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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. j., Xiao Teboul, Lydia Wong, Michael D. White, j.cqueline K. Meehan, Terrence F. Weninger, Wolfgang j. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, j.mes M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, j.mes Daly, Mark j. Denegre, j.mes M. Doe, Brendan Dolan, Mary E. Edie, sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, j.an Guo, Shiying Horner, Neil R. Hsu, Chih-Wei johnson, sara j. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, j.remy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. j. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas j. Ryder, Edward Samocha, Kaitlin E. Seavitt, j.hn R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, j.nathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. j.stice, Monica j. Parkinson, Helen E. Moore, Mark Wells, sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David j. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maj. Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada j.ckson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanj.ng Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Sodium lanthanide fluoride core-shell nanocrystals： A general perspective on epitaxial shell growth

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Nano Research 2013年第8期6卷 547-561页

作者： Noah j. j. johnson Frank C. j. M. van Veggel Department of Chemistry University ofVictoria P.O. Box3065 Victoria British Columbia Canada V8W 3V6

Understanding the structural characteristics and growth mechanism（s） are essen-tial for generating core-shell nano-heterostructures with distinctive properties. Especially in lanthanide-based nanocrystals, rational design of the core-shell composition can be utilized to enhance/tune the optical properties of the final nanostructure, or can be used to integrate multiple functional applications （e.g., luminescent/magnetic）. In this article, we review the progress in our current understanding of the epitaxial shell growth in sodium lanthanide fluoride （NaLnF4） nanocrystals. In order to understand epitaxial shell growth the core nanocrystals have to be uniform, and to date the synthesis of high quality near uniform size/shape dispersion controlled synthesis of lanthanide-based nanocrystals has been achieved mainly with this class of nanocrystals. The progress in core-shell synthesis and the epitaxial shell growth mechanism in this class of nanocrystals （NaLnF4） are reviewed, and a general perspective is provided on the core-shell morphology based on different characterization techniques. While there has been tremendous progress in studying the impact of core-shell structures in various functional applications, this review also highlights, in our view, the still limited understanding of ways to control the core-shell morphology and it emphasizes some important, unanswered questions that remain to be addressed to maximize their performance.

关键词： upconvertingnanocrystals core-shell lanthanides epitaxy

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Pressure-dependent phase transition of 2D layered silicon telluride(Si2le3)and manganese intercalated silicon telluride

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Nano Research 2019年第9期12卷 2373-2377页

作者： Virginia L. johnson Auddy Anilao Kristie j. Koski Department of Chemistry University of CaliforniaDavisDavisCA 95616USA

Two-dimensional(2D)layered silicon telluride(SizTes)nanocrystals were compressed to 12 GPa using diamond anvil cell *** measurements show a color change from transparent red to opaque black indicating a semiconductor-to-metal phase *** scattering was used to observe the stiffening of the crystal lattice and subsequent phase behavior.A possible phase transition was *** 9.5±0.5 GPa evidenced by the disappearance of the Atg stretching *** was intercalated with elemental manganese to^1 at.%.Intercalation lowers the pressure of the proposed phase transition to 7.5±1 *** modes show both phonon stiffening and phonon softening,suggesting negative linear *** results provide fundamental insight into the high-pressure optical phonon behavior of silicon telluride and illuminate how a specific electron-donating intercalant can chemically alter pressure-dependent optical phonon behavior.

关键词： silicon telluride Si2Te3 high pressure diamond anvil cell two-dimensional(2D)layered material

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Effect of Laser Inj.ction Seeder on Rotationally Resolved Spectra of Benzonitrile

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Chinese Physics Letters 2010年第8期27卷 77-79页

作者：徐海峰 johnson Philip M. SEARS Trevor j. Institute of Atomic and Molecular Physics 3ilin University~ Changchun 130012 Chemistry Department Stony Brook University Stony Brook NY 11974 USA Department of Chemistry Brookhaven National Laboratory Upton NY 11973 USA

High resolution lasers are necessary to derive the most information from molecular spectra. However, their use uncovers some photophysical processes that compromise the ability to resolve rotational structure. We study the influence of laser optical mode structure on the high resolution spectra of the S1 states of benzonitrile in a supersonic molecular beam using an Ar^＋ pumped cw ring dye laser which is amplified by a pulsed Nd： YA G laser. The latter could be operated either in one optical mode by inj.cting （seeding） its oscillator with a single mode diode laser, or with many optical modes by not using the seeder. Rotationally resolved lines are obtained when the oscillator of the YAG laser are operated in one single optical mode, but only a continuum is seen when the YAG laser has multiple modes. It is argued that the ac Stark effect is the most probable reason for broadening and blurring the rotational lines.

关键词： OPTICAL detectors INj.CTION lasers NITRILES MOLECULAR spectra MOLECULAR beams ND-YAG lasers STARK effect

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Comparative Transcriptomic Profiling of Vitis vinifera Under High Light Using a Custom-Made Array and the Affymetrix GeneChip

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Molecular Plant 2011年第6期4卷 1038-1051页

作者： Luisa C. Carvalho Belmiro j. Vilela Phil M. Mullineaux sara Amancio CBAA Instituto Superior de Agronomia Universidade Tecnica de Lisboa Tapada da Ajuda 1349-017 Lisboa Portugal DDSB John Innes Centre Colney Norwich NR4 7UH UK Department of Biological Sciences University of Essex Colchester CO4 3SQ UK

Understanding abiotic stress responses is one of the most important issues in plant research nowadays. Abiotic stress, including excess light, can promote the onset of oxidative stress through the accumulation of reactive oxygen species. Oxidative stress also arises when in vitro propagated plants are exposed to high light upon transfer to ex vitro. To determine whether the underlying pathways activated at the transfer of in vitro grapevine to ex vitro conditions reflect the processes occurring upon light stress, we used Vitis vinifera Affymetrix GeneChip （VvGA） and a custom array of genes responsive to light stress （LSCA） detected by real-time reverse transcriptase PCR （qRT-PCR）. When gene-expression profiles were compared, ＇protein metabolism and modification＇, ＇signaling＇, and ＇anti-oxidative＂ genes were more represented in LSCA, while, in VvGA, ＇cell wall metabolism＇ and ＇secondary metabolism＇ were the categories in which gene expression varied more significantly. The above functional categories confirm previous studies involving other types of abiotic stresses, enhancing the common attributes of abiotic stress defense pathways. The LSCA analysis of our experimental system detected strong response of heat shock genes, particularly the protein rescuing mechanism involving the cooperation of two ATP-dependent chaperone systems, Hsp100 and Hsp70, which showed an unusually late response during the recovery period, of extreme relevance to remove non-functional, potentially harmful polypeptides arising from misfolding, denaturation, or aggregation brought about by stress. The success of LSCA also proves the feasibility of a custommade qRT-PCR approach, particularly for species for which no GeneChip is available and for researchers dealing with a specific and focused problem.

关键词： Quantitative real-time PCR Vitis vinifera GeneChip light stress Heat Shock Proteins oxidative and photooxidative stress.

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The nature of the companion of PSR j.719-1438: a white dwarf or an exotic obj.ct?

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Research in Astronomy and Astrophysics 2012年第7期12卷 813-816页

作者： j. E. Horvath Instituto de Astronomia Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We raise the possibility that the very dense, compact companion of PSR j.719-1438, which has a j.piter-like mass, is an exotic quark obj.ct rather than a light helium or carbon white dwarf. The exotic hypothesis naturally explains some of the observed features, and provides quite strong predictions for this system, to be confirmed or refuted in feasible future studies.

关键词： binary pulsars -- exotic matter-- pulsars: individual (PSR j.719-1438)

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Advanced imaging in surveillance of Barrett’s esophagus: Is the j.ice worth the squeeze?

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World j.urnal of Gastroenterology 2019年第25期25卷 3108-3115页

作者： sara A Cerrone Arvind j.Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health System

Esophageal cancer is on the *** known precursor lesion is Barrett’s esophagus(BE).Patients with dysplasia are at higher risk of developing esophageal *** the gold standard for surveillance endoscopy involves taking targeted biopsies of abnormal areas as well as random biopsies every 1-2 cm of the length of the Barrett’*** studies have shown that this surveillance can miss dysplasia and *** imaging technologies have been developed that may help detect dysplasia in *** opinion review discusses advanced imaging in BE surveillance endoscopy and its utility in clinical practice.

关键词： Barrett’s esophagus Advanced imaging Chromoendoscopy Endomicroscopy

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Individual variation in ballooning dispersal by black widow spiderlings： The effects of family and social rearing

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Current Zoology 2015年第3期61卷 520-528页

作者： j. Chadwick johnson Rebecca HALPIN Dale STEVENS II Annika VANNAN j.sse LAM Katie BRATSCH School of Mathematical and Natural Sciences (2352) Arizona State University at the West Campus Glendale AZ 85306 USA

Individual behavioral variation is ubiquitous across taxa and important to understand if we wish to fully use beha- vioral data to understand the ecology and evolution of organisms. Only recently have studies of individual variation in dispersal behavior become a focus of research. A better understanding of individual variation in dispersal behavior is likely to improve our understanding of population dynamics. In particular, the dynamics of critically small populations （endangered species） and large populations （pest species） may be driven by unique dispersal variants. Here we documented individual variation in the ballooning dispersal behavior of Western black widow spiderlings Latrodectus hesperus, an urban pest species found in superabundant in- festations throughout cities of the desert Southwest USA. We found a great deal of family-level variation in ballooning dispersal, and this variation was highly consistent （repeatable） across time. Maternal egg investment was a poor predictor of this ballooning dispersal. Instead, we show that spiderlings reared in isolation are significantly slower to disperse than spiderlings raised in a more natural setting surrounded by full siblings. Thus, our study examines a widespread but poorly understood dispersal behavior （ballooning）, and suggests urban pest population dynamics are likely driven by the interaction of variation in individuals, families and social environments

关键词： Individual variation Dispersal Spiders Ballooning Social rearing

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA j.mes L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain inj.ry(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Quantifying relations between altered hydrology and fish community responses for streams in Minnesota

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Ecological Processes 2022年第1期11卷 536-560页

作者： j.ffrey R.Ziegeweid Gregory D.johnson Aliesha L.Krall Kara Fitzpatrick sara B.Levin U.S.Geological Survey California Water Science Center6000 J StPlacer HallSacramentoCA 85819USA U.S.Geological Survey Upper Midwest Water Science Center2280 Woodale DrMounds ViewMN 55112USA Minnesota Pollution Control Agency 520 Lafayette RdSt.PaulMN 55155USA Minnesota Pollution Control Agency 7678 College RoadSuite 105BaxterMN 56425USA

Background:Altered hydrology is a stressor on aquatic life,but quantitative relations between specific aspects of streamflow alteration and biological responses have not been developed on a statewide scale in *** sub-sets regression analysis was used to develop linear regression models that quantify relations among five categories of hydrologic metrics(i.e.,duration,frequency,magnitude,rate-of-change,and timing)computed from streamgage records and six categories of biological metrics(i.e.,composition,habitat,life history,reproductive,tolerance,trophic)computed from fish-community samples,as well as fish-based indices of biotic integrity(FIBI)scores and FIBI scores normalized to an impairment threshold of the corresponding stream class(FIBI_BCG4).Relations between hydrology and fish community responses were examined using three hydrologic datasets that represented periods of record,long-term changes,and short-term changes to flow regimes in streams of ***:Regression models demonstrated significant relations between hydrologic explanatory metrics and fish-based biological response metrics,and the five regression models with the strongest linear relations explained over 70%of the variability in the biological metric using three hydrologic metrics as explanatory ***-based biological metrics demonstrated the strongest linear relations to hydrologic *** most commonly used hydrologic metrics were related to bankfull flows and aspects of flow ***:Final regression models represent paired streamgage records and biological samples throughout the State of Minnesota and encompass differences in stream orders,hydrologic landscape units,and watershed *** methods can support evaluations of stream fish communities and facilitate targeted efforts to improve the health of fish *** also can be applied to locations outside of Minnesota with continuous streamgage data and fish-community sampl

关键词： EflowStats Best subset regression Altered hydrology Fish community Indices of biotic integrity Ecological flows

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