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Variability of waste copper slag concrete and its effect on the seismic safety of reinforced concrete building: A case study

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Frontiers of structural and Civil Engineering 2022年第1期16卷 117-130页

作者： swetapadma PANDA Nikhil P.ZADE Pradip sARKAR Robin davis Department of Civil Engineering Institute of Technical Education and ResearchOdisha 751030India Department of Civil Engineering National Institute of Technology RourkelaOdisha 769008India Department of Civil Engineering National Institute of Technology CalicutKerala 673601India

Proven research output on the behavior of structures made of waste copper slag concrete can improve its utilization in the construction industry and thereby help to develop a sustainable built *** numerous studies on waste copper slag concrete can be found in the published literature,no research has focused on the structural application of this type of *** particular,the variability in the strength properties of waste copper slag concrete,which is required for various structural applications,such as limit state design formulation,reliability-based structural analysis,etc.,has so far not attracted the attention of *** paper quantifies the uncertainty associated with the compressive-,flexural-and split tensile strength of hardened concrete with different dosages of waste copper slag as fine ***-fit probability distribution models are proposed based on statistical analyses of strength data generated from laboratory *** addition,the paper presents a reliability-based seismic risk assessment of a typical waste copper slag incorporated reinforced concrete framed building,considering the proposed distribution *** results show that waste copper slag can be safely used for seismic resistant structures as it results in an identical probability of failure and dispersion in the drift demand when compared with a conventional concrete building made of natural sand.

关键词： waste copper slag quantification of variability goodness-of-fit test seismic risk assessment PsDM

Protein-protein complexation in bioluminescence

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Protein & Cell 2011年第12期2卷 957-972页

作者： Maxim s.Titushin Yingang Feng john Lee Eugene s.Vysotski Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Department of Biochemistry and Molecular Biology University of GeorgiaAthensGA 30602USA Laboratory of Photobiology Institute of Biophysics Russian Academy of SciencesSiberian BranchKrasnoyarsk 660036Russia

In this review we summarize the progress made towards understanding the role of protein-protein interactions in the function of various bioluminescence systems of marine organisms,including bacteria,jellyfish and soft corals,with particular focus on methodology used to detect and characterize these *** some bioluminescence systems,protein-protein interactions involve an“accessory protein”whereby a stored substrate is efficiently delivered to the bioluminescent enzyme *** types of complexation mediate energy transfer to an“antenna protein”altering the color and quantum yield of a bioluminescence *** structures of the complexes reveal an important role of electrostatic forces in governing the corresponding weak interactions and define the nature of the interaction *** most reliable structural model is available for the protein-protein complex of the Ca2+-regulated photoprotein clytin and green-fluorescent protein(GFP)from the jellyfish Clytia gregaria,solved by means of Xray crystallography,NMR mapping and molecular *** provides an example of the potential strategies in studying the transient complexes involved in *** is emphasized that structural studies such as these can provide valuable insight into the detailed mechanism of bioluminescence.

关键词： green-fluorescent protein(GFP) photoprotein luciferase lumazine protein Förster resonance energy transfer(FRET) docking

Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer

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World Journal of Gastroenterology 2012年第36期18卷 5021-5026页

作者： sφren R Rafaelsen Chris Vagn-Hansen Torben sφrensen john Plφen Anders Jakobsen Department of Radiology DCCG SouthInstitute of Regional Health Services ResearchUniversity of Southern DenmarkVejle HospitalKabbeltoft 257100 VejleDenmark Department of Oncology DCCG SouthInstitute of Regional Health Services ResearchUniversity of Southern DenmarkVejle HospitalKabbeltoft 257100 VejleDenmark

AIM： To evaluate the agreement between transrectal ultrasound （TRUs） and magnetic resonance imaging （MRI） in classification of ≥ T3 rectal tumors. METHODs： From January 2010 to January 2012, 86 consecutive patients with ≥ T3 tumors were included in this study. The mean age of the patients was 66.4 years （range： 26-91 years）. The tumors were all ≥ T3 on TRUs. The sub-classification was defined by the penetration of the rectal wall： a： 0 to 1 mm; b： 1-5 mm, c： 6-15; d：〉 15 mm. Early tumors as ab （≤ 5 ram） and advanced tumors as cd （〉 5 mm）. All patients underwent TRUs using a 6.5 MHz transrectal transducer. The MRI was performed with a 1.5 T Phil- ips unit. The TRUs findings were blinded to the radiol- ogist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread REsULTs： TRUs found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor, where- as MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors. No patients with tumors classified as advanced by TRUs were found to be early on MRI. The kappa value in classifying early versus advanced T3 rectal tumors was 0.93 （95% CI： 0.85-1.00）. We found a kappa value of 0.74 （95% CI： 0.63-0.86） for the total sub-classification between the two methods. The mean maximal tumor outgrowth measured by TRUs, 5.5 mm ± 5.63 mm and on MRI, 6.3 mm ±6.18 mm, P = 0.004. In 19 of the 86 patients the following CT scan or surgery revealed distant metastases; of the 51 patients in the ultrasound ab group three （5.9%） had metastases, whereas 16 （45.7%） of 35 in the cd group harbored distant metastases, P = 0.00002. The odds ratio of having distant metastases in the ultra- sound cd group compared to the ab group was 13.5 （95% CI： 3.5-51.6）, P = 0.00002. The mean maximal ultrasound measured outgrowth was 4.3 mm （95% CI： 3.2-5.5 mm） in patients without distant metastases, while the mean maximal outgrowth was 9.5 mm （95% CI： 6.2-12.8 ram） in the patients with metastases, P = 0

关键词： Ultrasound Magnetic resonance imaging Rectal cancer Tumor staging Metastases

Appendiceal mucocoeles and pseudomyxoma peritonei

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World Journal of Gastroenterology 2007年第16期13卷 2381-2384页

作者： Anupam Dixit john HP Robertson satvinder s Mudan Charles Akle Department Third Floor the London Clinic London W1G 6BW United Kingdom

Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions.

关键词： Appendix Mucocele Pseudomyxoma peritonei surgical treatment

Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 1-14页

作者： Minoru Koi stephanie s Tseng-Rogenski john M Carethers Department of Internal Medicine and Comprehensive Cancer Center University of MichiganAnn ArborMI 48109-5368United States

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MsI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMsI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MsIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAsT) as a result of functional somatic inactivation of the DNA MMR protein MsH3 via a nuclear-to-cytosolic displacement. The trigger for MsH3 displacement appears to be inflammation and/or oxidative stress, and unlike MsI-H CRC patients, patients with MsI-L/EMAsT CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MsH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system.

关键词： Microsatellite instability Microsatellite stable Elevated microsatellite alterations at selected tetranucleotide repeats Colorectal cancer Mismatch repair Inflammation MsH3

DNA origami mediated electrically connected metal–semiconductor junctions

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Nano Research 2020年第5期13卷 1419-1426页

作者： Basu R.Aryal Dulashani R.Ranasinghe Tyler R.Westover Diana G.Calvopia Robert C.davis john N.Harb Adam T.Woolley Department of Chemistry and Biochemistry Brigham Young UniversityProvoUT 84602USA Department of Chemical Engineering Brigham Young UniversityProvoUT 84602USA Department of Physics and Astronomy Brigham Young UniversityProvoUT 84602USA

DNA-based nanofabrication of inorganic nanostructures has potential application in electronics,catalysis,and *** DNA metallization has generated conductive DNA-assembled nanostructures;however,the use of semiconductors and the development of well-connected nanoscale metal-semiconductor junctions on DNA nanostructures are still at an early ***,we report the first fabrication of multiple electrically connected metal-semiconductor junctions on individual DNA origami by location-specific binding of gold and tellurium *** attachment to DNA origami was via DNA hybridization for Au and by electrostatic interaction for *** gold plating was used to create nanoscale metal-semiconductor interfaces by filling the gaps between Au and Te ***-point electrical characterization indicated that the Au-Te-Au junctions were electrically connected,with current-voltage properties consistent with a schottky ***-based nanofabrication of metal-semiconductor junctions opens up potential opportunities in nanoelectronics,demonstrating the power of this bottom-up approach.

关键词： current-voltage measurement DNA nanofabrication electroless plating gold nanorods nanoelectronics tellurium nanorods

Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 772-798页

作者： Alexa R Weingarden samuel J s Rubin john Gubatan Division of Gastroenterology and Hepatology Department of MedicineStanford UniversityRedwood CityCA 94063United States stanford University school of Medicine Stanford UniversityRedwood CityCA 94063United States

Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer *** re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)***,these therapies can also induce autoimmune-like side effects in healthy tissue across the *** of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI *** also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology.

关键词： Immune checkpoint inhibitors Cytotoxic T-lymphocyte antigen 4 Programmed cell death protein-1 Inflammatory bowel disease Gastrointestinal cancer

Can an 8^(th) grade student learn point of care ultrasound?

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World Journal of Emergency Medicine 2019年第2期10卷 109-113页

作者： Alexander s.Kwon shadi Lahham john C.Fox sage Hill school Department of Emergency Medicine UC Irvine Medical Center UC Irvine School of Medicine

BACKGROUND: Point-of-care ultrasound has gained widespread use in developing countries due to decreased cost and improved telemedicine capabilities. Ultrasound training, specifi cally image acquisition skills, is occurring with more frequency in non-medical personnel with varying educational levels in these underdeveloped areas. This study evaluates if students without a high school education can be trained to acquire useful FAsT images, and to determine if an 8^(th) grade student can teach peers these ***: The 8^(th) grade students at a small middle school were divided into two groups. One group received training by a certified medical sonographer, while the other group received training by a peer 8^(th) grade student trainer who had previously received training by the sonographer. After training, each student was independently tested by scanning the four FAsT locations. A blinded ultrasound expert evaluated these images and deemed each image adequate or inadequate for clinical ***: Eighty video image clips were obtained. The overall image adequacy rate was 74%. The splenorenal window had the highest rate at 95%, followed by retrovesical at 90%, hepatorenal at 75%, and subxiphoid cardiac at 35%. The adequacy rate of the sonographer-trained group was 78%, while the adequacy rate of the student-trained group was 70%. The difference in image adequacy rate between the two groups was not signifi cant(P-value 0.459).CONCLUsION: The majority of 8^(th) graders obtained clinically adequate FAsT images after minimal training. Additionally, the student-trained group performed as well as the sonographer-trained group.

关键词： Point of care ultrasound FAsT Image acquisition Training

Update of endoscopy in liver disease:More than just treating varices

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World Journal of Gastroenterology 2012年第5期18卷 401-411页

作者： Christoforos Krystallis Gail s Masterton Peter C Hayes john N Plevris Centre for Liver and Digestive Disorders The Royal InfirmaryUniversity of EdinburghEdinburgh EH16 4SAUnited Kingdom

The management of complications in liver disease is often complex and *** has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver *** this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal *** main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary *** is clear that the role of the endoscopy in liver disease is well beyond that of just treating *** the technology in endoscopy expands,so does the role of the endoscopist in liver disease.

关键词： Cirrhosis Portal hypertension Varices En-doscopic ultrasound Esophageal capsule Endoscopicretrograde cholangiopancreatography Endomicros-copy spyglass