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General Psychiatry 2020年第1期33卷 23-29页

作者： Donald J Robinaugh mackenzie L Brown olivia m Losiewicz Payton J jones Luana marques Amanda W Baker Department of Psychiatry Massachusetts General HospitalBostonMassachusettsUSA Department of Psychiatry Harvard Medical SchoolBostonMassachusettsUSA Department of Psychology Harvard UniversityCambridgeMassachusettsUSA

Background Treatments for anxiety disorders are among the most effective in ***,there is considerable room for *** In this paper,we discuss the value of ecological momentary assessment as a research method and clinical *** We begin by describing ecological momentary assessment and its advantages,including the ability to collect ecologically valid information about mental disorders,in real time,in individual *** then illustrate the value of this approach for anxiety disorder treatment using two patients with panic disorder who completed ecological momentary assessments for 2 weeks before and after a cognitive-behavioural therapy *** focus especially on two key pieces of information provided by ecological momentary assessment data:information about symptom dynamics and information about the relationships among symptoms as they unfold overtime within individual *** Although considerable work is needed to further develop this methodology in the context of anxiety disorder treatment,we believe that these pieces of information may ultimately inform.o.r understanding of how anxiety disorder treatments have their effect and how those treatments can be tailored to individual patients.

关键词： disorders moment treatment

Advances in active fire detection using a multi-tem.o.al method for next-generation geostationary satellite data

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International Journal of Digital Earth 2019年第9期12卷 1030-1045页

作者： Bryan Hally Luke Wallace Karin Reinke Simon jones Andrew Skidmore School of Science RMIT UniversityMelbourneAustralia Bushfire and Natural Hazards Cooperative Research Centre MelbourneAustralia Faculty for Geo-Information Science and Earth observation(ITC) University of TwenteEnschedeNetherlands Department of Environmental Science Macquarie UniversitySydneyAustralia

A vital com.o.ent of fire detection from remote sensors is the accurateestimation of the background temperature of an area in fire’s absence,assisting in identification and attribution of fire activity. Newgeostationary sensors increase the data available to describebackground temperature in the tem.o.al domain. Broad area methodsto extract the expected diurnal cycle of a pixel using this tem.o.ally richdata have shown potential for use in fire detection. This paper describesan application of a method for priming diurnal temperature fitting ofimagery from the Advanced Himawari Imager. The BAT method is usedto provide training data for temperature fitting of target pixels, to whichthresholds are applied to detect thermal anomalies in 4 μm imageryover part of Australia. Results show the method detects positive thermalanomalies with respect to the diurnal model in up to 99% of caseswhere fires are also detected by Low Earth orbiting (LEo) satellite activefire products. In absence of LEo active fire detection, but where aburned area product recorded fire-induced change, this method alsodetected anomalous activity in up to 75% of cases. Potentialimprovements in detection time of up to 6 h over LEo products are alsodemonstrated.

关键词： Fire detection diurnal variation geostationary sensors broad area training advanced himawari imager

Assessment of VIIRS 375 m active fire using tropical peatland combustion algorithm applied to Landsat-8 over Indonesia’s peatlands

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International Journal of Digital Earth 2020年第12期13卷 1695-1716页

作者： Parwati Sofan David Bruce Wilfrid Schroeder Eriita jones Jackie marsden Scarce Resources and Circular Economy(ScaRCE) University of South AustraliaScienceTechnologyEngineering and Mathematics(STEM)Adelaide/Mawson LakesAustralia Remote Sensing Application Center of Indonesian Institute of Aeronautics and Space(LAPAN) JakartaIndonesia National oceanic and Atmospheric Administration(NoAA) College ParkMDUSA dImagery LandgateMidlandAustralia

VIIRS 375 m active fire data(VNP14ImG),the highest spatial resolution available cost-free fire product,were assessed for representing fire in typical degraded tropical peatlands in *** results of applying the Tropical Peatland Combustion Algorithm to Landsat-8(ToPeCAl-L8)daytime imagery were utilised as the fire *** permit the comparison of non-simultaneous VNP14ImG and ToPeCAl-L8,peatland fire propagation speeds resulting from previous study using TET-1 data in Central Kalimantan’s peatlands were *** peatland fires were still within 750 m from their source over 15 h under uniform conditions,except for very large *** detection rates of nighttime VNP14ImG compared with ToPeCAl-L8 showed about 80%agreement for small fire areas(or fires larger than 14 ha,a dissolved 375 m buffer(cluster buffer)of VNP14ImG active fires with an integration of nighttime and daytime acquisitions,produced a probability of detection up to 90%.These results generated a recommendation for implementing cluster buffer analysis and integration of nighttime and daytime analysis of VNP14ImG data for better accuracy in fire detection for ground fire *** also demonstrate the utility of the ToPeCAl-L8 algorithm with VIIRS 375 m active fire data.

关键词： Active fire assessment VIIRS 375 m active fire(VNP14ImG) ToPeCAlLandsat-8 peatland fires

G protein controls stress readiness by modulating transcriptional and metabolic hom.o.tasis in Arabidopsis thaliana and marchantia polymorpha

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molecular Plant 2022年第12期15卷 1889-1907页

作者： Ting-Ying Wu Shalini Krishnam.o.thi Kulaporn Boonyaves Isam Al-Darabsah Richalynn Leong Alan m.jones Kimitsune Ishizaki Kang-Ling Liao Daisuke Urano Temasek Life Sciences Laboratory SingaporeSingapore Department of mathematics University of ManitobaWinnipegMBCanada Singapore-mIT Alliance for Research and Technology SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore 117558Singapore Departments of Biology and Pharmacology University of North CarolinaChapel HillNCUSA Graduate School of Science Kobe UniversityKobeHyogo 657-8501Japan

The core G protein signaling module,which consists of Gαand extra-large Gα(XLG)subunits coupled with the Gβγdimer,is a master regulator of various stress *** this study,we compared the basal and salt stress-induced transcriptomic,metabolomic and phenotypic profiles in Gα,Gβ,and XLG-null mutants of two plant species,Arabidopsis thaliana and marchantia polymorpha,and showed that G protein mediates the shift of transcriptional and metabolic hom.o.tasis to stress readiness *** demonstrated that such stress readiness serves as an intrinsic protection mechanism against further stressors through enhancing the phenylpropanoid pathway and abscisic acid ***,WRKY transcription factors were identified as key intermediates of G protein-mediated hom.o.tatic *** and mathematical model comparisons between *** and *** revealed evolutionary conservation of transcriptional and metabolic networks over land plant evolution,whereas divergence has occurred in the function of plant-specific atypical XLG *** together,our results indicate that the shifts in transcriptional and metabolic hom.o.tasis at least partially act as the mechanisms of G protein-coupled stress responses that are conserved between two distantly related plants.

关键词： hom.o.tatic adjustments transcriptional regulation metabolic regulation heterotrimeric G protein evolutionary conservation

Arabinan metabolism during Seed Development and Germination in Arabidopsis

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molecular Plant 2009年第5期2卷 966-976页

作者： Leonardo D. Gomez Clare G. Steele-King Louise jones Jonathan m. Foster Supachai Vuttipongchaikij Simon J. mcQueen-mason CNAP Department of Biology University of York Heslington York YO10 5YW United Kingdom

Arabinans are found in the pectic network of many cell walls, where, along with galactan, they are present as side chains of Rham.o.alacturonan I. Whilst arabinans have been reported to be abundant polymers in the cell walls of seeds from a range of plant species, their proposed role as a storage reserve has not been thoroughly investigated. In the cell walls of Arabidopsis seeds, arabinose accounts for approximately 40% of the monosaccharide com.o.ition of non- cellulosic polysaccharides of embryos. Arabinose levels decline to -15% during seedling establishment, indicating that cell wall arabinans may be mobilized during germination. Immunolocalization of arabinan in embryos, seeds, and seedlings reveals that arabinans accumulate in developing and mature embryos, but disappear during germination and seedling establishment. Experiments using 14C-arabinose show that it is readily incorporated and metabolized in growing seedlings, indicating an active catabolic pathway for this sugar. We found that depleting arabinans in seeds using a fungal arabinanase causes delayed seedling growth, lending support to the hypothesis that these polymers may help fuel early seedling growth.

关键词： Cell walls development embryogenesis and seed development Arabidopsis arabinan arabinose carbohydrate metabolism physiology of plant growth.

The stadium effect:rodent damage patterns in rice fields explored using giving-up densities

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Integrative Zoology 2017年第6期12卷 438-445页

作者： Clare R.jones Renee P.LoRICA James m.VILLEGAS Angelee F.RAmAL Finbarr G.HoRGAN Grant R.SINGLEToN Alexander m.STUART Crop and Environmental Sciences Division International Rice Research InstituteMetro ManilaPhilippines Natural Resources Institute University of GreenwichChatham MaritimeKentUK Centre for Compassionate Conservation University of Technology SydneyNew South WalesAustralia

Rodents are globally im.o.tant pre-harvest pests of *** Southeast Asia,rodent damage to growing rice crops is com.o.ly concentrated towards the center of rice fields,away from the field edge,resulting in a clear pattern known as the“stadium effect.”To further understand this behavior of rodent pests and to develop recommendations for future research and management,we examined the relation between giving-up densities(GUDs)and damage *** Tanay,Luzon,Philippines,GUD trays containing pieces of coconut in a matrix of sand were placed at 4 different distances from the field edge to quantify the perceived risk of predation in a rice field pest,Rattus *** were recorded during a dry and wet season crop at the reproductive and ripening stages of *** addition,assessments of active burrows,tracking tile activity and rodent damage to the rice crop,were conducted in the dry *** were significantly lower in the center of the rice fields than on the field edges,suggesting that rodent damage to rice is greater in the middle of rice fields due to a lower perceived predation ***,this perception of predation risk(or fear)increases towards the field edge and was greatest on the rice bund,where there was no vegetation *** discuss the implications for rodent management and rodent damage assessments in rice *** is the first documented use of GUDs in a rice agro-ecosystem in Asia;thus we identify the challenges and lessons learned through this process.

关键词： habitat use landscape of fear pest management Rattus tanezumi rodent behavior

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纳米Al粉的热脱附研究(英文)

含能材料 2005年第5期13卷 295-300页

作者： Queenie S m Kwok Nichole Emery David EG jones Canadian Explosives Research Laboratory Natural Resources CanadaKing's College LondonCanadian Explosives Research Laboratory Natural Resources Canada

纳米Al粉有独特热行为,能增强某些含能材料的性能。然而,纳米Al粉与水的反应性高,导致纳米Al粉“老化”,降低了它在含能复合材料中的作用。由于纳米Al粉的老化反应与吸附至其表面的水有关,因此应特别关注水的吸、脱附作用。本文用TG和TG... 详细信息

纳米Al粉有独特热行为,能增强某些含能材料的性能。然而,纳米Al粉与水的反应性高,导致纳米Al粉“老化”,降低了它在含能复合材料中的作用。由于纳米Al粉的老化反应与吸附至其表面的水有关,因此应特别关注水的吸、脱附作用。本文用TG和TG-FTIR-mS研究了纳米Al粉吸附气体的热脱附。结果表明,所研究的纳米Al粉含12%(质量)的吸附气体。用FTIR和mS检测到水和Co2的脱附。用多重加热速率和等温研究,得到了吸附气体的脱附过程动力学参数。对不同方法得到的脱附活化能进行了比较。

关键词：物理化学 Al 纳米尺寸热作用脱附动力学热脱附纳米 Al 脱附活化能动力学参数含能材料复合材料加热速率 FTIR

moving beyond hydroxychloroquine:the novel lysosomal autophagy inhibitor RoC-325 shows significant potential in preclinical studies

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Cancer Communications 2019年第1期39卷 620-622页

作者： Trace m.jones Claudia Espitia Wei Wang Steffan T.Nawrocki Jennifer S.Carew University of Arizona Cancer Center TucsonAZ 85724USA Division of Translational and Regenerative medicine Department of MedicineUniversity of ArizonaTucsonAZ 85721USA Department of Pharmacology and Toxicology University of ArizonaTucsonAZ 85721USA Arizona Center for Drug Discovery TucsonAZ 85721USA

Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived *** of its role in maintaining cellu-lar hom.o.tasis,autophagy is frequently stimulated in response to stress conditions such as those im.o.ed by chemotherapy,nutrient deprivation,and microenviron-mental *** this capacity,autophagy serves as a mechanism to generate alternative sources of metabolic fuel that promote survival when preferred energy gener-ating pathways are impaired[1].over the past decade,stress-induced autophagy has emerged as an im.o.tant driver of malignant progression and anticancer drug *** all classes of clinically relevant anti-cancer agents,as well as radiotherapy,have been dem.o.strated to stimulate autophagy in preclinical studies[2].In the overwhelming majority of cases,genetically or pharmacologically impairing autophagy has been shown to yield therapeutic benefit in a manner that significantly improves the efficacy of the relevant agents or modalities[3].

关键词： impaired autophagy beyond

magnetic nanowires fabricated by anodic aluminum.o.ide template—a brief review

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Science China(Physics,mechanics & Astronomy) 2011年第7期54卷 1181-1189页

作者： LI WuXia ZHANG Jun SHEN TieHan jones Grenville A GRUNDY Philip J Institute of Physics Chinese Academy of Sciences Beijing 100190 China Faculty of Physics and Electronic Technology Hubei University Wuhan 430062 China Joule Physics Laboratory College of Science and Technology University of Salford Salford M5 4WT UK

Anodic aluminum.o.ide （AAo） with highly ordered nanoscale pores which are monodisperse and mutually parallel can be produced through a self-organized electrochemical process. Subsequent deposition of materials into the nanopores produces AA0 embedded nanowire arrays. Whilst the templates can be further removed to obtain free individual nanowires, the em- bedded nanowires form an interesting nanocom.o.ite structure. Recent research activities on the fabrication and characteriza- tion of AAo template based magnetic nanowires are reviewed in this article. Studies of specific systems are given as an exam- ple of the research in the area.

关键词： anodic aluminum.o.ides electrochemical deposition magnetic nanowires templates magneto-optical properties

Gait analysis in swine,sheep,and goats after neurologic injury:a literature review

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Neural Regeneration Research 2023年第9期18卷 1917-1924页

作者： Jacob W.Sveum Raveena R.mishra Taylor L.marti Jalon m.jones Daniel J.Hellenbrand Amgad S.Hanna Department of Neurological Surgery University of Wisconsin School of Medicine and Public Health(UWSMPH)MadisonWIUSA

medical research on neurologic ailments requires representative animal models to validate treatments before they are translated to human clinical *** are the predominant animal model used in neurological research despite limited anatomic and physiologic similarities to *** a result,functional testing designed to assess locomotor recovery after neurologic impairment is well established in rodent ***,large r,more clinically relevant models have not been as well *** achieve similar locomotor testing standardization in larger animals,the models must be accessible to a wide array of ***-human primates are the most relevant animal model fo r translational research,however ethical and financial barriers limit their *** review focuses on swine,sheep,and goats as large animal alternatives for transitional studies between rodents and non-human *** objective of this review is to compare motor testing and data collection methods used in swine,sheep,and goats to encourage testing standardization in these larger animal *** Pubmed database was analyzed by searching combinations of swine,sheep,and goats,neurologic injuries,and functional *** were categorized by animal model,data collection method,and assessment *** and sheep were used in the majority of the studies,while only two studies were found using *** functional assessments included open pen analysis,treadmill walking,and guided free *** collection methods included subjective behavioral rating scales and objective tools such as pressure-sensitive mats and image-based analysis ***,swine and sheep were well-suited for a variety of assessment designs,with treadmill walking and guided free walking offering the most consistency across multiple *** collection methods varied,but image-based gait analysis software provided the most robust *** studies should be conducted to stan

关键词： functional testing gait analysis goats large animals neurologic injury sheep spinal cord injury swine