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Evaluation of 1031 primary titanium nitride coated mobile bearing total knee arthroplasties in an orthopedic clinic

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World Journal of Orthopedics 2017年第12期8卷 922-928页

作者： Stefan J M Breugem Jeroen Linnartz Inger Sierevelt jon d Bruijn Marcel J M driessen Orthopedium Orthopedic Clinic Slotervaart Hospital

AIM To evaluate the influence of the titanium nitride(TiN) coating on the results of a total knee arthroplasty(TKA). METHOdS A total of 910 patients(338 men; 572 woman), with a mean age of 65(range 36-94) undergoing 1031 primary TKAs were assessed. Clinical evaluation and patientreported outcomes were gathered one year after surgery. The questionnaires included the Knee injury and Osteoarthritis Outcome Score(KOOS)-dutch version, Visual Analogue Scale(VAS) pain scores in rest and during active knee movement, VAS-satisfaction scores, and EQ-5 d-3 L health scores. This was aimed to assess the overall knee function and patient satisfaction, and to enable us to make a gross comparison to other *** At a mean follow-up of 46 mo(range 1-92) the overall implant survival was 97.7% and 95.1% for any operative reason related to the implant. Twenty-three knees(2.2%) required revision surgery. Arthrofibrosis was the most common indication for a re-operation. The clinical evaluation and patient-reported outcomes revealed good to excellent patient satisfaction and function of the arthroplasty. The median postoperative VAS-pain scores on a scale of 0-100, at one year after surgery were 1 in rest and 2 during *** The Ti N coated, mobile bearing TKA results are excellent and similar to those of other widely used TKA designs. Residual pain of the knee remains a concern and the Ti N coating in combination with the mobile bearing does not seem to be the simple solution to this problem. Future research will have to show that the coating gives a better survival than the cobalt chrome version.

关键词： Total knee arthroplasty Titanium nitride coating Mobile bearing Pain Satisfaction and survival

Modelling of compacted graphite cast iron solidification-discussion of microstructure parameters

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China Foundry 2020年第2期17卷 144-149页

作者： Jacques Lacaze Urko de la Torre jon Sertucha Anna Regordosa Centre Inter-universitaire de Recherche et d’Ingénierie des Matériaux(CIRIMAT) Universitéde ToulouseToulouseFrance Fundación AZTERLAN DurangoSpain

A melt maintained for hours in a press pour unit allowed the following changes over time from spheroidal graphite to compacted graphite iron by casting thermal cups at regular time *** provided extensive experimental information for checking the possibility of simulating solidification of compacted graphite irons by means of a microstructure modelling *** solidification,compacted graphite develops very much as lamellar graphite but with much less *** this basis,a simulation of the thermal analysis records was developed which considers solidification proceeding in a pseudo binary Fe-C *** simulated curves were compared with the experimental ones obtained from three representative alloys that cover the whole microstructure change during the holding of the *** most relevant result is that the parameter describing branching capability of graphite is the most important for reproducing the minimum eutectic temperature and the recalescence which are so characteristic of the solidification of compacted graphite cast irons.

关键词： compacted graphite irons thermal analysis stable eutectic metastable eutectic simulation

Tri-axial accelerometry shows differences in energy expenditure and parental effort throughout the breeding season in long-lived raptors

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Current Zoology 2022年第1期68卷 57-67页

作者： Pascual LOPEZ-LOPEZ Arturo MPERONA Olga EGEA-CASAS jon MORANT Vicente URIOS Movement Ecology Laboratory Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of Valencia.C/Catedratico JoseBeltran 2E-46980 PaternaValenciaSpain department of Ornithology Aranzadi Sciences SocietyDonostia-S.SebastianGuipuzcoa 03690Spain Vertebrates Zoology Research Group University of AlicanteApdo.99Alicante E-03080Spain

Cutting-edge technologies are extremely useful to develop new workflows in studying ecological data,particularly to understand animal behavior and movement trajectories at the individual *** parental care is a well-studied phenomenon,most studies have been focused on direct observational or video recording data,as well as experimental ***,what happens out of our sight still remains *** high-frequency GPS/GSM dataloggers and tri-axial accelerometers we monitored 25 Bonelli’s eagles Aquila fasciata during the breeding season to understand parental activities from a broader *** used recursive data,measured as number of visits and residence time,to reveal nest attendance patterns of biparental care with role specialization between *** data interpreted as the overall dynamic body acceleration,a proxy of energy expenditure,showed strong differences in parental effort throughout the breeding season and between ***,males increased substantially their energetic requirements,due to the increased workload,while females spent most of the time on the ***,during critical phases of the breeding season,a low percentage of suitable hunting spots in eagles’territories led them to increase their ranging behavior in order to find food,with important consequences in energy consumption and mortality *** results highlight the crucial role of males in raptor species exhibiting biparental ***,we exemplify how biologging technologies are an adequate and objective method to study parental care in raptors as well as to get deeper insight into breeding ecology of birds in general.

关键词： biologging GPS movement ecology OdBA space use telemetry

Pigs fed camelina meal increase hepatic gene expression of cytochrome 8b1, aldehyde dehydrogenase, and thiosulfate transferase

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Journal of Animal Science and Biotechnology 2014年第2期5卷 215-221页

作者： William jon Meadus Pascale duff Tanya Mcdonald William R Caine AAFC-Lacombe 6000 C&E TrailLacombeABCanada T4L 1 W1 School of Innovation Olds College4500-50th St.OldsABCanada T4H 1R6 Caine Research Consultinq Box #1124NiskuABCanada T9E 8A8

Comelina sotivo is an oil seed crop which can be grown on marginal lands. Camelina seed oil is rich in omega-3 fatty acids （〉35%） and y-tocopherol but is also high in erucic acid and glucosinolates. Camelina meal, is the by-product after the oil has been extracted. Camelina meal was fed to 28 d old weaned pigs at 3.7% and 7.4% unt age 56 d. The camelina meal supplements in the soy based diets, improved feed efficiency but also significantly increased the liver weights. Gene expression analyses of the livers, using intra-species microarrays, identified increased expression of phase 1 and phase 2 drug metabolism enzymes. The porcine versions of the enzymes were confirmed by real time PCR. Cytochrome 8b1 （CYPSB1）, aldehyde dehydrogenase 2 （Aldh2）, and thiosulfate transferase （TST） were all significantly stimulated. Collectively, these genes implicate the camelina glucosinolate metabolite, methyl-sulfinyldecyl isothiocyanate, as the main xeniobiotic, causing increased hepatic metabolism and increased liver weight.

关键词： Camelina meal Gene expression Glucosinolates Pig liver

The past,present,and future of the Siberian Grouse(Falcipennis falcipennis)under glacial oscillations and global warming

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Avian Research 2022年第1期13卷 57-63页

作者： Wendong Xie Kai Song Siegfried Klaus jon E.Swenson Yue-Hua Sun Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China College of Life Science Hebei UniversityBaoding071002China Lindenhöhe 5 D-07749JenaGermany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesPO Box 5003NO-1432ÅsNorway

Global climate change has a significant effect on species,as environment conditions change,causing many species'distributions to *** the last three million years,the earth has experienced glacial oscillations,forcing some species to survive in ice-free refugia during glacial periods and then disperse *** this study,by assessing the potential distribution of Siberian Grouse(Falcipennis falcipennis),we used Global Circular Models and Representative Concentration Pathways to model their pattern of range changes during glacial oscillations and the potential impact of present global *** used 158 location records of Siberian Grouse to generate a full climate model using 19 bioclimate variables in *** discarded variables with a correlation coefficient larger than 0.8 and relatively lower modeling contributions between each pair of correlated *** the remaining variables,we created a normally uncorrelated simple climate model to predict the possible distribution of Siberian Grouse from the most recent Ice Age to present and to *** we added geographical data and the human interference index to construct a multiple factor full model to evaluate which were important in explaining the distribution of Siberian *** Total Suitability Zone(P≥0.33)of Siberian Grouse is about 243,000km^(2) and the Maximum Suitability Zone(P≥0.66)is 36,000km^(2) and is confined to the Russian Far *** habitat modeling suggested that annual precipitation,annual mean temperature,and the distance from lakes are the most explanatory variables for the current distribution of Siberian *** distribution center moved to the southeast during the Last Glacial Maximum and spread back to the northwest after the ice melted and temperatures *** total area range of Siberian Grouse experienced a dramatic loss during the Last Glacial *** warming is presently forcing the Siberian Grouse to migrate northward with a contraction of

关键词： Climate change Falcipennis falcipennis Ice age refugia Last glacial maximum

Big dNA as a tool to dissect an age-related macular degeneration-associated haplotype

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Precision Clinical Medicine 2019年第1期2卷 1-7页

作者： jon M.Laurent Xin Fu Sergei German Matthew T.Maurano Kang Zhang Jef d.Boeke Institute for Systems Genetics department of Biochemistry and Molecular Pathology department of Pathology NYU Langone Health Shiley Eye Institute UCSD School of Medicine

Age-related Macular degeneration(AMd)is a leading cause of blindness in the developed world,especially in aging populations,and is therefore an important target for new therapeutic ***,there have been several studies demonstrating strong associations between AMd and sites of heritable genetic variation at multiple loci,including a highly significant association at *** 10q26 risk region contains two genes,HTRA1 and ARMS2,both of which have been separately implicated as causative for the disease,as well as dozens of sites of non-coding *** date,no studies have successfully pinpointed which of these variant sites are functional in AMd,nor definitively identified which genes in the region are targets of such regulatory *** order to efficiently decipher which sites are functional in AMd phenotypes,we describe a general framework for combinatorial assembly of large‘synthetic haplotypes’along with delivery to relevant disease cell types for downstream functional *** demonstrate the successful and highly efficient assembly of a first-draft 119kb wild-type‘assemblon’covering the HTRA1/ARMS2 risk *** further propose the parallelized assembly of a library of combinatorial variant synthetic haplotypes covering the region,delivery and analysis of which will identify functional sites and their effects,leading to an improved understanding of AMd *** anticipate that the methodology proposed here is highly generalizable towards the difficult problem of identifying truly functional variants from those discovered via GWAS or other genetic association studies.

关键词： CRISPR gene editing synthetic biology age related macular degeneration HTRA1

Progress in additive manufacturing on new materials: A review

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Journal of Materials Science & Technology 2019年第2期35卷 242-269页

作者： Neng Li Shuai Huang Guodong Zhang Renyao Qin Wei Liu Huaping Xiong Gongqi Shi jon Blackburn 3d Printing Research & Engineering Technology Center Beijing Institute of Aeronautical Materials TWI Ltd Granta Park Great Abington

Recent efforts and advances in additive manufacturing(AM) on different types of new materials are presented and reviewed. Special attention is paid to the material design of cladding layers, the choice of feedstock materials, the metallurgical behavior and synthesis principle during the AM process, and the resulted microstructures and properties, as well as the relationship between these factors. Thereafter,the trend of development in the future is forecasted, including: Effects of the particles size and size distribution of powders; Approaches for producing fine microstructures; Opportunities for creating new materials by AM; Wide applications in reconditioning of damaged components; Challenges for deep understanding and applications of the AMed new materials. The idea of "develop Materials" or "Create Materials" by AM is highlighted, but a series of scientific, technological and engineering problems remain to be solved in future.

关键词： Additive manufacturing Feedstock material Laser and electron beam melting Microstructure Property

Measuring and Visualizing Research Collaboration and Productivity

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Journal of data and Information Science 2018年第1期3卷 54-74页

作者： jon Garner Alan L.Porter Andreas Leidolf Michelle Baker Search Technology Inc. School of Public Policy Georgia Institute of Technology Ecology Center Utah State University department of Biology Utah State University

Purpose： This paper presents findings of a quasi-experimental assessment to gauge the research productivity and degree of interdisciplinarity of research center outputs. Of special interest, we share an enriched visualization of research co-authoring patterns. design/methodology/approach： We compile publications by 45 researchers in each of 1） the iUTAH project, which we consider here to be analogous to a ＂research center,＂ 2） CG1-a comparison group of participants in two other Utah environmental research centers, and 3） CG2--a comparison group of Utah university environmental researchers not associated with a research center. We draw bibliometric data from Web of Science and from Google Scholar. We gather publications for a period before iUTAH had been established （2010-2012） and a period after （2014-2016）. We compare these research outputs in terms of publications and citations thereto. We also measure interdisciplinarity using Integration scoring and generate science overlay maps to locate the research publications across disciplines. Findings： We find that participation in the iUTAH project appears to increase research outputs （publications in the After period） and increase research citation rates relative to the comparison group researchers （although CG 1 research remains most cited, as it was in the Before period）. Most notably, participation in iUTAH markedly increases co-authoring among researchers--in general; and for junior, as well as senior, faculty; for men and women： across organizations; and across disciplines. Research limitations： The quasi-experimental design necessarily generates suggestive, not definitively causal, findings because of the imperfect controls. Practical implications： This study demonstrates a viable approach for research assessment of a center or program for which random assignment of control groups is not possible. It illustrates use of bibliometric indicators to inform R＆d program management. Originality/value： New visualizations

关键词： Bibliometrics Interdisciplinarity Multidisciplinarity Research evaluation Research collaboration mapping Science visualization Scientometrics Social networkanalysis

Solid-State NMR Spectroscopic Study of Chromophore-Protein Interactions in the Pr Ground State of Plant Phytochrome A

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Molecular Plant 2012年第3期5卷 698-715页

作者： Chen Song Lars-Oliver Essen Wolfgang Ga＇rtner jon Hughes J6rg Matysik Leids Instituut voor Chemisch Onderzoek Universiteit Leiden PO Box 9502 2300 RA Leiden The Netherlands Fachbereich Chemie Philipps-Universita＇t Marburg Hans-Meerwein-Stral3e D-35032 Marburg Germany Max-Planck-lnstitut for Bioanorganische Chemie StiftstraBe 34-36 D-45470 MCu＇lheim an der Ruhr Germany Pflanzenphysiologie Justus-Liebig-Universita＇t SenckenbergstraBe 3 D-35390 Giessen Germany

despite extensive study, the molecular structure of the chromophore-binding pocket of phytochrome A （phyA）, the principal photoreceptor controlling photomorphogenesis in plants, has not yet been successfully resolved. Here, we report a series of two-dimensional （2-d） magic-angle spinning solid-state NMR experiments on the recombi- nant N-terminal, 65-kda PAS-GAF-PHY light-sensing module of phytochrome A3 from oat （Avena sativa）, assembled with uniformly 13C- and lSN-labeled phycocyanobilin （u-[13C,15N]-***3）. The Pr state of this protein was studied regarding the electronic structure of the chromophore and its interactions with the proximal amino acids. Using 2-d 13C-13C and 1HJSN experiments, a complete set of 13C and 15N assignments for the chromophore were obtained. Also, a large number of 1H-13C distance restraints between the chromophore and its binding pocket were revealed by inter- facial heteronuclear correlation spectroscopy. 13C doublings of the chromophore A-ring region and the C-ring carbox- ylate moiety, together with the observation of two Pr isoforms, Pr-I and Pr-II, demonstrate the local mobility of the chromophore and the plasticity of its protein environment. It appears that the interactions and dynamics in the binding pocket of phyA in the Pr state are remarkably similar to those of cyanobacterial phytochrome （Cphl）. The N-terminus of the region modeled （residues 56-66 of phyA） is highly mobile. differences in the regulatory processes involved in plant and Cphl phytochromes are discussed.

关键词： solid-state NMR plant phytochrome chromophore-protein interaction signal transduction