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现代商业研究 2013年第7期 94-94页

作者： Luke johnson 邹策

企业家需要办公室吗?答案似乎越来越倾向于不需要。Chris Ward在其新书《不在办公室工作》中,提倡利用临时的无线热点网络工作。作者列举了27岁的jon Favreau如何在星巴克写就美国总统Obama的首次就职演讲;以及Richard Tait如何在一家... 详细信息

企业家需要办公室吗?答案似乎越来越倾向于不需要。Chris Ward在其新书《不在办公室工作》中,提倡利用临时的无线热点网络工作。作者列举了27岁的jon Favreau如何在星巴克写就美国总统Obama的首次就职演讲;以及Richard Tait如何在一家咖啡馆里开始创作《脑力大作战》游戏等等。

关键词：巴克无线热点美国总统企业产出行政管理工作电话交流台式电脑工作比临时会议地方工作

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W.G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.‘t Hart Sandra Amor jon d.Laman Leonie A.Boven

drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS). We demonstrate neuronal antigens within CLN of MS patients. In monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage, the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph nodes. In addition, CNS antigens drained to the spinal-cord-draining lumbar lymph nodes. In human MS CLN, neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC), whereas the majority of myelincontaining cells were anti-inflammatory. This may reflect a different origin of the cells or different drainage mechanisms. Indeed, neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7, whereas myelin antigen-containing cells in situ and in vitro did. Nevertheless, CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type mice. We conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS damage. Furthermore, the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.'t Hart Sandra Amor jon d.Laman Leonie A.Boven

drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS).We demonstrate neuronal antigens within CLN of MS *** monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage,the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph *** addition,CNS antigens drained to the spinal-cord-draining lumbar lymph *** human MS CLN,neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC),whereas the majority of myelincontaining cells were *** may reflect a different origin of the cells or different drainage ***,neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7,whereas myelin antigen-containing cells in situ and in vitro ***,CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type *** conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS ***,the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

甜味剂L-天冬氨酰-d,L-氨基丙二酸甲基葑基双酯的合成及其代谢的研究

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Acta Biochimica et Biophysica Sinica 1984年第6期 581-585页

作者：刘寅曾周乐王小玉谢伟军许廷森中国科学院上海有机化学研究所中国科学院上海生物化学研究所

N-苄氧羰基-β-苄基L-天冬氨酸和N-苄氧羰基-d,L-氨基丙二酸甲基葑基双酯用混合酸酐法缩合成保护的二肽,经钯黑脱保护基后得L-天冬氨酰-d,L-氨基丙二酸甲基葑基双酯,这个二肽的甜度高、甜质好、无苦后味。通过大白鼠的组织(脑、心、肾... 详细信息

N-苄氧羰基-β-苄基L-天冬氨酸和N-苄氧羰基-d,L-氨基丙二酸甲基葑基双酯用混合酸酐法缩合成保护的二肽,经钯黑脱保护基后得L-天冬氨酰-d,L-氨基丙二酸甲基葑基双酯,这个二肽的甜度高、甜质好、无苦后味。通过大白鼠的组织(脑、心、肾、脾、胰、胃、肠、肝)匀浆对此二肽甜味剂的分解代谢的研究说明,它能分解成为L-天冬氨酸、甘氨酸及葑醇,并通过体内代谢又可成为谷氨酸和丙氨酸等一般的氨基酸。因而,极其可能作为一个有实用价值而无毒性的甜味剂,应用于糖尿病、肥胖病等患者以及其他方面。

关键词：丙二酸天冬二元羧酸天门冬 d,L 食品添加剂甜味剂双酯链烷基甲基氨酰

丰中子奇A核^(145,147)Ce的集体带结构

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高能物理与核物理 2000年第11期24卷 1018-1023页

作者： M.萨哈伊朱胜江甘翠云朱凌燕杨利明许瑞清全明吉姜卓张征 J. H. Hamilton A. V. Ramayya B. R. S. Babu J. K. Hwang W. C. Ma J. Komicki J. d. Cole R. Aryaeinejad M. W. drigert J. O. Rasmussen M. A. Stoyer S. Y. Chu K E. Gregorich M. F. Mohar S. G. Prussi 清华大学物理系北京100084 department of Physics Vanderbilt University department of Physics Mississippi State University IdahoNationalEngineering Laboratory Lawrence Berkeley Laboratory Joint Institute for Nuclear Research

通过对２５２Ｃｆ自发裂变产生的瞬发γ谱的测量，对丰中子奇Ａ核１４５，１４７Ｃｅ的高自旋态进行了研究，首次识别了１４５Ｃｅ的集体带结构，扩展了１４７Ｃｅ的集体带结构，扩展了１４７Ｃｅ的能级，并新识别了３个边带，粒子－转... 详细信息

通过对２５２Ｃｆ自发裂变产生的瞬发γ谱的测量，对丰中子奇Ａ核１４５，１４７Ｃｅ的高自旋态进行了研究，首次识别了１４５Ｃｅ的集体带结构，扩展了１４７Ｃｅ的集体带结构，扩展了１４７Ｃｅ的能级，并新识别了３个边带，粒子－转子模型的计算指出，１４５，１４７Ｃｅ的晕带可能来自于νｉ１３／２轨道的耦合，１４５Ｃｅ基态起源于（νｈ９／２νｆ７／２）组态混合，而１４７Ｃｅ基态则起源于νｈ９／２轨道．在这两个核中未观测到明显的八极形变带，然而，在１４７Ｃｅ中观测到的一个边带，可能显露出八极关联的迹象．

关键词：核结构集体带结构丰中子奇A核铈

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