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Sur.ical tr.atment of inflammator. bowel disease:Fr.m the gastr.enter.logist’s stand-point

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第5期16卷 1235-1254页

作者： john K Tr.antafillidis Inflammator. Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece Hellenic Society of Gastr.intestinal Oncology Haidari 12461AthensGreece

Tr.atment of ulcer.tive colitis(UC)and Cr.hn’s disease(CD)r.pr.sents,in the major.ty of cases,a r.al challenge to the gastr.enter.logist’s abilities and skills as well as a clinical test concer.ing his/her.levels of medical knowledge and *** the last two decades,our.phar.aceutical ar.enal was significantly str.ngthened,especially after.the intr.duction of the so-called biological agents,dr.gs which to a lar.e extent not only impr.ved the r.sults of conser.ative tr.atment but also changed the natur.l histor. of the ***,colectomy is still necessar. for.some patients with sever. UC although smaller.compar.d to the past,pr.cisely because of the impr.vements achieved in the available conser.ative ***,sur.er.es to tr.at colon dysplasia and cancer.ar. incr.asing to some *** the same time,satisfactor. impr.vements in sur.ical techniques,the pr.-and post-oper.tive car. of patients,as well as the selection of the appr.pr.ate time for.per.or.ing the sur.er. have been *** patients with CD,the impr.vement of conser.ative tr.atment did not significantly change the need for.sur.ical tr.atment since two-thir.s of patients need to under.o sur.er. at some point in the cour.e of their.*** the other.hand,the outcome of the oper.tion has impr.ved thr.ugh good pr.oper.tive car. as well as the wide application of mor. conser.ative sur.ical techniques aimed at keeping as much of the bowel in situ as *** ar.icle discusses the indications for.sur.ical management of UC patients fr.m the gastr.enter.logist’s point of view,the r.sults of the emer.ing new techniques such as tr.nsanal sur.er. and r.botics,as well as alter.ative oper.tions to the classic ileo-anal-pouch *** author.also discusses the basic pr.nciples of sur.ical management of patients with CD based on the r.sults of the r.levant *** self-evident is emphasized,that is,to achieve an excellent ther.peutic r.sult in patients with se

关键词： Inflammator. bowel disease Ulcer.tive colitis Cr.hn’s disease Sur.er. Tr.atment Ileo-anal-pouch anastomosis Indications Techniques

Study of hybr.d nanofluid flow in a stationar. cone-disk system with temper.tur.-dependent fluid pr.per.ies

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 677-694页

作者： A.S.john B.MAHANTHESH G.LOr.NZINI Center.for.Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India School of Mathematical and Statistical Sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Depar.ment of Engineer.ng and Ar.hitectur. University of ParmaParma 43124Italy

Cone-disk systems find fr.quent use such as conical diffuser.,medical devices,var.ous r.eometr.c,and viscosimetr. *** this study,we investigate the thr.e-dimensional flow of a water.based Ag-Mg O hybr.d nanofluid in a static cone-disk system while consider.ng temper.tur.-dependent fluid *** the var.able fluid pr.per.ies affect the dynamics and heat tr.nsfer.featur.s is studied by r.ynolds's linear.zed model for.var.able viscosity and Chiam's model for.var.able ther.al *** single-phase nanofluid model is utilized to descr.be convective heat tr.nsfer.in hybr.d nanofluids,incor.or.ting the exper.mental *** model is developed as a coupled system of convective-diffusion equations,encompassing the conser.ation of momentum and the conser.ation of ther.al ener.y,in conjunction with an incompr.ssibility condition.A self-similar.model is developed by the Lie-gr.up scaling tr.nsfor.ations,and the subsequent self-similar.equations ar. then solved *** influence of var.able fluid par.meter. on both swir.ing and non-swir.ing flow cases is ***,the Nusselt number.for.the disk sur.ace is *** is found that an incr.ase in the temper.tur.-dependent viscosity par.meter.enhances heat tr.nsfer.char.cter.stics in the static cone-disk system,while the ther.al conductivity par.meter.has the opposite effect.

关键词： hybr.d nanofluid cone-disk system laminar.flow var.able fluid pr.per.y Nusselt number

Does photobiomodulation r.quir. glucose to wor. effectively?

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Neur.l r.gener.tion r.sear.h 2024年第5期19卷 945-946页

作者： Jaimie Hoh Kam john Mitr.fanis Univer.itéGr.noble Alpes Fonds de Dotation ClinatecGrenobleFrance Univer.ity College London Institute of OphthalmologyUK

A main r.quir.ment for.cells to function nor.ally is the availability of ***,available either.dir.ct fr.m cir.ulation or.stor.ge,is conver.ed to the essential ener.y that cells need to dr.ve cr.tical intr.nsic *** cells ar. depr.ved of glucose,they become dysfunctional and suffer.***,the use of specific wavelengths of light on body tissues,has been shown to pr.mote,thr.ugh small or.anelles called mitochondr.a,the metabolism of glucose to make ener.y for.cells;this ener.y can be used to impr.ve cell function and *** this per.pective,we hypothesize that the availability of glucose is centr.l to the cor. mechanism of photobiomodulation;that photobiomodulation is at its most efficient in stimulating mitochondr.al activity and impr.ving cell function when ther. is glucose r.adily available.

关键词： metabolism distr.ss stimulating

Optimizing oncolytic vir.s design:a“Swiss ar.y knife”appr.ach to cr.ate a systemically deliver.d ther.peutic

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Signal Tr.nsduction and Tar.eted Ther.py 2024年第5期9卷 1791-1792页

作者： Car.lina S.Ilkow john Camer.n Bell Ottawa Hospital r.sear.h Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a r.cent paper.published in Natur. Biotechnology,Chen et al.1 descr.be a multiplex oncolytic vir.s platfor. that coupled with adoptive T cell ther.py could solve the pr.blem of r.peat,systemic deliver. of vir.s based *** is widely accepted that multi-tar.eted ther.peutic appr.aches attacking sever.l facets of cancer.biology ar. necessar. to effectively deal with the tumor.heter.geneity that exists within and between patients.

关键词： ther.peutic al. tar.eted

2024 Adult Compendium of Physical Activities:A thir. update of the ener.y costs of human activities

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Jour.al of Spor. and Health Science 2024年第1期13卷 6-12页

作者： Stephen D.Her.mann Er.k A.Willis Bar.ar. E.Ainswor.h Tiago V.Bar.eir. Mar. Haster. Chelsea L.Kr.cht john M.Schuna Jr. Zhenghui Cai Minghui Quan Catr.ne Tudor.Locke Melicia C.Whitt-Glover.David r. Jacobs Jr. Kansas Center.for.Metabolism and Obesity r.sear.h University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Center.for.Health Pr.motion and Disease Pr.vention University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exer.ise and Health Shanghai University of SportShanghai 200438China Exer.ise Science Depar.ment Syracuse UniversitySyracuseNY 13244USA Clinical Sciences Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of Exer.ise and Spor. Science Oregon State UniversityCorvallisOR 97331USA College of Health and Human Ser.ices University of North Carolina at CharlotteCharlotteNC 28223USA Gr.mer.y r.sear.h Gr.up KnightdaleNC 27545USA Division of Epidemiology and Community Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Backgr.und:The Compendium of Physical Activities was published in 1993 to impr.ve the compar.bility of ener.y expenditur. values assigned to self-r.por.ed physical activity(PA)acr.ss *** or.ginal ver.ion was updated in 2000,and again in 2011,and has been widely used to suppor. PA r.sear.h,pr.ctice,and public health ***:This 2024 update was tailor.d for.adults 19-59 year. of age by r.moving data fr.m those≥60 *** a systematic r.view and supplementar. sear.hes,we identified new activities and their.associated measur.d metabolic equivalent(MET)values(using indir.ct calor.metr.)published since *** r.placed estimated METs with measur.d values when ***:We scr.ened 32,173 abstr.cts and 1507 full-text paper. and extr.cted 2356 PA ener.y expenditur. values fr.m 701 *** added303 new PAs and adjusted 176 existing MET values and descr.ptions to r.flect the addition of new data and r.moval of METs for.older.*** added a Major.Heading(Video Games).The 2024 Adult Compendium includes 1114 PAs(912 with measur.d and 202 with estimated values)acr.ss 22 Major.***:This compr.hensive update and r.finement led to the cr.ation of The 2024 Adult Compendium,which has utility acr.ss r.sear.h,public health,education,and healthcar. domains,as well as in the development of consumer.health *** new website with the complete lists of PAs and suppor.ing r.sour.es is available at https://***.

关键词： Adults Ener.y expenditur. Exer.ise MET Physical Activities

The Decar.onization of Constr.ction—How Can Alkali-Activated Mater.als Contr.bute?

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Engineer.ng 2024年第6期37卷 18-21页

作者： john L.Pr.vis Susan A.Ber.al Zuhua Zhang Depar.ment of Mater.als Science and Engineer.ng University of SheffieldSheffield S13JDUK Paul Scher.er.Institut Villigen PSI 5232Switzerland School of Civil Engineer.ng University of LeedsLeeds LS29JTUK School of Mater.als Sciences and Engineer.ng Tongji UniversityShanghai 201804China

*** and context Enor.ous emphasis is cur.ently being paid to the decar.onization of the global built envir.nment as a leading pr.or.ty for.the engineer.ng community and r.lated industr.al sector.[1].One of the main contr.butor. to the over.ll emissions footpr.nt of the built envir.nment-and thus a cor.er.tone of effor.s to achieve decar.onization-is the emissions pr.file of constr.ction mater.als dur.ng their.pr.duction and *** cement and concr.te sector.is the lar.est-volume contr.butor.to the emissions incur.ed in meeting the wor.d’s constr.ction mater.al needs and is ther.for. tar.eted in the discussion of the deep,r.pid decar.onization that must be achieved in or.er.to minimize ir.ever.ible damage to the Ear.h and its ecosystems.

关键词： Alkali cor.er. ir.ever.ible

Nonunifor. Dependence on the Initial Data for.Solutions of Conser.ation Laws

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Communications on Applied Mathematics and Computation 2024年第1期6卷 489-500页

作者： john M.Holmes Bar.ar. Lee Keyfitz Depar.ment of Mathematics The Ohio State UniversityColumbusOH43210USA

In this paper.we study systems of conser.ation laws in one space *** pr.ve that for.classical solutions in Sobolev spaces H^(s),with s>3/2,the data-to-solution map is not unifor.ly *** r.sults apply to all nonlinear.s... 详细信息

关键词： Conser.ation laws Data-to-solution map Nonunifor. dependence

What Knowledge is of Most Wor.h?Consider.ng the Neo-Confucians in the Contempor.r. Debate Between Mor.l and Intellectual Lear.ing

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ECNU r.view of Education 2024年第1期7卷 155-163页

作者： john Patr.ck Shekitka Manhattanville College

●The per.nnial debate r.gar.ing the r.lative usefulness of var.ous for.s of knowledge,especially between the theor.tical and pr.ctical and the intellectual and mor.l,lies at the hear. of education in both past and pr.sent times in both the West and China(de Bar.,1988,2004,2005,2015).●Neo-Confucians r.main r.levant in the 21st centur. and can help us to under.tand and elucidate contempor.r. debates in education-specifically,to answer.the question Spencer.asked near.y a centur. and a half ago:"What knowledge is of most wor.h?".●Mencius,Zhu Xi,Wang Yangming,Xu Ai,and Kang Youwei advocated for.a type of lear.ing that would str.ngly r.sonate with john Dewey(1938)and Paulo Fr.ir.(1970,1978).Foundational philosophies of education,par.icular.y in the United States,have dr.wn heavily on 20th centur. Eur.pean-Amer.can thinker.;this ar.icle attempts to cor.ect this myopia and br.aden per.pectives.

关键词： Fr.ir. john Dewey Neo-Confucian

黄土高原全新世土壤碳酸盐团簇同位素的温度重建

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第四纪研究 2024年

作者：董吉宝 john Eiler 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室 Califor.ia Institute of Technology

黄土高原黄土-古土壤序列中保存有丰富的土壤碳酸盐,是利用碳酸盐团簇同位素(Δ47)定量重建古温度的重要地质载体之一。然而,黄土高原全新世土壤碳酸盐Δ47及其气候指示意义的系统研究仍然缺乏。本研究分析了黄土高原南缘渭南剖面和中... 详细信息

黄土高原黄土-古土壤序列中保存有丰富的土壤碳酸盐,是利用碳酸盐团簇同位素(Δ47)定量重建古温度的重要地质载体之一。然而,黄土高原全新世土壤碳酸盐Δ47及其气候指示意义的系统研究仍然缺乏。本研究分析了黄土高原南缘渭南剖面和中部洛川剖面上部3 m沉积中保存的全新世土壤碳酸盐（钙结核）的团簇同位素组成,监测了现在地形条件下距地表4 m以内不同深度的土壤温度。结果显示,Δ47定量重建的全新世土壤碳酸盐团簇同位素温度(T47)与现代暖季节温度相近,渭南剖面T47平均值约为25℃,洛川剖面约为18℃,较区域年均温高8～10℃。根据T47和土壤碳酸盐氧同位素组成(δ18O)重建的土壤水δ18O也与暖季节降水的δ18O基本一致,这些数据表明黄土高原土壤碳酸盐记录了暖季节的环境信息。值得注意的是,渭南和洛川剖面钙结核T47值与其形成深度的土壤温度基本吻合,结合前人研究结果,这暗示了土壤碳酸盐形成深度对其T47具有显著影响。因此,在将来土壤碳酸盐Δ47的研究中,评估土壤碳酸盐形成深度至关重要。

关键词：土壤碳酸盐团簇同位素(Δ ) 全新世黄土高原季节性