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Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review

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World Journal of Clinical Cases 2019年第24期7卷 4366-4376页

作者： Guo-hui Zhang Xiao-Yan Guo Gao-Zhao Liang Qing Wang Graduate School Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Urology The Second Affiliated HospitalShenzhen UniversityShenzhen 518100Guangdong ProvinceChina

BAckGROUND Inflammatory myofibroblastic tumor(IMT) is a rare mesenchymal tumor that is characterized by spindle cells differentiated from muscle fibroblasts and infiltration of various types of inflammatory cells. IMT can occur at any age and at any anatomic site. The most common location of IMT is the bladder in the genitourinary tract. Only scarce cases of kidney IMT have been reported in the *** SUMMARY A 77-year-old woman, with a history of bilateral renal calculus for 15 years, was admitted to the Department of Urology of our hospital complaining of recurrent painless gross hematuria for one month. The treatment with cephalosporin was ineffective. Computed tomography imaging showed a mixed density and slightly heterogeneously enhanced lesion in the middle pole of the left kidney and ipsilateral adrenal enlargement. The patient underwent surgical treatment by retroperitoneoscopic left radical nephrectomy plus adrenalectomy. A large number of typical spindle cells surrounded by plasma cells and lymphocytes were observed microscopically. Immunohistochemical analyses indicated that these spindle cells were positive for vimentin, cytokeratin(ck), Ki-67, ck7,CD34, and CD31 and were focally positive for CD10 and anaplastic lymphoma kinase(ALK-1). Thus, a diagnosis of IMT was made definitively. The patient recovered well after operation, and no recurrence or metastasis was noted during the 22-mo *** Since kidney IMT is very rare and lacks characteristic clinical manifestation, it is easily misdiagnosed as a malignant tumor before operation. Surgery remains the best choice for diagnosis and treatment, and such cases must be followed carefully because of the uncertain biological behavior of this tumor. This report suggests that renal calculus may be one of the causes of IMT, but further investigation is necessary to prove it.

关键词： Inflammatory myofibroblastic tumor Kidney Diagnosis Renal calculus Case report

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A Point-of-Care Test System for Biochemical Blood Analysis Based on ADUC824

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稀有金属材料与工程 2006年第A3期35卷 75-79页

作者： hui Wang Qing Tian Liying Jiang Chunxiu Liu Zonghui Guo Xinxia Cai State Key Laboratory of Transducer Technology Institute of Electronics Chinese Academy of Science Chinese Academy of Sciences Beijing 100080 China Graduate School of Chinese Academy of Sciences Beijing 100080 China

A point-of-care test system has been studied in this *** was used to determine substances in blood such as Hemoglobin (HB),Aspartate Aminotransferase (AST),Creatine Kinase (ck) and so *** on the principle of amperometric determination,the research on detecting weak current signals was carried *** the same time as to the weak signals (nA level),magnifying,sampling and processing the signals were also *** by ADUC824 and assisted by other units, every substance could be determined automatically and rapidly integrated with the corresponding *** the experiment, the minimum detectable current of the instrument (YT2005-1) is 0.2 *** regard to the 1 nA which the experiment demanded,it could be up to the *** the system can provide results in 180 s with a long term stability.

关键词： point-of-care test ADUC824 weak signals HB,AST and ck

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Effects of water and fertilizer deficit regulation with drip irrigation at different growth stages on fruit quality improvement of kiwifruit in seasonal arid areas of Southwest China

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Journal of Integrative Agriculture 2023年第10期22卷 3042-3058页

作者： ZHA Yu-xuan CHEN Fei WANG Zhi-hui JIANG Shou-zheng CUI Ning-bo State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065P.R.China

For a long time,seasonal drought occurs frequently in Southwest China,and the management of water and fertilizer in kiwifruit orchards has no quantitative standards,which seriously affects the yield and quality of ***,the effects of water and fertilizer deficit regulation with drip irrigation(WFDRDI)on the quality of kiwifruit at different growth stages were explored to achieve water and fertilizer saving,and green and efficient production of *** select‘Jin Yan'kiwifruit and set two water deficit levels(W_(D20%)and W_(D40%))and three fertilizer deficit levels(F_(D15%),F_(D30%)and F_(D45%))at bud burst to leafing stage(stageⅠ),flowering to fruit set stage(stageⅡ),fruit expansion stage(stageⅢ)and fruit maturation stage(stageⅣ),respectively,with a full irrigation and fertilization as the control treatment(ck)in 2017and *** showed that the WFDRDI at stageⅡandⅢhad significant effect on fruit physical quality of kiwifruit,specifically,theⅢ-WD40%F_(D30%)andⅢ-W_(D20%)F_(D45%)treatments significantly increased fruit firmness by 13.62 and 15.59%(P<0.05),respectively;theⅡ-W_(D40%)F_(D15%)andⅢ-W_(D40%)F_(D15%)treatments significantly increased dry matter by 8.19 and 6.47%(P<0.05),respectively;theⅢ-W_(D20%)F_(D15%)treatment significantly increased single fruit weight and fruit volume by 9.33 and 12.65%(P<0.05),respectively;theⅡ-W_(D20%)F_(D15%)treatment significantly increased fruit water content by 1.99%(P<0.05).The WFDRDI had an obvious effect on fruit chemical quality of ***Ⅲ-W_(D20%)F_(D45%),Ⅳ-W_(D40%)F_(D15%)andⅣ-W_(D20%)F_(D30%)treatments significantly increased vitamin C(Vc)content by 69.96,36.96 and 34.31%(P<0.05),respectively;theⅢ-W_(D40%)F_(D15%)andⅣ-W_(D40%)F_(D15%)treatments significantly increased total soluble solid(TSS)content by 3.79 and 17.05%(P<0.05),respectively,and significantly increased soluble sugar content by 28.61 and 34.79%(P<0.05),respectively;the contents of fructose,glucose and sucrose also had a significan

关键词： water deficit fertilizer deficit water and fertilizer coupling fruit physical quality fruit chemical quality

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Bile acids and metabolic surgery

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Liver Research 2021年第3期5卷 164-170页

作者： hui Xue Luyao Huang Jui Tu Lili Ding Wendong Huang Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina Department of Diabetes Complications and Metabolism Institute of Diabetes and Metabolism Research CenterBeckman Research InstituteCity of Hope National Medical CenterDuarteCAUSA

The epidemic of obesity and its co-mortalities has reached an alarming level ***,metabolic surgeries,especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy,are the most effective and sustainable treatments for obesity,type 2 diabetes,non-alcoholic steatohepatitis,as well as other metabolic ***,the invasive nature of the surgeries limits their broad ap-plications to the general ***,developing alternative non-invasive approaches to mimic metabolic surgery is an important direction of the *** studies have identified several potential metabolic surgery-induced downstream endocrine mediators,among which bile acids are key candidate signaling *** acids are profoundly altered by metabolic surgery,which contributes to the metabolic effects of the *** this review,we focus on the most recent studies on the roles of bile acids and bile acid receptors farnesoid X receptor and Takeda G protein-coupled receptor 5 in mediating the metabolic effects of metabolic *** conclude that targeting bile acid pathways may be a promising pharmacological approach to mimic the beneficial effects of metabolic surgery.

关键词： Metabolic surgery Obesity Type 2 diabetes(T2D) Non-alcoholic fatty liver disease(NAFLD) Bile acid Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5)

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Garcinol suppresses the growth of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,acetylation and dimerization

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中国药理学与毒理学杂志 2015年第S1期29卷 82-83页

作者： Muthu K SHANMUGAM Snehajyoti CHATTERJEE Peramaiyan RAJENDRAN Feng LI Parijat SENAPATI Kwong Fai WONG Alan Prem KUMAR john MLUK Kam Man hui Gautam SETHI Tapas K KUNDU Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Jawaharlal Nehru Centre for Advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Jakkur P.O. Bangalore 560064 India Cancer Science Institute of Singapore National University of Singapore Singapore 117456 School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Institute of Molecular and Cell Biology Singapore 138673

OBJECTIVE Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide and the third cause of global cancer *** of signal transducer and activator of transcription 3(STAT3)is commonly observed in tumor cells and is a critical mediator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,metastasis and *** drug-targeted therapies,besides being expensive,are associated with serious side effects and ***,novel agents that can suppress STAT3 activation have potential for both prevention and treatment of *** the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude mice *** The effect of garcinol on HCC cell lines wasdetermined by MTT assay,immunoblotting,DNA binding assays,immuno-fluorescenceand immune-histochemical *** effect of garcinolon the inhibition of tumor growth in vivo was also investigated using HCCxenograft tumor modelin athymic nu/nu *** We found that garcinol could inhibit constitutive STAT3 activation in a dose-and time-dependent manner both by inhibiting STAT3 phosphorylation and acetylation in HCC *** investigated for molecular mechanism(s),we found that garcinol interferes with the dimer formation of STAT3 thereby inhibits its nuclear *** modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppresses its dimerization in *** understand the cellular mechanism(s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dimerization bygarcinol,STAT3 DNA binding ability gets *** inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and ***,when administered i.p.,garcinol inhibited the growth of human HCC xenograft tumors in

关键词： STAT3 HCC garcinol acetylation dimerization nude m

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Effects of Earthworms and Ryegrass on the Removal of Fluoranthene from Soil

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Pedosphere 2013年第4期23卷 523-531页

作者： JING Yong-Ping LIU Man-Qiang YIN Qi-Peng LI hui-Xin HU Feng College of Resources and Environmental Sciences Nanjing Agricultural University

Earthworms can promote the bioremediation of contaminated soils through enhancing plant growth and microorganism development. The individual and combined effects of earthworms and ryegrass （Lolium multifloram Lain.） on the removM of fiuoranthene from a sandy-loam alluvial soil were investigated in a 70-d microcosm experiment. The experiment was set up in a complete factorial design with treatments in four replicates： without earthworms or ryegrass （control, ck）, with earthworms only （E）, with ryegrass only （P）, and with both earthworms and ryegrass （EP）. The residual fluoranthene, microbial biomass C, and polyphenol oxidase activity in the soil changed significantly （P 〈 0.01） with time. In general, the residual concentration of fluoranthene in the soil decreased sharply from 71.8-88.7 to 31.7-37.4 mg kg-1 in 14 d, and then decreased gradually to 19.7-30.5 mg kg-1 on the 70th d. The flu- oranthene concentration left in the soil was the least with both earthworms and ryegrass, compared to the other treatments at the end of the experiment. Half-life times of fluoranthene in the E, P, and EP treatments were 17.8%-36.3% smaller than that of ck. More fluoranthene was absorbed by earthworms than ryegrass. However, the total amounts of fluoranthene accumulated in both the ryegrass and earthworms were small, only accounting for 0.01%-1.20% of the lost fluoranthene. Therefore, we assumed that microbial degradation would play a dominant functional role in fluoranthene removal from soil. We found that earthworms significantly increased microbial biomass C and polyphenol oxidase activity （P 〈 0.01） in the presence of ryegrass at the end of the experiment. Furthermore, microbial biomass C and polyphenol oxidase activity were significantly （P 〈 0.05） and negatively related to the residual fluoranthene concentration. This implied that earthworms might promote the removal of fluoranthene from soil via stimulating microbial biomass C and polyphenol oxidase activity.

关键词： microbial biomass C microbial degradation plant growth polyphenol oxidase activity residual concentration

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Pre-induction dexamethasone does not decrease postoperative nausea and vomiting after microvascular decompression for facial spasm

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Chinese Medical Journal 2014年第14期127卷 2711-2712页

作者： Fang Qiwu Qian Xiaoyan An Jianxiong Wen hui Wu Jianping Cope, Doris K. Williams, john P. China Med Univ Aviat Gen Hosp Dept Anesthesiol Pain Med & Crit Care Med Beijing 100012 Peoples R China Chinese Acad Sci Beijing Inst Translat Med Beijing 100012 Peoples R China Univ Pittsburgh Dept Anesthesiol Pittsburgh PA 15213 USA

complications in neurosurgical patients consequent to elevated intracranial and arterial pressure.1 Dexamethasone （Dex） was applauded to reduce the incidence of PONV,2 but some literatures showed dexamethasone did not reduce the incidence of PONV.1＇3 The aim of this study was to determine whether a single-dose of dexamethasone before induction of general anesthesia would affect PONV after MVD for facial spasm.

关键词： dexamethasone postoperative nausea vomiting

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Polyaspartic acid mediates the absorption and translocation of mineral elements in tomato seedlings under combined copper and cadmium stress

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Journal of Integrative Agriculture 2019年第5期18卷 1130-1137页

作者： HU Mei-mei DOU Qiao-hui CUI Xiu-min LOU Yan-hong ZHUGE Yu-ping National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources/College of Resource and Environment Shandong Agricultural University

Polyaspartic acid(PASP)is a nontoxic,biodegradable,environmentally friendly polymer and is widely used as a fertilizer synergist in agricultural *** many old orchards and vegetable gardens,highly fertile soil is often accompanied by severe heavy metal *** present study was designed to investigate mineral element interactions mediated by PASP under copper(Cu)+cadmium(Cd)combined stress to provide reasonable suggestions for scientific fertilization.A pot experiment was conducted in which tomato seedlings served as plant materials.A concentration of 700 mgPASP and foliar spraying application methods were selected based on previous *** treatments were applied:normal soil(control(ck)),Cu+Cd(combined stress),Cu+Cd+PASP,and normal soil+*** plant biomass,root activity,and mineral elements were measured,and these data were analyzed by Data Processing System(DPS)statistical *** results showed that,under Cu+Cd combined stress,PASP promoted stem diameter growth,root activity and chlorophyll content and ultimately increased the biomass of tomato seedlings to different ***,the content of both Cu and Cd and their individual accumulation in plants *** increased the distribution of Cu and Cd in the roots under Cu+Cd combined stress,and the translocation ability from the roots to shoots was significantly *** respect to essential elements,PASP promoted mainly the absorption and translocation of potassium(K),calcium(Ca),and magnesium(Mg),which greatly exerted physiological ***,the variation trends of Cu and Cd under normal soil conditions contrasted with those under stress *** respect to essential elements other than K,Ca,and Mg,PASP mostly restrained their absorption but promoted their *** regulatory mechanism of PASP differed between the combined stress conditions and normal soil *** the combined stress conditions,PASP seemed to mainly promote these

关键词： tomato seedlings polyaspartic acid Cu+Cd combined stress

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Effects of Long-Term Organic Amendments on Soil Organic Carbon in a Paddy Field: A Case Study on Red Soil

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Journal of Integrative Agriculture 2014年第3期13卷 570-576页

作者： HUANG Qing-hai LI Da-ming LIU Kai-lou YU Xi-chu YE hui-cai HU hui-wen XU Xiao-lin WANG Sai-lian ZHOU Li-jun DUAN Ying-hua ZHANG Wen-ju National Engineering and Technology Research Center for Red Soil Improvement Jiangxi Institute of Red Soil Key Laboratory of Crop Nutrition and Fertilization Ministry of Agricultural/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

Soil organic carbon （SOC） is one of the main carbon reservoirs in the terrestrial ecosystem. It is important to study SOC dynamics and effects of organic carbon amendments in paddy fields because of their vest expansion in south China. A study was carried out to evaluate the relationship between the SOC content and organic carbon input under various organic amendments at a long-term fertilization experiment that was established on a red soil under a double rice cropping system in 1981. The treatments included non-fertilization （ck）, nitrogen-phosphorus-potassium fertilization in early rice only （NPK）, green manure （Astragalus sinicus L.） in early rice only （OM1）, high rate of green manure in early rice only （OM2）, combined green manure in early rice and farmyard manure in late rice （OM3）, combined green manure in early rice, farmyard manure in late rice and rice straw mulching in winter （OM4）, combined green manure in early rice and rice straw mulching in winter （OMS）. Our data showed that the SOC content was the highest under OM3 and OM4, followed by OM1, OM2 and OM5, then NPK fertilization, and the lowest under non-fertilization. However, our analyses in SOC stock indicated a significant difference between OM3 （33.9 t ha^-1） and OM4 （31.8 t ha^-1）, but no difference between NPK fertilization （27 t ha^-1） and nonfertilization （28.1 t ha^-1）. There was a significant linear increase in SOC over time for all treatments, and the slop of linear equation was greater in organic manure treatments （0.276-0.344 g kg-1 yr^-1） than in chemical fertilizer （0.216 g kg^-1 yr^-1） and no fertilizer （0.127 g kg^-1 yr^-1）.

关键词： long-term field experiment organic amendments soil organic carbon paddy soil derived from red earth

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青藏高原吉隆-鲁谷(Hi-Climb)层析成像与印藏碰撞的消减作用

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地球物理学报 2007年第5期50卷 1427-1436页

作者：钱辉姜枚 Chen Wangping john Nabelek Zhao Dapeng 赵磊王亚军中国地质科学院地质研究所国土资源部大陆动力学重点实验室 Dept. Geology Univ. of Illinois1310 W.Green St.UrbanaILUnited States 61801 College Ocean.Atm.Sci. Oregon State UniversityCorvallisORUnited States 97331-550 Geodynamics Research Center Ehime UniversityMatsuyama

利用中美合作Hi-Climb项目北段吉隆-鲁谷剖面的天然地震探测数据，拾取2004-2005年期间5级以上地震事件的P波与4级以上地震的Pn波震相的走时，通过多震相层析成像反演获得青藏高原腹地的地下500 km以上的P波速度扰动结构.结果表明雅江... 详细信息

利用中美合作Hi-Climb项目北段吉隆-鲁谷剖面的天然地震探测数据，拾取2004-2005年期间5级以上地震事件的P波与4级以上地震的Pn波震相的走时，通过多震相层析成像反演获得青藏高原腹地的地下500 km以上的P波速度扰动结构.结果表明雅江地区为北向倾斜的低速扰动，班公-怒江断裂下方存在向南俯冲并被印度板块俯冲挤压而回折的高速体，建立了印度板块在冈底斯地块下方拆沉并被雅江低速体穿越的构造样式.说明印度板块俯冲在到达班公-怒江缝合带之前已经开始消减，与拆沉位置对比发现，印度板块的前锋深部呈现多期多级次特征，并受到地幔热循环作用的影响.

关键词：层析成像青藏高原拆沉作用雅鲁藏布缝合带班公怒江缝合带

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