检索结果-南通市图书馆

Microsystems & Nanoengineering 2019年第1期5卷 50-58页

作者： Han Sang park Will J.Eldridge Wen-Hsuan Yang Michael Crose Silvia Ceballos john D.roback Jen-Tsan Ashley Chi Adam Wax Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Molecular Genetics and Microbiology Duke UniversityDurhamNC 27708USA Duke Center for Genomic and Computational Biology Duke UniversityDurhamNC 27708USA Department of Biochemistry Duke UniversityDurhamNC 27708USA Department of Pathology and Laboratory Medicine Emory University School of MedicineAtlantaGA 30322USA

Changes in the deformability of red blood cells can reveal a range of *** example,cells which have been stored for transfusion are known to exhibit progressively impaired ***,this aspect of red blood cells has been characterized previously using a range of *** this paper,we show a novel approach for examining the biophysical response of the cells with quantitative phase ***,optical volume changes are observed as the cells transit restrictive channels of a microfluidic chip in a high refractive index *** optical volume changes indicate an increase of cell’s internal density,ostensibly due to water ***,we characterize these changes over time for red blood cells from two *** storage day 29,a significant decrease in the magnitude of optical volume change in response to mechanical stress was *** exchange of water with the environment due to mechanical stress is seen to modulate with storage time,suggesting a potential means for studying cell storage.

关键词： impaired fluid transfusion

LIQUID CrYSTAL BASED rOTATING OrTHOGONAL POLArIZATION IMAGING SYSTEM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2009年第3期2卷 245-251页

作者： QUN ZHU IAN M.STOCKFOrD john A.CrOWE STEPHEN P.MOrGAN School of Electrical and Electronic Engineering University of Nottingham University Park NottinghamUK NG72RD

rotating orthogonal polarization imaging provides images of the polarization properties of scattering media which are free from surface *** the technique has been demonstrated using manually rotated Glan–Thompson polarizers to control and analyze the polarization state of the light entering and emerging from the *** paper describes a system that performs these functions using liquid crystal *** system is tested using a polarizing target embedded within a scattering medium and is compared with Monte Carlo *** results compare well with those obtained with manual rotation of *** liquid crystal based approach has advantages over the previous system in terms of ease of use,speed,and repeatability and is therefore an important step towards taking the technique into routine clinical use.

关键词： Liquid crystal polarization orthogonal surface reflection scattering tissue.

record-Setting Ocean Warmth Continued in 2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2020年第2期37卷 137-142页

作者： Lijing CHENG john ABrAHAM Jiang ZHU Kevin ETrENBErTH john FASULLO Tim BOYEr ricardo LOCArNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of St.Thomas School of EngineeringMinnesota 55105USA National Center for Atmospheric research BoulderColorado 80307USA National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Department of Meteorology&Atmospheric Science The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyHangzhou 310012China

Human-emitted greenhouse gases(GHGs)have resulted in a long-term and unequivocal warming of the planet(IPCC,2019).More than 90%of the excess heat is stored within the world's oceans,where it accumulates and causes inc... 详细信息

关键词： greenhouse warming ocean

SUrrOGATE TECHNOLOGIES FOr CONTINUOUS SUSPENDED-SEDIMENT MONITOrING IN THE UNITED STATES

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SURROGATE TECHNOLOGIES FOR CONTINUOUS SUSPENDED-SEDIMENT MON...

Mapping landslide susceptibility at the Three Gorges reservoir, China, using gradient boosting decision tree,random forest and information value models

第九次河流泥沙国际学术大会

作者： john r.GrAY Jeffrey W.GArTNEr U.S. Geological Survey 415 National Center Reston Virginia 20192. U.S. Geological Survey 345 Middlefield Road Menlo Park California 94025.

＜正＞Traditional methods for characterizing suspended sediments in surface waters are being replaced or augmented by methods that produce continuous, quantifiably accurate surrogate data that are safer, and （or） less expensive to obtain. Optical properties of water such as turbidity and optical backscatter are the most commonly used surrogates for suspended-sediment concentration, but use of other techniques such as acoustic backscatter, laser diffraction, digital photo-optic, and pressure-difference technologies is increasing for concentration and, in some cases, particle-size distribution determinations. When suspended sediment surrogate data meet consensus accuracy criteria and appropriate sediment-record computation techniques are applied, these technologies have the potential to revolutionize the way fluvial-sediment data are collected, analyzed, and made available in the United States.

关键词： Suspended sediment Sediment surrogate Monitoring research Sediment data quality

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Mountain Science 2020年第3期17卷 670-685页

作者： CHEN Tao ZHU Li NIU rui-qing TrINDEr C john PENG Ling LEI Tao Institute of Geophysics and Geomatics China University of GeosciencesWuhan 430074China Geomatics Technology and Application key Laboratory of Qinghai Province Xining 810001China School of Civil and Environmental Engineering The University of New South WalesSydneyNSW 2052Australia China Institute of Geo-Environment Monitoring Beijing 100081China School of Electronical and Information Engineering Shaanxi University of Science and TechnologyXi’an 710021China

This work was to generate landslide susceptibility maps for the Three Gorges reservoir(TGr) area, China by using different machine learning models. Three advanced machine learning methods, namely, gradient boosting decision tree(GBDT), random forest(rF) and information value(InV) models, were used, and the performances were assessed and compared. In total, 202 landslides were mapped by using a series of field surveys, aerial photographs, and reviews of historical and bibliographical data. Nine causative factors were then considered in landslide susceptibility map generation by using the GBDT, rF and InV models. All of the maps of the causative factors were resampled to a resolution of 28.5 m. Of the 486289 pixels in the area,28526 pixels were landslide pixels, and 457763 pixels were non-landslide pixels. Finally, landslide susceptibility maps were generated by using the three machine learning models, and their performances were assessed through receiver operating characteristic(rOC) curves, the sensitivity, specificity,overall accuracy(OA), and kappa coefficient(KAPPA). The results showed that the GBDT, rF and In V models in overall produced reasonable accurate landslide susceptibility maps. Among these three methods, the GBDT method outperforms the other two machine learning methods, which can provide strong technical support for producing landslide susceptibility maps in TGr.

关键词： Mapping landslide susceptibility Gradient boosting decision tree random forest Information value model Three Gorges reservoir

Classifying forest inventory data into species-based forest community types at broad extents： exploring tradeoffs among supervised and unsupervised approaches

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2018年第1期5卷 91-107页

作者： jennifer k.costanza don faber-langendoen john w.coulston david n.wear Department of Forestry and Environmental resources North C arolina State University3041 Cornwalis RdResearch Triangle ParkRaleighNC 27709USA NatureServe 4600 N.Fairfax Dr7th FloorArlingtonVA 22203USA Southern research Station USDA Forest ServiceBlacksburgVAUSA Southern research Station USDA Forest ServiceRaleighNCUSA

Background： Knowledge of the different kinds of tree communities that currently exist can provide a baseline for assessing the ecological attributes of forests and monitoring future changes. Forest inventory data can facilitate the development of this baseline knowledge across broad extents, but they first must be classified into forest community types. Here, we compared three alternative classifications across the United States using data from over 117,000 U.S. Department of Agriculture Forest Service Forest Inventory and Analysis （FIA） plots. Methods： Each plot had three forest community type labels：（1）＂FIA＂ types were assigned by the FIA program using a supervised method; （2）＂USNVC＂ types were assigned via a key based on the U.S. National Vegetation Classification; （3）＂empirical＂ types resulted from unsupervised clustering of tree species information. We assessed the degree to which analog classes occurred among classifications, compared indicator species values, and used random forest models to determine how well the classifications could be predicted using environmental variables. results： The classifications generated groups of classes that had broadly similar distributions, but often there was no one-to-one analog across the classifications. The Iongleaf pine forest community type stood out as the exception： it was the only class with strong analogs across all classifications. Analogs were most lacking for forest community types with species that occurred across a range of geographic and environmental conditions, such as Ioblolly pine types, indicator species metrics were generally high for the USNVC, suggesting that LJSNVC classes are floristically well-defined. The empirical classification was best predicted by environmental variables. The most important predictors differed slightly but were broadly similar across all classifications, and included slope, amount of forest in the surrounding landscape, average minimum temperature, and other climate variab

关键词： Big data Correspondence analysis Dominant species Forest communities Global change,Hierarchical classification Indicator species random forests Species assemblages

The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2015年第6期7卷 557-567页

作者： Feng Qian Jing Deng Yong Gyu Lee Jimmy Zhu Manjula Karpurapu Sangwoon Chung Jun-Nian Zheng Lei Xiao Gye Young park john W.Christman School of Pharmacy Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghaiChina Department of Internal Medicine Section of PulmonaryAllergyCritical Careand Sleep MedicineThe Ohio State UniversityColumbusUSA Department of Physiology and Biophysics College of MedicineUniversity of Illinois at ChicagoChicagoUSA Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical CollegeXuzhouChina Department of Medicine Section of PulmonaryCritical Careand Sleep MedicineUniversity of Illinois at ChicagoChicagoUSA

The transcription factor PU.1 is involved in regulation of macrophage differentiation and ***,the role of PU.1 in alternatively activated macrophage(AAM)and asthmatic inflammation has yet been *** we report that PU.1 serves as a critical regulator of AAM polarization and promotes the pathological progress of asthmatic airway *** response to the challenge of DrA(dust mite,ragweed,and Aspergillus)allergens,conditional PU.1-deficient(PU/Er(T)^(+/-))mice displayed attenuated allergic airway inflammation,including decreased alveolar eosinophil infiltration and reduced production of IgE,which were associated with decreased mucous glands and goblet cell *** reduced asthmatic inflammation in PU/Er(T)^(+/-) mice was restored by adoptive transfer of IL-4-induced wild-type(WT)***,after treating PU/Er(T)^(+/-) mice with tamoxifen to rescue PU.1 function,the allergic asthmatic inflammation was significantly *** vitro studies demonstrate that treatment of PU.1-deficient macrophages with IL-4 attenuated the expression of chitinase 3-like 3(Ym-1)and resistin-like molecule alpha 1(Fizz-1),two specific markers of AAM *** addition,PU.1 expression in macrophages was inducible in response to IL-4 challenge,whichwas associated with phosphorylation of signal transducer and activator of transcription 6(STAT6).Furthermore,DrAchallenge in sensitized mice almost abrogated gene expression of Ym-1 and Fizz-1 in lung tissues of PU/Er(T)^(+/-) mice compared with WT *** data,all together,indicate that PU.1 plays a critical role in AAM polarization and asthmatic inflammation.

关键词： PU.1 alternatively activated macrophage asthmatic inflammation Th2 IL-4

Preoperative nuclear stress testing in the very old patient population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2020年第5期12卷 210-219页

作者： Amgad N Makaryus john N Makaryus Joseph A Diamond Department of Cardiology Northwell HealthNew Hyde ParkNY11042United States Department of Cardiology Nassau University Medical CenterEast MeadowNY 11554United States

BACKGrOUND Elderly patients awaiting moderate to high-risk surgery may undergo nuclear stress testing(NST)in order to evaluate their cardiovascular *** prognostic utility of such testing in the very elderly(≥85 years)has yet to be fully *** and nonogenarians frequently have a number of concurrent conditions including a high rate of coronary disease,and therefore the prognostic value of NST for their preoperative risk assessment has been *** evaluation assesses the ability of nuclear stress testing to predict peri-operative cardiac outcomes in this patient *** To investigate the ability of NST to predict peri-operative cardiac outcomes in elderly patients awaiting moderate to high-risk *** Patients≥85 years undergoing pre-operative NST were retrospectively *** undergoing low-risk surgery were *** adverse cardiac events(MACE)were considered any adverse event that occurred prior to discharge and included acute heart failure,arrhythmia,acute myocardial infarction,unstable angina,or *** between patient risk factors,MACE,and the obtained results of the pre-operative stress testing,ejection fraction(r≥40%),summed stress score(≤8,≥9),and the summed difference score(≤0,>0)were *** A total of 69 patients(mean age 88±2.6 years,31 males)underwent nuclear stress testing prior to *** were 41(60%)patients found to have an abnormal ***(23%)patients were noted to experience post-operative *** significant associations between risk factors and MACE were *** with an abnormal NST and/or a summed stress score≥9 weresignificantly(Pre likely to develop peri-operative *** Indicated preoperative NST is useful to assess pre-operative risk in elderly patients≥85 years undergoing moderate to high-risk surgery.

关键词： Pharmacologic nuclear stress testing Prognosis Elderly Preoperative assessment Outcomes

Predicting glass structure by physics-informed machine learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1839-1847页

作者： Mikkel L.Bødker Mathieu Bauchy Tao Du john C.Mauro Morten M.Smedskjaer Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark Physics of Amorphous and Inorganic Solids Laboratory(PArISlab) Department of Civil and Environmental EngineeringUniversity of CaliforniaLos AngelesCA90095USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA

Machine learning(ML)is emerging as a powerful tool to predict the properties of materials,including *** ML models with knowledge of how glass composition affects short-range atomic structure has the potential to enhance the ability of composition-property models to extrapolate accurately outside of their training ***,we introduce an approach wherein statistical mechanics informs a ML model that can predict the non-linear composition-structure relations in oxide *** combined model offers an improved prediction compared to models relying solely on statistical physics or machine learning ***,we show that the combined model accurately both interpolates and extrapolates the structure of Na_(2)O–SiO_(2)***,the model is able to extrapolate predictions outside its training set,which is evidenced by the fact that it is able to predict the structure of a glass series that was kept fully hidden from the model during its training.

关键词： glasses structure glass

Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

regenerative Biomaterials 2023年第1期10卷 1248-1260页

作者： rinat Nigmatullin Caroline STaylor Pooja Basnett Barbara Lukasiewicz Alexandra Paxinou Lorena rLizarraga-Valderrama john WHaycock Ipsita roy Higher Steaks Ltd. 25 Cambridge Science Park RdMiltonCambridge CB40FWUK School of Life Sciences College of Liberal Arts and SciencesUniversity of WestminsterLondon W1B 2HWUK Department of Materials Science&and Engineering The University of SheffieldSheffield S37HQUK Foundation of research and Technology Hellas Institute of Chemical Engineering and High Temperature Chemical Processes(FORTH/ICE-HT)P.O.Box 1414GR 26504RionPatrasGreece School of Life Sciences Queen’s Medical CentreUniversity of NottinghamNottingham NG72UHUK

Polyhydroxyalkanoates are natural,biodegradable,thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue *** describe a comparative evaluation of three medium chain length polyhydroxyalkanoates(mcl-PHAs),namely poly(3-hydroxyoctanoate),poly(3-hydroxyoctanoate-co-3-hydoxydecanoate)and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate),one short chain length polyhydroxyalkanoate,poly(3-hydroxybutyrate),P(3HB)and synthetic aliphatic polyesters(polycaprolactone and polylactide)with a specific focus on nerve regeneration,due to mechanical properties of mcl-PHAs closely matching nerve *** vitro biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell *** mcl-PHAs supported cell adhesion and *** the three mcl-PHAs,P(3HO-co-3HD)exhibited superior properties with regards to numbers of cells adhered and viable cells for both cell types,number of neurite extensions from NG108-15 cells,average length of neurite extensions and Schwann ***,similar characteristics were observed for flat P(3HB)surfaces,high rigidity of this biomaterial,and FDA-approved polymers such as PLLA,limits their applications in peripheral nerve ***,we have designed,synthesized and evaluated these materials for nerve tissue engineering and regenerative medicine,the interaction of mcl-PHAs with neuronal and Schwann cells,identifying mcl-PHAs as excellent materials to enhance nerve regeneration and potentially their clinical application in peripheral nerve repair.

关键词： peripheral nerve injury nerve regeneration biomaterials mcl-polyhydroxyalkanoates Schwann cells NG108-15