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Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

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Translational Neurodegeneration 2022年第1期11卷 129-147页

作者： yasmine y.Fathy Laura E.Jonkman john J.Bol Evelien Timmermans Allert J.Jonker Annemieke J.M.Rozemuller Wilma D.J.van de Berg Amsterdam UMC Department of Anatomy and NeurosciencesSection Clinical Neuroanatomy and BiobankingAmsterdam NeuroscienceVrije University AmsterdamO|2 Life Sciences buildingDe Boelelaan 11081081 HZ Amster-damNetherlands Amsterdam Neuroscience Program NeurodegenerationAmsterdamthe Netherlands Amsterdam UMC Department of Pathol-ogyAmsterdam NeuroscienceVrije University AmsterdamDe BoelelaanAmsterdamNetherlands Department of Neurology Erasmus Medical CenterPostbus 20403000 CA RotterdamNetherlands.

Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occurs early,preceeding and exceeding neuronal loss,and contributes to the spread of pathology,yet is poorly described outside the nigrostriatal *** insula,a cortical brain hub,was recently discovered to be highly vulnerable to pathology and plays a role in cognitive deficits in PD and *** aim of this study was to evaluate morphological features as well as burden of proteinopathy and axonal degeneration in the anterior insular sub-regions in PD,PD with dementia(PDD),and ***:α-Synuclein,phosphorylated(p-)tau,and amyloid-βpathology load were evaluated in the anterior insular(agranular and dysgranular)subregions of post-mortem human brains(n=27).Axonal loss was evaluated using modified Bielschowsky silver staining and quantified using *** damage was comprehensively studied using immunofluorescent multi-labelling and 3D confocal laser-scanning ***:Compared to PD and PDD,DLB showed significantly higherα-synuclein and p-tau pathology load,argyrophilic grains,and more severe axonal loss,particularly in the anterior agranular ***,the dysgranular insula showed a significantly higher load of amyloid-βpathology and its axonal density correlated with cognitive performance.p-Tau contributed most to axonal loss in the DLB group,was highest in the anterior agranular insula and significantly correlated with CDR global scores for *** and myelin showed degenerative changes including swellings,demyelination,and detachment of the axon-myelin ***:Our results highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies,leading to impaired axonal integrity in PD,PDD and DLB,disrupting their functional properties and potentially con

关键词： α-Synuclein Insular subregions Axonal length density Alzheimer’s disease pathology Neurofilament Myelin

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Backward Sled Pulling Load-Velocity Relationship in youth: A Backward-Forward Comparison

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Journal of Science in Sport and Exercise 2020年第4期2卷 330-335页

作者： Aaron Uthoff john Cronin AUT-Sports Performance Research Institute New Zealand School of Sport and RecreationAUT MillenniumAuckland University of Technology17 Antares PlRosedaleAuckland 0632New Zealand

Purpose To establish the load-velocity relationships during backward sled pulling and compare this to forward sled pulling and determine the reliability of running speeds and associated load-velocity regression slopes in youth *** Twenty-one boys(age,13.6±0.28 years old;height,1.72±0.09 m;mass,66.1±8.2 kg;maturity,0.57±0.72 years from peak height velocity)performed backward and forward resisted running on three ***-velocity relationships were established using an un-resisted sprint and resisted sled pull with loads of 25%-81%body mass(BM)in both directions,and the reliability of sprint times at each load and the load-velocity regression slopes were *** The load-velocity data was reliable across multiple testing occasions for backward(CV≤7.2%;ICC 0.67-0.91)and forward sled pulling(CV≤7.2%;ICC 0.66-0.91).From the regression lines(R2≥0.99;P≤0.01),it was observed that averaged loads across the sample of 31%,46% and 61% BM resulted in 27%,38% and 48% decrease in velocity during backward sled pulling and 23%,33% and 43% during forward sled *** backward and forward loads by∼13% and~15% BM respectively,reliably resulted in∼10% decreases in *** If contractile overload of the lower limbs is a focus of training then practitioners should preferentially use back-ward sled *** backward and forward sled pulling can be used in a similar manner regarding loading,though back-ward velocity is more sensitive to load and therefore overloading backward motion should be prescribed with this in mind.

关键词： Backward running Resisted sprinting youth Exercise prescription

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Cracking the Codes of Cortical Glial Progenitors:Evidence for the Common Lineage of Astrocytes and Oligodendrocytes

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Neuroscience Bulletin 2021年第4期37卷 437-439页

作者： Hao Huang john LRubenstein Mengsheng Qiu Nina Ireland Laboratory of Developmental Neurobiology Department of Psychiatry and Behavioral SciencesUniversity of CaliforniaSan FranciscoCA94158USA Institute of Life Sciences College of Life and Environmental SciencesCollege of Basic Medical ScienceHangzhou Normal UniversityHangzhou311121China

During the development of the central nervous system(CNS),neuroepithelial cells in the ventricular zone are multipotent stem cells that can generate neurons and macroglia(astrocytes or oligodendrocytes).It is generall... 详细信息

关键词： cytes ventricular progenitor

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Provenance of sediments from Barra del Tordo and Tesoro beaches, Tamaulipas State, northwestern Gulf of Mexico

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Journal of Palaeogeography 2021年第3期10卷 382-398页

作者： Mayla A.Ramos-Vazquez john S.Armstrong-Altrin Posgrado en Ciencias del Mar y Limnologpa Universidad Nacional Autonoma de MexicoCiudad UniversitariaCiudad de Mexico 04510Mexico Universidad Nacional Autonoma de Mexico Instituto de Ciencias del Mar y LimnologiaUnidad de Procesos Oceanicos y CosterosCiudad UniversitariaCiudad de Mexico 04510Mexico

The mineralogy, bulk sediment geochemical composition, and U–Pb ages of detrital zircons retrieved from the Barra del Tordo(Tordo) and Tesoro beach sediments in the northwestern Gulf of Mexico were analyzed to determine their provenance. The beach sediments are mainly composed of quartz, ilmenite, magnetite, titanite,zircon, and anorthite. The weathering proxies such as the Chemical Index of Alteration(CIA), Chemical Index of Weathering(CIW), and Plagioclase Index of Alteration(PIA), reveal a moderate-to-high intensity of weathering in the source area. The chondrite-normalized rare earth element(REE) patterns are similar to felsic igneous rocks, with large negative europium anomaly(Eu/Eu^(*)= ~ 0.47–0.80 and ~ 0.57–0.67 in the Tordo and Tesoro beach sediments,respectively).Three major zircon U–Pb age groups are identified in the Tordo and Tesoro beach sediments, i.e., Proterozoic(~2039–595 Ma), Mesozoic(~ 244–70.3 Ma), and Cenozoic(~ 65.9–1.2 Ma). The differences of the zircon age spectrum between the Tordo and Tesoro beach sediments are not significant. The comparison of zircon U–Pb ages in this study with ages of potential source terranes suggests that the Mesozoic and Cenozoic zircons of the studied Tordo and Tesoro beach sediments were derived from the Eastern Alkaline Province(EAP) and Mesa Central Province(MCP). Similarly, the likely sources for the Proterozoic zircons were the Sierra Madre Oriental(SMOr) and Oaxaquia in the northwestern Gulf of Mexico. The results of this study further indicate that the sediments delivered to the beaches by rivers and redistributed by longshore currents were crucial in determining the sediment provenance.

关键词： Geochemistry Sedimentary provenance Zircon U–Pb Beach sediment Rare earth elements Mexico

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Peroxisome proliferator-activated receptor γ ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor

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中国病理生理杂志 2012年第11期 2060-2060页

作者： Man Lung FUNG john y-J SHyy Department of Physiology Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Cardiovascular Research Center Xi'an Jiaotong UniversityXi'an 710061China

AIM:An elevated plasma level of 5-hydroxytryptamine(5-HT)and/or upregulation of 5-HT receptor signaling are implicated in vascular contraction and remodeling in pulmonary arterial hypertension(PAH).Recently,peroxisome... 详细信息

关键词： ameliorates pulmonary arterial hypertension by inhibiting 5-HT PPAR Peroxisome proliferator-activated receptor receptor

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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning yeh john y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Py(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Py 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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Approximation of partially smooth functions

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Science China Mathematics 2008年第4期51卷 553-561页

作者： john Erik FORN/ESS Erlend Fornaess WOLD Mathematics Department The University of Michigan Mathematisches Institut Universit■t Bern

In this paper we discuss approximation of partially smooth functions by smooth functions. This problem arises naturally in the study of laminated currents.

关键词： approximation currents test functions 57R30 32U40

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Identification of speckle-type POZ protein somatic mutations in African American prostate cancer

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Asian Journal of Andrology 2014年第6期16卷 829-832页

作者： Eric Buckles Chiping Qian Andrew Tadros Sumana Majumdar Jennifer Cvitanovic Jovanny Zabaleta john Estrada john Wilson Wanguo Liu Department of Biology School of Science Technology Engineering and Mathematics Dillard University New Orleans LA USA New Orleans LA USA Department of Genetics Louisiana State University Health Sciences Center New Orleans LA USA Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA USA Biospecimen Core Laboratory Louisiana Cancer Research Consortium New Orleans LA USA Department of Pediatrics Louisiana State University Health Sciences Center New Orleans LA USA.

The speckle-type POZ protein （SPOP） is a tumor suppressor in prostate cancer （PCa）. SPOP somatic mutations have been reported in up to 15% of PCa of those of European descent. However, the genetic roles of SPOP in African American （AA）-PCa are currently unknown. We sequenced the SPOP gene to identify somatic mutations in 49 AA prostate tumors and identified three missense mutations （p.y87C, p.F102S, and p.G111E） in five AA prostate tumors （10%） and one synonymous variant （p.11061） in one tumor. Intriguingly, all of mutations and variants clustered in exon six, and all of the mutations altered conserved amino acids. Moreover, two mutations （p.F102S and p.G111E） have only been identified in AA-PCa to date. Quantitative real-time polymerase chain reaction analysis showed a lower level of SPOP expression in tumors carrying SPOP mutations than their matched normal prostate tissues. In addition, SPOP mutations and novel variants were detected in 5 of 27 aggressive PCa and one of 22 less aggressive PCa （P 〈 0.05）. Further studies with increased sample size are needed to validate the clinicopathological significance of these SPOP mutations in AA-PCa.

关键词： African American mutation analysis prostate cancer speckle-type POZ protein

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A FIXED POINT APPROACH TO THE STABILITy OF A GENERAL MIXED ADDITIVE-CUBIC EQUATION ON BANACH MODULES

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Acta Mathematica Scientia 2012年第3期32卷 866-892页

作者：许天周 Rassias john Michael 许婉欣 School of Mathematics Beijing Institute of Technology Pedagogical Department E.E. Section of Mathematics and InformaticsNational and Capodistrian University of Athens4Agamemnonos Str.Aghia ParaskeviAthens 15342Greece School of Communication and Information Engineering University of Electronic Science and Technology of China Department of Electrical and Computer Engineering College of EngineeringUniversity of KentuckyLexington 40506USA

Using a fixed-point method, we establish the generalized Hyers-Ulam stability of a general mixed additive-cubic equation： f（kx ＋ y）＋ f（kx - y） = kf（x ＋ y）＋ kf（x - y）＋ 2f（kx） - 2kf（x） in Banach mod... 详细信息

关键词： Banach module stability additive function cubic function unital Banach algebra generalized metric space fixed-point JMRassias (or JMR) mixed product-sum of powers of norms

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Novel method for the identification of the maximum solid loading suitable for optimal extrusion of ceramic pastes

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Journal of Advanced Ceramics 2014年第1期3卷 7-16页

作者： Andrea AZZOLINI Vincenzo M.SGLAVO john A.DOWNS Department of Industrial Engineering Universitàdi TrentoVia Mesiano 7738123TrentoItaly

Gadolinia-doped ceria ceramic pastes were formulated with different solid loadings and extruded using lab-scale *** force to maintain a constant ram speed of 10 mm/min was *** radial shrinkage after drying was proportional to the solid loading and this allowed the determination of the maximum solid loading by an extrapolation *** order to obtain the apparent viscosity of the pastes,a novel approach based on the analysis of the slope of the extrusion pressure plot versus distance covered by the ram,was formulated for the direct determination of the shear stress upon *** agreement of the determined maximum solid loading with values calculated by two existing models confirmed that the proposed approach was an alternative and reliable method to identify the upper limit of the solid loading range for the formulation of extrudable ceramic pastes.

关键词： ceramic extrusion maximum solid loading drying shrinkage rheology

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