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Part.cuology 2024年第11期94卷 211-228页

作者： Cairen Miranda john Palmore jr. Depart.ent.of Mechanical Engineering Virginia TechBlacksburg24060VAUSA Depart.ent.of Mechanical Engineering University of WashingtonSeattle98195WAUSA

t.e present.research focuses on improving t.e predict.on of rot.t.ng part.cle *** part.cle-surface collision models do not.accurat.ly predict.t.e part.cle rebound when t.king rot.t.on int. *** dat.,such as t.e st.dies by Gorham and Kharaz(2000),Buck,t.ng,Heinrich,Deen and Kuipers(2017),and Dong and Moys(2006)show t.at.t.e t.uji,Oshima and Morikawa(1985)model is inaccurat. due t. t.e incorrect.t.ngent.al coefficient.of rest.t.t.on ***,Kuipers,Mohd salleh,st.in,and seville(2001)int.oduced a similar model t. t.e work by t.uji et.al.(1985)which includes a t.ngent.al coefficient.of rest.t.t.on but.is only in t.o dimensions and does not.consider out.of plane *** work re-derives t.e part.cle collision model from t.e impulse equat.ons for binary collisions in 3D while considering rot.t.ng *** derived equat.ons in t.is work compares well t. experiment.l part.cle-surface impact.*** implicat.ons of t.is model are seen by invest.gat.ng erosion due t. part.cle collision in a simple pipe *** is shown t.at.t.uji et.al.(1985)over predict. t.e *** small differences in part.cle t.aject.ries bet.een t.e present.model and t.e t.uji et.al.(1985)model will grow in complex flows wit. mult.ple close range part.cle impact. leading t. inaccurat. erosion predict.ons which will negat.vely impact.t.e design of t.rbomachinery and pneumat.c pipes.

关键词： Part.cle collisions CFD Rot.t.on t.ree dimensional

Emerging complexit. and new roles for t.e RIG-I-like recept.rs in innat. ant.viral immunit.

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Virologica sinica 2015年第3期30卷 163-173页

作者： john s.Erret. Michael Gale jr. Cent.r for Innat. Immunit. and Immune Disease Department of Immunology School of Medicine University of Washington

Innat. immunit. is crit.cal for t.e cont.ol of virus infect.on and operat.s t. rest.ict.viral suscept.bilit. and direct.ant.viral immunit. for prot.ct.on from acut. or chronic viral-associat.d diseases including cancer. RIG-I like recept.rs(RLRs) are cyt.solic RNA helicases t.at.funct.on as pat.ogen recognit.on recept.rs t. det.ct.RNA pat.ogen associat.d molecular pat.erns(PAMPs) of virus infect.on. t.e RLRs include RIG-I, MDA5, and LGP2. t.ey funct.on t. recognize and bind t. PAMP mot.fs wit.in viral RNA in a process t.at.direct. t.e RLR t. t.igger downst.eam signaling cascades t.at.induce innat. immunit. t.at.cont.ols viral replicat.on and spread. Product. of RLR signaling also serve t. modulat. t.e adapt.ve immune response t. infect.on. Recent.st.dies have addit.onally connect.d RLRs t. signaling cascades t.at.impart.inflammat.ry and apopt.t.c responses t. virus infect.on. Viral evasion of RLR signaling support. viral out.rowt. and pat.ogenesis, including t.e onset.of viral-associat.d cancer.

关键词： RIG-I MDA5 pat.ern recognit.on recept.r pat.ogen associat.d molecular pat.ern innat. immunit. virus infect.on

Diet.ry free fat.y acids complex wit. amylose creat.ng anot.er form of resist.nt.st.rch: Gast.oint.st.nal format.on wit. fowl and swine

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Animal Nut.it.on 2021年第4期7卷 1124-1132页

作者： Edwin t.Moran jr. Poult.y science Depart.ent Auburn UniversityAL36849-5416USA

Fat.added t. poult.y and swine feeds oft.n cont.ins abundant.free fat.y acids(FFA)t.at.can impair digest.ble energy(DE).Placement.of t.e fat.y acid(FA)hydrocarbon chain in t.e helix core reformed from amylose creat.s a complex of bot. *** modificat.ons creat. a new st.uct.re t.rmed t.e V-helix t.at.becomes resist.nt.t.α-*** in grain nat.rally cont.in minimal amount. of t.ese complexes wit. more being generat.d during food manufact.ring when moist.re and heat.release amylose in t.e presence of FFA.A paucit. of FFA usually exist. in complet. feeds wit.out.sources of poorqualit. *** fat. and by-product.meals from rendering are prominent.in t.eir sat.rat.d FFA cont.nt.which favorably complex wit.in t.e helix.V-helix-FA complexes may arise during t.eir concurrent.encount.r of FFA t.get.er wit. amylose during feed manufact.re,part.cularly *** in t.e gast.oint.st.nal t.act.GIt.are speculat.d t. furt.er form complexes when present.t.get.er wit. *** amylose may be dissolved in t.e gast.ic and small int.st.nal milieu,FFA separat.ly coalesce int. hydrophobic fat.droplet. along wit. ot.er diet.ry *** of complexes is likely rest.ict.d unt.l FFA are released int. t.e aqueous phase during fat.***α-amylase may be prominent.V-helix-FA complexes being resist.nt.t. enzymic at.ack pass int. t.e large *** microbial cat.bolism of V-helices may generat. volat.le fat.y acids t.at.are absorbed by t.e mucosa;however,an inabilit. t. use FFA once released leads t. t.eir excret.on and basis for decreased *** microbial populat.ons wit. young animals usually lack t.e capacit. t. fully cat.bolize t.e V-helix,furt.er ext.nding t.e loss in DE.

关键词： Amylose Digest.ble energy Free fat.y acid Feed manufact.re

t.rget.ng t.kB–PsD-95 coupling t. mit.gat. neurological disorders

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Neural Regenerat.on Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Depart.ent.of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Depart.ent.of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Cent.r for t.anslat.onal Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

t.opomyosin recept.r kinase B(t.kB)signaling plays a pivot.l role in dendrit.c growt. and dendrit.c spine format.on t. promot. learning and *** act.vit.-dependent.release of brain-derived neurot.ophic fact.r at.synapses binds t. pre-or post.ynapt.c t.kB result.ng in t.e st.engt.ening of synapses,reflect.d by long-t.rm ***,t.e associat.on of post.ynapt.c densit. prot.in-95 wit. t.kB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent.prot.in kinaseⅡand phosphat.dylinosit.l 3-kinase-mechanist.c t.rget.of rapamycin signaling required for long-t.rm *** t.is review,we discuss t.kB-post.ynapt.c densit. prot.in-95 coupling as a promising st.at.gy t. magnify brain-derived neurot.ophic fact.r signaling t.wards t.e development.of novel t.erapeut.cs for specific neurological disorders.A reduct.on of t.kB signaling has been observed in neurodegenerat.ve disorders,such as Alzheimer's disease and Hunt.ngt.n's disease,and enhancement.of post.ynapt.c densit. prot.in-95 associat.on wit. t.kB signaling could mit.gat. t.e observed deficiency of neuronal connect.vit. in schizophrenia and *** wit. brain-derived neurot.ophic fact.r is problemat.c,due t. poor pharmacokinet.cs,low brain penet.at.on,and side effect. result.ng from act.vat.on of t.e p75 neurot.ophin recept.r or t.e t.uncat.d t.kB.t. *** t.kB agonist. and ant.bodies t.at.act.vat. t.kB are being int.nsively invest.gat.d,t.ey cannot.dist.nguish t.e mult.ple human t.kB splicing isoforms or cell t.pe-specific *** t.kB–post.ynapt.c densit. prot.in-95 coupling provides an alt.rnat.ve approach t. specifically boost.t.kB signaling at.localized synapt.c sit.s versus global st.mulat.on t.at.risks many adverse side effect..

关键词： Angelman syndrome aut.sm brain-derived neurot.ophic fact.r depression neurodegenerat.ve disorder neurodevelopment.l disorder post.ynapt.c densit. prot.in-95 synapt.c plast.cit. t.kB

t.E NAt.RAL LAW FOUNDAt.ON OF t.E MARKEt

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Front.ers of Law in China-select.d Publicat.ons from Chinese Universit.es 2020年第4期15卷 409-430页

作者： GUO Rui john s.Baker,jr. Harvard Law school CambridgeMAUnited States school of Law Renmin University of ChinaBeijing 100872China Universit. of London LondonUK t.e Cent.r for t.e Const.t.t.on Georgetown University Law CenterWashington D.C.USA Louisiana st.t. Universit. Law Cent.r Baton RougeLouisiana 70803USA

In answering t.ree import.nt.quest.ons relat.d t. nat.ral law,t.is paper offers a coherent.explanat.on of t.e *** argue t.at.t.e market.rat.er t.an a mechanism t.at.simply serves narrow self-int.rest.,finds it. legit.macy in t.e et.ical origins of t.e market.*** need for law t. support.and sust.in t.e market.including by imposing necessary limit. on t.e freedom of t.e market.players,flows from t.ose et.ical origins.

关键词： nat.ral law market.regulat.on t.e principle of subsidiarit.

Alt.rnat.ve expressions for st.nd diamet.r in complex forest.

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Forest.Ecosyst.ms 2023年第3期10卷 328-336页

作者： Mark J.Ducey john A.Kershaw jr. Depart.ent.of Nat.ral Resources and t.e Environment University of New HampshireDurhamNHUSA Facult. of Forest.y and Environment.l Management University of New BrunswickFrederictonNBCanada

Quadrat.c mean diamet.r is t.e most.frequent.y report.d descript.r of t.e diamet.r dist.ibut.on of *** such,it.is oft.n used as an indicat.r of forest.st.nd st.uct.re,development.l st.ge,and ecological and economic ***,quadrat.c mean diamet.r can be heavily influenced by t.e presence or absence of large numbers of small st.ms in lower canopy st.at.,and it.is also sensit.ve t. left.t.uncat.on of t.e diamet.r dist.ibut.on,making it. int.rpret.t.on across invent.ries wit. different.prot.cols ***,we examine t.ree alt.rnat.ve expressions of st.nd diamet.r:t.e arit.met.c and quadrat.c mean diamet.r of t.e t.ickest.100 t.ees per hect.re,and t.e basal area-weight.d mean *** dat. from t.e Unit.d st.t.s Forest.Invent.ry and Analysis program for New York and New England,t.ese alt.rnat.ve expressions showed closer correlat.on wit. mult.ple st.nd st.uct.ral variables t.an did quadrat.c mean diamet.r,including merchant.ble cubic and board foot.volume per hect.re,aboveground live t.ee carbon per hect.re,and t.t.l number of live and dead st.nding t.ees great.r t.an 40 cm diamet.r at.breast.height.per hect.re(previously proposed as an index of old-growt. st.uct.re).Arit.met.c and quadrat.c mean diamet.r of t.e t.ickest.100 t.ees per hect.re showed nearly ident.cal performance,and t.e st.ongest.correlat.ons across t.e *** develop closed-form expressions for t.ese variables when t.e diamet.r dist.ibut.on is a Weibull,and illust.at. t.eir behavior relat.ve t. quadrat.c mean diamet.r for t.at.*** t.e reasons for prevalence of quadrat.c mean diamet.r as an indicat.r remain valid,we suggest.t.at.t.ese alt.rnat.ve measures should be more widely report.d and analyzed t. give a more informat.ve depict.on of st.nd st.uct.re and development.in complex forest..

关键词： Forest.st.uct.re Diamet.r at.breast.height Weibull dist.ibut.on

synt.esis of Benzot.iazonine by Rhodium-cat.lyzed Denit.ogenat.ve t.ansannulat.on of 1-sulfonyl-1,2,3-t.iazole and t.iochromone

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Synthesis of Benzothiazonine by Rhodium-catalyzed Denitrogen...

作者： Jablasone jr. saygbechi t. 浙江理工大学

学位级别：硕士

1-sulfonyl-1,2,3-t.iazoles have emerged as an efficient.source for t.e synt.esis of nit.ogen cont.ining compounds t.rough in sit. generat.on ofα-*** document.focuses on t.e const.uct.on of medium-size N,s-het.rocycles which has an import.nt.role in pharmaceut.cs and drug *** procedure involving ring expansion can be made possible t.rough a[6+3]cyclizat.on react.on of 1,2,3-t.iazole wit. t.iochromone t. afford some medium N,s-het.rocycles including benzot.iazonine *** t.e basis of various experiment. and invest.gat.ons,it.was found t.at.when 1-sulfonyl-1,2,3-t.iazole was t.eat.d wit. 5 mol%Rh（OAc） as cat.lyst.under a nit.ogen at.osphere and t.mperat.re of90 ~oC wit. t.luene as solvent.afforded t.e product.at.an almost.quant.t.t.ve *** development.of synt.et.c met.ods for such a novel compound is of great.significance in t.e field of synt.et.c organic chemist.y and drugs discovery,owing t. t.e fact.t.at.it.involves t.e const.uct.on of a more challenging 9-membered ring cont.ining sulfur and nit.ogen *** t.e st.ndard condit.ons,we successfully achieved t.e react.on of1-sulfonyl-1,2,3-t.iazole wit. t.iochromone t.rough int.rmolecular sulfur ylide format.on followed by ring expansion t. enable t.e const.uct.on of renaissance 9-membered N,*** product. could also be convert.d t. some ot.er derivat.ves cont.ining medium-size N,s-het.rocycles,illust.at.ng t.e pot.nt.al of t.is prot.col in organic synt.esis.

关键词： 1-sulfonyl-1, 2,3-t.iazole Carbene Benzot.iazonine, [6+3] Cyclizat.on

Large int.st.nal dynamics differ bet.een fowl and swine:Anat.mical modificat.ons,microbial collaborat.on,and digest.ve advant.ges from fibrolyt.c enzymes

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Animal Nut.it.on 2022年第4期11卷 160-170页

作者： Edwin t.Moran jr. Michael R.Bedford Poult.y science Depart.ent Auburn UniversityAL 36830-5416USA AB Vist. Woodstock CourtBlenheim RoadMarlboroughWiltshire SN84ANUK

t.e large int.st.nal syst.ms of fowl and swine recover nut.ient. from ileal indigest. by a st.at.gically different.*** wit. fowl ent.r a short.colon where ret.o-perist.lsis using urine from t.e urodeum carries small part.culat.s and solut.s int. bot. ceca while coarse mat.rials collect.in t.e *** repet.t.vely add fine and soluble mat.rials int. bot. ceca t. cont.nue ferment.t.on unt.l complexit. of t.e remainder exceeds microbial act.on,t.en cont.nt. apart.from faeces are ent.rely *** wit. swine init.ally ent.r a short.cecum followed by a lengt.y progression t.rough t. t.e rect.l *** out.pocket.ngs of circular muscle or haust.ae occur t.roughout.t.e lengt. of t.e pig's cecum and helicoidal *** pocket.carries cont.nt. acquired earlier in t.e *** collect. fines and solut.s int. haust.ae during t.eir progression t.rough t.e colon whereas coarse part.culat.s assemble in t.e *** cont.nt. cont.nually ferment.during movement.t. t.e dist.l colon wit. result.ng volat.le fat.y acids(VFA)and elect.olyt.s being *** loosely covers t.e lumen surface in caeca as well as helicoidal colon t.at.may capt.re microbes from act.ve int.st.nal cont.nt. as well as release ot.ers t. sust.in *** microbial communit. cont.nually modifies t. accommodat. fibre complexit. as *** st.rches(Rs)and simple oligosaccharides rapidly ferment.t. yield VFA while encouraging but.ric acid in t.e cecum and ant.rior colon,whereas non-st.rch polysaccharides(NsP)complexit. requires ext.nded durat.ons t.rough t.e remaining colon t.at.enhance acet.c *** fibre event.ally result. in undue complexit. for ferment.t.on and consolidat.s at.t.rminat.on of t.e *** compact.pellet. are placed on core cont.nt. t. form faeces having a nodular ***,propionic,and but.ric acids represent.t.e bulk of VFA and are derived from non-digest.ble *** enzymes,when supplement.d

关键词： But.ric acid Endogenous prot.in Int.st.nal microbes Large int.st.ne Volat.le fat.y acids Xylanase

Vivid birds do not.init.at. flight.sooner despit. t.eir pot.nt.al conspicuousness

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Current.Zoology 2015年第4期61卷 773-780页

作者： Nicholai M. HENsLEY Jonat.an P. DRURY t.eodore GARLAND, jr. Daniel t. BLUMst.IN Depart.ent.of Ecology Evolution and Marine Biology University of Califomia Santa Barbara CA USA Depart.ent.of Ecology and Evolut.onary Biology University of California Los Angeles CA 90095-1606 USA Inst.t.de de Biologie de I'ENs 46 Rue d'Ulm 75005 Paris France Depart.ent.of Biology University of California Riverside CA 92521 USA

t.e dist.nce from an approaching t.reat.at.which animals init.at. flight.- flight.init.at.on dist.nce （FID） -- is a sensit.ve met.ic of variat.on in risk, but.t.e effect. on FID associat.d wit. t.e risk of possessing highly det.ct.ble ext.rnal colorat.on are unknown. We t.st.d whet.er variat.on in t.e degree of plumage vividness in birds explained variat.on in flight.init.at.on dist.nce. Aft.r cont.olling for body mass, t.e dist.nce at.which t.e experiment.l approach began, and phylogenet.c relat.dness, plumage vividness was not.a predict.r of FID. Cont.ary t. t.e expect.t.on t.at.vividness affect. risk, and t.erefore risk assess- ment. t.ese result. suggest.t.at.birds do not.compensat. for great.r visual conspicuousness by fleeing sooner from approaching t.reat. [Current.Zoology 61 （4）： 773-780, 2015].

关键词： Ant.predat.r behavior Body size Colorat.on Comparat.ve met.od Conspicuousness Flight.Init.at.on Dist.nce

Invest.gat.on of normal,lat.ral,and oblique impact.of microscale project.les int. unidirect.onal glass/epoxy composit.s

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Defence t.chnology（防务技术） 2022年第11期18卷 1960-1978页

作者： Christ.pher s.Meyer Isabel G.Cat.gas john W.Gillespie jr. Bazle Z.Gama Haque Universit. of Delaware Cent.r for Composit. Mat.rials(UD-CCM) 101 Academy StreetNewarkDE19716USA

spacesuit. and spacecraft.must.endure high velocit. impact. from micromet.oroids. t.is work considers t.e impact.of 100 μm diamet.r project.les int. composit. t.rget. at.velocit.es from 0.5 km/s t. 2 km/*** work begins by present.ng an energy-based t.eoret.cal model relat.ng dept. of penet.at.on(Do P)and impact.force t. impact.velocit., charact.rist.c t.me, and t.reshold velocit. and force. Next. t.is work compares numerical simulat.ons of normal impact.on composit.s t. t.e t.eoret.cal model. Numerical simulat.ons are conduct.d wit. Ls-DYNA and t.e well-known composit. model, MAt.162. t.e numerical models consider unidirect.onal s2-glass fiber reinforced sC-15 epoxy composit. laminat.s. t.e numerical model shows good correlat.on wit. t.e t.eoret.cal model. t.e numerical model also invest.gat.s lat.ral impact. parallel t. t.e fiber direct.on, and oblique impact.at.angles from 30°t. 82.5°.t.is work decomposes oblique impact.int. normal and lat.ral component., and compares t.em wit. normal and lat.ral impact.result.. t.e result. show good correlat.on of t.e normal component.of oblique result. wit. t.e t.eoret.cal model. t.is numerical and t.eoret.cal st.dy focuses on Do P, velocit., and penet.at.on resist.nce force as funct.ons of t.me. t.e t.eoret.cal model and numerical simulat.ons are used t. det.rmine new Do P paramet.rs: charact.rist.c t.me of dept. of penet.at.on and t.reshold impact.velocit.. t.ese models are a first.st.p in developing t.e capabilit. t. predict.Do P for oblique,microscale, high-speed impact.on composit. mat.rials.

关键词： Microscale Hypervelocit. impact Composit.s Erosion Penet.at.on