Optimizing management in autoimmune hepatitis with liver failure at initial presentation

作     者：Jonathan R Potts Sumita Verma 

作者机构：Department of MedicineBrighton and Sussex Medical School 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第16期

页      面：2070-2075页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Autoimmune hepatitis Liver failure Liver transplantation Corticosteroids 

摘      要：Autoimmune hepatitis (AIH) is a disease of unknown etiology,its hallmark being ongoing hepatic *** its very nature,it is a chronic condition,although increasingly,we are becoming aware of patients with acute presentations,some of whom may have liver *** are very limited published data on patients with AIH with liver failure at initial diagnosis,which consist mostly of small retrospective *** a consequence,the clinical features and optimal management of this cohort remain poorly defined.A subset of patients with AIH who present with liver failure do respond to corticosteroids,but for the vast majority,an urgent liver transplantation may offer the only hope of long-term *** present,there is uncertainty on how best to stratify such a cohort into responders and non-responders to corticosteroids as soon as possible after hospitalization,thus optimizing their *** editorial attempts to answer some of the unresolved issues relating to management of patients with AIH with liver failure at initial ***,it must be emphasized that,at present,this editorial is based mostly on small retrospective studies,and it is an understatement that multicenter prospective studies are urgently needed to address this important clinical issue.