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陆生蜗牛壳体日分辨率氧同位记录定量重建"千年一遇"超级暴雨

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Science Bulletin 2024年第14期69卷 2281-2288页

作者：王国桢董吉宝韩韬刘成程罗凡杨昊天何妙宏唐国强赵楠钰张倩薛刚 john Dodson 李秋立晏宏 State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Laoshan Laboratory Qingdao 266061China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710049China National observation and Research Station of Earth Critical Zone on the Loess Plateau of Shaanxi Xi’an 710061China Xi’an Institute for Innovative Earth Environment Research Xi’an 710061China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China School of Biological Earth and Environmental SciencesUniversity of New South WalesSydney 2052Australia State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Yunnan Key Laboratory of Earth System Science Yunnan UniversityKunming 650500China University of Chinese Academy of Sciences Beijing 100049China

A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A pressing question is whether rainstorms of this intensity can be effectively documented by geological archives to understand better their historical variabilities beyond the range of meteorological ***,four land snail shells were collected from Zhengzhou,and weekly to daily resolved snail shellδ^(18)o records from June to September of 2021 were obtained by gas-source mass spectrometry and secondary ion mass *** daily resolved records show a dramatic negative shift between 06/18/2021 and 09/18/2021,which has been attributed to the"7.20"Zhengzhou ***,the measured amplitude of this shift is consistent with the theoretical value estimated from the flux balance model and instrumental data for the"7.20"Zhengzhou *** results suggest that the ultra-high resolutionδ^(18)o of land snail shells have the potential to reconstruct local synoptic scale rainstorms quantitatively,and thus fossil snail shells in sedimentary strata can be valuable material for investigating the historical variability of local rainstorms under different climate backgrounds.

关键词： Rainstorm Land snail shell d18o Paleoweather Central China

Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains

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Chinese Science Bulletin 2005年第18期50卷 2080-2089页

作者： YU Jinhai ZHoU Xinmin Y. S. o'reilly ZHAo Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China GEMoC ARC National Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney N.S.W. 2109 Australia

The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the Yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high Si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range.

关键词：麻粒岩锆石同位素变质结构沉积岩石

卫生保健管理 : 国际视野 : the global perspective 1

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Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease

丛书名：当代卫生事业管理学术丛书

2015年

作者： Jens-UweNiehoff 张亮 JochenBreinlinger-o'reilly

本书通过总结作者们在学术和实践领域的广泛国际经验，从国际视野反映和讨论了卫生保健管理，提供国际卫生保健管理相关的知识、经验、观点和意见，总结国际卫生保健管理的最新前沿知识和国际进展。

ISBN: (纸本)9787030422019

关键词：临床医学预防医学与公共卫生学

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2005年第41期11卷 6445-6449页

作者： Mark T Cartmell Hans-Ulrich Schulz Derek A o'reilly Bing'Mei Yang Volker Kielstein Simon P Dunlop Walter Halangk Andrew G Demaine Andrew N Kingsnorth Department of Surgery Derriford Hospital Plymouth United Kingdom Department of Gastroenterology Derriford Hospital Plymouth United Kingdom Department of Molecular Medicine Plymouth Postgraduate Medical School Plymouth United Kingdom Department of Surgery University of Magdeburg Magdeburg Germany outpatient Clinic for Addiction Diseases Magdeburg Germany

AIM: To investigate a possible role for a recently identified polymorphism in the gene of cytochrome P450 2E1, the presence of which is associated with high activity of the enzyme. METHoDS: Two hundred and thirty-nine alcohol consumers, ICD 10.1/.2 (ALC), and 208 normal controls were studied. PCR amplification of the CYP2E1 gene region was performed to assess polymorphic variation. Fisher's exact test was used to assess the ***: Twelve normal controls (5.8%) possessed the insertion. Five ALC (2.1%) had the insertion; of these 2 of 144 with,alcohol induced chronic pancreatitis, none of 28 with alcoholic liver disease and 3 of 67 without endorgan disease had the polymorphism. A significantly Lower frequency of subjects possessed the insertion than normal controls [P = 0.049 (genotype analysis P = 0.03)]. To further assess, if there was a relationship to alcohol problems per se or end-organ disease, we compared patients with alcohol induced end-organ disease vs alcoholic controls without end-organ disease vs normal controls which again showed a significant difference [P = 0.045 (genotype analysis,P = 0.011)], further sub-group analysis did not identify which group(s) accounted for these ***: We have shown the frequencies of this high-activity polymorphism in alcohol related patient groups for the first time. The frequency is significantly less in alcoholics than normal controls, as with high activity polymorphisms of alcohol dehydrogenase. The biological significance, and whether the relevance is solely for alcoholism or is there a relationship to end-organ disease,would benefit from the assessment in the populations with a greater frequency of this polymorphism.

关键词： CYP2E1 Alcohol Chronic pancreatitis Liver disease Polymorphism

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老牌企业靠什么自我颠覆

企业家信息 2024年第5期 4-5页

作者：安迪·宾斯迈克尔·图什曼查尔斯·奥赖利三世李君(翻译) 战略创新咨询公司Change Logic 哈佛商学院(Harvard Business School) 斯坦福商学院(Stanford Graduate School of Business) 不详

随着股价在过去十年中上涨了8000%以上,英伟达公司(Nvidia)的成功无人质疑。它现在雄居全球最有价值的十大公司之一,而这得益于它从世界领先的图形处理器供应商,转型为人工智能和自动驾驶计算领域的领军企业。有传统观点认为,成熟公司... 详细信息

随着股价在过去十年中上涨了8000%以上,英伟达公司(Nvidia)的成功无人质疑。它现在雄居全球最有价值的十大公司之一,而这得益于它从世界领先的图形处理器供应商,转型为人工智能和自动驾驶计算领域的领军企业。有传统观点认为,成熟公司无法通过彻底的创新来彻底改造自己和所在行业。但英伟达的CEo黄仁勋颠覆了这一点。

关键词：图形处理器人工智能自动驾驶供应商计算领域自我颠覆

Investigation into viability of using two-stage(pre-placed aggregate)concrete in Irish setting

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Frontiers of Structural and Civil Engineering 2010年第1期4卷 127-132页

作者： john o’MALLEY Hakim S.ABDELGAD Dublin Institute of Technology DublinIreland Department of Civil Engineering Al-fateh UniversityTripoliLibya

Two-stage(pre-placed aggregate)concrete(TSC)consists of coarse aggregate,which is first deposited into the formwork,and grout,which is later pumped into the formwork from the bottom up to bind the stone together into a *** the course of this study the formation of grout for two stage concrete was investigated using readily available 5 mm sand mixed in a slow speed paddle *** fume and a superplasticizer were used in the mix to see if the necessary stability and fluidity could be achieved without the use of a specialized plant,essentially to see if TSC could be produced on a small scale using native Irish aggregates.A much higher degree of sedimentation was recorded during testing than was *** a result,the use of 5 mm sand and a slow speed mixer in combination were found to be not conducive to the successful production of TSC grout,without further research and testing.

关键词： grout pre-placed concrete two-stage concrete(TSC)

Antiplasmodial and analgesic activities of Clausena anisata

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 214-219页

作者： Jude E okokon Ette o Etebong john A Udobang Grace E Essien Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of UyoUyoNigeria

objective:Antiplasmodial and analgesic activities of the leaf extract and fractions of Clausena anisata(***) were evaluated for antimalarial and analgesic ***:The crude leaf extract(39-117mg/kg) and fractions(chloroform and acqeous;78mg/kg) of C. anisata were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei(***) infections in mice using suppressive,prophylactic and curative models and analgesic activity against acetic acid,formalin and heat-induced ***,5 mg/kg and pyrimethamine,1.2mg/kg were used as positive *** films made from tail blood of each mouse were used to assess the level of parasitaemia of the ***:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine-sensitive *** in prophylactic,suppressive and curative models in *** reductions were statistically significant(Po improved the mean survival time(MST) from 17 to 21 days relative to control(Pon chemically and thermally-induced pains,the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in *** inhibitions were statistically significant(Pose-dependent fashion. Conclusions:The antiplasmodial and analgesic effects of this plant may in part be mediated through its chemical constituents and it can be concluded that the *** possess significant antimalarial and analgesic properties.

关键词： Clausena anisata antiplasmodial antimalarial analgesic

Complications arising in simple and polycystic liver cysts

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World Journal of Hepatology 2012年第12期4卷 406-411页

作者： Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A o’reilly Department of HepatoPancreato-Biliary Surgery North Manchester General HospitalManchester M8 5RBUnited Kingdom Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical CenterPO Box 9101Code 455 NijmegenThe Netherlands Department of Radiology North Manchester General HospitalManchester M8 5RBUnited Kingdom The University of Manchester Manchester Academic Health Science CentreManchesterUnited Kingdom

Liver cysts are common,affecting 5%-10% of the *** are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require *** is no consensus on their management because complications are so *** aim of this study was to perform a collected review of how a series of complications were managed at our *** different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The *** and radiological imaging were obtained from case notes and computerised *** a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver *** final patient with a simple liver cyst mimicking a hydatid was managed by open liver *** conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in *** mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic *** management with somatostatin analogues is a potentially new and exciting treatment option but requires further study.

关键词： Liver Cysts Complications Polycystic

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悉尼地铁中央车站澳大利亚悉尼

世界建筑导报 2024年第4期39卷 80-83页

作者： john McAslan Partners with Woods Bagot 约翰•麦卡兰建筑事务所+伍兹•贝格建筑事务所

悉尼中央车站是澳大利亚最大的火车站,也是悉尼的标志性建筑。新地铁站的设计由约翰·麦卡兰建筑事务所和澳大利亚伍兹·贝格建筑事务所共同主导完成。耗资9.55亿澳元的中央车站项目包括为这座令人印象深刻的20世纪初建筑打造引人注目... 详细信息

悉尼中央车站是澳大利亚最大的火车站,也是悉尼的标志性建筑。新地铁站的设计由约翰·麦卡兰建筑事务所和澳大利亚伍兹·贝格建筑事务所共同主导完成。耗资9.55亿澳元的中央车站项目包括为这座令人印象深刻的20世纪初建筑打造引人注目的新主入口序列,并以一个独特的50米跨度拱形屋顶作为中心亮点。新的候车室为预计在未来20年每天有45万名旅客通过的车站现场提供了更加流畅的交通流,这是该项目的另一个关键元素,通过深入的、富有质感的地铁箱体空间,通往地铁站台。与约翰·麦卡兰建筑事务所设计的金丝雀码头方案一样,该项目不仅使车站成为经过重新设计的21世纪地标建筑,而且旨在刺激中央车站周边地区的再生和街道生活。

关键词：建筑事务所地标建筑主入口标志性建筑地铁站台候车室澳大利亚悉尼卡兰