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PDK Inhibitor Reverses BCRP-mediated Drug Resistance

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PDK Inhibitor Reverses BCRP-mediated Drug Resistance

Author Correction:Manifold learning of four-dimensional scanning transmission electron microscopy

2011年全国药物化学学术会议——药物的源头创新

作者： lI,Tian-Wen~1,SHANG,Pei-Hua~1,CHENG,Chang-Mei`(*,1),CHEN,Zhe-Sheng~(*,2),ZHAO,Yu-Fen~1 1 Key laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing,100084 2 Department of Pharmaceutical Sciences,College of Pharmacy and Allied Health Professions,St. john''s University,New York,NY 11439

＜正＞（R）-l,l,l-trifluoro-2-hydroxy-2-methylpropanamides,represented by AZD7545,were known as pyruvate dehydrogenase kinase（PDK） inhibitor 1,***,it was reported that Mitapiatin, fusion of cisplatin and another PDK...

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npj Computational Materials 2020年第1期6卷 1073-1073页

作者： Xin li Ondrej E.Dyck Mark P.Oxley Andrew R.lupini leland McInnes john Healy Stephen Jesse Sergei V.Kalinin Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge USA Institute for Functional Imaging of Materials Oak Ridge National Laboratory Oak Ridge USA Tutte Institute for Mathematics and Computing Ottawa Canada

The original version of the published Article had a mistake in the Acknowledgements *** Acknowledgments have been updated to the following:This research was supported by the US Department of Energy,Basic Energy Sciences,Materials Sciences and Engineering Division(M.P.O.,A.R.l.,S.V.K.)and conducted at the Center for Nanophase Materials Sciences,which is a US DOE Office of Science User Facility(X.l.,O.E.D.,S.J.).*** *** support from Tutte Institute for Mathematics and Computing,Canada.

关键词： section ledgment Manifold

美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新

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中国肺癌杂志 2010年第3期13卷 171-189页

作者： Christopher G. AZZOlI Sherman Baker JR Sarah TEMIN William PAO Timothy AlIFF Julie BRAHMER David H. johnSON Janessa l. lASKIN Gregory MASTERS Daniel MIlTON luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHIllER Reily SMITH Thomas J. SMITH john R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) From the Memorial Sloan-Kettering Cancer Center New York NY Virginia Commonwealth University Massey Cancer Center Richmond American Society of Clinical Oncology Alexandria Virginia Cancer Center Richmond VA Vanderbilt-Ingram Cancer Center Nashville TN Northwest Oncology & Hematology Associates Coral Springs FL Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore National Cancer Institute Bethesda MD Helen F. Graham Cancer Center Newark DE Hematology/Oncology of Indiana PC Indianapolis IN Nebraska Cancer Specialists PC Omaha NE Samuel Oschin Comprehensive Cancer Institute Los Angeles CA University of Texas Southwestern Medical Center Dallas TX British Columbia Cancer Agency Vancouver British Columbia Canada 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐... 详细信息

本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。

关键词：临床实践指南非小细胞肺癌选择化疗美国临床肿瘤学会细胞毒性药物表皮生长因子受体 receptor 肺癌患者

Search for the doubly charmed baryon ■

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 8-22页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr S.Amato Y.Amhis l.An l.Anderlini G.Andreassi M.Andreotti F.Archilli J.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter l.J.Bel V.Belavin S.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese S.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez l.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.l.Clarke M.Clemencic H.V.Cliff J.Closier J.l.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras l.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.l.Da Silva E.Dall'Occo J.Dalseno C.D'Ambrosio A.Danilina P.d'Argent A.Davis O.De Aguiar Francisco K.De Bruyn S.De Capua M Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance lAl Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayOrsayFrance lPNHE Sorbonne Universite Paris Diderot Sorbonne Paris Cite CNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma la Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland Natio

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the lHCb detector at centre-of-mass energies of 7,8 and 13 *** data correspond to a total integrated luminosity of 9 fb^-*** significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^*** limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc *** limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

The Chromosome-level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous lTR Retrotransposons in Driving Genome Size Evolution

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Molecular Plant 2020年第7期13卷 935-938页

作者： Qun-Jie Zhang Wei l i Kui li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-lei lin Xiao-lan Yang Yan Tong Dan Zhang Cui lu li-Ying Feng Chen-Feng Wang Xiao-Xin liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua liu and li-Zhi Gao Institution of Genomics and Bioinformatics South China Agricultural UniversityGuangzhou 510642China Novogene Bioinformatics Institute Building 301Zone A10 Jiuxianqiao North RoadChaoyang DistrictBeijing 100083China School of life Sciences Nanjing UniversityNanjing 210023China Plant Germplasm and Genomics Center Kunming Institute of BotanyChinese Academy of SciencesKunming 650204China University of the Chinese Academy of Sciences Beijing 100039China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou510640China Hunan Agricultural University Changsha 410128China Yunnan Pu’er Tea Tree Breeding Station No.212 Zhenxing AvenueSimao DistrictPu ErYunnan 665099China john A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA

Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,*** ***(CSA\Assam type)and *** ***(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;li et al.,2011;li et al.,2015;Xia et al,2017;liu et al.,2019).

关键词： Evolution Tree Reference

Innovative education and training in high power laser plasmas(PowerlaPs) for plasma physics, high power laser matter interactions and high energy density physics: experimental diagnostics and simulations

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High Power laser Science and Engineering 2020年第1期8卷 30-36页

作者： john Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil PBenis Andrea Ciardi Donna Cook Vasilios Dimitriou Brendan Dromey Ioannis Fitilis Giancarlo Gatti Anastasios Grigoriadis Marine Huault Jose Antonio Pérez Hernández Evaggelos Kaselouris Ondrej Klimo Michel Koenig George Koundourakis Milan Kucharik Jiri limpouch Richard liska Carlos Salgado lopez Sophia Malko Susana Olmos-Miguelanez Yannis Orphanos Valeria Ospina Nektarios APapadogiannis Stelios Petrakis Jan Psikal Maria Serena Rivetta Maria-ose Rodriguez-Conde Joao Jorge Santos Milan Sinor Alexandros Skoulakis Ioannis Tazes laura Tejada Pascual Calliope Tsitou Pavel Vachal luca Volpe Jiri Vyskocil Steven White Mark Yeung Ghassan Zerouli Michael Tatarakis York Plasma Institute University of YorkHeslingtonYork YO105DQUK Hellenic Mediterranean University Institute of Plasma Physics and Lasers-IPPL74100 Rethymnon73133 ChaniaCreteGreece University of Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Department of Physics University of IoanninaGR 45110 IoanninaGreece lUlI-CNRS CEASorbonne UniversiesEcole PolytechniqueInstitut Polytechnique de Paris-F-91128 Palaiseau CedexFrance Observatoire de Paris 5 Place J JanssenMeudon 92195France Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUK Centro de láseres Pulsados(ClPU) Edificio M5Parque CientficoC/Adaja 837185 VillamayorSalamancaSpain University of Salamanca 37008 SalamancaSpain Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PragueBrehova 711519Prague 1Czech Republic University Institute for Educational Sciences University of Salamanca37008 SalamancaSpain Group of Research“Interaction and e learning”(GRIAl) University of Salamanca37008 SalamancaSpain ClPU laser-Plasma Chair at University of Salamanca 37008 SalamancaSpain

The second and final year of the Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerlaPs,is *** PowerlaPs programme employs an innovative paradigm in that it is a multi-centre programme,where teaching takes place in five separate institutes with a range of different aims and styles of ***’in-class’time is limited to 4 weeks a year,and the programme spans 2 *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laser plasma interaction physics and inertial confinement *** are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Hellenic Mediterranean University and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just finished its second and final *** learning Teaching Training activities have been held at the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University,the University of Salamanca and the Institute of Plasma Physics and lasers of the Hellenic Mediterranean *** last of these institutes hosted two 2-week-long Intensive Programmes,while the activities at the other four universities were each 5 days in *** addition,a’Multiplier Event’was held at the University of Ioannina,which will be briefly *** this second year,the work has concentrated on training in both experimental diagnostics and simulation techniques appropriate to the study of plasma physics,high power laser matter interactions and high energy density *** nature of the programme will be described in detail,and some metrics relating to the activities carried out will be *** particular,this paper will f

关键词： laser plasma interactions postgraduate education

锌指转录因子Sp9是线性投射神经元发育所必需的

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科学新闻 2017年第4期 153-153页

作者： Qiangqiang Zhang Yue Zhang Chunyang Wang Zhejun Xu Qifei liang lei An Jiwen li Zhidong liu Yan You Miao He Ying Mao Bin Chen Zhi-Qi Xiong john l.Rubenstein 杨振纲复旦大学脑科学研究院复旦大学医学神经生物学国家重点实验室

文章简介由纹状体和纹状体神经元组成的纹状体中等大小的神经元(MSN)来自于外侧神经节隆起(lGE)。研究发现,转录因子Sp9在几乎所有纹状体MSN的lGE祖细胞中表达,并且Sp9表达维持在丝状体纹状肌阵挛MSN中。Sp9基因敲除小鼠由于肌阵挛性MS... 详细信息

文章简介由纹状体和纹状体神经元组成的纹状体中等大小的神经元(MSN)来自于外侧神经节隆起(lGE)。研究发现,转录因子Sp9在几乎所有纹状体MSN的lGE祖细胞中表达,并且Sp9表达维持在丝状体纹状肌阵挛MSN中。Sp9基因敲除小鼠由于肌阵挛性MSN祖细胞的增殖减少和Bax依赖性凋亡增加,而丧失大部分的纹状体MSN,而纹状体神经元的发育在很大程度上不受影响。Ch IP q PCR提供证据表明,Ascl1直接与Sp9启动子

关键词：纹状体神经元 MSN 祖细胞肌阵挛神经肌肉疾病 Sp9 转录因子

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奈西立肽在心脏瓣膜术后早期应用的临床价值

中国生化药物杂志 2015年第9期35卷 57-60页

作者：曾娟于涛李健侯晓林刘蓉安曾庆华四川省医学科学院.四川省人民医院全科医学中心四川成都610027 四川省医学科学院.四川省人民医院心脏外科四川成都610027 四川省医学科学院.四川省人民医院编辑部四川成都6100273 四川省医学科学院.四川省人民医院重症监护室四川成都610027

目的观察心脏瓣膜术后早期应用奈西立肽对心肌损伤及心功能的保护作用。方法连续收集2013年11月-2015年2月四川省人民医院心外科收治的心脏瓣膜病患者78例,随机分为奈西立肽组（n=38）和对照组（n=40）。奈西立肽组患者在术后常规心肌... 详细信息

目的观察心脏瓣膜术后早期应用奈西立肽对心肌损伤及心功能的保护作用。方法连续收集2013年11月-2015年2月四川省人民医院心外科收治的心脏瓣膜病患者78例,随机分为奈西立肽组（n=38）和对照组（n=40）。奈西立肽组患者在术后常规心肌保护治疗的基础上给予24-72 h的奈西立肽[0.01μg/（kg·min）]治疗。对照组患者术后仅接受常规心肌保护治疗。观察指标：1心肌肌钙蛋白（c Tn I）、磷酸肌酸激酶同工酶（CK-MB）：分别在术前、术后0、24、72 h抽取静脉血检测;2患者血肌酐（SCr）：分别在术前、术后7 d抽取静脉血检测;3左室射血分数（lVEF）：分别在术前、术后7 d行超声心动图测定;4ICU停留时间及机械辅助通气时间。结果 2组患者术后24 h c Tn I及CK-MB差异无统计意义;奈西立肽组术后72 h c Tn I为（5.10±2.03）ng/m l,显著低于对照组的（8.94±3.35）ng/m l（P〈0.05）,奈西立肽组CK-MB为（36.27±12.18）U/l,显著低于对照组的（23.24±14.67）U/l（P〈0.05）;2组患者术后7 d的SCr水平差异无统计学意义;术后7 d奈西立肽组lVEF为（60.47±8.60）%,较对照组（54.60±10.92）%明显改善（P〈0.05）;2组患者ICU停留时间差异无统计学意义,但奈西立肽组机械辅助通气时间[（3.14±1.95）d]明显短于对照组[（4.29±2.25）d,P〈0.05]。结论心脏瓣膜术后早期应用奈西立肽可减轻心肌损伤,改善心脏功能。

关键词：奈西立肽心脏瓣膜术肌钙蛋白肌酸激酶

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管理学能力培养取向