检索结果-南通市图书馆

World Journal of Gastroenterology 2014年第11期20卷 2971-2978页

作者： john M taylor Fox Chase Cancer Center PhiladelphiaPA 19111United States

Recent reports show that many cellular RNAs are processed to form circular species that are relatively abundant and resistant to host *** some cases,such circles actually bind host *** depletion of available microRNAs appears to have biological roles;for instance,in homeostasis and *** findings regarding host RNA circles support a speculative reappraisal of the origin and mode of replication of hepatitis delta virus,hepatitis delta virus(HDV),an agent with a small circular RNA genome;specifically,it is proposed that in hepatocytes infected with hepatitis B virus(HBV),some viral RNA species are processed to circular forms,which by a series of chance events lead to an RNA that can be both replicated by host enzymes and assembled,using HBV envelope proteins,to form particles some of which are *** a model also may provide some new insights into the potential pathogenic potential of HDV *** return,new insights into HDV might provide information leading to a better understanding of the roles of the host RNA circles.

关键词： Hepatitis B virus Hepatitis delta virus Circular RNA Ribozymes MicroRNA

Wrapping up the role of pericytes in Parkinson's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2395-2396页

作者： taylor john Stevenson Birger Victor Dieriks Department of Pharmacology University of AucklandAucklandNew Zealand Centre for Brain Research University of AucklandAucklandNew Zealand Department of Anatomy and Medical Imaging University of AucklandAucklandNew Zealand

Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.

关键词： homeostasis pericyte

Simulation and animation model to boost mining efficiency and enviro-friendly in multi-pit operations

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2015年第4期25卷 671-674页

作者： Tarshizi Ebrahim Sturgul john Ibarra Virginia taylor Danny Mining & Metallurgical Engineering Department University of Nevada Reno School of Civil Environmental and Mining Engineering University of Adelaide

A discrete-event system simulation and animation program was developed to enhance the efficiency of a truck-excavator operation and reduce the environmental impact of haulage in an open-cut coal mine with multiple-pit operations. In any mine, a key objective is to have sufficient equipment for production and not to have excess to where it becomes counterproductive. Due to the advent of responsible mining,environmental regulations, and eco-friendly practices, these factors must also be considered in the analysis. Simulation studies can be financially advantageous for both the optimization of existing mine operations and new development phases in a mine. This study is a new approach to use discrete-event system simulation for mine systems, in order to investigate and possibly reduce environmental impact considering mining haulage performance and production target. A hypothetical layout of a surface coal mine with two pit operations was used for the simulation and animation model. The simulation model includes the animation of the operation. Animation is helpful to enhance the benefit of a mine simulation model. GPSS/Hòand Proof Professionalòwere the software used for the investigation.

关键词： Simulation and animation Multiple-pit mining Equipment efficiency Truck-excavator allocation Environmental impact WEB-based simulation

Cognitive Linguistics and the Teaching of Grammar

在线全文

学校读者我要写书评

暂无评论

四川外语学院学报 2005年第5期21卷 10-17页

作者： john R. taylor University of Otago New Zealand

This article introduces some of the main themes in CL, with special focus on the role of constructions and idioms, and the way in which constructions and idioms are motivated. It is argued that a language can, in fact, be regarded as a very large set of idioms and constructions. This view contrasts with the more traditional view, that a language can be analyzed as a dictionary and a grammar . Some conclusions are drawn for foreign language pedagogy, and for the design of learning aids for language students.

关键词：语法教学高等教育英语教学认知语言学

Decomposing the drivers of residential space cooling energy consumption in EU-28 countries using a panel data approach

在线全文

学校读者我要写书评

暂无评论

能源与人工环境(英文) 2020年第4期1卷 432-442页

作者： Andreas Andreou john Barrett Peter G.taylor Paul E.Brockway Zia Wadud Sustainability Research Institute School of Earth and EnvironmentUniversity of LeedsLeedsLS29JTUK Low Carbon Energy Research Group School of Chemical and Process EngineeringUniversity of LeedsLeedsLS29JTUK Spatial Modelling and Dynamics Research Group Institute for Transport StudiesUniversity of LeedsLeedsLS29JTUK

While space cooling currently represents less than 1%of final energy use in the residential sector of the Euro-pean Union(EU-28),it was the fastest growing end-use during the 2000-15 period with a mean annual growth rate of 6%per ***,little is known about factors which have driven regional air-conditioning(AC)energy consumption over time,since the literature is limited to cross-sectional studies that lack differentiation between climatic and non-climatic *** projections for the EU’s electricity sector may therefore neglect the potential implications of rapidly growing AC *** develop a novel decomposition framework,which breaks down residential space cooling energy consumption in EU-28 countries into the effect of different components from 2000 to *** is extended to panel data models identifying specific drivers of space cooling’s climate-sensitive ***,we explore scenarios of residential AC energy consumption up to 2050 and evaluate their impact on summer time peak *** diffusion was found to be the key driver of space cooling energy consumption,but this effect was partly counterbalanced by efficiency *** weather influences AC equipment ownership rate in EU-28 households,personal income has a larger marginal *** baseline scenarios,AC diffusion saturates by 2050,while modestly increasing sectoral final energy ***,our range of scenario values for space cooling energy consumption in 2050 exceed the majority of those originat-ing from recently published *** a future renewables-driven electricity system,energy security risks may emerge from a scenario of fast AC up-take in new and renovated buildings,especially for colder European countries where modelled peak cooling electricity demand is shown to outgrow the projected expansion of solar *** findings have important implications for the EU’s strategy to decarbonise energy supply.

关键词： Space cooling AC diffusion Decomposition analysis Panel data model Peak demand

Understanding and managing sanitary risks due to rodent zoonoses in an African city: beyond the Boston Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2008年第1期3卷 38-50页

作者： Peter J.taylor Lorraine ARNTZEN Mel HAYTER Malcolm ILES john FREAN Steven BELMAIN Durban Natural Science Museum eThekwini Libraries and Heritage DepartmentDurbanSouth Africa National Institute for Communicable Diseases National Health Laboratory ServiceSandringhamSouth Africa City Health:Communicable Diseases eThekwini MunicipalityDurbanSouth Africa Natural Resources Institute Chatham MaritimeKentUK

The Boston Model describes a successful rodent management plan that succeeded in a first-world city in the *** third-world cities, which often contain informal shack settlements, it is debatable whether the Boston Modelwould apply. In Durban, a major harbor city of three million people on the east coast of South Africa, we investigatedthe sanitary risks due to rodents in both formal (residential and commercial) and informal (shacks) sectors,and we evaluated the relative merits of different management interventions suggested by the Boston Model. Bloodand tissue samples of six species (Rattus norvegicus, R. tanezumi, R. rattus, Mus musculus, Mastomys natalensis,Tatera brantsi) from 262 live-trapped rodents from 54 localities were tested for antibodies or DNA for plague (n =193: antibody test), leptospirosis (n = 221 for antibody test;n = 69 for polymerase chain reaction test for DNA) andtoxoplasmosis (n = 217: antibody test). We conducted a socioeconomic survey of 90 household to determine environmentaland socioeconomic disease risk factors in the shack settlement of Cato Crest . No rodents wereseropositive for plague, but nine Norway rats, R. norvegicus (4.1% of the sample tested) were seropositive fortoxoplasmosis, and 22 R. norvegicus (10.0% of sample tested) were seropositive for leptospirosis. Disease endemicareas were concentrated in Cato Crest and the commercial district of Durban. Serology tests of humans living inCato Crest (n = 219) showed 0% exposure to plague, 23% to leptospirosis and 35% to toxoplasmosis. Comparedwith shack-dwellers, the residents of brick houses had slightly lower levels of exposure to leptospirosis andtoxoplasmosis. Based on our results, environmental hygiene and rodent-trapping campaigns were launched in CatoCrest. The initiative owes much of its current success to implementation of the principles inherent in the BostonModel, even though certain elements were lacking.

关键词： Durban leptospirosis plague rodent zoonoses toxoplasmosis.

Some Dynamic and Combinatorial Properties of One Parameter Families of Unimodal Maps with Monotonicity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mathematics and System Science 2013年第6期3卷 301-308页

作者： john taylor Department of Mathematics and Natural Sciences American University of Ras al Khaimah 999041 UAE

It is known that certain one parameter families of unimodal maps of the interval have a topological universality with regard to their dynamic behavior [ 1, 2]. As a parameter is smoothly increased, a fascinating variety of dynamic behaviors are produced. For some families the behaviors are monotonic in the parameter, while in others they are not [3]. The question is what sort of conditions on a one parameter family will ensure this monotonicity of the behavior with the parameter？ The answer is unknown and will not be given here. What we do instead is to investigate certain geometric-dynamic-combinatorial consequences of assuming that the family has this monotonicity. Specifically, using tools of symbolic dynamics, state space is ＂course grained＂ with a finite alphabet. We decompose a non-invertible map into nonlinear but invertible pieces. From these invertible pieces, we form inverse maps via composition along words. Equations of motion are developed for both forward and inverse orbits （in both the variables of state space and the parameter）, and an equation relating forward and inverse motions at fix-points is exhibited. Finally, we deduce a list of conditions, each of which is equivalent to monotone behavior. One of these conditions states that simple parity characteristics of words correspond to definite dynamics near fixed-points and vice versa.

关键词： One parameter family unimodal map kneading theory connection equation.

Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2021年第1期4卷 69-84页

作者： Ganeshkumar Rajendran john A.taylor III Benjamin L.Woolbright Department of Urology University of Kansas Medical CenterKansas CityKS 66160USA

Cisplatin remains an integral part of the treatment for muscle invasive bladder cancer.A large number of patients do not respond to cisplatin-based chemotherapy and efficacious salvage regimens are *** has offered a second line of treatment;however,only approximately 20% of patients respond,and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to *** such,restoring sensitivity to cisplatin remains a major hurdle to improving patient *** potential source of compounds for enhancing cisplatin is naturally derived bioactive products such as phytochemicals,flavonoids and *** compounds can activate a diverse array of different pathways,many of which can directly promote or inhibit cisplatin *** purpose of this review is to understand current drug development in the area of natural products and to assess how these compounds may enhance cisplatin treatment in bladder cancer patients.

关键词： Cisplatin bladder cancer natural products apoptosis

Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2019年第2期35卷 295-300页

作者： Daniel Erskine john-Paul taylor Alan Thomas Daniel Collerton Ian McKeith Ahmad Khundakar Johannes Attems Christopher Morris Institute of Neuroscience Newcastle University Northumberland Tyne and Wear NHS Trust School of Science Engineering and Design Teesside University

Introduction Recurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies(DLB)and are typically well-formed,often consisting of figures,such as people or animals(1)Despite the profound impact upon patients and caregivers in DLB,the aetiopathology of visual hallucinations remains largely *** this article we discuss the anatomy of the human visual system,hypotheses of the genesis of visual hallucinations in DLB,and imaging and neuropathological studies that have attempted to understand visual hallucinations on a functional and anatomical basis.

关键词： Pathological Visual System Lewy Bodies