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Three-dimensional label-free morphology of CD8+T cells as a sepsis biomarker

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Light(Science & Applications) 2023年第12期12卷 2565-2576页

作者： MinDong Sung jong hyun Kim hyun-Seok Min Sooyoung Jang JaeSeong Hong Bo Kyu Choi JuHye Shin Kyung Soo Chung Yu Rang Park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Tomocube Inc155 Sinseong-roShinsung-dongYuseong-guDaejeonRepublic of Korea

Sepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality *** lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its *** aimed to investigate the potential of three-dimensional label-free CD8+T cell morphology as a biomarker for *** study included three-time points in the sepsis recovery cohort(N=8)and healthy controls(N=20).Morphological features and spatial distribution within cells were compared among the patients'*** developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell *** between the morphological features and clinical indices were *** morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival *** model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100%with only a few cells,and a strong correlation between the morphological features and clinical indices was *** study highlights the potential of three-dimensional label-free CD8+T cell morphology as a promising biomarker for *** approach is rapid,requires a minimum amount of blood samples,and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.

关键词： sepsis diagnosis Morphological

Rapid pressure-assisted sinter bonding in air using 200 nm Cu particles and enhancement of bonding strength by successive pressureless annealing

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Transactions of Nonferrous Metals Society of China 2022年第2期32卷 629-638页

作者： Myeong In KIM jong-hyun LEE Department of Materials Science and Engineering Seoul National University of Science and Technology232 Gongneung-roNowon-guSeoul 139-743Korea

To design an effective and realistically applicable sinter bonding process for power devices,we proposed a two-step process using a 200 nm Cu-particle-based paste to form a bondline having high-temperature sustainability and superior thermal *** process involved rapid pressure-assisted sinter bonding in air followed by pressureless annealing in a nitrogen *** the case of a paste prepared with a mixture of 20 wt.%malic acid and 80 wt.%ethylene glycol,sinter bonding at 300℃and 5 MPa for only 30 s resulted in a sufficient shear strength of 23.1 *** shear strength was significantly enhanced to 69.6 MPa by the additional pressureless aging for 30 ***,the two-step sinter bonding process is expected to provide an outstanding production rate as a next-generation sinter bonding process.

关键词： submicron Cu particles Cu paste malic acid sinter bonding successive annealing shear strength

Rapid detection of influenza A(H1N1)virus by conductive polymer-based nanoparticle via optical response to virus-specific binding

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Nano Research 2022年第3期15卷 2254-2262页

作者： Geunseon Park hyun-Ouk Kim jong-Woo Lim Chaewon Park Minjoo Yeom Daesub Song Seungjoo Haam Department of Chemical&Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Division of Chemical Engineering and Bioengineering College of Art Culture and EngineeringKangwon National UniversityChuncheon-siGangwon-do 24341Republic of Korea Biohealth-machinery Convergence Engineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea College of Pharmacy Korea UniversitySejong 30019Republic of Korea

A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral *** this study,conductive polymer-based nanoparticles have been developed as a tool for rapid diagnosis of influenza A(H1N1)*** distinctive property of a conductive polymer that transduces stimulus to respond,enabled immediate optical signal processing for the specific recognition of H1N1 *** poly(aniline-co-pyrrole)-encapsulated polymeric vesicles,functionalized with peptides,were fabricated for the specific recognition of H1N1 *** low solubility of conductive polymers was successfully improved by employing vesicles consisting of amphiphilic copolymers,facilitating the viral titer-dependent production of the optical *** optical response of the detection system to the binding event with H1N1,a mechanical stimulation,was extensively analyzed and provided concordant information on viral titers of H1N1 virus in 15 *** specificity toward the H1N1 virus was experimentally demonstrated via a negative optical response against the control group,***,the designed system that transduces the optical response to the target-specific binding can be a rapid tool for the diagnosis of H1N1.

关键词： influenza A(H1N1)virus conductive polymer optical property rapid detection

Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis

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Chinese Journal of Natural Medicines 2018年第2期16卷 97-104页

作者： Myoung-schook Yoou Sun-Young nam Kyoung Wan Yoon hyun-Ja Jeong hyung-Min Kim Department of Pharmacology College of Korean Medicine Kyung Hee University Department of Biotechnology Hoseo University Department of Food Science & Technology and Research Institute for Basic Science Hoseo University

Bamboo salt(BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis(AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene(DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis. BS administration reduced the total clinical severity and scratching frequencies, compared with the AD group. In the serum of DNFB-induced AD mice, the levels of IgE, histamine, thymic stromal lymphopoietin(TSLP), interleukin(IL)-5, and IL-13 were significantly reduced by BS treatment. BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions. BS markedly reduced the infiltration of inflammatory cells. Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD.

关键词： Bamboo salt Atopic dermatitis Thymic stromal lymphopoietin Caspase-1

Multiscale Image Dehazing and Restoration:An Application for Visual Surveillance

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Computers, Materials & Continua 2022年第1期70卷 1-17页

作者： Samia Riaz Muhammad Waqas Anwar Irfan Riaz hyun-Woo Kim Yunyoung nam Muhammad Attique Khan Department of Computer Science COMSATS University IslamabadWah Campus47040Pakistan Department of Computer Science COMSATS University IslamabadLahore CampusLahorePakistan Department of Electronics and Communication Engineering Hanyang UniversityAnsanKorea Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Computer Science HITEC University TaxilaTaxila47080Pakistan

The captured outdoor images and videos may appear blurred due to haze,fog,and bad weather *** droplets or dust particles in the atmosphere cause the light to scatter,resulting in very limited scene discernibility and deterioration in the quality of the image ***,image dehazing has gainedmuch popularity because of its usability in a wide variety of *** algorithms have been proposed to solve this ill-posed *** algorithms provide quite promising results in some cases,but they include undesirable artifacts and noise in haze patches in adverse *** of these techniques take unrealistic processing time for high image *** this paper,to achieve real-time halo-free dehazing,fast and effective single image dehazing we propose a simple but effective image restoration technique using multiple *** will improve the shortcomings of DCP and improve its speed and efficiency for high-resolution images.A coarse transmissionmap is estimated by using the minimumof different size *** a cascaded fast guided filter is used to refine the transmission *** introduce an efficient scaling technique for transmission map estimation,which gives an advantage of very low-performance degradation for a highresolution *** performance evaluation,quantitative,qualitative and computational time comparisons have been performed,which provide quiet faithful results in speed,quality,and reliability of handling bright surfaces.

关键词： Dehaze defog pixel minimum patch minimum edge preservation

GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro

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Signal Transduction and Targeted Therapy 2020年第1期5卷 255-257页

作者： Kyung Soo Hong June Hong Ahn jong Geol Jang jong Ho Lee Hong nam Kim Dongha Kim Wonhwa Lee Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Laboratory Medicine College of MedicineYeungnam UniversityYeungnam University Medical CenterDaegu 42415Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Department of Anatomy College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea

Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health *** is the first time that the WHO has declared a pandemic since H1N1 in *** of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(https://***/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics.

关键词： drugs mortality cytokine

Stress-Strain Partitioning Analysis in Dual Phase Steels

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Journal of Iron and Steel Research International 2011年第S1期18卷 310-311页

作者： Eun-Joon Chun nam-hyun Kang Yong-Ho Park Man-Been Moon Department of Materials Science and Engineering Pusan National UniversityBusan 609-735South Korea hyundai HYSCO R&D center 313Donggok-riSongsan-myeonDangjin-gunChungnam 343-831South Korea

Dual-Phase (DP) steels are made of ductile ferrite phase and hard martensite *** it became crucial in progress of automotive industry to save fuel consumption and reduce total weight of vehicles,we need more accurate estimation of distribution to mechanical properties in total amounts of *** steels have considerable difference of mechanical levels in each phase including ferrite and *** is why this study focuses on deconvolution of experimental tensile curve into ferrite and martensite using EBSD for calculation of phase volume fractions and Swift *** for certain parameter of each phase was conducted to produce the deconvolution curves.

关键词： dual phase steel Swift equation EBSD stress-strain partitioning

Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins,which impairs drought stress tolerance

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Journal of Integrative Plant Biology 2021年第3期63卷 431-437页

作者： Seong Gwan Yu Na hyun Cho jong Hum Kim Tae Rin Oh Woo Taek Kim Department of Systems Biology and Division of Life Science Yonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

Drought stress has detrimental effects on *** the abscisic acid(ABA)-mediated drought response is well established,defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely ***1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub *** of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal *** dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type *** results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress.

关键词： Arabidopsis drought stress E3 ligase proteotoxicity ubiquitination

Modern applications of scanning electrochemical microscopy in the analysis of electrocatalytic surface reactions

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Chinese Journal of Catalysis 2022年第1期43卷 59-70页

作者： C.hyun Ryu Yunwoo nam hyun S.Ahn Department of Chemistry Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea

Development of reaction-tailored electrocatalysts is becoming increasingly important as energy and environment are among key issues governing our sustainable *** are inherently optimized for application towards reactions of interest in renewable energy,such as those involved in water splitting and artificial photosynthesis,owing to its energy efficiency,simple fabrication,and ease of *** this view,it is important to secure logical design principles for the synthesis of electrocatalysts for various reactions of interest,and also understand their catalytic mechanisms in the respective reactions for improvements in further *** this review,we introduce several key methods of scanning electrochemical microscopy(SECM)in its applications towards electrocatalysis.A brief history and a handful of seminal works in the SECM field is introduced in advancing the synthetic designs of electrocatalysts and elucidation of the operating *** developments in nano-sizing of the electrodes in attempts for improved spatial resolution of SECM is also introduced,and the application of nanoelectrodes towards the investigation of formerly inaccessible single catalytic entities is shared.

关键词： Scanning electrochemical microscopy Electrocatalysis Surface reaction Electroanalytical chemistry In situ electrochemical analysis Direct quantification

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