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Advances in Alzheimer's Disease 2013年第1期2卷 1-6页

作者： jolanta Dorszewska jolanta florczak-wyspianska Anna Oczkowska Mateusz Dezor Michal Prendecki Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical SciencesPoznanPoland

Alzheimer’s disease (AD) is accompanied by elevated levels of homocysteine (Hcy). Homocysteine may induce elevated concentration of asymmetric dimethylarginine (ADMA). Both Hcy and ADMA are the amino acids thought to represent risk factors of vascular diseases. Studies were conducted on the plasma levels of Hcy and methionine (Met), estimated by HPLC with electrochemical detection, as well as on levels of ADMA and arginine (Arg), estimated by HPLC with fluorescent detection, in the AD patients with benign through to severe dementia estimated by MMSE scale and in a control group. The studies disclosed elevated levels of Hcy and ADMA in AD (Hcy, p < 0.001) as compared to controls, as well as in subjects older than 60 years of age (Hcy, p < 0.01). The AD patients with severe dementia have shown elevated levels of Hcy (p < 0.05) as compared to the patients with moderate dementia. The concentration of Metand Arg showed a downward trend in AD patientswith severe dementia. The highest levels of ADMA have been demonstrated in AD patients in the early stages of the disease. In parallel, in AD with varying degrees of dementia and subjects older than 60 years of age a disturbed turnover was observed of Hcy to Met and of Arg to ADMA. Similarly to Hcy, ADMA seems to be a potential risk factor of AD and important factor for progress of dementia.

关键词： Homocysteine ADMA Dementia Alzheimer’s Disease

Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease 2014年第1期3卷 24-32页

作者： jolanta Dorszewska Agata Rozycka Anna Oczkowska jolanta florczak-wyspianska Michal Prendecki Mateusz Dezor Izabela Postrach Pawel P.Jagodzinski Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Department of Biochemistry and Molecular Biology Poznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical Sciences10Fredry Str.61-701 PoznanPoland

Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.

关键词： TP53 8-oxo2dG p53 OGG1 AD

Acetic acid additive in NaNO_(3)aqueous electrolyte for long-lifespan Mg-air batteries

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Journal of Magnesium and Alloys 2024年第2期12卷 825-839页

作者： Yaqing Zhou Fan Sun Gunahua Lin Sandrine Zanna Antoine Seyeux Philippe Marcus jolanta´Swiatowska Chimie ParisTech-CNRS PSL UniversityInstitut de Recherche de Chimie Paris11 rue Pierre et Marie CurieParis 75005France

Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environmental sustainability,and ***,the fast hydrogen evolution reaction(HER)in NaCl-based aqueous electrolytes impairs the performance of Mg-air batteries and leads to poor specific capacity,low energy density,and low ***,the conventionally used NaCl solute was proposed to be replaced by NaNO_(3)and acetic acid additive as a corrosion inhibitor,therefore an electrolyte engineering for long-life time Mg-air batteries is *** resulting Mg-air batteries based on this optimized electrolyte demonstrate an improved discharge voltage reaching~1.8 V for initial 5 h at a current density of 0.5 mA/cm^(2) and significantly prolonged cells'operational lifetime to over 360 h,in contrast to only~17 h observed in NaCl electrolyte.X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry were employed to analyse the composition of surface film and scanning electron microscopy combined with transmission electron microscopy to clarify the morphology changes of the surface layer as a function of acetic acid *** thorough studies of chemical composition and morphology of corrosion products have allowed us to elucidate the working mechanism of Mg anode in this optimized electrolyte for Mg-air batteries.

关键词： Acetic acid additive in NaNO_(3)electrolyte Electrolyte engineering Corrosion surface film Surface characterization Hydrogen evolution

ON AN EQUATION CHARACTERIZING MULTI-CAUCHY-JENSEN MAPPINGS AND ITS HYERS-ULAM STABILITY

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Acta Mathematica Scientia 2015年第6期35卷 1349-1358页

作者： Anna BAHYRYCZ Krzysztof CIEPLINSKI jolanta OLKO Institute of Mathematics Pedagogical University AGH University of Science and Technology Faculty of Applied Mathematics

In this paper, we give two characterizations of multi-Cauchy-Jensen mappings. One of them reduces the system of n equations defining these mappings to a single functional equation. We also prove, using the fixed point... 详细信息

关键词： multi-Cauchy-Jensen mapping (generalized) Hyers-Ulam stability Cauchy'sfunctional equation Jensen's functional equation fixed point method

Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin

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World Journal of Gastroenterology 2014年第45期20卷 16902-16912页

作者： jolanta Jaworek Stanis?aw Jan Konturek Department of Medical Physiology Faculty of Health Sciences Jagiellonian University Collegium Medicum Chair of Physiology Medical Faculty Jagiellonian University Collegim Medicum

Acute pancreatitis is a nonbacterial disease of the *** severe form of this ailment is characterized by high *** acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense *** has been shown that the hormones ghrelin,leptin and melatonin are able to modulate the immune function of the organism and to protect the pancreas against inflammatory *** studies have demonstrated that the application of these substances prior to the induction of acute pancreatitis significantly attenuated the intensity of the inflammation and reduced pancreatic tissue *** pancreatic protective mechanisms of the above hormones have been related to the mobilization of non-specific immune defense,to the inhibition of nuclear factor kappa B and modulation of cytokine production,to the stimulation of heat shock proteins and changes of apoptotic processes in the acinar cells,as well as to the activation of antioxidant system of the pancreatic *** protective effect ofghrelin seems to be indirect and perhaps dependent on the release of growth hormone and insulin-like growth factor *** and ghrelin,but not melatonin,employ sensory nerves in their beneficial action on acute *** is very likely that ghrelin,leptin and melatonin could be implicated in the natural protection of the pancreatic gland against inflammatory damage because the blood levels of these substances increase in the initial phase of pancreatic *** above hormones could be a part of the innate resistance system which might remove noxious factors and could suppress or attenuate the inflammatory process in the pancreas.

关键词： Acute pancreatitis Protection Ghrelin Leptin Melatonin

Factors associated with intensification of antihypertensive drug therapy in patients with poorly controlled hypertension

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Journal of Geriatric Cardiology 2019年第1期16卷 19-26页

作者： Olga Siga Barbara Wizner Barbara Gryglewska jolanta Walczewska Tomasz Grodzicki Department of Internal Medicine and Gerontology Jagiellonian University Medical College

Objective To assess antihypertensive management of older patients with poor blood pressure(BP)*** Physicians,voluntary participating in the study,included six consecutive hypertensive patients during routine *** had to have been previously recognized and averaged office BP was>140 and/or>90 mmHg in spite of>6 weeks of antihypertensive *** physicians completed a questionnaire on patients'history of cardiovascular(CV)risk factors,comorbidities,home BP monitoring,anthropometric data and the *** Mean age of the 6462 patients was 61 years,7%were>80 years,51%were ***士SD office BP values were 158士13/92土10 *** most commonly prescribed antihypertensive drugs were:diuretics(67%),ACE inhibitors(64%),calcium channel blockers(58%)and卩-blockers(54%),and their use increased with *** monotherapy or dual therapy,43%of the patients and 40%had their latest treatment modification within six *** BP monitoring was a factor that accelerated the modification of the *** patients had to have less chance on faster modification of antihypertensive therapy in spite of presence of diabetes and higher systolic *** Our study suggests that a large number of outpatients with poor BP control receive suboptimal antihypertensive therapy,especially in primary *** older patients,higher BP values in the office settings are more frequently accepted by physicians even in case of higher CV *** home BP monitoring hastens the decision to intensify of antihypertensive treatment.

关键词： Antihypertensive therapy Comorbidities Modification of therapy Older patients Uncontrolled hypertension

Blood concentration of aminothiols in children with relapse of nephrotic syndrome

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世界儿科杂志:英文版 2016年第3期12卷 353-359页

作者： Marcin Tkaczyk Monika Miklaszewska jolanta Lukamowicz Wojciech Fendler Division of Nephrology Polish Mother's Memorial Hospital Research Institute of lodz281/289 Rzgowska st.93-338lodzPoland Department of Pediatric Nephrology Collegium Medicum of Jagiellonian UniversityWielicka 26530-663 KrakowPoland Center of Medical Diagnostics Polish Mother's Memorial Hospital Research Institute of lodzPoland281/289 Rzgowska st.93-338 lodzPoland Medical University of lodz al.Kosciuszki 4lodzPoland

Background:The role of idiopathic nephrotic syndrome(INS)in the pathogenesis of atherosclerosis in childhood has not been clearly ***,antioxidative defense in INS is thought to be *** study aimed to assess the changes of plasma concentration of selected aminothiols in the blood of children with INS at various stages of the ***:This cross-sectional study was conducted in 125 children aged 2-18 *** children were divided into 4 groups:group A,early relapse(n=37);group B,early remission for 4-6 weeks from the onset(n=37);group C,late steroid-free remission(n=31);and group D,long-term remission for 2-5 years(n=20).Control group(E)consisted of 30 age-and gender-matched healthy *** study protocol comprised an analysis of plasma concentrations of glutathione,homocysteine,cysteine and cysteinylglycine by high-performance liquid *** of protein-bound and free aminothiols were *** injury was assessed by thrombomodulin,PAI-1 concentration,and von Willebrand factor ***:The children with INS had unbalanced aminothiol metabolism only in relapse and early remission,that shifted towards increased oxidative *** of cyclosporine A caused a significant increase in homocysteine and cysteine *** in aminothiol metabolism were significantly related to endothelial ***:The fi ndings of this study may be helpful in elucidating the pathogenesis of premature atherosclerosis in patients with INS refractory to the treatment or in the case of frequent relapse.

关键词： aminothiols children cyclosporine A homocysteine nephrotic syndrome

Oxidative stress factors in Parkinson's disease

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Neural Regeneration Research 2021年第7期16卷 1383-1391页

作者： jolanta Dorszewska Marta Kowalska Michał Prendecki Thomas Piekut Joanna Kozłowska Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical SciencesPoznanPoland

Parkinson's disease(PD) is the second most common cause of *** the last two decades, various hypotheses have been proposed to explain the etiology of *** these is the oxidant-antioxidant theory, which asserts that local and systemic oxidative damage triggered by reactive oxygen species and other free radicals may promote dopaminergic neuron *** reactive oxygen species formation, one of the underlying causes of pathology in the course of PD has been evidenced by various studies showing that oxidized macromolecules including lipids, proteins, and nucleic acids accumulate in brain tissues of PD *** oxidation may produce various lesions in the course of *** incurred as a result of DNA oxidation may further enhance reactive oxygen species production in the brains of PD patients, exacerbating neuronal loss due to defects in the mitochondrial electron transport chain, antioxidant depletion, and exposure to toxic oxidized *** protein products of SNCA, PRKN, PINK1, DJ1, and LRRK2 genes are associated with disrupted oxidoreductive homeostasis in *** is the first gene linked with familial PD and is currently known to be affected by six mutations correlated with the disorder: A53T, A30P, E46K, G51D, H50Q and *** encodes Parkin, an E3 ubiquitin ligase which mediates the proteasome degradation of redundant and disordered proteins such as glycosylated α-*** 100 mutations have been found among the 12 exons of ***1, a mitochondrial kinase highly expressed in the brain, may undergo loss of function mutations which constitute approximately 1–8% of early onset PD *** than 50 PD-promoting mutations have been found in *** in DJ-1, a neuroprotective protein, are a rare cause of early onset PD and constitute only 1% of *** 20 mutations have been found in DJ1 among PD patients thus *** in the LRRK2 gene are the most common known cause of familial autosomal d

关键词： genetic factors molecular parameters oxidative stress Parkinson's disease pharmacotherapy surgical therapies

Legends of the dashboard: an empirical evaluation of split and joint layout designs for geovisual analytics interfaces

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International Journal of Digital Earth 2023年第1期16卷 1395-1417页

作者： Izabela Gołębiowska Tomasz Opach ArzuÇöltekin jolanta Korycka-Skorupa Jan Ketil Rød Faculty of Geography and Regional Studies University of WarsawWarsawPoland Department of Geography Norwegian University of Science and TechnologyTrondheimNorway Institute for Interactive Technologies University of Applied Sciences and Arts Northwestern SwitzerlandWindischSwitzerland

Geodashboards are often designed with explanatory elements guiding *** elements(*** or annotations)need to be carefully designed to mitigate split attention or information integration *** this paper,we report expert interviews followed by a controlled experiment where we compare two interface designs with a focus on the split attention effect:(1)a multiple-legend layout with explanatory elements located next to each view,and(2)a single-legend layout with all explanatory elements gathered in one *** legend layouts did not affect the performance,but affected user satisfaction.75%of the participants preferred the multiple-legend layout,and rated it with a higher usability score,mainly attributing this preference to the proximity of legend elements to the view of *** tracking data strongly and clearly verifies that participants indeed make use of the proximity:With the single-legend,the majority of eye-movement transitions were between the single-legend and the closest view to the legend,whereas with multiple-legend participants have shorter and more frequent legend visits,as well as more transitions between legends and *** together,the design lesson we learned from this experiment can be summarized as‘split the legend elements,but make it close to the explained elements’.

关键词： Geodashboard layout design legend split attention user study eye tracking

The Bioconversion of Municipal Solid Waste in the Biodrying Reactor

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Journal of Environmental & Earth Sciences 2019年第1期1卷 33-37页

作者： Maria Zgadlo Marlena Debicka jolanta Latosińska Kielce University of Technology Faculty of EnvironmentalGeomatic and Energy EngineeringDepartment of Waste Managemental.Tysiaclecia PP 725-314 KielcePoland

The bioconversion process of municipal solid waste was assessed on the basis of the results obtained from the biodrying reactor working at a full industrial *** bio-reactor is a part of mechanical-biological installation following mechanical *** bio-reactor was equipped with measuring devices allowing the analysis of the parameters like:temperature both inside the waste and also air above the waste and also the humidity of waste during the 14 days of the biodrying *** kinetics of bioconversion was assessed basing on measured the loss of ignition(LOI)parameter detected during the biodrying *** LOI value of the samples varied from 17.03%*** 30.34%*** on the location inside the *** estimated kinetic rate constant kT of the bioconversion of biomass in the industrial reactor was kT=*** analyzed case study the calorific value of product leaving the full-scale bio-reactor is too low to use this product as an alternative *** w'as stated the reason of this is too low a share of the carbon-rich fraction in the feedstock.

关键词： Biodrying of waste Mechanical-biological treatment(MBT) Kinetics of waste bioconversion