Interleukin-1α and tumor necrosis factor-α expression on the compressed side of gingiva during orthodontic tooth movement
Interleukin-1α and tumor necrosis factor-α expression on the compressed side of gingiva during orthodontic tooth movement作者机构：Department of Orthodontics College of Dentistry Yonsei University Seoul Korea Department of Periodontics College of Dentistry Yonsei University Seoul Korea Division of Orthodontics Department of Dentistry Ewha Womans University Seoul Korea
出 版 物：《Open Journal of Stomatology》 (口腔学期刊（英文）)
年 卷 期：2012年第2卷第3期
页 面：182-187页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Tooth Movement Gingiva Compressed Side IL-1α TNF-α
摘 要：Objectives: The aim of this study was to investigate the effect of orthodontic loading on the expression of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in compressed gingiva. Materials and Methods: Twenty-four male Wistar rats were used with four rats as controls at day 0. In ten rats, corticotomy was performed on either left or right side and the re-maining side was served as control, and killed at 7 and 14 days. In the remaining ten rats, maxillary right and left first molars were moved orthodontically with a constant force of 20 g;appliance and appliance in conjunction with cortictomy (appliance-corticotomy) were sequentially alternated between left and right sides and euthanized at 7 and 14 days. Real time polymerase chain reactions of compressed gingiva excised from the euthanized rats was performed to measure mRNA expressions of IL-1α and TNF-α. Results: There were no significant differences in the expression of IL-1α between all the groups. On the other hand, TNF-α from the pressure side in the ap- pliance group and the appliance in conjunction with corticotomy group showed significant increase on the 7th day compared to that of either control or corticotomy group. Conclusions: Orthodontic loading induced the elevation of TNF-α in compressed
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