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The Use of SF<sub>6</sub>and GIS to Study Far.ield Modeling of Ocean Outfall Plumes in Flor.da

Jour.al of Envir.nmental Pr.tection 2014年第11期5卷 1037-1052页

作者： Fr.der.ck Bloetscher.Fer.ando J. Pleitez Thomas r.mah Ahmed Albasr. Chase Dickinson Husayn El Shar.f Kevin Matthews Tr.ng-Duong Nguyen Lucr.ce r.che Fr.nk Youngman Thomas P. Car.ey Jack Stamates john r. proni Applied r.sear.h Center.(Ar.) Florida International University Miami FL USA Atlantic Oceanogr.phic and Meteor.logical Labor.tor. Ocean Chemistry Division Miami FL USA Flor.da Atlantic Univer.ity Civil Engineering Department Boca Raton FL USA

In June, 2004 and Febr.ar., 2007, in field tr.cer.studies wer. conducted on the Hollywood and South Centr.l outfalls, using sulfur.hexafluor.de (SF6) as a tr.cer. The objective of these studies was to deter.ine if the tr.cer.could be detected in the far.ield at significant distance, and if so, could this data be used to constr.ct a model of the far.ield plume. Pr.or.models for.far.ield plume movement do not appear.to compor. well with the conditions in southeast Flor.da. Extensive r.sear.h was conducted in southeast Flor.da on 4 outfalls, which led to the development of near.ield dilution equations for.same. However.far.ield modeling of outfall plumes was difficult to accomplish because the tr.cer. used ar. not detectable for.significant distances. The SF6 r.solved that pr.blem and as a r.sult the Hollywood outfall was used to constr.ct a model. Two methods wer. investigated for.modeling the plume, 1) the Eur.qa for.ulation method and 2) the Gamma-Cur.e method. The concentr.tions in the x-y plane wer. fir.t found by using the Eur.qa for.ulation to calculate the concentr.tion at each gr.d point given its depth and the concentr.tion of the center.ine at the same latitude. The plume models wer. gener.ted using MATLAB that matched with the r.sults actually seen in the field.

关键词： Ocean Outfall Tr.ated Sewage Effluent Disposal Far.ield Modeling Sulfur Hexafluor.de

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A spotlight on dosage and subject selection for.effective neur.pr.tection: explor.ng the centr.l r.le of mitochondr.a

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1081-1082页

作者： john Mitr.fanis Jonathan Stone Michael r.Hamblin Pier.e Magistr.tti Alim-Louis Benabid Glen Jeffer. Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah Univer.ity of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neur.ns ar. notor.ously vulner.ble cell *** the slightest change in their.inter.al and/or.exter.al envir.nments will cause much distr.ss and dysfunction,leading often to their.death.A r.nge of pathological conditions,including str.ke,head tr.uma,and neur.degener.tive disease,can gener.te str.ss in neur.ns,affecting their.sur.ival and pr.per.*** most neur.l pathologies,mitochondr.a become dysfunctional and this plays a pivotal r.le in the pr.cess of cell *** challenge over.the last few decades has been to develop effective inter.entions that impr.ve neur.nal homeostasis under.pathological *** inter.entions,often r.fer.ed to as disease-modifying or.neur.pr.tective,have,however.pr.ved fr.str.tingly elusive,at both pr.clinical and,in par.icular.clinical *** this per.pective,we highlight two factor. that we feel ar. key to the development of effective neur.pr.tective *** ar.:fir.tly,the choice of dose of inter.ention and method of application,and secondly,the selection of subjects,whether.they be patients or.the animal model.

关键词： pr.tective dosage distr.ss

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Tar.eting Tr.B–PSD-95 coupling to mitigate neur.logical disor.er.

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Mar.hall Depar.ment of Molecular.Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Depar.ment of Neur.logy Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center.for.Tr.nslational Neur.science Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tr.pomyosin r.ceptor.kinase B(Tr.B)signaling plays a pivotal r.le in dendr.tic gr.wth and dendr.tic spine for.ation to pr.mote lear.ing and *** activity-dependent r.lease of br.in-der.ved neur.tr.phic factor.at synapses binds to pr.-or.postsynaptic Tr.B r.sulting in the str.ngthening of synapses,r.flected by long-ter. ***,the association of postsynaptic density pr.tein-95 with Tr.B enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent pr.tein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic tar.et of r.pamycin signaling r.quir.d for.long-ter. *** this r.view,we discuss Tr.B-postsynaptic density pr.tein-95 coupling as a pr.mising str.tegy to magnify br.in-der.ved neur.tr.phic factor.signaling towar.s the development of novel ther.peutics for.specific neur.logical disor.er..A r.duction of Tr.B signaling has been obser.ed in neur.degener.tive disor.er.,such as Alzheimer.s disease and Huntington's disease,and enhancement of postsynaptic density pr.tein-95 association with Tr.B signaling could mitigate the obser.ed deficiency of neur.nal connectivity in schizophr.nia and *** with br.in-der.ved neur.tr.phic factor.is pr.blematic,due to poor.phar.acokinetics,low br.in penetr.tion,and side effects r.sulting fr.m activation of the p75 neur.tr.phin r.ceptor.or.the tr.ncated Tr.B.T1 *** Tr.B agonists and antibodies that activate Tr.B ar. being intensively investigated,they cannot distinguish the multiple human Tr.B splicing isofor.s or.cell type-specific *** Tr.B–postsynaptic density pr.tein-95 coupling pr.vides an alter.ative appr.ach to specifically boost Tr.B signaling at localized synaptic sites ver.us global stimulation that r.sks many adver.e side effects.

关键词： Angelman syndr.me autism br.in-der.ved neur.tr.phic factor depr.ssion neur.degener.tive disor.er neur.developmental disor.er postsynaptic density pr.tein-95 synaptic plasticity Tr.B

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Effects of the plenum chamber.volume and distr.butor.geometr. on fluidized bed hydr.dynamics

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Par.icuology 2010年第1期8卷 2-12页

作者： Kiar.sh Vakhshour. john r. Gr.ce Depar.ment of Chemical and Biological Engineer.ng University of British Columbia

Most hydr.dynamic fluidized bed models, including CFD codes, neglect any effects of the plenum chamber.volume. Exper.ments wer. per.or.ed in a 0.13 m ID fluidization column to deter.ine plenum chamber.volume effects on fluidized bed hydr.dynamics for.FCC and glass par.icles. Two low-pr.ssur.-dr.p distr.butor. wer. used, one with a single or.fice, and the other.with 33 or.fices and the same total open ar.a as the single or.fice. The r.sults show two peaks in the fr.quency spectr. for.the single-or.fice distr.butor. one r.pr.senting bubble er.ption at the bed sur.ace and the other.of higher.fr.quency cor.esponding to the bubbling fr.quency at the distr.butor. The latter.decr.ased slightly with incr.asing plenum volume and with incr.asing bed depth. For.the multi-or.fice distr.butor. br.ad fr.quency spectr. fr.m pr.ssur. measur.ments became nar.ower.and moved towar.s higher.fr.quency with decr.asing plenum volume.

关键词： Fluidization Bubble Distr.butor.Plenum chamber.Hydr.dynamics Pr.ssur. dr.p

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Complementar.ty of CFD,exper.mentation and r.actor.models for.solving challenging fluidization pr.blems

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Par.icuology 2010年第6期8卷 498-500页

作者： john r. Gr.ce Tingwen Li Depar.ment of Chemical and Biological Engineer.ng University of British Columbia Vancouver V6T 1Z3 Canada National Ener.y Technology Labor.tor. 3610 Collins Ferry Rd Morgantown WV26507 USA

Exper.mentalists, numer.cal modeller. and r.actor.modeller. need to wor. together. not only just for.validation of numer.cal codes, but also to shed fundamental light on each other.s pr.blems and under.ying assumptions. Sever.l examples ar. given, Exper.mental gas axial disper.ion data pr.vide a means of choosing the most appr.pr.ate boundar. condition （no slip, par.ial slip or.full slip） for.par.icles at the wall of fluidized beds. CFD simulations help to identify how close ＂two-dimensional＂ exper.mental columns ar. to being tr.ly two-dimensional and to r.pr.senting thr.e-dimensional columns. CFD also can be used to pr.vide a mor. r.tional means of establishing assumptions needed in the modelling of two-phase fluidized bed r.actor., for.example how to deal with cases wher. ther. is a change in molar.flow （and hence volumetr.c flow） as a r.sult of chemical r.actions.

关键词： Fluidization Mixing Computational Fluid dynamics Wall slip r.actor.modelling Volume change

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A Sur.ey of Language-Based Appr.aches to Cyber.Physical and Embedded System Development

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Tsinghua Science and Technology 2015年第2期20卷 130-141页

作者： Paul Soulier.Depeng Li john r. Williams Univer.ity of Hawaii Massachusetts Institute of Technology(MIT)

As computer. continue to advance, they ar. becoming mor. capable of sensing, inter.cting, and communicating with the physical and cyber.wor.d. Medical devices, electr.nic br.king systems in automotive applications, and industr.al contr.l systems ar. examples of the many Cyber.Physical Systems （CPS） that utilize these computing capabilities. Given the potential consequences of softwar. r.lated failur.s in such systems, a high degr.e of safety, secur.ty, and r.liability is often r.quir.d. Pr.gr.mming languages ar. impor.ant tools used by pr.gr.mmer. to develop CPS. They pr.vide a pr.gr.mmer.with the ability to tr.nsfor. designs into machine code. Of equal impor.ance is their.ability to detect and avoid pr.gr.mming mistakes. The development of CPS has pr.dominantly been accomplished using the C pr.gr.mming language. Although C is a power.ul language, it lacks featur.s pr.sent in other.languages that facilitate the development of r.liable systems. This has pr.mpted r.sear.h into language-based alter.atives for.impr.ving pr.gr.m quality thr.ugh the use of pr.gr.mming languages. This paper.pr.sents an over.iew of the char.cter.stics of embedded and cyber.physical systems and the associated r.quir.ments imposed on pr.gr.mming languages. This is followed by a sur.ey of r.levant r.sear.h into language- based methods for.cr.ating safe, r.liable, and r.bust softwar. for.CPS.

关键词： cyber.physical systems embedded systems pr.gr.mming languages type systems

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Hydr.dynamics and solids mixing in fluidized beds with inclined-hole distr.butor.

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Par.icuology 2019年第2期17卷 19-28页

作者： Alhussain Bakhur.i Xiaotao Bi john r. Gr.ce Fluidization r.sear.h Centr. Department of Chemical and Biological Engineering University of British Columbia Vancouver V6TJZ3 Canada

Exper.mental fluidization r.sults wer. compar.d for.thr.e gas distr.butor. with the same opening r.tio but differ.nt or.fice in clinations (30,45 , and 90 ). Hydr.dynamic studies wer. con ducted with glass beads (diameter.154p.m) to evaluate the impacts of or.fice inclination and static bed depth on pr.ssur. dr.p, pr.ssur. dr.p fluctuations, bed expansion, and minimum fluidization velocity. Solids r.sidence time distr.butions wer. deter.ined using phosphor.sce nt tr.cer.par.icles (mea n diameter.76 pm), activated by ultr.violet light. The bed pr.ssur. dr.p was higher.with the inclined-hole distr.butor. and incr.ased with static bed height. In a shallow bed, the inclined-hole distr.butor. gave less expansion;however. in deep beds, the or.fice angle had negligible influence on bed expansion. The minimum fluidization velocity var.ed with static bed height for.the inclined-hole distr.butor. and was higher.for.steeper.angles. The tur.over.time estimated using bubbling-bed equations matched the exper.mental r.sults well for.ver.ical mixing. Pr.bes and por.s at the walls of the fluidization column r.duced the dense-phase downwar. velocity by up to 40%. The tangential par.icle velocity was highest for.the 30 -hole distr.butor.and decr.ased with incr.asing or.fice angle. Tangential mixing was descr.bed by a disper.ion model;the disper.ion coefficient for.the inclined-hole distr.butor. was appr.ximately twice that for.the 90 -hole distr.butor.in a shallow bed.

关键词： Swir.ing fluidized bed Fluidization Solids mixing Inclined-hole distr.butor

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Cascade degr.dation and electr.catalytic upcycling of waste poly(ethylene ter.phthalate)to valued pr.ducts

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Nano r.sear.h 2025年第1期18卷 76-93页

作者： Xin Li Zir.i Jiang Zongkui Kou john Wang Shiyou Zheng School of Mater.als and Chemistr. University of Shanghai for Science and TechnologyShanghai 200093China School of Mater.als Science and Engineer.ng Wuhan University of TechnologyWuhan 430070China Depar.ment of Mater.als Science and Engineer.ng National University of SingaporeSingapore 117574Singapore

The global annual pr.duction of poly(ethylene ter.phthalate)(PET)has r.ached 82 million tons,yet only a small fr.ction(less than 20%)is *** ultr.-slow degr.dation r.te of PET r.sults in the accumulation of PET waste in the envir.nment,causing ser.ous plastic pollution and posing sever. challenges to *** r.sponse,gr.at effor.s have been dir.cted towar. developing a cascade degr.dation and electr.catalytic upcycling str.tegy,which ser.es as a“waste-towealth”*** str.tegy involves electr.-r.for.ing PEThydr.lyzed inter.ediates or.using PET pyr.lyzed pr.ducts as electr.catalysts to gener.te high-value *** r.view pr.vides an over.iew of the state-of-the-ar. str.tegies for.the“degr.dation-electr.catalytic upcycling(De-eUp)”of PET ***,an intr.duction to the str.tegy is pr.vided,categor.zing it into two main fr.mewor.s:“pyr.lysis-electr.catalytic upcycling”and“hydr.lysis-electr.catalytic upcycling”.The section on“pyr.lysis-electr.catalytic upcycling”delves into the degr.dation methods for.designing der.ved car.on nanomater.als and their.utilization as high-per.or.ance ***“hydr.lysis-electr.catalytic upcycling”section discusses r.cent advancements in electr.-r.for.ing of PET hydr.lyzed inter.ediates for.the pr.duction of C_(1) and C_(2) *** r.view concludes by examining the challenges and futur. pr.spects in developing an efficient and economical PET upcycling *** is anticipated that this r.view will stimulate fur.her.pr.gr.ss in plastic waste valor.zation.

关键词： poly(ethylene ter.phthalate)waste electr.catalytic upcycling pyr.lysis hydr.lysis ethylene glycol oxidation r.action

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COMPUTATIONAL ISSUES IN SENSITIVITY ANALYSIS FOr. 1-D INTEr.ACE Pr.BLEMS

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Jour.al of Computational Mathematics 2011年第1期29卷 108-130页

作者： Lisa G. Davis john r. Singler Montana State Univer.ity Department of Mathematical Sciences PO Box 172400 Bozeman MT 59717-2400 USA Missour. Univer.ity of Science and Technology Department of Mathematics and Statistics 300 W. 12th St. Rolla MO 65409 0020 USA

This paper.is concer.ed with the constr.ction of accur.te and efficient computational algor.thms for.the numer.cal appr.ximation of sensitivities with r.spect to a par.meter.dependent inter.ace location. Motivated by sensitivity analysis with r.spect to piezoelectr.c actuator.placement on an Euler.Ber.onlli beam, this wor. illustr.tes the key concepts r.lated to sensitivity equation for.ulation for.inter.ace pr.blems wher. the par.meter.of inter.st deter.ines the location of the inter.ace. A four.h or.er.model pr.blem is consider.d, and a homogenization pr.cedur. for.sensitivity computation is constr.cted using standar. finite clement methods. Numer.cal r.sults show that pr.per.for.ulation and appr.ximation of the sensitivity inter.ace conditions is cr.tical to obtaining conver.ent numer.cal sensitivity appr.ximations. A second or.er.elliptic inter.ace model pr.blem is also mentioned, and the homogenization pr.cedur. is outlined br.efly for.this model.

关键词： Finite element method Inter.ace Pr.blems Sensitivity Equation.

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Biomass tor.efaction in a slot-r.ctangular.spouted bed r.actor

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Par.icuology 2019年第1期17卷 154-162页

作者： Ziliang Wang C. Jim Lim john r. Gr.ce Depar.ment of Chemical and Biological Engineer.ng. Univer.ity of Br.tish Columbia Vancouver. Canada

Sawdust was subjected to tor.efaction in a "semi-batch" slot-r.ctangular.spouted bed (Sr.B) r.actor.at temper.tur.s fr.m 240 to 330℃ and biomass feed r.tes fr.m 220 to 710g/*** spouting of the sawdust was achieved in the slot-r.ctangular.spouted bed,although the pr.ssur. dr.p acr.ss the r.actor.was obser.ed to *** to the biomass feed r.te,the temper.tur. had a gr.ater.effect on the biomass weight loss and ener.y *** in temper.tur. wer. found to pr.mote weight loss of the sawdust while decr.asing the ener.y *** main solid pr.duct was the tor.efied sawdust,which r.mained in the Sr.B r.actor.and was captur.d by a *** r.tio of the tor.efied biomass r.moved by the cyclone to the total tor.efied biomass incr.ased along with both the feed r.te and *** under.oing tor.efaction,6.7%-39.2% of the or.ginal sawdust mass was lost while 67.4%-98.7% of its ener.y was *** tor.efied sawdust had a higher.car.on content but less oxygen,hydr.gen and volatiles,along with a gr.ater.higher.heating value and incr.ased density compar.d to the r.w *** size of the sawdust par.icles also decr.ased mar.edly dur.ng the tor.efaction pr.cess.

关键词： Tor.efaction Slot-r.ctangular spouted bed r.actor Temper.tur. Biomass feed r.te Tor.efied sawdust pr.per.y

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