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EECP in the treatment of endothelial dysfunction： preventing progression of cardiovascular disease

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Journal of Geriatric Cardiology 2010年第2期7卷 79-87页

作者： john ck hui William E Lawson Gregory W Barsness Cardiology Division State University of New York Stony Brook New York USA Cardiovascular Disease and Internal Medicine Mayo Clinic College of Medicine Rochester Minn USA

Enhanced external counterpulsation Extemal counterpulsation （ECP） was originally conceived to be a circulatory assist device to promote blood flow to areas of the heart muscle that were lacking adequate blood supply due to obstruction of the coronary artery. During ECP the lower extremities are compressed to squeeze both arterial and venous blood back to the heart during diastole, increasing coronary perfusion pressure and right ventricular filling. The compression is released during systole,

关键词：心血管疾病功能障碍血管内皮体外预防治疗冠状动脉血液供应

Reaction Mechanism and Product Branching Ratios of OH+C2H3F Reaction:A Theoretical Study

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Chinese Journal of Chemical Physics 2020年第2期33卷 203-209,I0003页

作者： Chih-Hao Chin Tong Zhu john Zeng-hui Zhang School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062China Department of Chemistry New York UniversityNew York 10003United States of America

Ab initio CCSD(T)/CBS//B3LYP/6-311G(d,p)calculations of the potential energy surface for possible dissociation channels of HOC2H3F,as well as Rice-Ramsperger-Kassel-Marcus(RRKM)calculations of rate constants,were carried out,in order to predict statistical product branching ratios in dissociation of HOC2H3F at various internal *** most favorable reaction pathway leading to the major CH2CHO+HF products is as the following:OH+C2H3F→i2→TS14→i6→TS9→i3→TS3→CH2CHO+HF,where the rate-determining step is HF elimination from the CO bridging position via TS11,lying above the reactants by 3.8 kcal/*** CH2O+CH2F products can be formed by F atom migration from Cαto Cβposition via TS14,then H migration from O to Cαposition via TS16,and C-C breaking to form the products via TS5,which is 1.8 kcal/mol lower in energy than the reactants,and 4.0 kcal/mol lower than TS11.

关键词： Ab initio Potential energy surface Reaction mechanism Rice-Ramsperger-Kassel-Marcus Branching ratio

Twisting Sliding Mode Control of an Electrostatic MEMS Micromirror for a Laser Scanning System

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IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 1060-1067页

作者： hui Chen Zhendong Sun Weijie Sun john Tze Wei Yeow the School of Computer and Information Engineering Henan UniversityKaifeng 475000China the Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190 China the College of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China the Systems Design Engineering University of WaterlooWaterloo N2L3G1Canada IEEE

In this paper,we present a twisting control scheme with proportional-integral-derivative(PID)sliding surface for a two-axis electrostatic torsional micromirror,and the utilization of the proposed scheme in a laser scanning *** experimental results of set-point regulation verify that the proposed scheme provides enhanced transient response and positioning performance as compared to traditional sliding mode *** evaluate the tracking performance of the closed-loop system,triangular waves with different frequencies are used as desired *** the proposed scheme the experimental results verified that the closed-loop controlled micromirror follows the given triangular trajectories precisely.A micromirror-based laser scanning system is developed to obtain *** compared with open-loop control,the experimental results demonstrated that the proposed scheme is able to reduce the distortion of the raster scan,and improve the imaging performance in the presence of cross-coupling effect.

关键词： Electrostatic micromirror imaging microelectromechanical system(MEMS) twisting algorithm

Single-nucleus RNA and ATAC sequencing reveals the impact of chromatin accessibility on gene expression in Arabidopsis roots at the singlecell level

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Molecular Plant 2021年第3期14卷 372-383页

作者： Andrew Farmer Sandra Thibivilliers Kook hui Ryu john Schiefelbein Marc Libault National Center for Genome Resources Santa FeNM 87505USA Department of Agronomy and Horticulture Center for Plant Science InnovationUniversity of Nebraska-LincolnBeadle CenterLincolnNE 68503USA Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

Similar to other complex organisms,plants consist of diverse and specialized cell *** gain of unique biological functions of these different cell types is the consequence of the establishment of cell-typespecific transcriptional *** a necessary step in gaining a deeper understanding of the regulatory mechanisms controlling plant gene expression,we report the use of single-nucleus RNA sequencing(sNucRNA-seq)and single-nucleus assay for transposase accessible chromatin sequencing(sNucATACseq)technologies on Arabidopsis *** comparison of our single-nucleus transcriptomes to the published protoplast transcriptomes validated the use of nuclei as biological entities to establish plant cell-type-specific ***,our sNucRNA-seq results uncovered the transcriptomes of additional cell subtypes not identified by single-cell *** to our transcriptomic approach,the sNucATAC-seq approach led to the distribution of the Arabidopsis nuclei into distinct clusters,suggesting the differential accessibility of chromatin between groups of cells according to their *** reveal the impact of chromatin accessibility on gene expression,we integrated sNucRNA-seq and sNucATAC-seq data and demonstrated that cell-type-specific marker genes display cell-type-specific patterns of chromatin *** data suggest that the differential chromatin accessibility is a critical mechanism to regulate gene activity at the cell-type level.

关键词： single-cell RNA-seq single-nucleus ATAC-seq Arabidopsis root

Integral sliding mode based optimal composite nonlinear feedback control for a class of systems

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Control Theory and Technology 2014年第2期12卷 139-146页

作者： Zhou ZHENG Weijie SUN hui CHEN john T. W. YEOW College of Automation Science and Engineering South China University of Technology

This paper presents an optimization method of designing the integral sliding mode （ISM） based composite nonlinear feedback （CNF） controller for a class of low order linear systems with input saturation. The optimal CNF control is first designed as a nominal control to yield high tracking speed and low overshoot. The selection of all the tuning parameters for the CNF control law is turned into a minimization problem and solved automatically by particle swarm optimization （PSO） algorithm. Subsequently, the discontinuous control law is introduced to reject matched disturbances. Then, the optimal ISM-CNF control law is achieved as the sum of the optimal CNF control law and the discontinuous control law. The effectiveness of the optimal ISM-CNF controller is verified by comparing with a step by step designed one. High tracking performance is achieved by applying the optimal ISM-CNF controller to the tracking control of the micromirror.

关键词： Composite nonlinear feedback Integral sliding mode Input saturation PSO Micromirror

Application of Biochar on the runoff purification performance of porous asphalt pavement

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Transportation Safety and Environment 2021年第4期3卷 115-124页

作者： Jiawen Liu hui Li john Harvey Hengji Zhang Yu Tian Key Laboratory of Road and Traffic Engineering of the Ministry of Education College of Transportation EngineeringTongji University4800 Cao’an RdShanghai 201804China Pavement Research Center Department of Civil and Environmental EngineeringUniversity of CaliforniaDavisCA 95616USA Shanxi Yellow River Frontier Materials Research Institute Co. Ltd.Taiyuan 030000China

Biochar is currently applied in many low-impact development measures,such as biofilters and filter ***,its application in permeable pavement is *** to the wide range of raw material sources,biochar may also contain nutrients and heavy *** its leachate will cause contamination during application remains *** on the static leachate contamination test,this study first evaluated the leachate contamination risks of three types of biochar and porous asphalt mixture(PA)with three biochar *** the pavement infiltration test,the purification performance of PA with biochar fillers and filter layers was further *** results show that biochar contains nitrogen and phosphorus,and the leaching contamination of coconut shell is the most obvious;when the biochar is applied as a filler in PA,the leaching contamination decreases,while the pollutant purification performance is not obvious;when 3−5 mm rice straw biochar is used as a filter layer,the removal rate of total suspended solids can be 100%,but it is accompanied by more serious nitrogen and phosphorus leaching,and the greater the thickness,the more serious the degree of *** water cleaning can remove the phosphates contained in biochar,but have little effect on ***,before the application of biochar,cleaning measures should be taken to minimize its leaching contamination.

关键词： urban runoff biochar porous asphalt mixture filter layer purification performance

Key Crowdsourcing Technologies for Product Design and Development

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International Journal of Automation and computing 2019年第1期16卷 1-15页

作者： Xiao-Jing Niu Sheng-Feng Qin john Vines Rose Wong hui Lu School of Design Northumbria University Newcastle Business School Northumbria University

Traditionally, small and medium enterprises(SMEs) in manufacturing rely heavily on a skilled, technical and professional workforce to increase productivity and remain globally competitive. Crowdsourcing offers an opportunity for SMEs to get access to online communities who may provide requested services such as generating design ideas or problem solutions. However, there are some barriers preventing them from adopting crowdsourcing into their product design and development(PDD) practice. In this paper, we provide a literature review of key crowdsourcing technologies including crowdsourcing platforms and tools, crowdsourcing frameworks,and techniques in terms of open call generation, rewarding, crowd qualification for working, organization structure of crowds, solution evaluation, workflow and quality control and indicate the challenges of integrating crowdsourcing with a PDD process. We also explore the necessary techniques and tools to support the crowdsourcing PDD process. Finally, we propose some key guidelines for coping with the aforementioned challenges in the crowdsourcing PDD process.

关键词： Crowdsourcing technologies product design and development(PDD) communication information sharing design evaluation feedback

The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)in rat

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Acta Pharmaceutica Sinica B 2021年第4期11卷 1003-1009页

作者： Xiangjun Meng Zhi Zhang Jin Tong hui Sun john Paul Fawcett Jingkai Gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun 130012China Beijing Institute of Drug Metabolism Beijing 102209China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug *** the in vivo fate of PEG-PLA is required to evaluate its overall safety and promote the development of PEG-PLA-based nanocarrier drug delivery ***,acquiring such understanding is limited by the lack of a suitable analytical method for the bioassay of *** this study,the pharmacokinetics,biodistribution,metabolism and excretion of PEG-PLA were investigated in rat after intravenous *** results show that unchanged PEG-PLA is mainly distributed to spleen,liver,and kidney before being eliminated in urine over 48 h mainly(>80%)in the form of its PEG *** study provides a clear and comprehensive picture of the in vivo fate of PEG-PLA which we anticipate will facilitate the scientifc design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems and thereby enhance their clinical development.

关键词： Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid) Polymer Nanocarrier material Pharmacokinetics Biodistribution Metabolism Excretion Rat

A review of converting woody biomass waste into useful and eco-friendly road materials

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Transportation Safety and Environment 2022年第1期4卷 2-16页

作者： Xue Zhang hui Li john THarvey Ali AButt Ming Jia Jiawen Liu Key Laboratory of Road and Traffic Engineering of the Ministry of Education College of Transportation EngineeringTongji University4800 Cao’an RdJiading DistrictShanghai 201804China Univerisity of California Pavement Research Center Department of Civil and Environmental EngineeringUniversity of CaliforniaDavisDavisCalifornia95616-8500USA Urban Mobility Institute Tongji University4800 Cao’an RdJiading DistrictShanghai 201804China

Because of abundant reserves and renewable and environmentally friendly properties,the utilization of woody biomass waste in road engineering can alleviate the shortage of fossil fuels and carbon emissions so as to mitigate global climate change and achieve sustainable development of road *** paper synthesizes the state of the art about the strategies of applying five kinds of resources derived from waste woody biomass,including biochar,bio-oil,lignin,wood ash and nanocellulose to road *** on the characteristics analysis of the five materials,it can be concluded that biochar can comprehensively improve the road performance of asphalt and its mixtures,and has the potential of runoff purification;bio-oil can soften asphalt and improve its lowtemperature performance,but has negative effects on high-temperature performance;lignin increases the asphalt ageing resistance and can be used as a regenerant,and will improve the overall performance of asphalt mixtures if combined with other modifiers;wood ash can increase subgrade bearing capacity and bring significant environmental benefits;nanocellulose improves the strength of cement mortar,but there is a lack of research on its effects on performance of pavement materials and the interaction mechanism;the lifecycle environmental and economic assessment of woody biomass-modified road materials is not ***,prospects were also summarized to show the opportunities for future study,such as the establishment of a database for *** review provides useful insights for the utilization of woody biomass as road materials to achieve waste management and sustainable development.

关键词： Road material Biomass Biochar Bio-oil Lignin Nanocellulose