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Hist.rically significant.event. in t.e discovery of RANK/RANKL/OPG

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世界骨科杂志：英文版 2013年第4期4卷 186-197页

作者： t.john Mart.n Depart.ent.of Medicine and St.Vincent.s Inst.t.t. of Medical Research University of MelbourneFitzroy 3065 Victoria Australia

Aft.r it.was suggest.d 30 years ago t.at.t.e ost.oblast.lineage cont.olled t.e format.on of ost.oclast., met.ods were developed t.at.est.blished t.is t. be t.e case, but.t.e molecular cont.ols were elusive. Over more t.an a decade much evidence was obt.ined for signaling mechanisms t.at.regulat.d t.e product.on of a membrane- bound regulat.r of ost.oclast.genesis, in t.e course of which int.rcellular communicat.on in bone was revealed in it. complexit.. t.e discovery of regulat.on by t.mor necrosis fact.r ligand and recept.r families was made in t.e last.few years of t.e t.ent.et. cent.ry, leading since t.en t. a new physiology of bone, and t. excit.ng drug development.

关键词： Recept.r act.vat.r of nuclear fact.rκB ligand Ost.oprot.gerin Recept.r act.vat.r of nuclear fact.rκB Ost.oclast. Bone biology

Philippine ret.noblast.ma init.at.ve mult.-eye cent.r st.dy 2010-2020

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2024年第1期17卷 144-156页

作者： Roland Joseph D.t.n Gary john V.Mercado Pat.icia E.Cabrera Paulit. Pamela P.Ast.dillo Rolando Enrique D.Domingo Josept.Mari S.Poblet. Charmaine Grace M.Cabebe Adriel Vincent.R.t. Melissa Anne S.Gonzales Jocelyn G.Sy Belt.an Alexis A.Aclan Jayson t.So Fat.ma G.Regala Kimberley Amanda K.Comia Josemaria M.Cast.o Mara August.ne S.Galang Aldous Dominic C.Cabanlas Benedict. Juan E.Aguilar Gabrielle S.Evangelist. Jo Michael Maniwan Andrei P.Mart.n Calvin Y.Mart.nez john Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apost.l Beat.iz M.Priet. Depart.ent.of Opht.almology and Visual Sciences Philippine General HospitalManila 1000Philippines Depart.ent.of Opht.almology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Depart.ent.of Opht.almology Manila Doctors HospitalManila 1000Philippines Depart.ent.of Opht.almology Rizal Medical CenterPasig City 1600Philippines Depart.ent.of Opht.almology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Depart.ent.of Opht.almology Southern Philippines Medical CenterDavao City 8000Philippines Depart.ent.of Opht.almology East Avenue Medical CenterQuezon City 1100Philippines Depart.ent.of Opht.almology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Depart.ent.of Opht.almology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Cent.r Legazpi City 4500Philippines Depart.ent.of Opht.almology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:t. provide a comprehensive and more represent.t.ve nat.onal dat. on t.e disease,especially on t.eat.ent.opt.ons and out.omes,and t. det.rmine access of ret.noblast.ma pat.ent. from Luzon,Visayas and Mindanao t. eye care,and det.rmine if access is associat.d wit. delay in consult.t.on,st.ging and ***:Cohort.st.dy of ret.noblast.ma pat.ent. seen in eleven inst.t.t.ons locat.d in t.e t.ree major areas of t.e Philippines namely Luzon,Vizayas and Mindanao from ***:t.t.lly 636 pat.ent.,involving 821 eyes,were ***(57%)were from Luzon and were seen in inst.t.t.ons in Luzon(72%).Annually,58±10 new cases were seen wit. 71%having unilat.ral *** delay of consult.t.on remained long at.9(3,17)mo,longest.in pat.ent. wit. unilat.ral disease(Pt.ose from t.e Visayas(Pt.e Int.rnat.onal Ret.noblast.ma St.ging Syst.m,only 35%of pat.ent. had St.ge 1 while 47%already had ext.aocular *** was t.e most.common t.eat.ent.received by 484 pat.ent. while int.avenous chemot.erapy was received by *** were 250(39%)pat.ent. alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)wit. no ***:t.is st.dy present. t.e largest.cohort.of ret.noblast.ma pat.ent. in t.e Philippines in t.rms of pat.ent.’and part.cipat.ng inst.t.t.ons’number and geographical locat.on and t.pe of inst.t.t.on(privat. and public).It.also present. more comprehensive dat. on t.e t.eat.ent. used and out.omes(survival,globe salvage,and vision ret.nt.on rat.s).Delay in consult.t.on was st.ll long among pat.ent. leading t. advanced disease st.ge and lower survival *** increasing capacit. t. diagnose and manage ret.noblast.ma in t.e count.y,t.e delay of consult.t.on remains long primarily due t. accessibilit. issues t. eye care inst.t.t.ons especially in t.e Visayas and financial *** delay was st.ll significant.t.at.overall survival rat. remain low.

关键词： ret.noblast.ma Philippines clinical profile

Boundary Element.: t.eory and Applicat.ons 1st ed.

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t.ends in out.at.ent.breast.cancer surgery among Medicare fee-for-service pat.ent. in t.e Unit.d St.t.s from 1993 t. 2002

2002年

作者： Kat.ikadelis, john t.

ISBN: (数字)9780080528243

ISBN: (纸本)9780080441078

t.e aut.or's ambit.on for t.is publicat.on was t. make BEM accessible t. t.e st.dent.as well as t. t.e professional engineer. For t.is reason, his maint.sk was t. organize and present.t.e mat.rial in such a way so t.at.t.e book becomes "user-friendly" and easy t. comprehend, t.king int. account.only t.e mat.emat.cs and mechanics t. which st.dent. have been exposed during t.eir undergraduat. st.dies. t.is effort.led t. an innovat.ve, in many aspect., way of present.ngBEM, including t.e derivat.on of fundament.l solut.ons, t.e int.gral represent.t.on of t.e solut.ons and t.e boundary int.gral equat.ons for various governing different.alequat.ons in a simple way minimizing a recourse t. mat.emat.cs wit. which t.e st.dent.is not.familiar. t.e indicial and t.nsorial not.t.ons, t.ough t.ey facilit.t. t.e aut.or's work and allow t. borrow ready t. use expressions from t.e lit.rat.re, have been avoided in t.e present.book. Nevert.eless, all t.e necessary preliminary mat.emat.cal concept. have been included in order t. make t.e book complet. and *** t.e book, every concept.is followed by example problems, which have been worked out.in det.il and wit. all t.e necessary clarificat.ons. Furt.ermore, each chapt.r of t.e book is enriched wit. problems-t.-solve. t.ese problems serve a t.reefold purpose.

关键词： Boundary element.met.ods.

来源：畅想之星图书光盘版（南... 评论

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Chinese Journal of Cancer 2011年第3期30卷 197-203页

作者： john Bian1 Michael t. Halpern At.ant. Vet.rans Affairs Medical Cent.r Rt. Int.rnat.onal

t.e pract.ce of out.at.ent.breast.cancer surgery has been cont.oversial in t.e Unit.d St.t.s. t.is st.dy aimed t. updat. t.me t.ends and geographic variat.on in out.at.ent.breast.cancer surgery among elderly Medicare fee-for-service women in t.e Unit.d St.t.s. Using t.e 1993-2002 linked Surveillance, Epidemiology and End Result. (SEER)-Medicare claims dat. and t.e Area Resource Files, we ident.fied 2 st.dy samples, including t.e women whose breast.cancers were t.e first.ever-diagnosed cancer at.age 65 years or older from 9 regions cont.nuously covered by t.e SEER regist.ies since 1993. t.e first.sample included t.e women receiving unilat.ral mast.ct.my for st.ge 0-IV cancer; t.e second included t.e women receiving t.e breast.conserving surgery wit. lymph node dissect.on (BCS/LND) for st.ge 0-II cancer. t.e proport.ons of pat.ent. receiving out.at.ent.surgery increased from 3.2% t. 19.4% for mast.ct.my and from 48.9% t. 77.8% for BCS/LND from 1993 t. 2002. We observed subst.nt.al geographic variat.on in t.e average proport.on of t.e pat.ent. receiving out.at.ent.surgery in t.e st.died areas across t.e 10-year period, ranging from 3.9% in Connect.cut.t. 27.2% in Ut.h for mast.ct.my and from 54.7% in Hawaii t. 78.1% in Seat.le, Washingt.n, for BCS/LND. As t.e popularit. of out.at.ent.breast.cancer surgery cont.nues t. grow, more evidence-based analyses relat.d t. qualit. and out.omes of out.at.ent.breast.cancer surgery among various populat.ons are needed in order t. facilit.t. t.e public debat.s about.st.t. and federal mandat.d healt. benefit.legislat.ons.

关键词：医疗费用有偿服务乳腺癌手术门诊患者美国 SEER

Comparing t.e Soil Conservat.on Service model wit. new machine learning algorit.ms for predict.ng cumulat.ve infilt.at.on in semi-arid regions

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Pedosphere 2022年第5期32卷 718-732页

作者： Khabat.KHOSRAVI Phuong t.t.NGO Rahim BARZEGAR john QUILt. Mohammad t.AALAMI Dieu t.BUI Depart.ent.of Wat.rshed Management.Engineering Ferdowsi University of MashhadMashhad 93(Iran) Depart.ent.of Eart. and Environment Florida International UniversityMiami 33199(USA) Inst.t.t. of Research and Development Duy Tan UniversityDa Nang 550000(Vietnam) Depart.ent.of Bioresource Engineering McGill UniversitySte Anne de Bellevue QC H9X(Canada) Facult. of Civil Engineering University of TabrizTabriz 51(Iran) Depart.ent.of Civil and Environment.l Engineering University of WaterlooWaterloo N2L 3G1(Canada) Depart.ent.of Business and It University of South-Eastern NorwayNotodden 3603(Norway)

Wat.r infilt.at.on int. soil is an import.nt.process in hydrologic cycle;however,it. measurement.is difficult.t.me-consuming and *** and physical models have been developed t. predict.cumulat.ve infilt.at.on(CI),but.are oft.n *** t.is st.dy,several novel st.ndalone machine learning algorit.ms(M5Prime(M5P),decision st.mp(DS),and sequent.al minimal opt.mizat.on(SMO))and hybrid algorit.ms based on addit.ve regression(AR)(i.e.,AR-M5P,AR-DS,and AR-SMO)and weight.d inst.nce handler wrapper(WIHW)(i.e.,WIHW-M5P,WIHW-DS,and WIHW-SMO)were developed for CI *** Soil Conservat.on Service(SCS)model developed by t.e Unit.d St.t.s Depart.ent.of Agricult.re(USDA),one of t.e most.popular empirical models t. predict.CI,was considered as a ***,154 measurement. of CI(explanat.ry/input.variables)were t.ken from 16 sit.s in a semi-arid region of Iran(Illam and Lorest.n provinces).Six input.variable combinat.ons were considered based on Pearson correlat.ons bet.een candidat. model input.(t.me of measuring and soil bulk densit.,moist.re cont.nt.and sand,clay,and silt.percent.ges)and *** dat.set.was divided int. t.o subgroups at.random:70%of t.e dat. were used for model building(t.aining dat.set.and t.e remaining 30%were used for model validat.on(t.st.ng dat.set..t.e various models were evaluat.d using different.graphical approaches(bar chart.,scat.er plot.,violin plot.,and t.ylor diagrams)and quant.t.t.ve measures(root.mean square error(RMSE),mean absolut. error(MAE),Nash-Sut.liffe efficiency(NSE),and percent.bias(PBIAS)).t.me of measuring had t.e highest.correlat.on wit. CI in t.e st.dy *** best.input.combinat.ons were different.for different.*** result. showed t.at.all hybrid algorit.ms enhanced t.e CI predict.on accuracy compared t. t.e st.ndalone *** AR-M5P model provided t.e most.accurat. CI predict.ons(RMSE=0.75 cm,MAE=0.59 cm,NSE=0.98),while t.e SCS model had t.e lowest.performance(RMSE=4.77 cm,MAE=2.64 cm,NSE=

关键词： addit.ve regression hybrid algorit.ms empirical model soil wat.r infilt.at.on weight.d inst.nces handler wrapper

Endoscopic ult.asound-guided port.l pressure gradient.ident.fies pat.ent. wit. previously undiagnosed clinically significant.port.l hypert.nsion

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Port.l Hypert.nsion & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scot. F.D.Edelson john G.Quiles Cyrus V.Edelson Eric M.Mont.iny Christ.an L.Horn john P.Magulick Don C.Rockey Depart.ent.of Gast.oent.rology and Hepat.logy Brooke Army Medical CenterFort Sam HoustonTexasUSA Depart.ent.of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Depart.ent.of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA john H.St.oger Jr.Hospit.l of Cook Count. ChicagoIllinoisUSA Digest.ve Disease Research Cent.r Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Port.l hypert.nsion(PH)is a complicat.on of cirrhosis t.at.leads t. hepat.c *** t.e port.l pressure gradient.PPG)provides valuable informat.on for disease assessment.st.ging,and *** t.is st.dy,we aimed t. report.t.e ut.lizat.on of endoscopic ult.asound(EUS)-guided PPG(EUS-PPG)measurement. in a real-world ***:t.is ret.ospect.ve analysis included pat.ent. at.a t.rt.ary care cent.r who underwent.EUS-PPG bet.een February 2021 and May *** most.common indicat.on was t. est.blish or exclude t.e diagnosis of cirrhosis,followed by an assessment.of surgical risk in t.e set.ing of suspect.d *** demographic and clinical dat. were collect.d,and st.t.st.cal analysis was performed using t.e St.dent.s t.***:Eight.en pat.ent. underwent.*** success was achieved in 17 of t.e 18 *** complicat.ons were *** mean scores of Child-Pugh,Model for End-St.ge Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** t.e 18 pat.ent.,t.o present.d wit. esophageal varices and six wit. port.l hypert.nsive *** mean PPG was 5.8±4.5 mmHg,and five pat.ent. exhibit.d clinically significant.PH(CSPH).Of t.e 18 pat.ent.,15 underwent.concurrent.EUS-liver biopsy,which was 100%successful and provided diagnost.c hist.logy for all *** PPG dat. led t. changes in t.e clinical management.of 17 ***:EUS-PPG is safe and t.chnically *** Child-Pugh score did not.correlat. well wit. t.e presence of CSPH;however,PPG measurement. result.d in changes in t.e management.of almost.all *** st.dies correlat.ng EUS-PPG wit. ot.er assessment. of liver diseases are required.

关键词： EUS port.l hypert.nsion port.l pressure gradient

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乐活健康

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 10-11,39,40页

作者： Pat.ick McCreless john Meyer 不详

03一名医生从自己的中风体验中学到的三件事或许能拯救你的生命当朱利安·金医生正在示范一个小型外科手术时,他走路开始出现异常。他自己没有注意到,但手术室里有人注意到了“当时我脑出血了……和高血压有关,”金医生说,“我甚至不知... 详细信息

03一名医生从自己的中风体验中学到的三件事或许能拯救你的生命当朱利安·金医生正在示范一个小型外科手术时,他走路开始出现异常。他自己没有注意到,但手术室里有人注意到了“当时我脑出血了……和高血压有关,”金医生说,“我甚至不知道我有高血压。”

关键词：外科手术高血压手术室脑出血医生朱利安

Superior ant.body and membrane prot.in‑specific t.cell responses t. CoronaVac by int.adermal versus int.amuscular rout.s in adolescent.

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World Journal of Pediat.ics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet.Chung t.un Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.t.ang Sara Chaot.ai t.z Chun Kwan john K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.t.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.t.m Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei t. Yu Lung Lau Depart.ent.of Paediat.ics and Adolescent.Medicine The University of Hong KongHong KongChina School of Public Healt. The University of Hong KongHong KongChina HKU‑Past.ur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Inst.t.t. for Bioresources and Biot.chnology Ishikawa Prefectural UniversityNonoichiJapan Depart.ent.of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Cent.r for Immunology and Infect.on C2i Hong KongChina

Background Opt.mising t.e immunogenicit. of COVID-19 vaccines t. improve t.eir prot.ct.on against.disease is *** dosing by int.adermal(ID)administ.at.on has been shown t. be equally immunogenic as int.amuscular(IM)administ.at.on for several vaccines,but.t.e immunogenicit. of ID inact.vat.d whole severe acut. respirat.ry syndrome coronavirus 2(SARS-CoV-2)at.t.e full dose is *** st.dy(NCt.4800133)invest.gat.d t.e superiorit. of ant.body and t.cell responses of full-dose CoronaVac by ID over IM administ.at.on in *** Part.cipant. aged 11–17 years received t.o doses of IM or ID vaccine,followed by t.e 3rd dose 13–42 days *** and cellular immunogenicit. out.omes were measured post.dose 2(IM-CC versus ID-CC)and post.dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administ.red t. 173 and 104 adolescent.,*** Spike prot.in(S)immunoglobulin G(IgG),S-recept.r-binding domain(RBD)IgG,S IgG Fcγrecept.r IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid prot.in(N),and membrane prot.in(M)pept.de pool]-specific int.rleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled t.e superior and non-inferior crit.ria for ID-CC compared t. IM-CC,whereas IgG avidit. was *** ID-CCC,S-RBD IgG,surrogat. virus neut.alisat.on t.st.90%plaque reduct.on neut.alisat.on t.t.e(PRNt.0),PRNt.0,S IgG avidit.,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),int.rferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior t. *** est.mat.d vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups report.d more local,mild adverse *** t.is is t.e first.st.dy t. demonst.at. superior ant.body and M-specific t.cell responses by ID inact.vat.d SARSCoV-2 vaccinat.on and serves as t.e basis for fut.re research t. improve t.e

关键词： CoronaVac Coronavirus disease 2019 Immunit. Int.adermal Vaccine

A Review on t.e Management.of Biliary Complicat.ons aft.r Ort.ot.pic Liver t.ansplant.t.on

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Journal of Clinical and t.anslat.onal Hepat.logy 2019年第1期7卷 61-71页

作者： Brian t.Moy john W.Birk Depart.ent.of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Ort.ot.pic liver t.ansplant.t.on is t.e definit.ve t.eat.ent.for end-st.ge liver disease and hepat.cellular *** complicat.ons are t.e most.common complicat.ons seen aft.r t.ansplant.t.on,wit. an incidence of 10-25%.t.ese complicat.ons are seen bot. in deceased donor liver t.ansplant.and living donor liver *** t.eat.ent.of biliary complicat.ons wit. endoscopic ret.ograde cholangiopancreat.graphy(commonly known as ERCP)has become a mainst.y in t.e management.*** success rat. has reached 80%in an experienced endoscopist.s *** unsuccessful wit. ERCP,percut.neous t.anshepat.c cholangiography can be an alt.rnat.ve *** recognit.on and t.eat.ent.has been shown t. improve morbidit. and mort.lit. in post.liver t.ansplant.*** focus of t.is review will be a learned discussion on t.e t.pes,diagnosis,and t.eat.ent.of biliary complicat.ons post.ort.ot.pic liver t.ansplant.t.on.

关键词： Biliary t.act.complicat.on Ort.ot.opic liver t.ansplant.t.on St.ict.re Bile leak