Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology

作     者：Hwei-Fang Tsai Ping-Ning Hsu 

作者机构：Department of Internal MedicineTaipei Medical University Shuang Ho HospitalTaipeiTaiwan Gradute Institute of Clinical MedicineCollege of MedicineTaipei Medical UniversityTaipeiTaiwan Graduate Institute of ImmunologyCollege of MedicineNational Taiwan UniversityTaipeiTaiwan 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2010年第7卷第4期

页      面：255-259页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Health Research Institute(NHRI-EX95-9532SI) National Science Council,Taiwan(NSC90-2314B075B003 and NSC91-2320B-002) China Medical University(CMU96-266,CMU97-299) 

主　　题：apoptosis CagA chemokine Helicobacter pylori TRAIL 

摘      要：Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa,leading to chronic gastritis,peptic ulcers,gastric carcinoma and gastric mucosa-associated lymphoid tissue(MALT)*** studies have shown that apoptosis of gastric epithelial cells is increased during *** *** induced by microbial infections are factors implicated in the pathogenesis of *** *** enhanced gastric epithelial cell apoptosis in *** infection has been suggested to play an important role in the pathogenesis of chronic gastritis and gastric *** addition to directly triggering apoptosis,*** induces sensitivity to tumor-necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL)-mediated apoptosis in gastric epithelial cells via modulation of TRAIL apoptosis ***,*** infection induces infiltration of T lymphocytes and triggers inflammation to augment *** *** infection,there was significantly increased CCR61CD31 T-cell infiltration in the gastric mucosa,and the CCR6 ligand,CCL20 chemokine,was selectively expressed in inflamed gastric *** results implicate that the interaction between CCL20 and CCR6 may play a role in recruiting T cells to the sites of inflammation in the gastric mucosa during Helicobacter *** these mechanisms,chemokine-mediated T lymphocyte trafficking into inflamed epithelium is initiated and the mucosal injury in Helicobacter infection is *** article will review the recent novel findings on the interactions of *** with diverse host epithelial signaling pathways and events involved in the initiation of gastric pathology,including gastric inflammation,mucosal damage and development of MALT lymphomas.