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Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea

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Frontiers of Medicine 2019年第6期13卷 713-722页

作者： Seo Yeon baik Hyunah Kim So Jung Yang Tong Min Kim Seung-Hwan Lee Jae Hyoung Cho Hyunyong Lee Hyeon Woo Yim Kun-Ho Yoon Hun-Sung Kim Department of Medical Informatics College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea College of Pharmacy Sookmyung Women’s UniversitySeoul 04310Republic of Korea Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Clinical Research Coordinating Center Catholic Medical CenterThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Preventive Medicine College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in *** compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first *** analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years *** included 3678 patients and analyzed the changes in *** GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,P<0.001).When comparing the GFR among different statins,significant differences were observed between atorvastatin and fluvastatin(−5.3%±0.7%vs.1.2%±2.2%,P<0.05)and between atorvastatin and simvastatin(−5.3%±0.7%vs.−0.7%±0.8%,P<0.05).In pitavastatin(odds ratio[OR]=0.64,95%confidence interval[CI]=0.46-0.87,P<0.005)and simvastatin(OR=0.69,95%CI=0.53-0.91,P<0.008),the GFR rate that decreased by<60 mL/min/1.73 m2 was significantly lower than that of *** long-term statin intake,GFR changed with the type of *** work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription.

关键词： statin glomerular filtration rate HMG-CoA reductase inhibitor chronic kidney disease

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer

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World Journal of Gastroenterology 2015年第12期21卷 3547-3553页

作者： Yong Sik Yoon Yong Beom Cho Kyu Joo Park Seung Hyuk baik Sang Nam Yoon Seung-Bum Ryoo Kil Yeon Lee Hungdai Kim Ryung-Ah Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center epartment of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Seoul National University College of Medicine Department of Surgery Yonsei University College of Medicine Severance Hospital Department of Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Surgery Kyung Hee University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Surgery Ewha Womans University School of Medicine

AIM: To determine the clinicopathologic characteristics of surgically treated ulcerative colitis(UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer(CAC) to those without CAC. METHODS: Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without ***: Among 415 UC patients, 383(92.2%) underwent total proctocolectomy, and of these, 342(89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients(11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy(P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-yearoverall survival rate was 82.2%.CONCLUSION: Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.

关键词： Ulcerative colitis Colorectal neoplasms Colorectal

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韩国的中国认识与中国现代史研究

近代史研究 2011年第2期 143-156页

作者：白永瑞韩国延世大学史学系国学研究院

一、序论2008年夏天，北京举办了奥运会，华丽的奥运开幕式展现在世人的面前，他们由此对中国产生怎样的印象呢？在耳边不时会听到“21世纪是中国的世纪”的声音的现实中，这一问题也具有更为重要的意义。

关键词：现代史研究中国韩国 2008年 21世纪奥运会开幕式

活力东亚的1919:作为革命起点的“五四”与“三一”

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探索与争鸣 2019年第5期 52-62,174页

作者：白永瑞韩国延世大学

五四运动与三一运动如镜子般互相映照。从全球化历史中的“同时性”的视角出发,可重新定位两者在世界史上的意义。在关注“五四”与“三一”的同时性时,也应注重对两者的个别性进行比较,从“连动的东亚”视角重新审视这两个事件。随着... 详细信息

五四运动与三一运动如镜子般互相映照。从全球化历史中的“同时性”的视角出发,可重新定位两者在世界史上的意义。在关注“五四”与“三一”的同时性时,也应注重对两者的个别性进行比较,从“连动的东亚”视角重新审视这两个事件。随着纷纷被卷入世界体系,帝国日本、半殖民地中国、殖民地韩国这三者在世界体系的等级结构中处于各自不同的地位。关注分处不同地位却又相互作用的东亚的状况,是为了透视(半)殖民地现代的复杂性,从中找出超克现代的契机,也意味着同时进行“现代适应与现代超克”的“双重课题论”的有效性。这两个事件从20世纪20年代开始在社会历史的变化中被不断重新诠释,如何(再)记忆两者不只是历史问题,也是现实问题。现在正是需要探索重新解读两者方法的转折点。可以尝试将两者分别称为“五四革命”与“三一革命”来挑战这个课题。“五四”与“三一”中出现的民众集结样貌,为以革命来概括理解这两个事件的历史意义提供了根据。“五四”与“三一”虽然是两个国家国别史的一部分,但同时也与东亚区域史、全球史相互作用。

关键词：现代性半殖民东亚区域史共和全球本土学

O-GlcNAc通过抑制Wnt信号通路影响上唇发育的实验研究

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口腔疾病防治 2016年第5期24卷 273-279页

作者：朴正国邹瑞闫璟 Seok-Kee baik Hye-jin Tak Sang-Hwy Lee 广州医科大学附属口腔医院.广州口腔病研究所.口腔医学重点实验室广东广州510140 Dept.of Applied Life Science College of DentistryYonsei University Dept.of Oral and Maxillofacial Surgery College of DentistryYonsei University

目的探讨氧联乙酰葡萄糖胺(O-linked N-acetylglucosamine,O-Glc NAc)影响上唇发育时上皮层的消失过程中,Wnt信号通路在其中发挥的作用。方法通过在鸡胚唇部植入浸有O-GlcNAc促进剂氧联乙酰葡萄糖胺转移酶(O-GlcNAc transferase,OGT)、O... 详细信息

目的探讨氧联乙酰葡萄糖胺(O-linked N-acetylglucosamine,O-Glc NAc)影响上唇发育时上皮层的消失过程中,Wnt信号通路在其中发挥的作用。方法通过在鸡胚唇部植入浸有O-GlcNAc促进剂氧联乙酰葡萄糖胺转移酶(O-GlcNAc transferase,OGT)、O-GlcNAc的抑制酶氧联乙酰葡萄糖胺水解酶(O-Glc NAcase,OGA)以及OGA的抑制剂链脲佐菌素(streptozoticin,SZT)的琼脂糖微球,构建O-Glc NAc高表达与低表达以及反向高表达实验组,并继续孵育24 h,茜素红—阿利新蓝骨组织染色观察胚胎骨、软骨发生的变化,TUNEL法检测细胞凋亡情况,免疫组化染色法检测Wnt信号系包括GSK-3β、β-catenin在内的一系列信号因子。结果 O-GlcNAc过表达组OGT和STZ中,上皮层的消失出现延迟,骨染色发现胚胎唇部出现骨缺损,TUNEL检测与正常组相比未发现明显细胞凋亡,但GSK-3β在细胞质内表达增加,β-catenin细胞核内表达减少;正常侧及O-GlcNAc低表达组OGA中上唇发育未受影响。结论 O-GlcNAc过表达时引起上皮层的消失发生延迟,这并非由细胞凋亡减少引起,而是可能通过抑制Wnt信号通路,导致GSK-3β、β-catenin在内的相关信号因子变化,这些变化将影响上唇发育并可能导致唇腭裂的发生。

关键词： Wnt信号通路氧联乙酰葡萄糖胺细胞凋亡鸡胚上唇

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连动的东亚与三一运动:持续学习的革命

华东师范大学学报（哲学社会科学版） 2019年第6期51卷 80-90,176,177页

作者： [韩]白永瑞韩国延世大学

从全球与"连动的东亚"的视角而言,1919年朝鲜三一运动的起因是因为"三一"的参与者们希望利用国际秩序变动的缝隙,挪用"全球性瞬间",使本国的社会变革能呼应世界史的转型。此外,殖民当局的压迫,也构成了"三一"这一集体性抗争的原因。"三... 详细信息

从全球与"连动的东亚"的视角而言,1919年朝鲜三一运动的起因是因为"三一"的参与者们希望利用国际秩序变动的缝隙,挪用"全球性瞬间",使本国的社会变革能呼应世界史的转型。此外,殖民当局的压迫,也构成了"三一"这一集体性抗争的原因。"三一"的主体、媒介和目标共同组成了"民"的集结经验,而贯穿其中的特点是殖民地条件下的现代性及传统性的并存及其意义的重构。如果说革命不只是指颠覆政权,而是指社会整体的大规模转型,即思想、文化的根本性变化和民众主体力量的增强,那么"三一"就可以被视为"革命"。由于"三一"的结果表现为"渐进的、累积性的成就",因而可以称之为"持续学习的革命"或"现在进行中的革命"。

关键词：三一运动殖民性东亚共和文明转型国民代表革命

Interleukin-1α and tumor necrosis factor-α expression on the compressed side of gingiva during orthodontic tooth movement

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Open Journal of Stomatology 2012年第3期2卷 182-187页

作者： Hyoung-Seon baik Chong-Kwan Kim Won Hee Lim Youn Sic Chun Department of Orthodontics College of Dentistry Yonsei University Seoul Korea Department of Periodontics College of Dentistry Yonsei University Seoul Korea Division of Orthodontics Department of Dentistry Ewha Womans University Seoul Korea

Objectives: The aim of this study was to investigate the effect of orthodontic loading on the expression of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in compressed gingiva. Materials and Methods: Twenty-four male Wistar rats were used with four rats as controls at day 0. In ten rats, corticotomy was performed on either left or right side and the re-maining side was served as control, and killed at 7 and 14 days. In the remaining ten rats, maxillary right and left first molars were moved orthodontically with a constant force of 20 g;appliance and appliance in conjunction with cortictomy (appliance-corticotomy) were sequentially alternated between left and right sides and euthanized at 7 and 14 days. Real time polymerase chain reactions of compressed gingiva excised from the euthanized rats was performed to measure mRNA expressions of IL-1α and TNF-α. Results: There were no significant differences in the expression of IL-1α between all the groups. On the other hand, TNF-α from the pressure side in the ap- pliance group and the appliance in conjunction with corticotomy group showed significant increase on the 7th day compared to that of either control or corticotomy group. Conclusions: Orthodontic loading induced the elevation of TNF-α in compressed

关键词： Tooth Movement Gingiva Compressed Side IL-1α TNF-α

Hepatocellular carcinoma,decompensation,and mortality based on hepatitis C treatment:A prospective cohort study

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World Journal of Gastroenterology 2022年第30期28卷 4182-4200页

作者： Gwang Hyeon Choi Eun Sun Jang Young Seok Kim Youn Jae Lee In Hee Kim Sung Bum Cho Han Chu Lee Jeong Won Jang Moran Ki Hwa Young Choi Dahye baik Sook-Hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907JeonbukSouth Korea Department of Internal Medicine Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea Cancer Control and Population Health Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408South Korea

BACKGROUND Prospective studies of the long-term outcomes of patients with hepatitis C virus(HCV)infection after treatment with interferon-based therapy(IBT)or directacting antivirals(DAA)are limited in many Asian *** To elucidate the incidences of hepatocellular carcinoma(HCC)and death/transplantation based on treatment with IBT or DAA,to compare the outcomes of the sustained virologic response(SVR)to IBT and DAA,and to investigate outcome-determining factors after *** This cohort included 2054 viremic patients(mean age,57 years;46.5%male;27.4%with cirrhosis)prospectively enrolled at seven hospitals between 2007 and *** were classified as the untreated group(n=619),IBT group(n=578),and DAA group(n=857).Outcomes included the incidences of HCC and death/*** incidences of the outcomes for each group according to treatment were calculated using an exact method based on the Poisson distribution.A multivariate Cox regression analysis was performed to determine the factors associated with HCC or death/transplantation,followed by propensity score matching to confirm the *** During a median of 4.1 years of follow-up,HCC and death/transplantation occurred in 113 and 206 patients,respectively,in the entire *** with the untreated group,the incidences of HCC and death/transplantation were significantly lower in the IBT group[adjusted hazard ratio(aHR)0.47,95%CI:0.28-0.80 and aHR 0.28,95%CI:0.18-0.43,respectively]and the DAA group(aHR 0.58,95%CI:0.35-0.96,and aHR 0.19,95%CI:0.20-0.68,respectively).Among 1268 patients who attained SVR with IBT(n=451)or DAA(n=816),the multivariable-adjusted analysis showed no differences in the risks of HCC(HR 2.03;95%CI:0.76-5.43)and death/transplantation(HR 1.38;95%CI:0.55-3.49)between the two *** was confirmed by a propensity score-matching *** factors for HCC after SVR were age,genotype 1,and the presence of *** Treatment and achieving SVR

关键词： Hepatitis C virus Direct-acting antiviral Sustained virologic response Hepatocellular carcinoma Mortality

Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors

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Light(Science & Applications) 2014年第1期3卷 5-12页

作者： Byoungchoo Park Soo Hong Yun Chan Youn Cho Young Chan Kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh Inchan Hwang Ku Youn baik Young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi Department of Electrical and Biological Physics Kwangwoon UniversitySeoul 139-701Republic of Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 139-701Republic of Korea

Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver *** demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)***,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection *** highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors.

关键词： attenuated total reflection optical sensors photocurrent generation polymer photovoltaic devices surface plasmon