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Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

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Asian Journal of Andrology 2012年第2期14卷 320-324页

作者： Mee-Young Lee In-Sik Shin Chang-seob seo Nam-Hun Lee Hye-Kyung Ha jong-Keun Son Hyeun-Kyoo Shin Herbal Medicine EBM Research Center Korea institute of Oriental MedicineExporo 483Yusung-guDaejeon 305-811Koreaand Coilege of Pharmacy Yeungnam UniversityGyonsan 712-749Korea

Benign prostatic hyperplasia （BPH） is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract （MFME） improves BPH, using the testosterone propionate （TP）-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP （3 mg kg-1） dissolved in corn oil, for 4 weeks. MFME was administered daily by oral garage at a dose of 200 mg kg-1 for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight （prostate/body weight ratio） was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone （DHT） in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound（s） responsibility for inducing the protective effect against BPH and determine its mechanism of action,

关键词： benign prostatic hyperplasia dihydrotestosterone Melandrium firmum (S. et Z.)RoHRB prostate testosterone

Molecular mechanisms of apoptosis induced by Scorpio water extract in human hepatoma HepG2 cells

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World Journal of Gastroenterology 2005年第7期11卷 943-947页

作者： Kang-beom Kwon Eun-Kyung Kim Jung-Gook Lim Eun-Sil Jeong Byung-Cheul Shin Young-Se Jeon Kang-San Kim Eun-A seo Do-Gon Ryu Department of Physiology Department of Rehabilitation Medicine Department of Internal Medicine Department of Food and Nutrition

AIM: To clarify the mechanism underlying the anti-mutagenic and anti-cancer activities of Scorpio water extract (SWE). METHODS: Human hepatoma HepG2 cells were incubated with various concentrations of SWE. After 24-h incubation, cytotoxicity and apoptosis evaluations were determined by MTT and DNA fragmentation assay, respectively. After treatment with SWE, mitochondrial membrane potential (MMP) was determined by measuring the retention of the dye 3,3'-dihexyloxacarbocyanine (DiOC6(3)) and the protein expression including cytochrome C and poly-(ADPribose) polymerase (PARP) were measured by Western blotting. Caspase-3 and -9 enzyme activities were measured using specific fluorescence dyes such as Ac-DEVD-AFC and Ac-LEHD-AFC. RESULTS: We found that treatment with SWE induced apoptosis as confirmed by discontinuous DNA fragmentation in cultured human hepatoma HepG2 cells. Our investigation also showed that SWE-induced apoptosis of HepG2 cells were associated with intracellular events including disruption of MMP, increased translocation of cytochrome C from mitochondria to cytosol, activation of caspase-3, and PARP. Pre-treatment of N-acetyl-Asp-Glu-Val-Asp-CHO (Ac-DEVD-CHO), a caspase-3 specific inhibitor, or cyclosporin A (CsA), an inhibitor of MMP disruption, completely abolished SWE-induced DNA fragmentation. CONCLUSION: These results suggest that SWE possibly causes mitochondrial damage, leading to cytochrome C release into cytosol and activation of caspases resulting in PARP cleavage and execution of apoptotic cell death in HepG2 cells. These results further suggest that Scorpio may be a valuable agent of therapeutic intervention of human hepatomas.

关键词： Scorpio Human hepatoma HepG2 cell Apoptosis

Recent advances in plant membrane-bound transcription factor research: Emphasis on intracellular movement

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Journal of Integrative Plant Biology 2014年第4期56卷 334-342页

作者： Pil Joon seo Department of Bioactive Material Sciences Chonbuk National University Research Center of Bioactive Materials Chonbuk National University Department of Chemistry and Research Institute of Physics and Chemistry Chonbuk National University

Transcription factors constitute numerous signal transduction networks and play a central role in gene expression regulation. Recent studies have shown that a limited portion of transcription factors are anchored in the cellular membrane, storing as dormant forms. Upon exposure to environmental and developmental cues, these transcription factors are released from the membrane and translocated to the nucleus, where they regulate associated target genes. As this process skips both transcriptional and translational regulations, it guarantees prompt response to external and internal signals. Membrane- bound transcription factors （MTFs） undergo several unique steps that are not involved in the action of canonical nuclear transcription factors： proteolytic processing and intracellular movement. Recently, alternative splicing has also emerged as a mechanism to liberate MTFs from the cellular membranes, establishing an additional activation scheme independent of proteolytic processing. Multiple layers of MTF regulation add complexity to transcriptional regulatory scheme and ensure elaborate action of MTFs. In this review, we provide an overview of recent findings on MTFs in plants and highlight the molecular mechanisms underlying MTF liberation from cellular membranes with an emphasis on intracellular movement.

关键词： Alternative splicing basic leucine zipper membrane-boundtranscription factor bZIP28 intracellular movement membrane-bound transcription factor NTL proteolytic processing

Electrically focus-tuneable ultrathin lens for high-resolution square subpixels

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Light(Science & Applications) 2020年第1期9卷 1066-1078页

作者： Sehong Park Gilho Lee Byeongho Park Youngho seo Chae bin Park Young Tea Chun Chulmin Joo Junsuk Rho jong Min Kim James Hone seong Chan Jun School of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Electrical Engineering Division Engineering DepartmentUniversity of Cambridge9 JJ Thomson AvenueCambridge CB3 OFAUK Department of Electronic Material Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Mechanical Engineering Columbia University500 West 120th StreetMudd 220New YorkNY 10027USA

Owing to the tremendous demands for high-resolution pixel-scale thin lenses in displays,we developed a graphenebased ultrathin square subpixel lens(USSL)capable of electrically tuneable focusing(ETF)with a performance competitive with that of a typical mechanical refractive *** fringe field due to a voltage bias in the graphene proves that our ETF-USSL can focus light onto a single point regardless of the wavelength of the visible light—by controlling the carriers at the Dirac point using radially patterned graphene layers,the focal length of the planar structure can be adjusted without changing the curvature or position of the lens.A high focusing efficiency of over 60% at a visible wavelength of 405 nm was achieved with a lens thickness of <13 nm,and a change of 19.42% in the focal length with a 9% increase in transmission was exhibited under a driving *** design is first presented as an ETF-USSL that can be controlled in pixel units of flat panel displays for visible *** can be easily applied as an add-on to high resolution,slim displays and provides a new direction for the application of multifunctional autostereoscopic displays.

关键词： visible driving competitive

Defect engineering of ternary Cu-In-Se quantum dots for boosting photoelectrochemical hydrogen generation

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Carbon Energy 2023年第12期5卷 215-228页

作者： Shi Li Sung-Mok Jung Wookjin Chung Joo-Won seo Hwapyong Kim Soo Ik Park Hyo Cheol Lee Ji Su Han Seung beom Ha In Young Kim Su-Il In Jae-Yup Kim Jiwoong Yang Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical Engineering Dankook UniversityYonginRepublic of Korea Department of Chemistry and Nanoscience College of Natural ScienceEwha Womans UniversitySeoulRepublic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

Heavy-metal-free ternary Cu–In–Se quantum dots(CISe QDs)are promising for solar fuel production because of their low toxicity,tunable band gap,and high light absorption *** defects significantly affect the photophysical properties of QDs,the influence on photoelectrochemical hydrogen production is not well ***,we present the defect engineering of CISe QDs for efficient solar-energy *** acid–base reactions between metal halide–oleylamine complexes and oleylammonium selenocarbamate are modulated to achieve CISe QDs with the controlled amount of Cu vacancies without changing their *** them,CISe QDs with In/Cu=1.55 show the most outstanding photoelectrochemical hydrogen generation with excellent photocurrent density of up to 10.7 mA cm-2(at 0.6 VRHE),attributed to the suitable electronic band structures and enhanced carrier concentrations/lifetimes of the *** proposed method,which can effectively control the defects in heavy-metal-free ternary QDs,offers a deeper understanding of the effects of the defects and provides a practical approach to enhance photoelectrochemical hydrogen generation.

关键词： copper-indium-selenide defect engineering photoelectrochemical hydrogen generation quantum dots solar hydrogen

Rapid determination of lithium-ion battery degradation: High C-rate LAM and calculated limiting LLI

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Journal of Energy Chemistry 2022年第4期31卷 663-671页

作者： Gyuwon seo Jaeyun Ha Moonsu Kim Jihyeon Park Jaewon Lee Eunoak Park Sungyool Bong Kiyoung Lee Soon jong Kwon Seung-pil Moon Jinsub Choi Jaeyoung Lee Electrochemical Reaction and Technology Laboratory School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005South Korea Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005South Korea Korea Electric Power Corporation Research Institute Daejeon 34056South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes(ifRC-CHESS) GISTGwangju 61005South Korea

Herein,incremental capacity-differential voltage (IC-DV) at a high C-rate (HC) is used as a non-invasive diagnostic tool in lithium-ion batteries,which inevitably exhibit capacity fading caused by multiple mechanisms during charge/discharge *** battery degradation modes are complex,the simple output of capacity fading does not yield any useful data in that *** IC and DV curves obtained under restricted conditions (<0.1C,25℃) were applied in non-invasive analysis for accurate observation of degradation symptoms,a facile,rapid diagnostic approach without intricate,complex calculations is critical in on-board ***,Li Ni_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC532)/graphite pouch cells were cycled at 4 and 6C and the degradation characteristics,i.e.,loss of active materials (LAM) and loss of lithium inventory (LLI),were parameterized using the IC-DV *** the incremental current cycling,the initial steep LAM and LLI slopes underwent gradual transitions to gentle states and revealed the gap between low-and high-current measurements.A quantitative comparison of LAM at high and low C-rate showed that a IC;revealed the relative amount of available reaction region limited by cell ***,this did not provide a direct relationship for estimating the LAM at a low ***,the limiting LLI,which is calculated at a C-rate approaching 0,was obtained by extrapolating the LLI through more than two points measured at high C-rate,and therefore,the LLI at 0.1C was accurately determined using rapid cycling.

关键词： Battery degradation Rapid degradation diagnosis Loss of active materials(LAM) Loss of lithium inventory(LLI) Incremental capacity(IC) Differential voltage(DV)

Effectiveness Analysis of DVFS and DPM in Mobile Devices

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Journal of Computer Science & Technology 2012年第4期27卷 781-790页

作者： Youngbin seo Jeongki Kim Euiseong seo Computer Science and Engineering Major University of Science and Technology217 Gajeong-roYuseong-guDaejeon 305-350Korea Electronics and Communications Research Institute 138 GajengnoYuseong-guDaejeonKorea College of Information and Communication Engineering Sungkyunkwan University2066 Seubu-roJangan-gu Suwon 440-746Korea

The demand for high-performance embedded processors in multimedia mobile electronics is growing and their power consumption thus increasingly threatens battery lifetime. It is usually believed that the dynamic voltage and frequency scaling （DVFS） feature saves significant energy by changing the performance levels of processors to match the performance demands of applications on the fly. However, because the energy efficiency of embedded processors is rapidly improving, the effectiveness of DVFS is expected to change. In this paper, we analyze the benefit of DVFS in state-of-the-art mobile embedded platforms in comparison to those in servers or PCs. To obtain a clearer view of the relationship between power and performance, we develop a measurement methodology that can synchronize time series for power consumption with those for processor utilization. The results show that DVFS hardly improves the energy efficiency of mobile multimedia electronics, and can even significantly worsen energy efficiency and performance in some cases. According to this observation, we suggest that power management for mobile electronics should concentrate on adaptive and intelligent power management for peripherM devices. As a preliminary design, we implement an adaptive network interface card （NIC） speed control that reduces power consumption by 1070 when NIC is not heavily used. Our results provide valuable insights into the design of power management schemes for future mobile embedded systems.

关键词： dynamic voltage scaling power management battery management energy eiffciency smart phone

Effect of Cristobalite and Quartz on the Properties of Gypsum Bonded Investment

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Journal of Materials Science & Technology 2008年第1期24卷 143-144页

作者： Yun-jong Kim Sang-Bae Kim Hyun-Hye Park Myeong-Deok seo Byoung-Cheon Lee Man-So Han Taik-Nam Kim Sung-Baek Cho Korea Institute of Geoscience and Mineral Resources (KIGAM) Gajeong-dong 30 Yuseong-kuDaejeon 305-350Korea Department of Materials Engineering Graduate School Paichai UniversityDaejeon 302-735Korea Dept.of Dental Laboratory Technology Daejeon Health Science College Korea

Generally the gold investment material consists of cristobalite,quartz and *** physical property of gold investment materials depends on its thermal expansion coefficients,compressive strength,and particles size *** the thermal expansion coefficient of cristobalite and quartz are 2.6×10^-6/℃and 2.32×10^-6/℃respectively,the composition ratio of each components influence the thermal and physical properties of gold investment *** the clinical applications,it is necessary to improve the properties of gold investment materials such as homogeneous size distribution and thermal expansion *** the present study,effect of inorganic fillers such as cristobalite and quartz on gold alloy investment was investigated to improve the properties of *** compressive strength and thermal expansion coefficients of the specimens were *** results showed that cristobalite and quartz were homogeneously distributed by milling. The optimum compressive strength was obtained at the ratio of 42：22 cristobalite and quartz,respectively.

关键词： Investment Cristobalite Quartz Thermal expansion coefficient Compressivestrength

Spontaneous rupture of hepatic metastasis from a thymoma: A case report

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World Journal of Gastroenterology 2016年第44期22卷 9860-9864页

作者： Ho Jae Kim Yong Eun Park Min seo Ki Se Ju Lee Seung Hun beom Dai Hoon Han Young Nyun Park Jun Yong Park Department of Internal Medicine Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine Department of Pathology Yonsei University College of Medicine

Bleeding resulting from spontaneous rupture of the liver is an infrequent but potentially life threatening complication that may be associated with an underlying liver disease. A hepatocellular carcinoma or hepatic adenoma is frequently reported is such cases. However, hemoperitoneum resulting from a hepatic metastatic thymoma is extremely rare. Here, we present a case of a 62-year-old man with hypovolemic shock induced by ruptured hepatic metastasis from a thymoma. At the first hospital admission, the patient had a 45-mm anterior mediastinal mass that was eventually diagnosed as a type A thymoma. The mass was excised, and the patient was disease-free for 6 years. He experienced sudden-onset right upper quadrant pain and was again admitted to our hospital. We noted large hemoperitoneum with a 10-cm encapsulated mass in S5/8 and a 2.3-cm nodular lesion in the right upper quadrant of the abdomen. He was diagnosed with hepatic metastasis from the thymoma, and he underwent chemotherapy and surgical excision.

关键词： Spontaneous rupture Hemoperitoneum Transarterial chemoembolization Hepatic metastasis Thymoma