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Nonmarine time-stratigraphy in a rift setting: An example from the Mid-Permian lower Quanzijie low-order cycle, Bogda Mountains, NW China

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Journal of Palaeogeography 2015年第1期4卷 27-51页

作者： jonathan Obrist-Farner Wan Yang Geology and Geophysics Program Missouri University of Science and TechnologyRolla Missouri 65409 USA Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences

Sedimentological and stratigraphic studies of seven stratigraphic sections of Permian Hongyanchi （HYC） and Quanzijie （QZJ） low-order cycles （LCs） in the Tarlong-Taodonggou half graben and Dalongkou area in Bogda Mountains, NW China, demonstrate effective approaches and methodology in cyclo- and time-stratigraphic analyses of complex fluviallacustrine deposits in an intracontinental rift setting. A new synchronous stratigraphic unit, the lower QZJ LC is defined. The lower and upper boundaries of this cycle include a regionally correlative disconformity, erosional unconformity, and conformity, across which significant and abrupt changes in palaeoenvironments and tectonic and climatic conditions occurred. The lower boundary is an erosional unconformity and disconformity with a high-relief topography that juxtaposes lacustrine deposits of the underlying HYC LC with the overlying meandering stream deposits of the lower QZJ LC, and was caused by a regional tectonic uplift. The up- per boundary is a disconformity and local erosional unconformity and conformity, juxtaposing stacked paleosols developed on fluvial sediments with overlying fluvial and loessial deposits of the upper QZJ LC. The paleosols indicate landscape stability and a prolonged period of subaerial exposure and minimal deposition and suggest that climatic conditions were semiarid with strong precipitation seasonality in the Tarlong-Taodonggou half graben and subhumid in the Dalongkou area. The fluvial-loessial deposits indicate a renewed tectonic uplift and a change in the atmospheric circulation pattern. The newly-defined lower QZJ LC facilitates accurate palaeogeographic reconstruction in the study area during a period of major tectonic and climatic changes. The interpreted tectonic and climatic conditions provide a critical data point in the mid-latitude east coast of NE Pangea during the Mid-Permian icehouse-hothouse transition. The results demonstrate that a process-response approach is effective in tim

关键词： fluvial loess cyclostratigraphy Permian China

Clinical variability and molecular heterogeneity inprostate cancer

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Asian Journal of Andrology 2016年第4期18卷 543-548页

作者： jonathan Shoag Christopher E Barbieri Department of Urology NewYork-Presbyterian Hospital Weill Cornell Medical College New York USA Sandra and Edward Meyer Cancer Center Weill Cornell Medica College New York USA.

Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.

关键词： cell biology ERG genomics molecular heterogeneity prostate cancer sequencing serine peptidase inhibitor, Kazaltype 1 SPOP tumor profiling

Penile rehabilitation following prostate cancer treatment： review of current literature

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Asian Journal of Andrology 2015年第6期17卷 916-922,I0007页

作者： jonathan Clavell-Hernandez Run Wang Division of Urology University of Texas Medical School at Houston Department of Urology Houston Texas USA University of Texas MD Anderson Cancer Center Houston Texas 77030 USA.

Radical prostatectomy （RP） and radiotherapy （RT） are highly effective in improving prostate cancer survival. However, both have a detrimental effect on erectile function （EF）. Penile rehabilitation consists of understanding the mechanisms that cause erectile dysfunction （ED） and utilizing pharmacologic agents, devices or interventions to promote male sexual function. For the past decade, many researchers have pursued to define effective treatment modalities to improve ED after prostate cancer treatment. Despite the understanding of the mechanisms and well-established rationale for postprostate treatment penile rehabilitation, there is still no consensus regarding effective rehabilitation programs. This article reviews a contemporary series of trials that assess penile rehabilitation and explore treatment modalities that might play a role in the future. Published data and trials related to penile rehabilitation after RP and RT were reviewed and presented. Although recent trials have shown that most therapies are well-tolerated and aid in some degree on EF recovery, we penile rehabilitation algorithm. However, advancements in options for penile rehabilitation. currently do not have tangible evidence to recommend an irrefutable research and technology will ultimately create and refine management

关键词： erectile dysfunction penile rehabilitation technology

Hierarchical methodology to evaluate the quality of disparate axle load data sources for pavement design

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第2期9卷 261-279页

作者： Steven Wood jonathan D.Regehr Transportation Division City of WinnipegWinnipegMB R3B 1B9Canada Department of Civil Engineering University of ManitobaMB R3T 5V6Canada

Axle load data are an essential input for pavement design,yet for most North American agencies,there is uncertainty about the quality of axle load data obtained from weigh-inmotion(WIM)systems,the applicability of these data for pavement design,and potential opportunities to integrate axle load data from disparate *** article presents a novel and practical methodology to evaluate the quality of axle load data from WIM systems and roadside weigh scales through a series of hierarchical analyses designed to test data *** applied using data from Manitoba,Canada,the methodology quantified the uncertainty of axle loads measured at the weigh scales and piezo-quartz WIM,concluding that both could be used for pavement design *** collected at piezo-polymer WIM sites exhibited poorer data validity;however,application of site-specific temperature correction factors significantly improved data validity at these *** article describes how other data quality dimensions,including spatial coverage,temporal coverage,and long-term data availability,could be considered when determining the suitability of disparate axle load data sources for pavement *** of the methodology enables a pragmatic evaluation of the quality and limitations of commonlyavailable axle load data,revealing uncertainties and data needs relevant for pavement design practice.

关键词： Road engineering Pavement design Axle load Weigh-in-motion Data quality Truck traffic

Global distribution of geothermal gradients in sedimentary basins

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Geoscience Frontiers 2023年第6期14卷 478-495页

作者： Folarin Kolawole jonathan C.Evenick Lamont-Doherty Earth Observatory at Columbia University New YorkNYUSA INPEX Corporation TokyoJapan

The heat budget of sedimentary basins is determined by heat transfer across the lithosphereasthenosphere boundary and lithospheric heat sources,such that the tectonic evolution of their host continental and oceanic lithosphere ultimately impact the present-day heat flow and average geothermal *** increase in availability of publicly-accessible geothermal gradient measurements across the world provides an opportunity to globally assess the dominant controls on the thermal regime of sedimentary ***,we compile a global dataset of152,000 unique data points with constrained bottomhole temperature measurements and assess the relationships between geothermal gradient and selected independent tectonic variables,including crustal and lithospheric thicknesses,crustal age,sediment thickness,and basin *** results show that in both oceanic and continental settings,geothermal gradients exhibit a non-linear,systematic variation with the tectonic *** find that oceanic geothermal gradients decrease with increasing crustal age and lithospheric *** gradients in the continents show no clear relationships with thermotectonic crustal age,but decrease with increasing crustal and lithospheric *** drop significantly at 1.5 km sediment-cover thickness,likely reflecting the effect of high sedimentation rates,but show a striking rise at>12 km thicknesses,potentially influenced by thinned lithosphere and thermal blanketing *** commonly-assumed‘normal’gradient of 25℃/km for continents is only valid for a narrow range(1.5–12.5 km)of sedimentary cover-thickness,and oceanic‘normal’gradient may be as high as 50–75℃/km for>20 Ma crustal age and>50 km-thick *** show that,conditionally,crustal age may best predict average geothermal gradients in oceanic settings,and lithosphere thickness in ***,we observe that tectonic basin types exhibit distinct ranges of gradients that reflect their prevalent tec

关键词： Geothermal gradient Oceanic crust Continental crust Lithosphere Tectonics

Sexual dimorphism in cranial shape and size in geomyoid rodents:multivariate and evolutionary perspectives

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Current Zoology 2022年第4期68卷 469-487页

作者： jonathan J M Calede Andrew Brown Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.300 Aronoff LaboratoryColumbusOH 43210USA The Ohio State University at Marion 1459 Mount Vernon AvenueMarionOH 43302USA College of Veterinary Medicine Texas A&M University660 Raymond Stotzer PkwyCollege StationTX 77843USA

Geomyoid rodents provide a great study system for the analysis of sexual *** are polygynic and many inhabit harsh arid environments thought to promote sexual *** fact,there has been extensive work published on the sexual size dimorphism of individual populations and species within this rodent ***,little work has been undertaken to assess the evolutionary patterns and processes associated with this sexual *** use multivariate analyses of cranial measurements in a phylogenetic framework to determine the distribution of size and shape dimorphism among geomyoids and test for Rensch’s *** results suggest that sexual dimorphism is more common in geomyids than heteromyids,but it is not in fact *** is evidence for variation in sexual dimorphism across ***,in many taxa,geographic variation appears to overwhelm existing sexual *** find support for the repeated independent evolution of shape and size dimorphism across geomyoid taxa,but we do not find support for an association between size and shape *** is no evidence for Rensch’s rule in geomyoids,whether at the superfamily or family ***,our findings suggest that there is no single explanation for the evolution of sexual dimorphism in geomyoids and that,instead,it is the product of numerous evolutionary *** studies incorporating phylogenetic relationships will be necessary to paint a more complete picture of the evolution of sexual dimorphism in geomyoids.

关键词： Geomyidae Heteromyidae phylogenetic comparative methods morphometrics Rensch’s rule

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Jumping droplets

Droplet 2024年第2期3卷 3-33页

作者： jonathan B.Boreyko Department of Mechanical Engineering Virginia TechBlacksburgVirginiaUSA

When microdroplets with quasi-spherical contact angles coalesce together on a low-adhesion substrate,the capillary-inertial expansion of the liquid bridge induces a dramatic out-of-plane jumping event due to symmetry *** the onset of merging,droplet jumping initiates after a capillary-inertial time scale of t_(ci)∼1–100μs with characteristic jumping speeds of order v_(j)∼0.1m/*** coalescenceinduced jumping-droplet effect is most commonly observed among a population of growing dew droplets on a superhydrophobic condenser,but can also occur by colliding deposited droplets together or during droplet sliding on fog *** this review,we cover the historical development of capillary-inertial jumping droplets,summarize the decade-long effort to rationalize the ultra-low energy conversion efficiency and critical droplet size of the phenomenon,and then present 15 variations on a theme of ***-inertial jumping droplets are not only a visceral illustration of the surprising power of surface tension at the microscale but they also have the potential to enhance phase-change heat transfer,enable selfcleaning surfaces,combat frost formation,harvest energy,and govern the rate of disease spread for wheat crops.

关键词： capillary illustration rational

Dangers of scientific bias against herbal drugs for coronavirus disease 2019

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Journal of Integrative Medicine 2020年第6期18卷 459-461页

作者： jonathan M.Fields Integrative Medicine US TamaracFL 33321USA

On May 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.

关键词： Herbal Coronavirus COVID-19 SARS-CoV-2 Medicine,Chinese traditional Complementary therapies

Long-term survival of participants in the prostate ：ancer prevention trial

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Asian Journal of Andrology 2014年第3期16卷 413-414页

作者： jonathan L Silberstein Oliver Sartor Department of Urology Tulane University School of Medicine New OrleansLouisiana USA. Department of Medicine Tulane University School of Medicine New OrleansLouisiana USA.

The Prostate Cancer Prevention Trial （PCPT） is a seminal study in the field of urology. More than 10years after its initial publication, updated data from this trial continue to shape our understanding of prostate cancer. Among the major findings from the PCPT has been the demonstration that prostate cancer is common in men with prostate-specific antigen （PSA） once thought to be in the normal range,~ finasteride prevents the development of benign prostatic hypertrophy,2 it increases the sensitivity of PSA3 and digital rectal examination.4 Furthermore the PCPT helped to establish the link between erectile dysfunction and cardiovascular disease,5 and perhaps most importantly finasteride demonstrated a 25% relative risk reduction in the diagnosis of prostate cancer compared with placebo.

关键词： survival participants PCPT