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Cognitive Linguistics and the Teaching of Grammar

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四川外语学院学报 2005年第5期21卷 10-17页

作者： john R. taylor University of Otago New Zealand

This article introduces some of the main themes in CL, with special focus on the role of constructions and idioms, and the way in which constructions and idioms are motivated. It is argued that a language can, in fact, be regarded as a very large set of idioms and constructions. This view contrasts with the more traditional view, that a language can be analyzed as a dictionary and a grammar . Some conclusions are drawn for foreign language pedagogy, and for the design of learning aids for language students.

关键词：语法教学高等教育英语教学认知语言学

Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies

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Neuroscience Bulletin 2019年第2期35卷 295-300页

作者： Daniel Erskine john-Paul taylor Alan Thomas Daniel Collerton Ian McKeith Ahmad Khundakar Johannes Attems Christopher Morris Institute of Neuroscience Newcastle University Northumberland Tyne and Wear NHS Trust School of Science Engineering and Design Teesside University

Introduction Recurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies(DLB)and are typically well-formed,often consisting of figures,such as people or animals(1)Despite the profound impact upon patients and caregivers in DLB,the aetiopathology of visual hallucinations remains largely *** this article we discuss the anatomy of the human visual system,hypotheses of the genesis of visual hallucinations in DLB,and imaging and neuropathological studies that have attempted to understand visual hallucinations on a functional and anatomical basis.

关键词： Pathological Visual System Lewy Bodies

Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer

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Cancer Drug Resistance 2021年第1期4卷 69-84页

作者： Ganeshkumar Rajendran john A.taylor III Benjamin L.Woolbright Department of Urology University of Kansas Medical CenterKansas CityKS 66160USA

Cisplatin remains an integral part of the treatment for muscle invasive bladder cancer.A large number of patients do not respond to cisplatin-based chemotherapy and efficacious salvage regimens are *** has offered a second line of treatment;however,only approximately 20% of patients respond,and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to *** such,restoring sensitivity to cisplatin remains a major hurdle to improving patient *** potential source of compounds for enhancing cisplatin is naturally derived bioactive products such as phytochemicals,flavonoids and *** compounds can activate a diverse array of different pathways,many of which can directly promote or inhibit cisplatin *** purpose of this review is to understand current drug development in the area of natural products and to assess how these compounds may enhance cisplatin treatment in bladder cancer patients.

关键词： Cisplatin bladder cancer natural products apoptosis

Virus entry mediated by hepatitis B virus envelope proteins

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World Journal of Gastroenterology 2013年第40期19卷 6730-6734页

作者： john M taylor Fox Chase Cancer Center PhiladelphiaPA19111United States

Hepatitis B virus(HBV),a major cause of human liver disease worldwide,encodes three envelope proteins needed for the attachment and entry of the virus into susceptible host cells.A second virus,hepatitis delta virus,which is known to enhance liver disease in HBV infected patients,diverts the same HBV envelope proteins to achieve its own assembly and *** the lab,lentiviral vectors based on human immunodeficiency virus type 1 can be assembled using the HBV envelope proteins,and will similarly infect susceptible *** article provides a partial review and some personal reflections of how these three viruses infect and of how recipient cells become susceptible,along with some consideration of questions that remain to be answered.

关键词： Hepatitis B virus Hepatitis delta virus Receptor Envelope proteins Entry

Host RNA circles and the origin of hepatitis delta virus

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World Journal of Gastroenterology 2014年第11期20卷 2971-2978页

作者： john M taylor Fox Chase Cancer Center PhiladelphiaPA 19111United States

Recent reports show that many cellular RNAs are processed to form circular species that are relatively abundant and resistant to host *** some cases,such circles actually bind host *** depletion of available microRNAs appears to have biological roles;for instance,in homeostasis and *** findings regarding host RNA circles support a speculative reappraisal of the origin and mode of replication of hepatitis delta virus,hepatitis delta virus(HDV),an agent with a small circular RNA genome;specifically,it is proposed that in hepatocytes infected with hepatitis B virus(HBV),some viral RNA species are processed to circular forms,which by a series of chance events lead to an RNA that can be both replicated by host enzymes and assembled,using HBV envelope proteins,to form particles some of which are *** a model also may provide some new insights into the potential pathogenic potential of HDV *** return,new insights into HDV might provide information leading to a better understanding of the roles of the host RNA circles.

关键词： Hepatitis B virus Hepatitis delta virus Circular R

Mycobacterium avium subspecies paratuberculosis in the causation of Crohn's disease

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World Journal of Gastroenterology 2000年第5期6卷 630-632页

作者： john Hermon-taylor Department of Surgery St.George's Hospital Medical SchoolLondon SW17 OREU.K.

Mycobacterium avium subspecies paratuberculosis(MAP),originally called johne’s bacillus was firstdescribed from Germany in 1895 as the cause of achronic inflammatory disease of the intestine in *** the 20th century progressed,clinical andsub-clinical MAP infection in farm animals inWestern Europe appeared to become *** the early reviews available

关键词： mycobacterium avium paratuberculosis Crohn’s disease immunologic tests immunocompetence mycobacterium avium subspecies paratuberculosis

Al_3Zr和Al_3Nb作为铝合金晶粒细化剂的晶体学研究(英文)

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2034-2040页

作者：汪锋邱冬刘峙麟 john taylor Mark EASTON 张明星 School of Mechanical and Mining Engineering The University of Queensland School of Physics and Materials Engineering Monash University

利用edge-to-edge matching模型从晶体学角度研究Al3Zr和Al3Nb两种金属间化合物作为铝合金晶粒细化剂的有效性。结果表明,Al3Zr和Al3Nb两种金属间化合物和铝之间的原子间距错配和面间距错配值都很小。此外,模型预测Al3Zr和Al3Nb两种金... 详细信息

利用edge-to-edge matching模型从晶体学角度研究Al3Zr和Al3Nb两种金属间化合物作为铝合金晶粒细化剂的有效性。结果表明,Al3Zr和Al3Nb两种金属间化合物和铝之间的原子间距错配和面间距错配值都很小。此外,模型预测Al3Zr和Al3Nb两种金属间化合物与铝之间存在良好的晶粒取向关系。根据模型理论可以从晶体学角度证明这两种金属间化合物对铝合金是有效的晶粒异质形核细化剂。本晶体学研究为包晶铝合金Al-Zr和Al-Nb中出现的明显晶粒细化现象提供了合理解释,同时为理解晶粒细化机理提供了新方法。

关键词：铝合金 Al3Zr Al3Nb 晶粒细化包晶晶体学 E2EM模型

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《心智语库--心智如何表征语言》介绍

当代语言学 2014年第2期16卷 240-242页

作者： john taylor 王天翼不详四川外国语学院国际关系学院重庆沙坪坝400031

john taylor的《心智语库：心智如何表征语言》（The Mental Corpus ： How the Mind Represents Language）一书2012年由牛津大学出版社出版，下面介绍本书主要内容。

关键词：心智语言表征牛津大学出版社 Mind How the

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 514-531页

作者： Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve john-Paul taylor Ian McKeith Dag Aarsland Simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer’s or Parkinson’s disease. These may not be sufficiently valid or sensitive to treatment changes in DLB, decreasing their utility. In this review, we discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific objective measures. We emphasize that the existing outcome measures require validation in the DLB population and that DLB-specific outcomes need to be developed. Finally, we highlight how the selection of outcome measures may vary between symptomatic and disease-modifying therapy trials.

关键词： Dementia with Lewy bodies Clinical trials Outcomes Measurement properties