检索结果-南通市图书馆

Built Heritage 2023年第3期7卷 18-33页

作者： ping-hsiang hsu Department of Tourism Management Taiwan Shoufu UniversityTainan CityTaiwanChina

To strengthen brand identity,enrich tourist experiences,and promote heritage education,Taijiang National Park proposed to reconstruct Taiwan,China’s Dutch Trading Post in a different location from where it was initially erected in the 17th *** paper is a case study of the reconstruction proposal for a lost colonial architectural complex in the context of heritage *** discusses the practical and academic issues of rebuilding long-lost colonial heritage *** author provided a first-hand account of the technical and practical reasoning for reconstructing a bygone complex erected by Dutch *** development phases of the Dutch Trading Post of Taiwan,China were first introduced,and then a reconstruction strategy was proposed to resolve conflicts with legal ***,a site selection process using GIS,a conceptually driven plan for reconstruction,and a 3D simulation were *** specific issues in heritage rebuilding were further discussed,including the decision to reconstruct a heritage building(complex),the authenticity of the reconstructed building if done in a different location from where it was initially situated,and the need to discover more archaeological facts.

关键词： colonial heritage building Dutch Trading Post Dutch East India Company(Vereenigde Oost-Indische Compagnie,VOC) tourism GIS(Geographical Information System) Taiwan,China

Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2010年第4期7卷 255-259页

作者： Hwei-Fang Tsai ping-Ning hsu Department of Internal Medicine Taipei Medical University Shuang Ho HospitalTaipeiTaiwan Gradute Institute of Clinical Medicine College of MedicineTaipei Medical UniversityTaipeiTaiwan Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwan

Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa,leading to chronic gastritis,peptic ulcers,gastric carcinoma and gastric mucosa-associated lymphoid tissue(MALT)*** studies have shown that apoptosis of gastric epithelial cells is increased during *** *** induced by microbial infections are factors implicated in the pathogenesis of *** *** enhanced gastric epithelial cell apoptosis in *** infection has been suggested to play an important role in the pathogenesis of chronic gastritis and gastric *** addition to directly triggering apoptosis,*** induces sensitivity to tumor-necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL)-mediated apoptosis in gastric epithelial cells via modulation of TRAIL apoptosis ***,*** infection induces infiltration of T lymphocytes and triggers inflammation to augment *** *** infection,there was significantly increased CCR61CD31 T-cell infiltration in the gastric mucosa,and the CCR6 ligand,CCL20 chemokine,was selectively expressed in inflamed gastric *** results implicate that the interaction between CCL20 and CCR6 may play a role in recruiting T cells to the sites of inflammation in the gastric mucosa during Helicobacter *** these mechanisms,chemokine-mediated T lymphocyte trafficking into inflamed epithelium is initiated and the mucosal injury in Helicobacter infection is *** article will review the recent novel findings on the interactions of *** with diverse host epithelial signaling pathways and events involved in the initiation of gastric pathology,including gastric inflammation,mucosal damage and development of MALT lymphomas.

关键词： apoptosis CagA chemokine Helicobacter pylori TRAIL

Tumor necrosis factor: The key to hepatitis B viral clearance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第8期15卷 731-733页

作者： I-Tsu Chyuan ping-Ning hsu Department of Internal Medicine Cathay General HospitalTaipeiTaiwanChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Department of Internal Medicine National Taiwan University HospitalTaipeiTaiwanChina

The immunopathogenesis of hepatitis B virus(HBV)involves a complex interaction of innate and adaptive immune response associated with several ***,due to experimental limitations,very limited and even no activation of the innate immune response can be demonstrated in acute HBV *** role of innate immunity and the key innate effectors for HBV clearance is still *** is also not clear whether clinical use of TNF inhibitors in treating rheumatoid arthritis and other autoimmune disease patients with chronic HBV infection would affect viral ***,in a recent paper in Cell Mol Immunol,Chyuan et *** that under TNF-αblockade,HBV viral clearance was impaired with persistent elevated HBV viral load in a dose and temporal-dependent manner.1 It demonstrates that a deficiency of TNF-αreduces viral clearance and promotes HBV persistence in a mouse model,and the impairment of HBV clearance under anti-TNF-αoccurs at an early time point of HBV infection,suggesting that HBV may reactivate during therapy with TNF *** results together with previous reports support that TNF is a key innate cytokine required to clear HBV.2,3 It also provides evidence that therapy with TNF inhibitors may impair immune response to HBV clearance.

关键词： Immunol impaired immunity

Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung hsu Yencheng Chao Yong Hu Yang Zhang Weifeng Hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P<0.001).Median overall survival was 20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

Second-line rescue treatment of Helicobacter pylori infection: Where are we now?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第40期24卷 4548-4553页

作者： Te-Fu Lin ping-I hsu Division of Gastroenterology and Hepatology Department of Internal Medicine Kaohsiung Veterans General Hospital

At present, the best rescue therapy for Helicobacter pylori(H. pylori) infection following failure of firstline eradication remains unclear. The Maastricht Ⅴ/Florence Consensus Report recommends bismuth quadruple therapy, or fluoroquinolone-amoxicillin triple/quadruple therapy as the second-line therapy for H. pylori infection. Meta-analyses have shown that bismuth quadruple therapy and levofloxacin-amoxicillin triple therapy have comparable eradication rates, while the former has more adverse effects than the latter. There are no significant differences between the eradication rates of levofloxacin-amoxicillin triple and quadruple therapies. However, the eradication rates of both levofloxacin-containing treatments are suboptimal. An important caveat of levofloxacin-amoxicillin triple or quadruple therapy is poor eradication efficacy in the presence of fluoroquinolone resistance. High-dose dual therapy is an emerging second-line therapy and has an eradication efficacy comparable with levofloxacinamoxicillin triple therapy. Recently, a 10-d tetracyclinelevofloxacin(TL) quadruple therapy comprised of a proton pump inhibitor, bismuth, tetracycline and levofloxacin has been developed, which achieves a markedly higher eradication rate compared with levofloxacin-amoxicillin triple therapy(98% vs 69%) in patients with failure of standard triple, bismuth quadruple or non-bismuth quadruple therapy. The present article reviews current second-line anti-H. pylori regimens and treatment algorisms. In conclusion, bismuth quadruple therapy, levofloxacin-amoxicillin triple/quadruple therapy, high-dose dual therapy and TL quadruple therapy can be used as second-line treatment for H. pylori infection. Current evidence suggests that 10-d TL quadruple therapy is a simple and effective regimen, and has the potential to become a universal rescue treatment following eradication failure by all firstline eradication regimens for H. pylori infection.

关键词： Helicobacter pylori Rescue treatment Levofloxacin-amoxicillin triple therapy Bismuth quadruple therapy Tetracycline-levofloxacin quadruple therapy High-dose dual therapy

中国式现代化进程中地方治理数智化变革风险及其实践规制

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

行政论坛 2024年第1期31卷 54-64页

作者：许丹姜晓萍西南民族大学公共管理学院四川大学公共管理学院

地方治理数智化变革引导基层治理变革的走向，是推进中国式现代化的重要基础。只有从中国式现代化视域审视地方治理数智化变革的基本逻辑，才能有效推动地方治理数智化的变革与创新。基于中国式现代化内涵的人民性、现代性、民主性和制... 详细信息

地方治理数智化变革引导基层治理变革的走向，是推进中国式现代化的重要基础。只有从中国式现代化视域审视地方治理数智化变革的基本逻辑，才能有效推动地方治理数智化的变革与创新。基于中国式现代化内涵的人民性、现代性、民主性和制度性叙事要求，新技术革命驱动下的地方治理数智化变革，不仅是整体智治价值理念、权责均衡关系结构的革新，而且是数据循证决策方式、体系再造底层规则的创新。然而，这一变革过程对技术理性的过度青睐导致了地方治理实践中对价值理性的忽视，极易引发工具支配的价值风险、责任缺位的伦理风险、技术至上的决策风险以及结构耗散的制度风险。倘若无法对这些风险进行有效的实践规制，那么技术应用的刚性一面将被发挥得淋漓尽致。为此，在地方治理数智化变革实践中，要通过政策环境持续优化、责任规约体系建构、人机交互系统重塑和技术治理规则增量，以纾解地方治理数智化变革的风险，使“赋能的智能技术”真正实现“高效能的治理”。

关键词：中国式现代化基层治理地方治理数智化

Transradial versus transfemoral rotablation for heavily calcified coronary lesions in contemporary drug-eluting stent era

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第5期12卷 489-496页

作者： Wei-Hsian Yin Chin-Kun Tseng Tien-ping Tsao hsu-Lung Jen Wen-Pin Huang Chien-Lung Huang Jiann-jong Wang Mason Shing Young Division of Cardiology Heart Center Cheng Hsin General Hospital Taipei Taiwan China Faculty of Medicine National Yang-Ming University Taipei Taiwan China Institute of Clinical Medicine National Yang-Ming University Taipei Taiwan China Cardiovascular Research Centre School of Medicine National Yang-Ming University Taipei Taiwan China

Background Although radial access for drug-eluting stent （DES） combined with rotational atherectomy （RA） in patients with calcified coronary lesions may be associated with a lower risk of major bleeding complications and obtain favorable clinical results compared with femoral access, the long-term outcome data of this approach were limited in contemporary DES era. Methods ＆ Results This retrospective study sought to compare in-hospital and long-term outcomes for patients undergoing RA via the transradial （TR） and transfemoral （TF） route in 126 consecutive patients （59 radial, 67 femoral） from 2009 to 2014. TR RA procedures were performed in 44/62 （71%） by the three TR operators, compared with 15/64 （23%） by the four TF operators in the present study. Significantly smaller diameter guide catheters and burrs （1.39 ± 0.16 mm vs. 1.53 ± 0.24 mm, P = 0.001） were used in the TR group. Procedural success rates were similar in both TR and TF groups. There was a significantly less major access site bleeding complications in favor of radial artery access （2% vs. 16%, P = 0.012）. The incidence of in-hospital death or myocardial infarction was low in both groups. Although a trend of lower adverse event rate was demonstrated in the TR group compared with the TF one, no statistical significance （21% vs. 27%, P = 0.135） was detected. Conclusions Radial access, a useful alternative to femoral access for RA and DES, can be safely and successfully performed on up to 71% of the patients with heavily calcified coronary lesions needing RA by experienced TR operators.

关键词： Calcified lesion Drug-eluting stent Rotablation Transfemoral Transradial

Plasmacytosis mimicking multiple myeloma in angioimmunoblastic T-cell lymphoma:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第17期12卷 3226-3234页

作者： Chia-Ching Lin hsu-Lin Lee Hsin-Yi Chuo Tuo-An Chen Ming-Yueh Liu Li-Mien Chen Division of Cardiovascular Surgery Department of SurgeryKaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology and Oncology Department of Internal MedicineTaichung Armed Forces General HospitalTaichung 411Taiwan Division of Hematology and Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Internal Medicine Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Pathology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Angioimmunoblastic T-cell lymphoma(AITL)is a common subtype of peripheral T-cell *** half of patients with AITL may concurrently present with *** numbers of plasma cells in the bone marrow are commonly observed at *** tumors mimic plasma cell myelomas,hindering a conundrum of clinical diagnoses and potentially delaying appropriate *** SUMMARY A 78-year-old woman experienced poor appetite,weight loss of 5 kg,fatigue 2 months before presentation,and shortness of breath 2 d before presentation,but no fever or night *** examination revealed splenomegaly and many palpable masses over the bilateral axillary regions,approximately>2 cm in size,with rubbery consistency and no *** tests revealed anemia and thrombocytopenia,lactate dehydrogenase level of 153 U/L,total protein level of 10.9 g/dL,albumin to globulin ratio of 0.2,and immunoglobulin G level more than the upper limit of 3000 mg/*** free kappa and lambda light chain concentrations were 451 and 614 mg/L,respectively.A pathological examination confirmed the diagnosis of *** initial treatment was the cyclophosphamide,epirubicin,vincristine,and prednisolone *** this treatment,pleural effusion was controlled,and the patient was discharged in a stable condition and followed up in our outpatient *** This report highlights the importance of differentiating reactive plasmacytosis from plasma cell myeloma in patients with hypergammaglobulinemia.A precise diagnosis of AITL requires a comprehensive evaluation,involving clinical,immunophenotypic,and histological findings conducted by a multidisciplinary team to ensure appropriate treatment.

关键词： Angioimmunoblastic T-cell lymphoma Plasmacytosis Multiple myeloma Lymphoma,Hypergammaglobulinemia Case report

Designing electrodes and electrolytes for batteries by leveraging deep learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research Energy 2024年第2期3卷 83-99页

作者： Chenxi Sui Ziyang Jiang Genesis Higueros David Carlson Po-Chun hsu Pritzker School of Molecular Engineering University of ChicagoChicagoIL 60637USA Civil and Environmental Engineering Duke UniversityDurhamNC 27708USA Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA

High-performance batteries are poised for electrification of vehicles and therefore mitigate greenhouse gas emissions,which,in turn,promote a sustainable ***,the design of optimized batteries is challenging due to the nonlinear governing physics and *** advancements have demonstrated the potential of deep learning techniques in efficiently designing batteries,particularly in optimizing electrodes and *** review provides comprehensive concepts and principles of deep learning and its application in solving battery-related electrochemical problems,which bridges the gap between artificial intelligence and *** also examine the potential challenges and opportunities associated with different deep learning approaches,tailoring them to specific battery ***,we aim to inspire future advancements in both fundamental scientific understanding and practical engineering in the field of battery ***,we highlight the potential challenges and opportunities for different deep learning methods according to the specific battery demand to inspire future advancement in fundamental science and practical engineering.

关键词： battery design fast-charging battery three-dimensional(3D)structure deep learning optimization

Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2015年第3期12卷 317-325页

作者： hsu Chyuan Hwei-Fang Tsai Horng-Tay Tzeng Chi-Chang Sung Chien-Sheng Wu Pei-Jer Chen ping-Ning hsu Department of Internal Medicine Cathay General Hospital Taipei Taiwan China Department of Internal Medicine Taipei Medical University 5iquang HOHospital Taipei Taiwan China Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan China Graduate Institute ofImmunology College of Medicine National Taiwan University Taipei Taiwan China Department of Internal Medicine Far Eastern Memorial Hospital NewTaipei City Taiwan China Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan China Departmentof Internal Medicine National Taiwan University Hospital Taipei Taiwan China These authors contributed equally to this work.

Hepatitis B virus （HBV） reactivation and recurrence are common in patients undergoing immunosuppression therapy. Tumor necrosis factor （TNF） blockage therapy is effective for the treatment of many autoimmune inflammatory diseases. However, the role of TNF-a blockage therapy in the innate and adaptive immune responses against HBV is still not clear. A detailed analysis of HBV infection under TNF-a blockage therapy is essential for the prophylaxis and therapy for HBV reactivation and recurrence. In this study, HBV clearance and T-cell responses were analyzed in a HBV-transfected mouse model under anti-TNF blockage therapy. Our results demonstrated that under TNF-a blockage therapy, HBV viral clearance was impaired with persistent elevated HBV viral load in a dose- and temporal-dependent manner. The impairment of HBV clearance under anti-TNF-a blockage therapy occurred at early time points after HBV infection. In addition, TNF-a blockade maintained a higher serum HBV viral load and increased the number of intrahepatic programmed cell death （PD）- 1highCD127low exhausted T cells. Furthermore, TNF-a blockade abolished Toll-like receptor 9 （TLR9） ligand-induced facilitation of HBV viral clearance. Taken together, TNF-a blockade impairs HBV clearance and enhances viral load, and these effects depend on early administration after HBV infection. Our results here demonstrate that early TNF-a blockade reduces viral clearance and persistently maintains elevated HBV viral load in a mouse model, suggesting that HBV may reactivate during theraoy with TNF-a-blocking agents.

关键词： HBV viral load hepatitis B virus tumor necrosis factor