Historically significant events in the discovery of RANK/RANKL/OPG

作     者：T John Martin 

作者机构：Department of Medicine and St Vincent’s Institute of Medical Research University of MelbourneFitzroy 3065 Victoria Australia 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)

年 卷 期：2013年第4卷第4期

页      面：186-197页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by The National Health and Medical Research Council(Australia) the Victorian Government OIS Program 

主　　题：Receptor activator of nuclear factorκB ligand Osteoprotegerin Receptor activator of nuclear factorκB Osteoclasts Bone biology 

摘      要：After it was suggested 30 years ago that the osteoblast lineage controlled the formation of osteoclasts, methods were developed that established this to be the case, but the molecular controls were elusive. Over more than a decade much evidence was obtained for signaling mechanisms that regulated the production of a membrane- bound regulator of osteoclastogenesis, in the course of which intercellular communication in bone was revealed in its complexity. The discovery of regulation by tumor necrosis factor ligand and receptor families was made in the last few years of the twentieth century, leading since then to a new physiology of bone, and to exciting drug development.