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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim Joon-Tae Kim Ji Sung Lee Beom Joon Kim jong-moo park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan park Sang-Soon park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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Extracellular nucleoprotein exacerbates influenza viruspathogenesis by activating Toll-like receptor 4 and the NLRP3inflammasome

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Cellular & Molecular Immunology 2022年第6期19卷 715-725页

作者： Chang-Ung Kim Yu-Jin Jeong Pureum Lee moo-Seung Lee jong-Hwan park Young-Sang Kim Doo-Jin Kim Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea Department of Biochemistry Chungnam National UniversityDaejeonSouth Korea Environmental Diseases Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea University of Science and Technology(UST) DaejeonSouth Korea College of Veterinary Medicine Chonnam National UniversityGwangjuSouth Korea

Host immune responses, such as those initiated by pattern recognition receptor (PRR) activation, are important for viralclearance and pathogenesis. However, little is known about the interactions of viral proteins with surface PRRs or, moreimportantly, the association of innate immune activation with viral pathogenesis. In this study, we showed that internalinfluenza virus proteins were released from infected cells. Among these proteins, nucleoprotein (NP) played a critical role inviral pathogenesis by stimulating neighboring cells through toll-like receptor (TLR)2, TLR4, and the NLR family pyrin domaincontaining 3 (NLRP3) inflammasome. Through the activation of these PRRs, NP induced the production of interleukin (IL)-1β andIL-6, which subsequently led to the induction of trypsin. Trypsin induced by NP increased the infectivity of influenza virus,leading to increases in viral replication and pathology upon subsequent viral infection. These results reveal the role of releasedNP in influenza pathogenesis and highlight the importance of the interactions of internal viral proteins with PRRs in theextracellular compartment during viral pathogenesis.

关键词： Influenza virus Viral protein release Nucleoprotein Toll-like receptor Cyotkine-trypsin cycle

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Early-stage primary signet ring cell carcinoma of the colon

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World Journal of Gastroenterology 2013年第24期19卷 3895-3898页

作者： Jae Hyun Kim Seun Ja park moo In park Won moon Sung Eun Kim Department of Gastroenterology Kosin University College of Medicine

Primary signet ring cell carcinoma of the colorectum detected at an early stage is very rare; most cases are detected at an advanced stage. Therefore, its progno-sis is poorer than that of ordinary colorectal cancer. A 56-year-old Korean man was seen at this hospital for management of signet ring cell carcinoma of the co-lon. Colonoscopic examination revealed a Ⅱa-like, ill-defined and flatly elevated 9-mm residual tumor in the cecum. Endoscopic mucosal resection was preformed. Pathological examination of the resected specimen re-vealed signet ring cell carcinoma that had invaded the lamina propria without venous or perineural invasion. Abdominal computed tomography (CT) and positron CT showed no evidence of primary lesions or distant me-tastasis. An additional laparoscopic right-hemicolectomy was performed; no residual tumor or lymph node me-tastasis was found. We report a case of primary signet ring cell carcinoma of the colon detected at an early stage and provide a review of the literature.

关键词： Colon carcinoma Signet ring cell carcino-ma Primary carcinoma Early stage Endoscopic muco-sal resection

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Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage

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World Journal of Gastroenterology 2007年第23期13卷 3265-3267页

作者： Kyu-jong Kim Won moon moo In park Seun Ja park Seung Hyun Lee Bong Kwon Chun Department of Internal Medicine Kosin University College of Medicine Busan South Korea Department of General Surgery Kosin University College of Medicine Busan South Korea Department of Pathology Kosin University College of Medicine Busan South Korea

Gastrointestinal stromal tumor is rare, which arises from the mesenchymal tissues in the gastrointestinal tract, and it is extremely rare in the appendix. Only a few cases have been found in this location to date. Although the annual incidence of lower gastrointestinal bleeding has been increasing, bleeding related to the appendix is quite rare. We herein present a very rare case of gastrointestinal stromal tumor incidentally found by appendiceal hemorrhage.

关键词： Gastrointestinal stromal tumor Gastrointestinal tract Appendix Lower gastrointestinal bleeding Appendiceal hemorrhage

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Superior mesenteric vein thrombosis induced by influenza infection:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4193-4199页

作者： Gyu Man Oh Kyoungwon Jung Jae Hyun Kim Sung Eun Kim Won moon moo In park Seun Ja park Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Among the various types and causes of mesenteric ischemia,superior mesenteric vein(SMV)thrombosis is a rare and ambiguous *** a patient presents with SMV thrombosis,past medical history should be reviewed,and the patient should be screened for underlying *** thrombosis may also occur due to systemic *** this report,we describe a case of SMV thrombosis complicated by influenza B *** SUMMARY A 64-year-old male visited the hospital with general weakness,muscle aches,fever,and abdominal *** patient underwent computed tomography(CT)and was diagnosed with SMV *** the patient’s muscle pain and fever could not be explained by the SMV thrombosis,the clinician performed a test for influenza,which produced a positive result for influenza *** patient had a thrombus in the SMV only,with no invasion of the portal or splenic veins,and was clinically *** treatment was prescribed without surgery or other *** follow-up CT scan showed improvement,and the patient was subsequently discharged with continued oral anticoagulant *** This case provides evidence that influenza may be a possible risk factor for SMV *** unexplained abdominal pain is accompanied by an influenza infection,examination of an abdominal CT scan may be necessary to screen for possible SMV thrombosis.

关键词： Influenza B virus Mesenteric ischemia Venous thrombosis Mesenteric vascular occlusion Influenza Human Case reports

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Simple colonoscopy reporting system checking the detection rate of colon polyps

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World Journal of Gastroenterology 2015年第31期21卷 9380-9386页

作者： Jae Hyun Kim Youn Jung Choi Hye Jung Kwon Seun Ja park moo In park Won moon Sung Eun Kim Department of Internal Medicine Kosin University College of Medicine

AIM: To present a simple colonoscopy reporting system that can be checked easily the detection rate of colon ***: A simple colonoscopy reporting system Kosin Gastroenterology(KG quality reporting system) was developed. The polyp detection rate(PDR),adenoma detection rate(ADR),serrated polyp detection rate(SDR),and advanced adenoma detection rate(AADR) are easily calculated to use this ***: In our gastroenterology center,the PDR,ADR,SDR,and AADR test results from each gastroenterologist were updated,every month. Between June 2014,when the program was started,and December 2014,the overall PDR and ADR in our center were 62.5% and 41.4%,respectively. And the overall SDR and AADR were 7.5% and 12.1%,***: We envision that KG quality reporting system can be applied to develop a comprehensive system to check colon polyp detection rates in other gastroenterology centers.

关键词： Colon polyp Detection rate Reporting system

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Congenital absence of the splenic artery and splenic vein accompanied with a duodenal ulcer and deformity

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World Journal of Gastroenterology 2009年第11期15卷 1401-1403页

作者： Eun Kyung Shin Won moon Seun Ja park moo In park Kyu jong Kim Jee Suk Lee Jin Hwan Kwon Department of Gastroenterology Kosin University College of MedicineBusanSouth Korea Department of Radiology Kosin University College of MedicineBusanSouth Korea

Congenital absence of the splenic artery is a very rare *** the best of our knowledge, congenital absence of the splenic artery accompanied with absence of the splenic vein has not been *** report a case of the absence of the splenic artery and vein in a 61-year-old woman who presented with postprandial epigastric discomfort. Upper gastrointestinal endoscopy showed a dilated, pulsatile vessel in the fundus and duodenal stenosis. An abdominal computed tomography(CT)scan revealed absence of the splenic vein with a tortuously engorged gastroepiploic ***-dimensional CT demonstrated the tortuously dilated left gastric artery and the left gastroepiploic artery with non-visualization of the splenic *** administration of a proton pump inhibitor,abdominal symptoms resolved without any recurrence of symptoms during 6 mo of follow-up.

关键词： Congenital Anomaly Splenic artery Splenic vein Duodenum Ulcer Deformity

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Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

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World Journal of Gastroenterology 2017年第6期23卷 1059-1066页

作者： Sung Eun Kim moo In park Seun Ja park Won moon Jae Hyun Kim Kyoungwon Jung Hae Koo Kim Young Dal Lee Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication *** study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and *** overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with H. pylori eradication therapy *** second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure.

关键词： Helicobacter pylori Disease eradication Treatment failure Bismuth Diabetes mellitus

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Ischemic colitis after mesotherapy combined with anti-obesity medications

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World Journal of Gastroenterology 2010年第12期16卷 1537-1540页

作者： jong Bin Kim Won moon Seun Ja park moo In park Kyu-jong Kim Jae Nam Lee Seong Joo Kang Lee La Jang Hee Kyung Chang Department of Internal Medicine Kosin University College of Medicine Department of Pathology Kosin University College of Medicine

Mesotherapy and anti-obesity medications are gradually gaining worldwide popularity for purposes of body contouring and weight *** adverse effects are various,but there is a tendency to disregard *** colitis is one of the most common diseases associated with non-obstructive blood vessel ***,there have been no case reports about the adverse effects resulting from mesotherapy only or in combination with anti-obesity *** report on an interesting case of ischemic colitis after mesotherapy combined with anti-obesity medications in a 39-year-old female who had no risk factors.

关键词： Mesotherapy Anti-obesity medications Adverse effects Ischemic colitis

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Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 935-940页

作者： Seong-Jae Kim Hwajin Kim Jeongsook park Inyoung Chung Hyug-moo Kwon Wan-Sung Choi Ji-Myong Yoo Department of Ophthalmology School of MedicineGyeongsang National University Institute of Health Science Gyeongsang National University Department of Anatomy and Neurobiology BK21 Biomedical CenterSchool of MedicineGyeongsang National University School of Nano-Bioscience and Chemical Engineering Ulsan National Institute and Science and Technology

AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were ***: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with ***: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.

关键词： aldose reductase diabetes tonicity response element binding protein retinopathy

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