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Colorectal surgeon consensus with diverticulitis clinical practice guidelines

World Journal of Gastrointestinal Surgery 2017年第11期9卷 224-232页

作者： Javariah Siddiqui Assad Zahid jonathan hong Christopher John Young Discipline of Surgery University of Sydney Department of Colorectal Surgery Royal Prince Alfred Hospital

AIM To determine the application of clinical practice guidelines for the current management of diverticulitis and colorectal surgeon specialist consensus in Australia and New *** A survey was distributed to 205 colorectal surgeons in Australia and New Zealand, using 22 hypothetical clinical *** The response rate was 102(50%). For 19 guidelinebased scenarios, only 11(58%) reached consensus(defined as > 70% majority opinion) and agreed with guidelines; while 3(16%) reached consensus and did not agree with guidelines. The remaining 5(26%) scenarios showed community equipoise(defined as less than/equal to 70% majority opinion). These included diagnostic imaging where CT scan was contraindicated, management options in the failureof conservative therapy for complicated diverticulitis, surgical management of Hinchey grade 3, proximal extent of resection in sigmoid diverticulitis and use of oral mechanical bowel preparation and antibiotics for an elective colectomy. The consensus areas not agreeing with guidelines were management of simple diverticulitis, management following the failure of conservative therapy in uncomplicated diverticulitis and follow-up after an episode of complicated diverticulitis. Fifty-percent of rural/regional based surgeons would perform an urgent sigmoid colectomy in failed conservative therapy of diverticulitis compared to only 8% of surgeons city-based(Fisher's exact test P = 0.016). In right-sided complicated diverticulitis, a greater number of those in practice for more than ten years would perform an ileocecal resection and ileocolic anastomosis(79% vs 41%, P < 0.0001).CONCLUSION While there are areas of consensus in diverticulitis management, there are areas of community equipoise for future research, potentially in the form of RCTs.

关键词： Diverticulitis Clinical practice guidelines Consensus

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A Numerical Study of Temporal Mixing Layer with Three-Dimensional Mortar Spectral Element Method

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Chinese Physics Letters 2011年第6期28卷 187-189页

作者： ZHANG Xu LIU Jin-hong jonathan W.N Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900 Mechanical Department University of WyomingLaramieUSA

We investigate a set of well-posed interface conditions of viscous fluxes of Navier–Stokes equations,extend them to three-dimensional Navier–Stokes equations and successfully study a temporally turbulent mixing *** evolution of a large vortex structure and the non-dimensional statistical quantities in the mixing layer are numerically *** span-wise energy spectrum of the mixing layer exhibits wide band features,which means that the simulation generates the desired amount of small *** results show that too many small scales are present due to insufficient dissipation and the amount of large scales is low,indicating too much dissipation for large-scale structures.

关键词： layer mixing dissipation

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Barriers and facilitators of peer support work in a large psychiatric hospital:a thematic analysis

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General Psychiatry 2021年第3期34卷 154-162页

作者： jonathan Han Loong Kuek hong Choon Chua Daniel Poremski Health Intelligence Unit Institute of Mental HealthSingapore

Background Peer support workers are an important addition to the mental healthcare ***,much of the literature and knowledge of the peer support role is derived from western *** concept is relatively new in Asian *** The study sought to improve the understanding of the barriers and facilitators of peer support work in a large psychiatric hospital in *** This study used qualitative data from a larger mixed-methods *** analysis was conducted based on the five steps recommended by Braun and Clarke(2006):(1)familiarisation of data whereby transcripts were read and reread,(2)generating initial codes,(3)searching for themes by gathering relevant codes,(4)reviewing themes and(5)defining and naming *** Four subthemes under the broader notion of facilitators(supportive figures,defined role,opportunities for personal growth and identifying personalised coping strategies)and three subthemes under the concept of barriers(unclear role,hostility from non-peer-support specialist staff and unsupportive working environments)were *** Our findings echoed those of previous studies conducted in western countries providing some evidences for the cross-cultural nature of these barriers and ***,the way their impact can be mitigated or enhanced is likely to be different owing to cultural barriers,such as the general consensus and acceptance of larger personal recovery *** research is required in community settings to better understand the boundaries and limitations of our *** information will allow us to continue improving peer support worker integration in diverse mental healthcare settings.

关键词： finding analysis gathering

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Hybrid gold/DNA nanowire circuit with sub-10nm nanostructure arrays

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Microsystems & Nanoengineering 2020年第1期6卷 221-228页

作者： Jong Seob Choi Hye Bin Park jonathan HTsui Byungyou hong Deok-Ho Kim Hyung Jin Kim Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21205USA Digital Healthcare Research Center Gumi Electronics and Information Technology Research Institute(GERI)350-27GumidaeroGumiGyeongbuk 39253South Korea College of Information and Communication Engineering Sungkyunkwan UniversitySuwon 440-746South Korea Department of Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA

We report on a simple and efficient method for the selective positioning of Au/DNA hybrid nanocircuits using a sequential combination of electron-beam lithography(EBL),plasma ashing,and a molecular patterning *** nanostructures produced by the EBL and ashing process could be uniformly formed over a 12.6 in 2 substrate with sub-10 nm patterning with good pattern *** addition,DNA molecules were immobilized on the selectively nanopatterned regions by alternating surface coating procedures of 3-(aminopropyl)triethoxysilane(APS)and diamond like carbon(DLC),followed by deposition of DNA molecules into a well-defined single DNA *** single DNA nanowires were used not only for fabricating Au/DNA hybrid nanowires by the conjugation of Au nanoparticles with DNA,but also for the formation of Au/DNA hybrid *** nanocircuits prepared from Au/DNA hybrid nanowires demonstrate conductivities of up to 4.3×10^(5) S/m in stable electrical *** selective and precise positioning method capable of controlling the size of nanostructures may find application in making sub-10 nm DNA wires and metal/DNA hybrid nanocircuits.

关键词： nanowires precise method

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Classification of hyperspectral images based on a convolutional neural network and spectral sensitivity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第3期21卷 240-248页

作者： Cheng-ming YE Xin LIU hong XU Shi-cong REN Yao LI jonathan LI Chongqing Engineering Research Center of Automatic Monitoring for Geological Hazards Chongqing 401120China Key Laboratory of Earth Exploration and Information Technology of Ministry of Education Chengdu University of TechnologyChengdu 610059China National Breeding Base of Technology and Innovation Platform for Automatic-monitoring of Geologic Hazards Chongqing Institute of Geology and Mineral ResourcesChongqing 401120China Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu 610041China Department of Geography and Environmental Management University of WaterlooWaterlooN2L 3G1Canada

In recent years,deep learning methods have gradually come to be used in hyperspectral imaging *** of the peculiarity of hyperspectral imaging,a mass of information is contained in the spectral dimensions of hyperspectral ***,different ob jects on a land surface are sensitive to different ranges of *** achieve higher accuracy in classification,we propose a structure that combines spectral sensitivity with a convolutional neural network by adding spectral weights derived from predicted outcomes before the final classification ***,samples are divided into visible light and infrared,with a portion of the samples fed into networks during ***,two key parameters,unrecognized rate(δ)and wrongly recognized rate(γ),are calculated from the predicted outcome of the whole ***,the spectral weight,derived from these two parameters,is ***,the spectral weight is added and an improved structure is *** improved structure not only combines the features in spatial and spectral dimensions,but also gives spectral sensitivity a primary *** with inputs from the whole spectrum,the improved structure attains a nearly 2%higher prediction *** applied to public data sets,compared with the whole spectrum,on the average we achieve approximately 1%higher accuracy.

关键词： Hyperspectral imaging Deep learning Convolutional neural network(CNN) Spectral sensitivity

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Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide Perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： Pui Kei KO jonathan E.HALPERT Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(PLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(EL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LEDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

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Organic-inorganic halide perovskites for memristors

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Journal of Semiconductors 2023年第9期44卷 39-46页

作者： Memoona Qammar Bosen Zou jonathan E.Halpert Department of Chemistry Hong Kong University of Science and Technology(HKUST)Clear Water Bay RoadKowloon 999077Hong Kong SARChina

Organic-inorganic halides perovskites(OHPs)have drawn the attention of many researchers owing to their astonishing and unique optoelectronic *** have been extensively used for photovoltaic applications,achieving higher than 26%power conversion efficiency to *** materials have potential to be deployed for many other applications beyond photovoltaics like photodetectors,sensors,light-emitting diodes(LEDs),and *** address the looming challenge of Moore’s law and the Von Neumann bottleneck,many new technologies regarding the computation of architectures and storage of information are being extensively *** the discovery of the memristor as a fourth component of the circuit,many materials are explored for memristive ***,researchers have advanced the exploration of OHPs for memristive *** materials possess promising memristive properties and various kinds of halide perovskites have been used for different applications that are not only limited to data storage but expand towards artificial synapses,and neuromorphic *** we summarize the recent advancements of OHPs for memristive applications,their unique electronic properties,fabrication of materials,and current progress in this field with some future perspectives and outlooks.

关键词： organic-inorganic halide perovskites resistive switching memristors

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Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness

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International Journal of Oral Science 2020年第1期12卷 40-49页

作者： Hannah Shong jonathan Akhavan Sung Hee Lee Reuben HKim Mo KKang No-Hee Park Ki-Hyuk Shin The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA

High-risk human papillomaviruses(HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α(TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase(h TERT)-immortalized cells. TNFαtreatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as(1) calcium resistance,(2)anchorage independence, and(3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in h TERTimmortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated h TERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting micro RNAs mi R-203 and mi R-200 c. Overexpression of mi R-203 and mi R-200 c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis.

关键词： carcinogenesis cytokine cancer

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A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota jonathan P.Hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World Premier International(WPI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular Photochromic X-ray induced Anion-directed folding Electron-deficient viologens

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A critical review:emerging bioeconomy and waste-to-energy technologies for sustainable municipal solid waste management

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Waste Disposal and Sustainable Energy 2019年第3期1卷 151-167页

作者： To-Hung Tsui jonathan W.C.Wong Department of Biology Institute of Bioresource and AgricultureSino-Forest Applied Research Centre for Pearl River Delta EnvironmentHong Kong Baptist UniversityKowloon TongHong KongChina

Municipal solid waste(MSW)management has emerged as probably the most pressing issue many governments nowadays are ***,Waste-to-Energy(WtE)is mostly associated with incineration,but now,with the emergence of the bioeconomy,it embraces a broader definition comprising any processing technique that can generate electricity/heat or produce a waste-derived *** the ambit of the circular economy many nations are looking for,additional effort must be made to be sure of acquiring the most updated information and paving a sustainable path for managing MSW in such a *** this regard,we have undertaken a critical review of various technologies,with their updated progress,involved in the exploitation of MSW as a renewable resource,along with the critical advantages and limitations on energy and material cycling for sustainable MSW ***,the most widely used method,is nowadays difficult to further apply due to its dubious reputation and social ***,to address the organic fraction of MSW which currently is mostly unrecycled and causes disposal issues,the biological approach presents an attractive *** new emphasis of bioeconomy leads us to understand how environmental biotechnologies should be better connected/integrated for more sustainable MSW *** article is concluded with advances of future prospects,which can serve as a timely reminder to encourage competent authorities/researchers to work towards further improvement of the present MSW management system.

关键词： Municipal solid waste management Sustainability Circular economy Bioeconomy Waste-to-energy Anaerobic digestion

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