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Macroscopic Ag nanostructure array patterns with high-density hotspots for reliable and ultra-sensitive SERS substrates

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Nano Research 2019年第10期12卷 2554-2558页

作者： Taeksu lee Soongeun Kwon San ghee Jung Hyungjun Lim Jae-jong lee Department of Nano Manufacturing Technology Korea Institute of Machinery and Materials(KIMM)156 Gajeongbuk-RoYuseong-GuDaejeon 34103Republic of Korea

Syn thesis of metal nano structures arrays with large amounts of small nano-gaps on a homoge nous macroscale is of significant in terest and importa nee in chemistry,biotech no logy,physics,and nan otech no logy because of their enhan ced ***,the fabricatio n of uncovered nano-gaps with high-density and uniformity is rather difficult due to the complex and multiple synthetic *** this research,a facile and low-cost approach is demonstraind for the synthesis of high-density small nano-gaps(about 3.4 nm)between silver nanostructure array patter ns(SNAPs)over a large *** nan o?hole patter ns were periodically gen erated over an entire substrate using nano-impri nt *** reacti on at the high over-potential produced multiple silver nano crystals inside the nano-hole patter ns,gen erati ng a high-de nsity of small and un covered ***,we fully dem on strate their applicati on in the rapid detectio n of rhodamine 6G(R6G)molecules by surface-enhaneed Raman scattering(SERS)spectroscopy with a very low detection limit(1 fM)as well as excellent signal uniformity(RSD<8.0%±2.5%),i ndicati ng an extra ordinary capability for single-molecule detecti on.

关键词： nanoImprint lithography surface-enhanced Raman scattering(SERS)spectroscopy electrodeposition nano patterning gold silver

Prediction of Cold and Heat Patterns Using Anthropometric Measures Based on Machine Learning

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Chinese Journal of Integrative Medicine 2018年第1期24卷 16-23页

作者： Bum Ju lee Jae Chul lee Jiho Nam jong Yeol Kim Medical Research Division Korea Institute of Oriental Medicine

Objective： To examine the association of body shape with cold and heat patterns, to determine which anthropometric measure is the best indicator for discriminating between the two patterns, and to investigate whether using a combination of measures can improve the predictive power to diagnose these patterns. Methods： Based on a total of 4,859 subjects （3,000 women and 1,859 men）, statistical analyses using binary logistic regression were performed to assess the significance of the difference and the predictive power of each anthropometric measure, and binary logistic regression and Naive Bayes with the variable selection technique were used to assess the improvement in the predictive power of the patterns using the combined measures. Results： In women, the strongest indicators for determining the cold and heat patterns among anthropometric measures were body mass index （BMI） and rib circumference; in men, the best indicator was BMI. In experiments using a combination of measures, the values of the area under the receiver operating characteristic curve in women were 0.776 by Naive Bayes and 0.772 by logistic regression, and the values in men were 0.788 by Naive Bayes and 0.779 by logistic regression. Conclusions： Individuals with a higher BMI have a tendency toward a heat pattern in both women and men. The use of a combination of anthropometric measures can slightly improve the diagnostic accuracy. Our findings can provide fundamental information for the diagnosis of cold and heat patterns based on body shape for personalized medicine.

关键词： cold and heat patterns personalized medicine cold syndrome predictive power machine learning data mining

The prognostic significance of percentage of tumour involvement according to disease risk group in men treated with radical prostatectomy

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Asian Journal of Andrology 2011年第6期13卷 828-832页

作者： jong Jin Oh Sang Cheol lee Chang Wook Jeong Cheol Yong Yoon Seong Jin Jeong Sung kyu Hong Seok-Soo Byun Yoon Kwan Rho Gheeyoung Choe Sang Eun lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea Department of Pathology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

We investigated the prognostic significance of percentage of tumour involvement （PTI） according to the clinicopathological features of prostate cancer among patients who underwent radical prostatectomy （RP）. A retrospective study of 534 patients who underwent RP between September 2003 and March 2008 without any neoadjuvant or adjuvant therapy was performed. The associations of PTI with various clinicopathological features and biochemical recurrence-free survival were examined via uni- and multivariate analyses. The predictive accuracy of the multivariate model was assessed with a receiver operating characteristics-derived area under the curve. PTI was demonstrated to be significantly associated with preoperative prostate-specific antigen （PSA） level （P=0.001）, pathological Gleason score （P〈0.001）, extraprostatic tumour extension （P〈0.001）, seminal vesicle invasion （P〈0.001） and positive surgical margin （P〈0.001） in univariate analyses. When patients were stratified into disease risk groups, PTI was an independent predictor of biochemical recurrence-free survival in multivariate analysis only among the low-risk group （P=0.033） but not the intermediate- （P=0.287） or the high-risk groups （P=0.828）. The addition of the PTI did not significantly increase the accuracy of the multivariate model devised for the prediction of biochemical recurrence-free survival among both total patients （P=-0.459） and the low-risk group （P=0.268）, respectively. In conclusion, although PTI appeared to be a more significant prognostic factor among patients with low-risk disease than among those with higher risk diseases, overall, the PTI may not provide additional prognostic information beyond what can already be obtained via established prognostic factors.

关键词： biochemical recurrence-free survival percentage of tumour involvement prognosis prostate cancer prostatectomy

Korea＇s Economic Growth and Catch-up： Implications for China

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China & World Economy 2016年第5期24卷 71-97页

作者： jong- Wha lee Professor of Economics and Director of the Asiatic Research Institute Korea University

This study investigates the economic growth and catch-up of Korea over the past half century. Korea＇s growth experience confirms the prediction of a ＂conditional convergence＂ theory. Cross-country regression further suggests that Korea＇s strong catch-up to the USA is also attributable to its favorable growth factors such as strong investment, lower fertility, greater trade openness, and improvements in human resources and rule of law. However, as Korea catches up to the USA and its steady-state level in per worker output, it will be subject to a growth slowdown unless improvements are made in those growth factors. While manufacturing-oriented and export-oriented development has served Korea＇s success well, poor productivity performance in the services sector has hampered overall productivity growth, Korea＇s experience implies that China＇s potential growth rates are likely to slow in the coming decades due to the convergence effect and with the rebalancing toward a domestic consumption and services-based economy. China needs to upgrade its rule of law, reform state-owned enterprises and improve productivity, particularly in its services sector, to sustain strong growth.

关键词： China convergence economic growth Korea structural change

Critical factors to inhibit water-splitting side reaction in carbon-based electrode materials for zinc metal anodes

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Carbon Energy 2022年第6期4卷 1080-1092页

作者： Dong Hyuk Kang Eunji lee Beom Sik Youn Son Ha jong Chan Hyun Juhee Yoon Dawon Jang Kyoung Sun Kim Hyungsub Kim Sang Moon lee Sungho lee Hyoung-Joon Jin Hyung-kyu Lim Young Soo Yun KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSeongbuk-guSouth Korea Division of Chemical Engineering and Bioengineering Kangwon National UniversityChuncheonGangwon-doSouth Korea Department of Eco-Polymer Science and Engineering Inha UniversityIncheonMichuhol-guSouth Korea Carbon Composite Materials Research Center Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)Jeollabuk-doSouth Korea Department of Chemical and Biological Engineering Korea UniversitySeoulSeongbuk-guSouth Korea Neutron Science Division Korea Atomic Energy Research Institute(KAERI)DaejeonYuseong-guSouth Korea Research Center for Materials Analysis Korea Basic Science Institute(KBSI)DaejeonYuseong-guSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSeongbuk-guSouth Korea

Zinc metal anodes(ZMA)have high theoretical capacities(820 mAh g−1 and 5855 mAh cm−3)and redox potential(−0.76 V *** hydrogen electrode),similar to the electrochemical voltage window of the hydrogen evolution reaction(HER)in a mild acidic electrolyte system,facilitating aqueous zinc batteries competitive in next-generation energy storage ***,the HER and byproduct formation effectuated by water-splitting deteriorate the electrochemical performance of ZMA,limiting their *** this study,a key factor in promoting the HER in carbon-based electrode materials(CEMs),which can provide a larger active surface area and guide uniform zinc metal deposition,was investigated using a series of threedimensional structured templating carbon electrodes(3D-TCEs)with different local graphitic orderings,pore structures,and surface *** ultramicropores of CEMs are the determining critical factors in initiating HER and clogging active surfaces by Zn(OH)2 byproduct formation,through a systematic comparative study based on the 3D-TCE series *** the 3D-TCEs had a proper graphitic structure with few ultramicropores,they showed highly stable cycling performances over 2000 cycles with average Coulombic efficiencies of≥99%.These results suggest that a well-designed CEM can lead to high-performance ZMA in aqueous zinc batteries.

关键词： aqueous batteries carbon electrode hydrogen evolution reaction multivalent ion zinc metal anode

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 114-122页

作者： lee jong-Eun Yoon Sung Sik lee Jae-Wook Moon Eun-Yi Department of Bioscience and Biotechnology Sejong UniversitySeoul 05006Republic of Korea

Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human *** promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic ***,we investigated whether varying levels of autophagic flux in glioblastoma lead to different efficacies of curcumin treatment using U87 MG and A172 human glioblastoma *** number of LC3 puncta,the number of cells with LC3 puncta and the level of LC3 Ⅱ,Atg5 and Atg7 protein were higher in U87 MG cells compared with A172 *** the cells were incubated with curcumin for 24 or 48 h,the percentage of cell death was higher in A172 cells compared with U87 MG *** the level of LC3 was lower,that of curcumin-induced LC3 was higher,in A172 cells than in U87 MG *** relative increases in cell death and LC3-mediated autophagy were greater under serum starvation in A172 cells compared with U87 MG ***-induced A172 cell death was reduced by serum *** both types of cells were transfected with LC3-GFP,the percentage of cell death was higher in A172 cells than that in U87 MG *** together,the data demonstrate that curcumin-mediated tumor cell death is regulated by the basal level of autophagic flux in different glioblastoma *** suggests that prior to the use of various curcumin therapeutics,the level of basal or induced autophagic flux should be carefully examined in tumor cells for the best efficacy.

关键词： Glioblastoma A172 U87MG Autophagic flux Curcumin

Effect of grain refinement on phase transformation behavior and mechanical properties of Cu-based alloy

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中国有色金属学会会刊：英文版 2009年第4期19卷 979-983页

作者： Gwon-Seung YANG jong-Kook lee Woo-Yang JANG Department of Advanced Materials Engineering Chosun University Department of Metallurgical Engineering Chosun University

A small amount of misch metal was added to Cu-Zn-Al alloy in order to study its effect on grain refinement,mechanical properties,phase transformation behavior and stabilization of *** is found that the addition of misch metal is very effective for reducing the grain *** coarse grains over 1 000 μm are refined to the size of 30 μm by the addition of 0.43%(mass fraction) misch *** grain size of thermo-mechanically treated alloys is barely affected by cold *** fracture strength and ductility increase significantly with the increase of misch metal content when tensile test is carried out below Mf ***,the fracture strength is larger in the case of post-quench ageing treatment than that in the case of direct quench ageing *** fracture mode is changed from transgranular brittle fracture to ductile fracture with void formation and coalescence by the addition of misch metal.

关键词：铜基合金力学性能相变行为晶粒细化金属拉伸试验晶粒尺寸断裂强度时效处理

Clinical efficacy of 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1924-1931页

作者： Yeon Ji Jo Ji Eun lee jong Soo lee Efficacy of nano-cyclosporine to DES with MGD 1 Department of Ophthalmology Pusan National University School of Medicine&Medical Research InstitutePusan National University HospitalPusan 49241Republic of Korea Department of Ophthalmology Pusan National University School of Medicine&Medical Research CenterYangsan Pusan National University HospitalYangsan 626-770Republic of Korea

AIM:To evaluate the clinical efficacy of topical 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome(DES)with meibomian gland dysfunction(MGD).METHODS:This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups:Group 1(n=24,conventional cyclosporine),Group 2(n=21,nano-emulsion cyclosporine),and Group 3(n=19,control).Lid margin telangiectasia(LMT),meibomian gland secretion(MGS),conjunctival injection(CI),corneal staining(CS),tear break-up time(TBUT),Schirmer test I(STI),Ocular Surface Disease Index(OSDI),and lipid layer thickness(LLT)was evaluated at 4,8,and 12wk of ***:In Group 3(control),LMT,CS,and CI improved after 8wk,MGS,TBUT after 12wk of *** Group 1(conventional cyclosporine),LMT,MGS,and TBUT improved significantly after 4wk,whereas CS,CI,STI,and LLT improved significantly after 8wk,and OSDI at *** Group 2(nano-cyclosporine),LMT,MGS,CS,CI,TBUT,and OSDI significantly improved after 4wk,and STI after ***,LLT was significantly higher than other groups after ***:Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control *** contrast,the nano-cyclosporine group shows more statistically improved CI and CS at 4wk,especially LLT at 4,8,and 12wk compared to the conventional cyclosporine group.

关键词： anti-inflammatory treatment cyclosporine dry eye disease meibomian gland dysfunction

A Transfer Learning-Based Approach to Detect Cerebral Microbleeds

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Computers, Materials & Continua 2022年第4期71卷 1903-1923页

作者： Sitara Afzal Imran Ullah Khan jong Weon lee Mixed Reality and Interaction Lab Department of SoftwareSejong UniversitySeoul143-747Korea

Cerebral microbleeds are small chronic vascular diseases that occur because of irregularities in the cerebrum *** and elderly people with brain injury and dementia can have small microbleeds in their brains.A recent study has shown that cerebral microbleeds could be remarkably risky in terms of life and can be riskier for patients with *** this study,we proposed an efficient approach to automatically identify microbleeds by reducing the false positives in openly available susceptibility-weighted imaging(SWI)data *** proposed structure comprises two different pretrained convolutional models with four *** stages include(i)skull removal and augmentation,(ii)making clusters of data samples using the k-mean classifier,(iii)reduction of false positives for efficient performance,and(iv)transfer-learning *** proposed technique was assessed using the SWI dataset available for 20 *** our findings,we attained an accuracy of 97.26%with a 1.8%false-positive rate using data augmentation on the AlexNet transfer learning model and a 1.1%false-positive rate with 97.89%accuracy for the ResNet 50 model with data augmentation *** results show that our models outperformed the existing approach for the detection of microbleeds.

关键词： Microbleeds deep convolutional neural network ResNet50 AlexNet computer-vision