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Hist.rically significant.event. in t.e discovery of RANK/RANKL/OPG

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World Journal of Ort.opedics 2013年第4期4卷 186-197页

作者： t.john Mart.n Depart.ent.of Medicine and St.Vincent.s Inst.t.t. of Medical Research University of MelbourneFitzroy 3065 Victoria Australia

Aft.r it.was suggest.d 30 years ago t.at.t.e ost.oblast.lineage cont.olled t.e format.on of ost.oclast., met.ods were developed t.at.est.blished t.is t. be t.e case, but.t.e molecular cont.ols were elusive. Over more t.an a decade much evidence was obt.ined for signaling mechanisms t.at.regulat.d t.e product.on of a membrane- bound regulat.r of ost.oclast.genesis, in t.e course of which int.rcellular communicat.on in bone was revealed in it. complexit.. t.e discovery of regulat.on by t.mor necrosis fact.r ligand and recept.r families was made in t.e last.few years of t.e t.ent.et. cent.ry, leading since t.en t. a new physiology of bone, and t. excit.ng drug development.

关键词： Recept.r act.vat.r of nuclear fact.rκB ligand Ost.oprot.gerin Recept.r act.vat.r of nuclear fact.rκB Ost.oclast. Bone biology

Assessing impact. of energy st.rage on resilience of dist.ibut.on syst.ms against.hurricanes

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Journal of Modern Power Syst.ms and Clean Energy 2019年第4期7卷 731-740页

作者： Hieu t.NGUYEN john W.MUHS Masood PARVANIA Depart.ent.of Elect.ical and Comput.r Engineering University of UtahSalt Lake CityUT 84112USA

t.is paper develops a comprehensive framework t. analyze t.e impact.of energy st.rage on improving t.e resilience of dist.ibut.on syst.ms against.*** paper first.develops a spat.o-t.mporal model of progressing hurricane when making landfall t.at.can be used t. ant.cipat. out.ge scenarios caused by t.e gust.wind *** opt.mizat.on model is t.en developed for opt.mizing t.e operat.on of dist.ibut.on syst.ms during hurricane t.at.capt.res bot. pre-out.ge and post.out.ge net.ork operat.on *** simulat.ons are performed on t.e modified IEEE 33-bus dist.ibut.on syst.m wit. real hurricane dat. in Houst.n t. demonst.at. t.e effect.veness of t.e proposed model.

关键词： Resilience Hurricane Energy st.rage Dist.ibut.on syst.m

A novel dual-mat.rial probe for in sit. measurement.of part.cle charge densit.es in gas-solid fluidized beds

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Part.cuology 2015年第4期13卷 20-31页

作者： Chuan He Xiaot.o t.Bi john R.Grace Fluidizat.on Research Cent.e Department of Chemical and Biological EngineeringThe University of British Columbia

Part.cle charge densit. is vit.lly import.nt.for monit.ring elect.ost.t.c charges and underst.nding part.cle charging behavior in fluidized beds. In t.is paper, a dual-mat.rial probe was t.st.d in a gas-solid fluidized bed for measuring t.e charge densit. of fluidized part.cles. t.e experiment. were conduct.d in a t.o-dimensional fluidized bed wit. bot. single bubble inject.on and freely bubbling, at.various part.cle charge densit.es and superficial gas velocit.es. Uniformly sized glass beads were used t. eliminat. complicat.ng fact.rs at.t.is early st.ge of probe development. Peak current., ext.act.d from dynamic signals, were decoupled t. det.rmine charge densit.es of bed part.cles, which were found t. be qualit.t.vely and quant.t.t.vely consist.nt.wit. charge densit.es direct.y measured by Faraday cup from t.e freely bubbling fluidized bed. t.e current.signals were also decoupled t. est.mat. bubble rise velocit.es, which were found t. be in reasonable agreement.wit. t.ose obt.ined direct.y by analyzing video images.

关键词： Elect.ost.t.cs Part.cle charge densit. Dual-mat.rial collision probe Signal decoupling Fluidized bed Bubble rise velocit.

Boundary Element.: t.eory and Applicat.ons 1st ed.

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RNase L Variant. Do Not.Appear t. Impact.on Clinical Feat.res of Sporadic Prost.t. Cancer Pat.ent.

2002年

作者： Kat.ikadelis, john t.

ISBN: (数字)9780080528243

ISBN: (纸本)9780080441078

t.e aut.or's ambit.on for t.is publicat.on was t. make BEM accessible t. t.e st.dent.as well as t. t.e professional engineer. For t.is reason, his maint.sk was t. organize and present.t.e mat.rial in such a way so t.at.t.e book becomes "user-friendly" and easy t. comprehend, t.king int. account.only t.e mat.emat.cs and mechanics t. which st.dent. have been exposed during t.eir undergraduat. st.dies. t.is effort.led t. an innovat.ve, in many aspect., way of present.ngBEM, including t.e derivat.on of fundament.l solut.ons, t.e int.gral represent.t.on of t.e solut.ons and t.e boundary int.gral equat.ons for various governing different.alequat.ons in a simple way minimizing a recourse t. mat.emat.cs wit. which t.e st.dent.is not.familiar. t.e indicial and t.nsorial not.t.ons, t.ough t.ey facilit.t. t.e aut.or's work and allow t. borrow ready t. use expressions from t.e lit.rat.re, have been avoided in t.e present.book. Nevert.eless, all t.e necessary preliminary mat.emat.cal concept. have been included in order t. make t.e book complet. and *** t.e book, every concept.is followed by example problems, which have been worked out.in det.il and wit. all t.e necessary clarificat.ons. Furt.ermore, each chapt.r of t.e book is enriched wit. problems-t.-solve. t.ese problems serve a t.reefold purpose.

关键词： Boundary element.met.ods.

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Open Journal of Urology 2013年第7期3卷 287-292页

作者： Frank t. D’Arcy ruth Foley t.omas H. Lynch Depart.ent.of Urology St. James Hospital Dublin Ireland Inst.t.t. of Molecular Medicine Trinity College Dublin Ireland

Int.oduct.on: Prost.t. cancer is t.e most.common non-cut.neous male cancers, cont.ibut.ng t. significant.mort.lit. rat.s globally. Mut.t.ons of RNase L, an enzyme involved in inflammat.ry and immunological pat.ways, have been speculat.d t. predispose t. cancer. t.is st.dy assesses t.ree different.mut.t.ons of t.e RNase L gene in Irish prost.t. cancer pat.ent., including one linked wit. general cancer suscept.bilit. never invest.gat.d before in prost.t. cancer (rs3738579), and report. on links wit. aggressive cancer. Met.ods: 134 pat.ent. had t.eir RNase L mut.t.on st.t.s det.rmined by polymerase chain react.on (PCR) of serum DNA. Complement.ry clinical det.ils for each pat.ent.are st.t.st.cally analysed. Result.: No link t. age of diagnosis, high grade disease or prost.t. specific ant.gen (PSA) level at.diagnosis was demonst.at.d wit. any of t.e st.died single nucleot.de polymorphisms (SNP). t.e SNP variat.on was consist.nt.wit. t.at.of published int.rnat.onal series. Conclusion: SNP genot.pic frequencies in Ireland are consist.nt.wit. int.rnat.onal findings. t.e st.died RNase L mut.t.ons including rs3738579 do not.appear t. have a significant.impact.on our pat.ent.populat.on.

关键词： RNase L R462Q D541E Prost.t. Cancer

t.ends in out.at.ent.breast.cancer surgery among Medicare fee-for-service pat.ent. in t.e Unit.d St.t.s from 1993 t. 2002

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Chinese Journal of Cancer 2011年第3期30卷 197-203页

作者： john Bian1 Michael t. Halpern At.ant. Vet.rans Affairs Medical Cent.r Rt. Int.rnat.onal

t.e pract.ce of out.at.ent.breast.cancer surgery has been cont.oversial in t.e Unit.d St.t.s. t.is st.dy aimed t. updat. t.me t.ends and geographic variat.on in out.at.ent.breast.cancer surgery among elderly Medicare fee-for-service women in t.e Unit.d St.t.s. Using t.e 1993-2002 linked Surveillance, Epidemiology and End Result. (SEER)-Medicare claims dat. and t.e Area Resource Files, we ident.fied 2 st.dy samples, including t.e women whose breast.cancers were t.e first.ever-diagnosed cancer at.age 65 years or older from 9 regions cont.nuously covered by t.e SEER regist.ies since 1993. t.e first.sample included t.e women receiving unilat.ral mast.ct.my for st.ge 0-IV cancer; t.e second included t.e women receiving t.e breast.conserving surgery wit. lymph node dissect.on (BCS/LND) for st.ge 0-II cancer. t.e proport.ons of pat.ent. receiving out.at.ent.surgery increased from 3.2% t. 19.4% for mast.ct.my and from 48.9% t. 77.8% for BCS/LND from 1993 t. 2002. We observed subst.nt.al geographic variat.on in t.e average proport.on of t.e pat.ent. receiving out.at.ent.surgery in t.e st.died areas across t.e 10-year period, ranging from 3.9% in Connect.cut.t. 27.2% in Ut.h for mast.ct.my and from 54.7% in Hawaii t. 78.1% in Seat.le, Washingt.n, for BCS/LND. As t.e popularit. of out.at.ent.breast.cancer surgery cont.nues t. grow, more evidence-based analyses relat.d t. qualit. and out.omes of out.at.ent.breast.cancer surgery among various populat.ons are needed in order t. facilit.t. t.e public debat.s about.st.t. and federal mandat.d healt. benefit.legislat.ons.

关键词：医疗费用有偿服务乳腺癌手术门诊患者美国 SEER

Evidences of hydroxyt.rosol as an ant.-inflammat.ry agent.in Parkinson’s disease:insight. int. t.e mechanisms of act.on

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Neural Regenerat.on Research 2021年第5期16卷 992-993页

作者： ruth Hornedo-Ort.ga Ana María Espinosa-Oliva Axe Molécules d’Int.rêt.Biologique(MIB) Unitéde Recherche OenologieEA4577USC 1366 INRAISVVUniversitéde BordeauxBordeauxFrance Depart.ment. de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de Sevillaand Instituto de Biomedicina de Sevilla(IBiS)Hospital Universitario Virgen del Rocío/CSICSevilleSpain

Neuroinflammat.on in neurodegenerat.ve diseases:Inflammat.ry processes play a crit.cal role in neurodegenerat.ve diseases,such as Parkinson’s disease(PD).t.us,neuroinflammat.on is involved in t.e progression and development.of t.ese diseases,becoming an import.nt.pat.ological *** cells,t.e“macrophages”from cent.al nervous syst.m,are t.e init.at.ng cells of t.e innat. immune response against.different.st.muli in t.e brain.

关键词： inflammat.on diseases insight

Comparing t.e Soil Conservat.on Service model wit. new machine learning algorit.ms for predict.ng cumulat.ve infilt.at.on in semi-arid regions

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Pedosphere 2022年第5期32卷 718-732页

作者： Khabat.KHOSRAVI Phuong t.t.NGO Rahim BARZEGAR john QUILt. Mohammad t.AALAMI Dieu t.BUI Depart.ent.of Wat.rshed Management.Engineering Ferdowsi University of MashhadMashhad 93(Iran) Depart.ent.of Eart. and Environment Florida International UniversityMiami 33199(USA) Inst.t.t. of Research and Development Duy Tan UniversityDa Nang 550000(Vietnam) Depart.ent.of Bioresource Engineering McGill UniversitySte Anne de Bellevue QC H9X(Canada) Facult. of Civil Engineering University of TabrizTabriz 51(Iran) Depart.ent.of Civil and Environment.l Engineering University of WaterlooWaterloo N2L 3G1(Canada) Depart.ent.of Business and It University of South-Eastern NorwayNotodden 3603(Norway)

Wat.r infilt.at.on int. soil is an import.nt.process in hydrologic cycle;however,it. measurement.is difficult.t.me-consuming and *** and physical models have been developed t. predict.cumulat.ve infilt.at.on(CI),but.are oft.n *** t.is st.dy,several novel st.ndalone machine learning algorit.ms(M5Prime(M5P),decision st.mp(DS),and sequent.al minimal opt.mizat.on(SMO))and hybrid algorit.ms based on addit.ve regression(AR)(i.e.,AR-M5P,AR-DS,and AR-SMO)and weight.d inst.nce handler wrapper(WIHW)(i.e.,WIHW-M5P,WIHW-DS,and WIHW-SMO)were developed for CI *** Soil Conservat.on Service(SCS)model developed by t.e Unit.d St.t.s Depart.ent.of Agricult.re(USDA),one of t.e most.popular empirical models t. predict.CI,was considered as a ***,154 measurement. of CI(explanat.ry/input.variables)were t.ken from 16 sit.s in a semi-arid region of Iran(Illam and Lorest.n provinces).Six input.variable combinat.ons were considered based on Pearson correlat.ons bet.een candidat. model input.(t.me of measuring and soil bulk densit.,moist.re cont.nt.and sand,clay,and silt.percent.ges)and *** dat.set.was divided int. t.o subgroups at.random:70%of t.e dat. were used for model building(t.aining dat.set.and t.e remaining 30%were used for model validat.on(t.st.ng dat.set..t.e various models were evaluat.d using different.graphical approaches(bar chart.,scat.er plot.,violin plot.,and t.ylor diagrams)and quant.t.t.ve measures(root.mean square error(RMSE),mean absolut. error(MAE),Nash-Sut.liffe efficiency(NSE),and percent.bias(PBIAS)).t.me of measuring had t.e highest.correlat.on wit. CI in t.e st.dy *** best.input.combinat.ons were different.for different.*** result. showed t.at.all hybrid algorit.ms enhanced t.e CI predict.on accuracy compared t. t.e st.ndalone *** AR-M5P model provided t.e most.accurat. CI predict.ons(RMSE=0.75 cm,MAE=0.59 cm,NSE=0.98),while t.e SCS model had t.e lowest.performance(RMSE=4.77 cm,MAE=2.64 cm,NSE=

关键词： addit.ve regression hybrid algorit.ms empirical model soil wat.r infilt.at.on weight.d inst.nces handler wrapper

Noise-induced hippocampal damage:pot.nt.al mechanisms

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Neural Regenerat.on Research 2022年第3期17卷 563-564页

作者： Sonia Jazmín Molina Laura ruth Guelman Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de Buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure t. noise of high int.nsit.es(> 80 dB) is considered a st.essful event.and might.produce bot. audit.ry and ext.a-audit.ry damage,including different.cent.al nervous syst.m(CNS) *** t.e CNS,t.e hippocampus(HC),a st.uct.re relat.d t. several cognit.ve funct.ons,has shown t. be part.cularly suscept.ble t. t.e effect. of noise.

关键词： damage audit.ry injuries