Clinical efficacy of 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

作     者：Yeon Ji Jo Ji Eun Lee Jong Soo Lee 

作者机构：Efficacy of nano-cyclosporine to DES with MGD 1 Department of OphthalmologyPusan National University School of Medicine&Medical Research InstitutePusan National University HospitalPusan 49241Republic of Korea Department of OphthalmologyPusan National University School of Medicine&Medical Research CenterYangsan Pusan National University HospitalYangsan 626-770Republic of Korea 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第12期

页      面：1924-1931页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by Biomedical Research Institute Grant(No.20200026) Pusan National University Hospital 

主　　题：anti-inflammatory treatment cyclosporine dry eye disease meibomian gland dysfunction 

摘      要：AIM:To evaluate the clinical efficacy of topical 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome(DES)with meibomian gland dysfunction(MGD).METHODS:This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups:Group 1(n=24,conventional cyclosporine),Group 2(n=21,nano-emulsion cyclosporine),and Group 3(n=19,control).Lid margin telangiectasia(LMT),meibomian gland secretion(MGS),conjunctival injection(CI),corneal staining(CS),tear break-up time(TBUT),Schirmer test I(STI),Ocular Surface Disease Index(OSDI),and lipid layer thickness(LLT)was evaluated at 4,8,and 12wk of ***:In Group 3(control),LMT,CS,and CI improved after 8wk,MGS,TBUT after 12wk of *** Group 1(conventional cyclosporine),LMT,MGS,and TBUT improved significantly after 4wk,whereas CS,CI,STI,and LLT improved significantly after 8wk,and OSDI at *** Group 2(nano-cyclosporine),LMT,MGS,CS,CI,TBUT,and OSDI significantly improved after 4wk,and STI after ***,LLT was significantly higher than other groups after ***:Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control *** contrast,the nano-cyclosporine group shows more statistically improved CI and CS at 4wk,especially LLT at 4,8,and 12wk compared to the conventional cyclosporine group.