063页

作者： Dong-Ho Lee Jiin You Je-Min Woo Jung Yoon Seo Young Cheol park jong-Seop Lee Hyunuk Kim jong-Ho moon Seung Bin park Greenhouse Gas Laboratory Korea Institute of Energy Research Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology Energy Material Laboratory Korea Institute of Energy Research

The influence of the dehydration by metal oxides on the synthesis of dimethyl carbonate （DMC） via oxidative carbonylation of methanol was studied. A Cu/Y-zeolite catalyst was prepared by the ion exchange method from CuCl2.2H2O and the commercial NH4-form of the Y type zeolite, The catalyst was characterized by X-ray fluorescence （XRF）, N2 adsorption （BET method）, X-ray diffraction （XRD）, and temperature-programmed de- sorption of ammonia （NH3-TPD） to evaluate its Cu and Cl content, surface area, structure, and acidity. Reaction tests were carried out using an autoclave （batch reactor） for 18 h at 403 K and 5.5 MPa （2CH3OH ＋ 1/2O2 ＋ CO （CH3O）2CO ＋ H2O）. The influence of various dehydrating agents （ZnO, MgO, and CaO） was examined with the aim of increasing the methanol conversion （XMeOH, MeOH conversion）. The MeOH conversion increased upon addition of metal oxides in the order CaO 〉〉 MgO 〉 ZnO, with the DMC selectivity （SDMC） following the order MgO 〉 CaO 〉 ZnO. The catalysts and dehydrating agents were characterized before and after the oxidative carbonylation of methanol by thermogravimetric and differential thermogravimetric （TG/DTG）, and XRD to con- firm that the dehydration reaction occurred via the metal oxide （MO ＋ H2O →M（OH）2）. The MeOH conversion increased from 8.7% to 14.6% and DMC selectivity increased from 39.0% to 53.1%, when using the dehydrating azent CaO.

关键词： Carbon monoxide Zeolite Catalyst Dimethyl carbonate Oxidative carbonylation Dehydrating agent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relative skeletal muscle mass and non-alcoholic fatty liver disease: from association to causation

引用

Hepatobiliary Surgery and Nutrition 2019年第5期8卷 509-511页

作者： Hee Yeon Kim jong Young Choi Yong-moon park Division of Hepatology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoulKorea Epidemiology Branch National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkNCUSA

The prevalence of nonalcoholic fatty liver disease(NAFLD)and its associated metabolic risk factors,including obesityand metabolic syndrome,have increased over the lastdecade in both developed and developing countries(1).NAFLD is considered to be the hepatic manifestation ofmetabolic syndrome and insulin resistance which is oneof multiple hits leading to NAFLD(2).

关键词： NAFLD liver hepatic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

EXPERIMENTAL ESTIMATION OF A SCALING EXPONENT FOR TIP VORTEX CAVITATION VIA ITS INCEPTION TEST IN FULL-AND MODEL-SHIP

引用

Journal of Hydrodynamics 2012年第5期24卷 658-667页

作者： LEE Jeung-Hoon JUNG Jae-Kwon LEE Kyung-Jun HAN Jae-moon park Hyung-Gil SEO jong-Soo Samsung Ship Model Basin(SSMB) Marine Research InstituteSamsung Heavy IndustriesScience TownDaejeon 305-380Korea

Tip vortex cavitation noise of marine propeller became primary concems to reduce hazardous environmental impacts from commercial ship or to keep the underwater surveillance of naval ships. The investigations of the tip vortex and its induced noise are normally conducted through the model test in a water cavitation tunnel. However the Reynolds number of model-test is much smaller than that of the full-scale, which subsequently results in the difference of tip vortex cavitation inception. Hence, the scaling law between model- and full-scales needs to be identified prior to the prediction and assessment of propeller noise in full scale. From previous researches, it is generally known that the incipient caivtation number of tip vortex can be represented as a power of the Reynolds number. However, the power exponent for scaling, which is the main focus of this research, has not been clearly studied yet. This paper deals with the estimation of scaling exponent based on tip vortex cavitation inception test in both full- and model-scale ships. Acoustical measurements as well as several kind of signal processing technique for an inception criterion suggest the scaling exponent as 0.30. The scaling value proposed in this study shows slight difference to the one of most recent research. Besides, extrapolation of model-ship noise measurement using the proposed one predicts the full-scale noise measurement with an acceptable discrepancy.

关键词： tip vortex cavitation underwater radiated noise scaling exponent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

VARIABILITY MODELING TO DEVELOP FLEXIBLE SERVICE-ORIENTED APPLICATIONS

引用

Journal of Systems Science and Systems Engineering 2011年第2期20卷 193-216页

作者： Joonseok park Mikyeong moon Keunhyuk YEOM Department of Computer Science and Engineering Pusan National University Division of Computer and Information Engineering Dongseo University

To cope with requirement changes flexibly and rapidly,the existing component-based paradigm is being evolved into a service-oriented computing *** main characteristic of the service-oriented computing paradigm is that service-oriented applications are developed as loosely coupled services that reflect business *** paradigm also promotes business agility,facilitating quick reactions to business ***,to enhance and support the benefits of the service-oriented computing paradigm,we must consider how to improve flexibility and reusability during the development of service-oriented *** propose the variability modeling approach to specify and control the common and distinguishing characteristics of service-oriented *** is,the key concepts of product-line technology can be used to make service-oriented applications more flexible and *** paper describes variability modeling at two levels;the composition level and the specification *** the composition level,we describe the variability of composition and the flow of domain services that fulfill business *** the specification level,we present a domain service that is an abstract service with *** use of our systematic variability modeling approach can greatly increase the flexibility,applicability,and reusability of service-oriented applications.

关键词： Variability software product line reuse service oriented software flexible service model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults： the Fifth Korea National Health and Nutrition Examination Survey

引用

Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 39-47页

作者： hee yeon kim chang wook kim chung-hwa park jong young choi kyungdo han anwar t merchant yong-moon park division of hepatology department of internal medicinecollege of medicinethe catholic university of korea222Banpo-daeroSeocho-guSeou1 06591Republic of Korea department of biostatistics college of medicinethe catholic university of korea222Banpo-daeroSeocho-guSeou1 06591Republic of Korea department of epidemiology and biostatistics arnold school of public healthuniversity of south carolinaColumbiaSC 29208USA epidemiology branch national institute of environmental health sciencesnational institutes of healthdepartment of health and human servicesResearch Triangle ParkNC 27709USA

BACKGROUND： Sarcopenia and non-alcoholic fatty liver dis- ease （NAFLD） share similar pathophysiological mechanisms, and the relationship between sarcopenia and NAFLD has been recently investigated. The study investigated whether low skel- etal muscle mass is differentially associated with NAFLD by gender in Korean adults. METHODS： We conducted a cross-sectional analysis of the data from the Fifth Korea National Health and Nutrition Examination Survey. The skeletal muscle index （SMI） was obtained by the appendicular skeletal muscle mass divided by the weight. NAFLD was defined as a fatty liver index （FLI）〉60 in the absence of other chronic liver disease. RESULTS： Among the included subjects, 18.3% （SE： 1.4%） in men and 7.0% （SE： 0.7%） in women were classified as having FLI-defined NAFLD. Most of the risk factors for FLI-defined NAFLD showed a significant negative correlation with the SMI in both genders. Multiple logistic regression analysis showed that low SMI was associated with FLI-defined NAFLD, inde- pendent of other metabolic and lifestyle parameters in both genders [males： odds ratio （OR）=1.35; 95% confidence inter- val （CI）： 1.17-1.54; females： OR=1.36; 95% CI： 1.18-1.55]. The magnitude of the association between FLI-defined NAFLD and low SMI was higher in middle aged to elderly males （OR-1.50; 95% CI： 1.22-1.84） than in males less than 45 years of age （OR=1.25; 95% CI： 1.02-1.52） and in premenopausal females （OR=l.50; 95% CI： 1.12-2.03） than in postmenopausal females （OR-1.36; 95% CI： 1.20-1.54）.CONCLUSIONS： Low SMI is associated with the risk of FLI- defined NAFLD independent of other well-known metabolic risk factors in both genders. This association may differ ac- cording to age group or menopausal status. Further studies are warranted to confirm this relationship.

关键词： Korea National Health and Nutrition Examination Survey non-alcoholic fatty liver disease sarcopenia skeletal muscle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence of premature ejaculation in young and middle-aged men in Korea： a multicenter intemet-based survey from the Korean Andrological Society

引用

Asian Journal of Andrology 2010年第6期12卷 880-889页

作者： Hyun Jun park jong Kwan park Kwangsung park Sung Won Lee Sae-Woong Kim Dae Yul Yang DU Geon moon Kweon-Sik Min Ki-Hak moon Sang-Kuk Yang Jae Seog Hyun Nam Cheol park Deparment of Urology Pusan National University School of medicine Busan 602739 Korea Deparment of Urology Chonbuk National University Medical School Jeonju 561712 Korea Deparment of Urology Chonnam National University Medical School Gwangju 501746 Korea Deparment of Urology Sungkyunkwan Univer＆ty School of Medicine Seou1135 710 Korea Deparment of Urology Catholic University College of Medicine Seoul 137701 Korea Deparment of Urology Hallym University College of Medicine Seoul 13 7701 Korea Deparment of Urology Korea University College of Medicine Seoul 152703 Korea Deparment of Urology lnje University College of Medicine Busan 614735 Korea Deparment of Urology Yeungnam University College of Medicine Daegu 705717 Korea Deparment of Urology Konkuk University School of Medicine Chungju 380704 Korea Deparment of Urology Gyeongsang National University School of Medicine Jinju 660702 Korea

In this study, we aimed to investigate the prevalence and perception of premature ejaculation （PE） in young and middle-aged Korean men. The study was conducted using an Internet-assisted questionnaire. A total of 2 037 Korean male adults, aged 20 years or older, were randomly sampled based on age and residency. The questionnaire developed by the PE Study Group of the Korean Andrological Society includes four categories （overall sexual function, symptoms, distress and treatment） with a total of 16 questions. For each question, symptoms were evaluated by a scale ranging from 0 to 10. Intravaginal ejaculation latency time was ‘5-10 min＇ in 38.6%, followed by ‘longer than 10 min＇ in 2919%, ‘2-5 min＇ in 23.6%, ‘1-2 min＇ in 5.4% and ‘shorter than 1 min＇ in 2.5%. In our series, 27.5% of respondents reported having PE. Control over ejaculation within a recent 3-month period was 6.2 points on average. Respondent complaints of PE-related stress averaged 7.1 points and stress-related complaints from sexual partners averaged 7.1 points. The effect of PE on sexual life was 6.8 points. Of the respondents determined as having PE, 42.6% responded that they were inclined to receive treatment. Results from this study suggest that the prevalence of PE diagnosed by the respondent on his own was approximately 27.5% in young and middle-aged men in Korea. PE-related stress had a significant effect on the stress, sexual activity and quality of life of the respondent and his sexual partner.

关键词： epidemiology premature ejaculation questionnaire sexual dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：