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The underlying mechanism of prodromal PD:insights from the parasympathetic nervous system and the olfactory system

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Translational Neurodegeneration 2017年第1期6卷 20-28页

作者： shu-Ying Liu Piu Chan A.jon stoessl Department of Neurobiology Neurology and GeriatricsXuanwu Hospital Capital Medical UniversityBeijing 100051China Beijing Key Laboratory on Parkinson’s Disease Parkinson Disease Center of Beijing Institute for Brain DisordersBeijing 100051China Pacific Parkinson’s Research Centre Division of Neurology and Djavad Mowafaghian Centre for Brain HealthUniversity of British Columbia and Vancouver Coastal HealthVancouver V6T 1Z3BCCanada

Neurodegeneration of Parkinson’s disease(PD)starts in an insidious manner,30–50%of dopaminergic neurons have been lost in the substantia nigra before clinical *** stage of the disease,during which the disease pathology has started but is insufficient to result in clinical manifestations,offers a valuable window for disease-modifying *** most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of *** this review,we consider the two potential portals,the vagus nerve and the olfactory bulb,through which abnormal alpha-synuclein can access the *** review the clinical,pathological and neuroimaging evidence of the parasympathetic nervous system and the olfactory system in the neurodegenerative process and using the two systems as models to discuss the internal homogeneity and heterogeneity of the prodromal stage of PD,including both the clustering and subtyping of symptoms and ***,we offer some suggestions on future directions for imaging studies in prodromal Parkinson’s disease.

关键词： Parkinson’s disease Prodromal Alpha-synuclein Parasympathetic nervous system Olfactory system subtype

A solution method for free vibration analysis of coupled laminated composite elliptical-cylindrical-elliptical shell with elastic boundary conditions

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Journal of Ocean Engineering and science 2022年第2期7卷 112-130页

作者： Kwanghun Kim Yongsu jon Kwangil An songhun Kwak Yongsu Han Department of Engineering Machine Pyongyang University of Mechanical EngineeringPyongyang 999093Democratic People’s Republic of Korea Information center Kim Chaek University of TechnologyPyongyang 950003Democratic People’s Republic of Korea College of Mechanical science and Technology Kim Chaek University of TechnologyPyongyang 950003Democratic People’s Republic of Korea

In this paper,an efficient,convenient and explicit method based on the Haar wavelet discretization ap-proach for analyzing the free vibration of the coupled laminated composite elliptical-cylindrical-elliptical shells(ECEss)with elastic boundary conditions is *** elliptical double curved shells are cou-pled on both end of cylindrical *** on the first-order shear deformation theory the equations of motion for ECEs are derived by means of Hamilton’s *** separation of variables is first per-formed;*** components and rotations of any point of the ECEs are expanded to the Haar wavelet series in the meridian direction and Fourier series in circumferential *** constants appearing from the integrating process are determined by boundary conditions,and thus the partial dif-ferential equations are transformed into algebraic *** solving the characteristic equation,the natural frequencies and mode shapes of coupled laminated composite ECEs are *** present re-sults have been compared with those of the published *** comparison results show that this method has high accuracy,high reliability and also a higher convergence rate in attaining the frequencies of the coupled laminated composite ***,the effects of the main parameters such as material properties,geometrical parameters,and various boundary conditions,on the vibrational behavior of the coupled ECEss,are ***,new free vibration analysis results of the coupled laminated com-posited ECEs,which can be used as benchmark data for researchers in this field,are reported through the parameter study.

关键词： Free vibration Haar wavelet discretization method Coupled shell structure Elastic boundary condition

Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates

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Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： sheba Goklany John C. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory sears Robert Zieve Kendra Quart Christopher Aussems jon Moma shannon Miller Zach Poteet Conner Coffin Courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United states. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care

Application of Multi-well subsidence Analysis of the Beryl Embayment,Viking Graben,Northern North sea

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Acta Geologica sinica(English Edition) 2006年第5期80卷 693-704页

作者： DOU Lirong jon D. TURNER Roger A. sCRUTTON China National Oil and Gas Exploration and Development Corporation CNPC Beijing 100034 China Department of Geology ＆ Geophysics The University of Edinburgh Edinburgh EH9 3JW Scotland UK

The Beryl Embayment is situated at the south end of the North Viking Graben in the North sea. Three sets of normal faults, with N-s, NW-sE and NE-sW orientations, have been recognized in the Beryl Embayment. High-resolution subsidence analysis of 73 wells, combined with some seismic data, has been used to document Middle to Late Jurassic subsidence patterns in this area. The high temporal resolution achieved （1 to 2 million years per data point） has also allowed an assessment to be made of temporal evolution of faults with different orientations, and a study made of how and when the East shetland Fault was linked and controlled sedimentary facies distributions. The results indicate that the East shetland Fault can be divided into northern and southern parts which were linked together during the Early-Mid Oxfordian. The Mid-Late Jurassic syn-rift phase can be divided into four stages： minor active extension stage during the Bathonian-Middle Callovian, early syn-rotational stage during the Late Callovian-Early-Mid Oxfordian, syn-rotational climax stage during the Late Oxfordian-Early Volgian, and late syn-rotational stage during the Mid-Late Volgian. The results also show that there was a sequential variation of extension direction of active normal faults with different orientations, with an overall shift in the dominant orientation of active normal faults from N-s in the Bathonian-Middle Oxfordian, through NNW-ssE in the Late Oxfordian-Early Volgian （≈N30°E）, to NW-sE （≈N45°E） in the Mid-Late Volgian.

关键词： high-resolution subsidence analysis normal fault rift basin Beryl Embayment Viking Graben

Distribution and space use of seed-dispersing rodents in central Pyrenees:implications for genetic diversity,conservation and plant recruitment

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Integrative Zoology 2018年第3期13卷 307-318页

作者： jon URGOITI Alberto MUÑOZ Josep Maria EsPELTA Raúl BONAL CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cultural Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especially relevant in alpine systems where such granivorous rodents reach the southernmost limit of their distribution and are especially sensitive to global *** analyzed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particular attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yellow-necked mouse,Apodemus flavicollis,in central Pyrenees,a typical Eurosiberian species that reaches its southernmost distribution limit in this *** also found the wood mouse,Apodemus sylvaticus,a related species more tolerant to Mediterranean *** rodents were spatially segregated by *** was rare at high altitudes,which might cause the genetic differentiation between populations of the different valleys reported *** also found other seed consumers like dormice,Elyomis quercinus,and voles,Myodes glareolus,with marked habitat *** suggest that population isolation among valleys may increase the genetic diversity of rodents,like *** also highlight the potential threat that global warming may represent for species linked to high-altitude refuges at the southern edge of its distribution,like Apodemus ***,we discuss how this threat may have a dimension in the conservation of alpine forests dispersed by these rodent populations.

关键词： DNA analysis Pyrenees rodents seed dispersal vegetation structure

The potential drivers in forming avian biodiversity hotspots in the East Himalaya Mountains of southwest China

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Integrative Zoology 2015年第2期10卷 171-181页

作者： Fumin LEI Yanhua QU Gang sONG Per ALsTRÖM jon FJELDsÅ Key Laboratory of Zoological systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina swedish species Information Centre Swedish University of Agricultural SciencesUppsalaSweden Centre of Macroecology Evolution and ClimateZoological MuseumUniversity of CopenhagenCopenhagenDenmark

Little has been published to describe or interpret Asian biodiversity hotspots,including those in the East Himalayan Mountains of southwest China(HMsC),thus making necessary a review of the current *** Pliocene and Pleistocene geological and glacial histories of the Asian continent differ from those of Europe and North America,suggesting different mechanisms of speciation and extinction,and,thus,different responses to climate changes during the Quaternary *** short review summarizes potential drivers in shaping and maintaining high species richness and endemism of birds in the *** geographical location at the junction of different biogeographical realms,the wide range of habitats and climates along the extensive elevational range,the complex topography and the distinct geological history of this region have probably contributed to the evolution of an exceptionally species-rich and endemic-rich,specialized montane avian *** Mountain systems in the HMsC may have provided refugia where species survived during the glacial periods and barriers for preventing species dispersal after the glacial *** studies are required to further test this refugia hypothesis by comparing more cold-tolerent and warm-tolerent species.

关键词： biodiversity hotspots East Himalayan Mountains of southwest China phylogeographical divergence Pleistocene glaciations species richness and endemism

self-Assembly Protein superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment

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Nano-Micro Letters 2020年第11期12卷 107-125页

作者： Tao Zheng Wentao Wang jon Ashley Ming Zhang Xiaotong Feng Jian shen Yi sun Department of Health Technology Technical University of Denmark2800 Kongens LyngbyDenmark Jiangsu Collaborative Innovation Center for Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Glioblastoma(GBM) remains a formidable challenge in *** therapy(CDT) that triggers tumor cell death by reactive oxygen species(ROs) could open up a new door for GBM ***,we report a novel CDT ***(Hb)and glucose oxidase(GOx) were employed as powerful CDT *** of encapsulating the proteins in drug delivery nanocarriers,we formulate multimeric superstructures as self-delivery entities by crosslinking *** blood cell(RBC) membranes are camouflaged on the protein superstructures to promote the delivery across blood-brain *** as-prepared RBC@Hb@GOx nanoparticles(NPs) offer superior biocompatibility,simplified structure,and high accumulation at the tumor *** successfully demonstrated that the NPs could efficiently produce toxic ROs to kill U87 MG cancer cells in vitro and inhibit the growth of GBM tumor in vivo,suggesting that the new CDT nanoagent holds great promise for treating GBM.

关键词： self-assembly protein superstructures Glioblastoma therapy Chemodynamic therapy self-delivery entities Blood-brain barrier

sensor Technology Handbook

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Influence of in vitro capacitation time on structural and functional human sperm parameters

2005年

作者： jon s. Wilson

ISBN: (纸本)9780750677295

Without sensors most electronic applications would not exist—they perform a vital function, namely providing an interface to the real world. The importance of sensors, however, contrasts with the limited information available on them. Today's smart sensors, wireless sensors, and microtechnologies are revolutionizing sensor design and applications. This volume is a comprehensive sensor reference guide to be used by engineers and scientists in industry, research, and academia to help with their sensor selection and system design. It is filled with hard-to-find information, contributed by noted engineers and companies working in the field today. The book offers guidance on selecting, specifying, and using the optimum sensor for any given application. The editor-in-chief, jon Wilson, has years of experience in the sensor industry and leads workshops and seminars on sensor-related topics. In addition to background information on sensor technology, measurement, and data acquisition, the handbook provides detailed information on each type of sensor technology, covering: · technology fundamentals · sensor types, w/ advantages/disadvantages · manufacturers · selecting and specifying sensors · applicable standards (w/ urls of related web sites) · interfacing information, with hardware and software info · design techniques and tips, with design examples · latest and future developments The handbook also contains information on the latest MEMs and nanotechnology sensor applications.

关键词： Detectors

来源：畅想之星图书光盘版（南... 评论

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Asian Journal of Andrology 2020年第5期22卷 447-453页

作者： Paula saez-Espinosa Natalia Huerta-Retamal Laura Robles-Gomez Manuel Aviles jon Aizpurua Irene Velasco Alejandro Romero Maria Jose Gomez-Torres Department of Biotechnology Faculty of ScienceUniversity of AlicanteAlicante 03080Spain FIsABI0-University Hospital of san Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Departm ent of Cell Biology and Histology Faculty of MedicineUniversity of Murcia and IMIB-ArrixacaMurcia 30100Spain IVF spain Reproductive MedicineAlicante 03540Spain University Hospital of san Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Human Fertility Cathedra University of AlicanteAlicante 03080Spain.

A cascade of dramatic physiological events is linked to the sperm acrosome reaction and binding to the oocyte's zona pellucida during human sperm ***,structural and functional sperm changes during capacitation currently remain poorly ***,we performed a multibiomarker approach based on the utilization of sperm concentration,motility,viability,morphology,acrosome reaction,tyrosine phosphorylation,DNA fragmentation,and lectin-binding sites to analyze the impact caused by swim-up selection times(uncapacitated,1 h capacitated,and 4 h capacitated)on sperm function and structure in normozoospermic *** found that a 4 h swim-up capacitation increased sperm quality,because a large number of cells with normal morphology and lower DNA fragmentation rates were ***,the long-term capacitation induced a higher percentage of cells with tyrosine phosphorylation of the principal piece as well as a redistribution of lectin-binding ***,the multivariate biomarkers analyzed showed a less variable distribution on spermatozoa recovered after 4 h capacitation than that with the shorter capacitation *** findings stress the importance of capacitation time as a relevant factor in sperm quality with potential biological reproductive implications both for basic research and in assisted reproduction techniques.

关键词： acrosome reaction capacitation DNA fragmentation glycocalyx lectin-binding sites membrane integrity protein phosphorylation sperm selection