The underlying mechanism of prodromal PD:insights from the parasympathetic nervous system and the olfactory system
作者机构：Department of NeurobiologyNeurology and GeriatricsXuanwu Hospital Capital Medical UniversityBeijing 100051China Beijing Key Laboratory on Parkinson’s DiseaseParkinson Disease Center of Beijing Institute for Brain DisordersBeijing 100051China Pacific Parkinson’s Research CentreDivision of Neurology and Djavad Mowafaghian Centre for Brain HealthUniversity of British Columbia and Vancouver Coastal HealthVancouver V6T 1Z3BCCanada
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2017年第6卷第1期
页 面：20-28页
核心收录：
学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 1009[医学-特种医学] 0812[工学-计算机科学与技术（可授工学、理学学位）]
主 题：Parkinson’s disease Prodromal Alpha-synuclein Parasympathetic nervous system Olfactory system Subtype
摘 要：Neurodegeneration of Parkinson’s disease(PD)starts in an insidious manner,30–50%of dopaminergic neurons have been lost in the substantia nigra before clinical *** stage of the disease,during which the disease pathology has started but is insufficient to result in clinical manifestations,offers a valuable window for disease-modifying *** most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of *** this review,we consider the two potential portals,the vagus nerve and the olfactory bulb,through which abnormal alpha-synuclein can access the *** review the clinical,pathological and neuroimaging evidence of the parasympathetic nervous system and the olfactory system in the neurodegenerative process and using the two systems as models to discuss the internal homogeneity and heterogeneity of the prodromal stage of PD,including both the clustering and subtyping of symptoms and ***,we offer some suggestions on future directions for imaging studies in prodromal Parkinson’s disease.
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