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Cardiac Toxicity of Azole Antifungals

作者： (美)乔恩·d. 马克曼(jon d. Markman)

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Pharmacology & Pharmacy 2013年第3期4卷 362-368页

作者： John d. Cleary Kayla R. Stover Jerry Farley William daley Patrick B. Kyle jon Hosler department of Biochemistry Jackson USA. department of Pathology Jackson USA department of Pharmacology and Toxicology Jackson USA University of Mississippi Schools of Medicine & Pharmacy Jackson USA

Cardiac toxicity is an uncommon side effect of anti-fungal therapy. Until the recent reports of itraconazole (ITZ) associated cardiac failure, amphotericin was the antifungal most frequently reported with arrhythmias. We evaluated the cardiac effect of azole antifungals, specifically ITZ, and possible mechanisms of toxicity. Ex vivo live-heart studies were performed utilizing Sprague dawley rats. Short exposure (dom crossover, dose ranging studies were performed with each pharmacologic agent. ITZ focused trials also included dose ranging utilizing a non-crossover design. The only azole found to have significant toxicity was ITZ. At ITZ ~ Ed25 (2 - 2.5 ug/mL) exposures, contractility decreased by 22.2% ± 15.7% and amplitude of left ventricular pressure decreased by 11% ± 0.17%. Electron micrograph and alterations in mitochondrial respiration suggest mitochondrial toxicity as an underlying mechanism. In conclusion, ITZ was associated with reductions in contractility, possibly secondary to mitochondrial dysfunction and dilated cardiomyopathy.

关键词： Mycology Azole Antifungals Itraconazole Animal Model

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Wide Repercussions

Beijing Review 2019年第21期62卷 28-29页

作者： Roach, Stephen Taylor, jon Goldstein, Avery

The U.S. raised tariffs on $200 billion worth of Chinese imports from 10 percent to 25 percent on May 10, the day the 11th round of *** and trade consultations ended in Washington, d.C., with no deal reached. But the decision was announced on May 5. On May 13, in response to the U.S. escalation of trade frictions, China announced that it will impose additional tariffs on some imported U.S. products as of June 1.

关键词： Wide Repercussions

强化型真皮再生模板调控真皮成纤维细胞生物学行为及诱导真皮再生作用的研究

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强化型真皮再生模板调控真皮成纤维细胞生物学行为及诱导真皮再生...

作者： Ho jon Kee 浙江大学

学位级别：硕士

背景:烧创伤、糖尿病溃疡和静脉性溃疡等各种急慢性因素极易影响人体最大的器官——皮肤,可造成不同程度的皮肤缺损。深度皮肤缺损的面积超过一定的范围,就会难以自愈,给患者及其家庭带来巨大的痛苦和沉重的经济负担。因此,治疗深度皮... 详细信息

背景:烧创伤、糖尿病溃疡和静脉性溃疡等各种急慢性因素极易影响人体最大的器官——皮肤,可造成不同程度的皮肤缺损。深度皮肤缺损的面积超过一定的范围,就会难以自愈,给患者及其家庭带来巨大的痛苦和沉重的经济负担。因此,治疗深度皮肤缺损的关键就是尽早封闭创面。最常见的临床治疗方法是自体皮肤移植,但是,感染风险、供皮区的匮乏和二次损伤等限制了自体皮肤移植的应用。真皮替代物是真皮再生的模板,在皮肤重建/再生中至关重要,它的出现为临床上深度皮肤缺损的治疗提供了一条新的途径。创面的修复主要由炎症细胞、血管内皮细胞、角质形成细胞、成纤维细胞、细胞外基质、生长因子及细胞因子等共同参与,其过程大致可以分为炎症期,增生期和重塑期,这三个过程相互重叠。皮肤损伤后,真皮成纤维细胞作为重要的修复细胞被激活、增殖、迁移、分化并合成多种细胞外基质(包括胶原和多糖类等)及分泌多种细胞因子,这种生物学行为被认为是创面修复的重要部分。基于前期的研究发现,采用具有良好生物相容性、可降解性的多孔结构胶原-壳聚糖(CCS)支架作为真皮支架材料与PLGA经编网(PLGAm)整合成强化型真皮支架,具有较高的机械强度,能够在体内诱导组织再生功能,具有巨大的临床应用潜在前景。目的:本项目在前期研究的基础上,体外部分通过在强化型聚乳酸-羟基乙酸编织网胶原壳聚糖支架(PLGAm/CCS)上接种人真皮成纤维细胞,与胶原壳聚糖支架(CCS)作对比,在体外环境条件下,考察PLGAm/CCS支架对真皮成纤维细胞生物学行为的影响。体内研究,将PLGAm/CCS支架移植到动物创面,考察真皮替代物在体内诱导组织再生情况及转归情况,为进一步研究真皮替代物的临床转化提供理论基础。方法:(1)强化型真皮再生模板的制备:将PLGA网置于模具中,注入0.5%胶原-壳聚糖溶液(质量比为9:1),4℃孵育过夜,-20℃下冷冻2h,然后冻干24h,得到厚度为2mm的PLGAm/CCS多孔支架;(2)体外细胞接种实验:随后将原代提取的人真皮成纤维细胞接种到PLGAm/CCS支架上,通过体外ELISA检测α-羟脯氨酸(α-Hp)和Ⅰ型胶原羧基末端肽(CICP)量的变化观察成纤维细胞的胶原合成能力;通过激光共聚焦(CLSM)观察PLGAm/CCS支架对成纤维细胞的影响;采用MTT法检测PLGAm/CCS支架对成纤维细胞的毒性作用;(3)体内实移植PLGAm/CCS支架入Sd大鼠体内,通过HE染色和免疫组织化学法观察移植PLGAm/CCS支架对大鼠创面的影响;(4)采用RT-qPCR和蛋白质免疫印迹法(WB)观察移植PLGAm/CCS支架后大鼠新生组织中Cd31、Col Ⅰ、Col Ⅲ和Elastin的RNA和蛋白质表达量的影响。结果:(1)PLGAm/CCS支架具有良好的机械强度,和合适的三维多孔结构;(2)PLGAm/CCS和CCS支架接种真皮成纤维细胞后,其上清液中α-Hp和CICP含量随培养时间的延长而升高,且两组支架间比较有显著性差异(Pd后,PLGAm/CCS支架组大鼠组织中Cd31、ColⅠ、ColⅢ和Elastin的mRNA和蛋白质表达量均显著高于CCS支架组(P<0.05)。结果表明,PLGAm/CCS支架可以诱导细胞快速长入、促进血管新生,促使新生组织形成。结论:强化型真皮再生模板(PLGAm/CCS)的机械强度高,具有良好的生物相容性,对真皮成纤维细胞的增殖能力基本没有影响且能促进人真皮成纤维细胞合成分泌胶原等细胞外基质。体内移植PLGAm/CCS支架促进血管新生,以及胶原纤维的生成和沉积,同时使胶原高度有序排列,促进创面修复再生。PLGAm/CCS具有潜在的临床转化价值。

关键词：胶原/壳聚糖支架编织网真皮成纤维细胞真皮再生真皮再生模板

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最后的转轮密码机

科技纵览 2021年第9期 30-38页

作者： jon d.Paul Peter Adams(照片) 不详

我在纽约长大,一直想成为一名间谍。当我1968年1月大学毕业时,冷战和越南战争正在激烈进行,间谍似乎是一个危险的职业选择。所以我成了一名电气工程师,为一家美国国防承包商设计实时频谱分析仪。

关键词：电气工程师越南战争实时频谱分析仪间谍承包商大学毕业一名

Transfer of motion through a microelectromechanical linkage at nanometer and microradian scales

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Microsystems & Nanoengineering 2016年第1期2卷 106-115页

作者： Craig R.Copeland Craig d.McGray jon Geist Vladimir A.Aksyuk Samuel M.Stavis Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland Nanocenter University of MarylandCollege ParkMD 20742USA Engineering Physics division National Institute of Standards and TechnologyGaithersburgMD 20899USA Modern Microsystems Silver SpringMD 20904USA

Mechanical linkages are fundamentally important for the transfer of motion through assemblies of parts to perform *** their behavior in macroscale systems is well understood,there are open questions regarding the performance and reliability of linkages with moving parts in contact within microscale *** challenges impede experimental studies to answer such *** this study,we develop a novel combination of optical microscopy methods that enable the first quantitative measurements at nanometer and microradian scales of the transfer of motion through a microelectromechanical *** track surface features and fluorescent nanoparticles as optical indicators of the motion of the underlying parts of the *** models allow precise characterization of the electrothermal actuation of the *** transfer of motion between translating and rotating links can be nearly ideal,depending on the operating *** coupling and decoupling of the links agree with an ideal kinematic model to within approximately 5%,and the rotational output is perfectly repeatable to within approximately 20 ***,stiction can result in nonideal kinematics,and input noise on the scale of a few millivolts produces an asymmetric interaction of electrical noise and mechanical play that results in the nondeterministic transfer of *** study establishes a new approach towards testing the performance and reliability of the transfer of motion through assemblies of microscale parts,opening the door to future studies of complex microsystems.

关键词： Electrothermal linkage microelectromechanical nanoparticle noise rotation tracking translation

冲突后非洲农业的恢复:关键资源使用权的作用

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人类环境杂志 1995年第6期24卷 343-348页

作者： jon d.Unruh 陈光伟亚利桑那大学干旱土地研究办公室

由冲突和饥荒引起的非洲人口的大规模迁移将对广大地区未来的资源利用、农业潜力和安全产生深远的影响。对广大农村居民而言,使用和获得资源的结构被破坏将危及这些资源的合理利用和生产能力。很多维持生计的生产者在冲突后的恢复将开... 详细信息

由冲突和饥荒引起的非洲人口的大规模迁移将对广大地区未来的资源利用、农业潜力和安全产生深远的影响。对广大农村居民而言,使用和获得资源的结构被破坏将危及这些资源的合理利用和生产能力。很多维持生计的生产者在冲突后的恢复将开始依赖那些土地肥沃、常年有水、能利用基础设施和有难民救济的地方——在非洲大陆比较干旱的地区情况更是如此。在索马里,恢复过程中将会出现对这种空间上有限的"关键资源"地区的依赖,因为大家都争相要求得到有价值的资源而且以不同方式利用资源的人聚集在这些地区。在对关键资源地区实行"恢复使用权"的计划中,恢复的成果可能包括新兴的实践混合体。

关键词：资源使用权农业非洲资源

Evaluation of the Precision Agricultural Landscape Modeling System (PALMS) in the Semiarid Texas Southern High Plains

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Open Journal of Soil Science 2013年第4期3卷 169-181页

作者： John R. Nelson Robert J. Lascano jon d. Booker Richard E. Zartman Timothy S. Goebel department of Agronomy Kansas State University Courtland Kansas USA department of Plant and Soil Sciences Texas Tech University Lubbock Texas USA. USdA-ARS Cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit Lubbock Texas USA

Accurate models to simulate the soil water balance in semiarid cropping systems are needed to evaluate management practices for soil and water conservation in both irrigated and dryland production systems. The objective of this study was to evaluate the application of the Precision Agricultural Landscape Modeling System (PALMS) model to simulate soil water content throughout the growing season for several years and for three major soil series of the semiarid Texas Southern High Plains (SHP). Accuracy of the model was evaluated by comparing measured and calculated values of soil water content and using root mean squared difference (RMSd), squared bias (SB), squared difference between standard deviations (SdSd), and lack of correlation weighted by the standard deviation (LCS). different versions of the model were obtained by modifying soil hydraulic properties, including saturated hydraulic conductivity (Ks) and residual (θr) and saturated (θs) soil volumetric water content, which were calculated using Rosetta pedotransfer functions. These modifications were combined with updated routines of the soil water solver in PALMS to account for rapid infiltration into dry soils that often occur in the SHP. Field studies were conducted across a wide range of soil and water conditions in the SHP. Soil water content was measured by neutron attenuation and gravimetrically throughout the growing seasons at each location to compare absolute values and the spatial distribution of soil water with PALMS calculated values. Use of Rosetta calculated soil hydraulic properties improved PALMS soil water calculation from 1% - 13% of measured soil volumetric water content (θv) depending on soil type. Large-scale models such as PALMS have the potential to more realistically represent management effects on soil water availability in agricultural fields. Improvements in PALMS soil water calculations indicated that the model may be useful to assess long-term implications of management practices

关键词： Model Validation Landscape Scale Hydrology Soil Water Content Cropping Systems

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高效政府

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精通3d STUdIO MAX R3创意设计

2018年

作者： (新加坡)jon S. T. Quah

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