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原发性肺静脉狭窄

世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 25-26页

作者： Holt D.B. moller J.H. Larson S. johnson m.c. 杜媛 Division of Pediatric cardiology Washington University St. Louis MO United States Dr.

原发性肺静脉狭窄（PVS）是一种死亡率极高的罕见疾病。对其预后预测因素或合适的干预时间尚所知甚少。在儿童心脏护理协会数据库（n=98126）中搜索1982-2002年间因PVS或闭锁而行心导管治疗或外科手术的患者。排除具有完全或部分肺静脉... 详细信息

原发性肺静脉狭窄（PVS）是一种死亡率极高的罕见疾病。对其预后预测因素或合适的干预时间尚所知甚少。在儿童心脏护理协会数据库（n=98126）中搜索1982-2002年间因PVS或闭锁而行心导管治疗或外科手术的患者。排除具有完全或部分肺静脉回流异常、三房心、心房转位术史或肺移植史的患者。通过发送问卷至儿童心脏护理协会各机构来获取附加数据。总共31例患者被确认为原发性PVS。除外肺移植，31例中有16例接受干预以减轻PVS。

关键词：肺静脉狭窄原发性肺静脉回流异常心脏护理心导管治疗 PVS 罕见疾病预测因素

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乳房过早发育患者活化的GNAS1基因突变

世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 41-42页

作者： Román R. johnson m.c. codner E. F.cassorla 郭战宏 Inst.of maternal and child ResearchS.Borja Arriarán clin.Hosp. Sch.of Med.University of ChileSantiagoChile

目的:为了确认在有乳房发育过大和(或)至少持续1年的慢性波动性的乳房过早发育而无其他性早熟体征、骨骼发育异常或m.c.ne-Albright综合征典型皮肤损害的女童的GNAS1基因突变。研究设计:笔者对前述23位女孩的白细胞DNA,应用等位基因特... 详细信息

目的:为了确认在有乳房发育过大和(或)至少持续1年的慢性波动性的乳房过早发育而无其他性早熟体征、骨骼发育异常或m.c.ne-Albright综合征典型皮肤损害的女童的GNAS1基因突变。研究设计:笔者对前述23位女孩的白细胞DNA,应用等位基因特异性的聚合酶链反应和酶切技术研究了其GNAS1基因的突变。结果:14例女童有波动性乳房发育,9例女童为乳房发育过大。分子学研究表明6例女童在密码子201的精氨酸由组氨酸代替[R201H(+)]。3例R201H(+)女童在平均实足年龄为10.8岁时出现月经初潮,9例R201H (-)女童在平均年龄为11岁时出现月经初潮。结论:在一些有慢性波动性乳房过早发育和(或)乳房发育过大而无其他m.c.ne-Albright综合征典型体征的女童可观察到GNAS1基因的活化突变。

关键词：乳房过早发育 GNAS1 基因突变月经初潮等位基因特异性聚合酶链反应典型体波动性性早熟分子学

Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.johnson Robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(Ecm) interactions leading to assembly of integrin adhesion complexes(IAcs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and m.c. as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

Gouty destruction of a patellar tendon reconstruction and novel revision reconstruction technique: A case report

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World Journal of Orthopedics 2024年第7期15卷 675-682页

作者： carl c Edge Jonathan Widmeyer Omar Protzuk maya johnson Robert O’connell Department of Orthopaedic Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports medicine OrthowestCarroltonGA 30117United States

BAcKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in *** typically manifested as intraarticular crystals or tophi,gout can also cause pathology at *** deposition within tendinous structures put them at risk for traumatic and degenerative ***,allografts can also be at risk of rupture in the setting of severe *** present the case of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUmmARY A 56-year-old female presented to clinic after feeling her left knee pop and collapse beneath her while descending *** had a history of tophaceous gout and left patellar tendon rupture with reconstruction and multiple revisions over the course of 19 *** patient presented with pain and extensor lag.A magnetic resonance image demonstrated a ruptured patellar tendon allograft reconstruction and avulsion fracture at the tibial *** patient was treated with a novel intervention of Achilles allograft with bone block in a unique configuration with a dermal allograft incorporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to active flexion over the course of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal activities and *** Failed patellar tendon reconstruction due to gouty infiltration is treated with dermal allograft augmented Achilles tendon reconstruction with bone block.

关键词： Gout Patella Reconstruction Dermal allograft Revision case report

consumer transparency in the production chain for plant varieties produced using new genom.c.techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： J.m.Lukasiewicz c.c.m.van de Wiel L.A.P.Lotz m.J.m.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genom.c.techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European commission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a common theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genom.c.techniques consumer transparency Plant products

Use of ketamine for severe asthma exacerbation in a pregnant patient with persistent bronchospasm: A case report

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Emergency and critical care medicine 2024年第3期4卷 130-133页

作者： johnson m. Abbas m. Abdo J. mansour m. Jones J. Pharm.c. Department Beaumont Health Dearborn MI United States Emergency center Beaumont Health Dearborn MI United States

Background Estimated 4%-8% of pregnancies are complicated by asthma. Adequate management in this population is critical to minimize complications. Patients presenting with asthma exacerbation are typically managed with standard bronchodilators and system.c.corticosteroids. However, additional agents may be used in patients with refractory asthma exacerbation. Ketamine has been used in refractory bronchospasm, although its efficacy in published literature is heterogeneous. case Presentation We present a case of a pregnant patient with severe asthma exacerbation refractory to standard and salvage treatment who achieved termination of bronchospasm with ketamine infusion. conclusion After receiving ketamine infusion for several days, the patient had improved air flow and achieved successful extubation, without experiencing rebound bronchospasm. Although this individual clinical case alone cannot change guidelines or directives to use in refractory asthma exacerbations, it offers a possible treatment option to patients and providers in unusually severe cases with extenuating risk factors. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Asthma Bronchospasms case Report Ketamine Pregnancy

Iso-propyl caprylate and iso-propyl linolenate synthetic fluids as novel alternatives in deep-water drilling operations:critical fluid properties and aerobic biodegradability assessments

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Petroleum 2024年第2期10卷 254-264页

作者： Adewale johnson Folayan Adewale Dosunmu Aleruchi Boniface Oriji Department of Petroleum and Gas Engineering University of Port Harcourt University of Port Harcourt

Present drilling fluids for deep water wells have severe degenerative effect on the environment with high operational and disposal costs. Thus, making them less desirable in recent times. Ester synthetic drilling fluid provides a novel environmentally friendly alternative but conventional ester-based drilling fluids exhibit high viscosities in deep-water wells causing excessive equivalent circulating density(EcD) and increased risk of lost circulation owing to narrow mud density window. This study experimentally investigates the critical fluid properties and aerobic biodegradability potentials of two newly developed deep-water synthetic ester drilling fluids namely: iso-propyl caprylate(cOIPE) and iso-propyl linolenate(LOIPE) synthetic fluids and their comparison with synthetic-paraffin(SP-SBF) and isomerized-olefin(IOSBF) synthetic hydrocarbon fluids. The esters of iso-propyl caprylate and iso-propyl linolenate were produced from the isolation of ester mixtures that were obtained from the homogeneous catalytic transesterification of coconut and linseed plant oil biomass respectively. The cOIPE was isolated from the coconut oil iso-propyl ester mixture by low-pressure fractional distillation technique. While fractional distillation and crystallization were used to isolate the LOIPE ester from the linseed oil iso-propyl ester mixture. meanwhile, the aerobic biodegradation investigation was conducted by a modified oxygen consumption respirometry technique. The Gc-mS analysis of the cOIPE and LOIPE showed that the former contains essentially of lower saturated carbon compounds(c8). Whereas the latter contains higher molecular weight and unsaturated carbon compounds(c18+). The cOIPE and LOIPE kinematic viscosity values are in good agreement with that of the reference synthetic hydrocarbon fluid samples(SP-SBF and IO-SBF).Although, the cOIPE synthetic ester has lower viscosity value owing to the presence of shorter chain and saturated carbon atoms(c8 esters). Similarly,

关键词： Aerobic biodegradation critical fluid properties Deep-water wells Esters' isolation: isomerized-olefin (IO-SBF) Iso-propyl caprylate (cOIPE) Iso-propyl linolenate (LOIPE) Respirometry technique Synthetic-paraffin (SP-SBF)

Impact of cOVID-19-related lifestyle changes on diabetic m.c.lar edema

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 97-106页

作者： Bryce P.johnson Yu-Guang He Zachary m.Robertson Angeline Wang Rafael L.Ufret-Vincenty Department of Ophthalmology UT Southwestern Medical CenterDallasTexas 75390-9057USA

AIm:To assess diabetic m.c.lar edema(DmE)progression during the early phases of the cOVID-19 pandem.c.when severe societal restrictions raised the concern of possible deterioration of health in patients with system.c.conditions,particularly those requiring frequent office ***:This is a multicenter retrospective chart review of 370 patients(724 eyes)with an established diagnosis of DmE seen on 3 separate visits between January 2019 and July *** 1 was January 2019 to February 2020(considered pre-cOVID-19),period 2 was march 2020 to December 2020(considered the height of the pandem.c.highest level of pandem.c.related clinical and societal regulations)and period 3 was January 2021 to July 2021(re-adjustment to the new“pandem.c.norms”).main outcome measures included visual acuity,body mass index(BmI),blood pressure(BP),hemoglobin A1c(HbA1c),m.c.lar thickness,patient adherence to scheduled ophthalmology visits,and DmE treatment(s)received at each *** facilitate measurement of m.c.lar thickness,each m.c.la was divided into 9 Early Treatment Diabetic Retinopathy Study(ETDRS)-defined m.c.lar sectors as measured by OcT ***:There was no change of BmI,systolic BP,and diastolic BP between any of the time ***1c showed a very small increase from period 1(7.6%)to period 2(7.8%,P=0.015)and decreased back to 7.6%at period 3(P=0.12).m.c.lar thickness decreased for 100%of m.c.lar *** central m.c.lar thickness decreased across all 3 periods from 329.5 to 316.6μm(P=0.0045).After analysis of multiple variables including HbA1c,BmI,adherence to scheduled appointments,different clinic centers,and treatment interventions,there was no easily identifiable subgroup of patients that experienced the increase in ***:DmE doesn’t worsen during the cOVID-19 pandem.c.instead sustaining a very small but statistically significant *** identifying a m.c.anism behind our findings is beyond the scope of this study,potential explanat

关键词： cOVID-19 diabetic m.c.lar edema diabetic retinopathy optical coherence tomography

Performance of evolutionary optimized m.c.ine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.m.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied m.c.anics Federal University of Juiz de Fora Department of computational modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. m.c.ine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using m.c.ine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve m.c.ine learning models to predict TOc. The six metaheuristics were integrated into four m.c.ine learning methods: extreme learning m.c.ine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining m.c.ine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning m.c.ines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated m.c.ine learning Evolutionary algorithms Geology