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Brain of the blind:transcriptomics of the golden-line cavefish brain

Current Zoology 2018年第6期64卷 765-773页

作者： Fanwei MENG Yahui ZhAO Tom TITUS Chunguang ZhANG john h.postlethwait State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Neuroscience University of OregonEugeneOR 97403USA

The genus Sinocyclocheilus (golden-line barbel) includes 25species of cave-dwelling blind fish (cavefish)and more than 30 surface-dwelling species with normal *** environments are dark and generally nutrient-poor with few *** of several genera evolved convergent morphological adaptations in visual,pigmentation,brain,olfactory,and digestive systems. We compared brain morphology and gene expression patterns in a cavefish Sinocyclocheilus anophthalmus with those of a closely related surface-dwelling species *** showed that cavefish have a longer olfactory tract and a much smaller optic tectum than surface *** by RNA-seq revealed that many genes upregulated in cavefish are related to lysosomes and the degradation and metabolism of proteins,amino acids,and *** down- regulated in cavefish tended to involve "activation of gene expression in cholesterol biosynthesis" and cholesterol degradation in the *** encoding Srebfs (sterol regulatory element- binding transcription factors)and Srebf targets,including enzymes in cholesterol synthesis,were downregulated in cavefish brains compared with surface fish *** gene encoding Cyp46a1, which eliminates cholesterol from the brain,was also downregulated in cavefish brains,while the total level of cholesterol in the brain remained *** brains misexpressed several genes encoding proteins in the hypothalamus-pituitary axis,including Trh,Sst,Crh,Pomc,and *** results suggest that the rate of lipid biosynthesis and breakdown may both be depressed in golden-line cavefish brains but that the lysosome recycling rate may be increased in cavefish;properties that might be related to differences in nutrient availability in caves.

关键词： cavefish cholesterol cyp46a optic tectum Sinocyclocheilus transcriptomics

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Zeros of the Eta and Zeta Functions

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Journal of Applied Mathematics and Physics 2025年第1期13卷 256-266页

作者： john h. heinbockel Independent Researcher Virginia Beach Virginia USA

The eta function is examined over the critical strip 0σ1and there is an investigation of the statement that all zeros of the zeta function must lie on the critical line Re(s)=1/2. A further investigation is made into... 详细信息

关键词： Riemann hypothesis Zeta Function Zeros Dirichlet Eta Function Zeros

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Two texture zeros for Dirac neutrinos in a diagonal charged lepton basis

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Chinese Physics C 2025年第1期49卷 127-138页

作者： Yessica Lenis john D.Gómez William A.Ponce Richard h.Benavides Instituto de Física Universidad de AntioquiaA.A.1226MedellínColombia Instituto Tecnológico Metropolitano Facultad de Ciencias Exactas y AplicadasCalle 73 N°76-354 via el voladorMedellínColombia

A systematic study of the neutrino mass matrix M_(v) with two texture zeros in a basis that the charged leptons are diagonal,and under the assumption that neutrinos are Dirac particles is *** study is conducted without any approximation,first analytically and then *** neutrino oscillation data is used in our *** implications of M_(v) on lepton CP violation and neutrino mass spectrum are explored.

关键词： neutrinos texture zeros Dirac particles

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Differentially-expressed opsin genes identified in Sinocyclocheilus cavefish endemic to China

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Current Zoology 2013年第2期59卷 170-174页

作者： Fanwei MENG Yahui ZhAO john h. postlethwait Chunguang ZhANG Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Institute of Neuroscience University of Oregon Eugene OR 97403 USA

Eye degeneration is a common troglomorphic character of cave-dwelling organisms. Comparing the morphology and molecular biology of cave species and their close surface relatives is a powerful tool for studying regressive eye evolution and other adaptive phenotypes. We compared two co-occurring and closely-related species of the fish genus Sinocyclocheilus, which is endemic to China and includes both surface- and cave-dwelling species. Sinocyclocheilus tileihornes, a cave species, had smaller eyes than Sinocyclocheilus angustiporus, a surface species. histological and immunohistochemical analyses revealed that the cave- fish had shorter cones and more disorderly rods than did the surface-dwelling species. Using quantitative PCR and in situ hybri- dization, we found that rhodopsin and a long-wavelength sensitive opsin had significantly lower expression levels in the cavefish. Furthermore, one of two short-wavelength-sensitive opsins was expressed at significantly higher levels in the cavefish. Changes in the expression ofopsin genes may have played a role in the degeneration of cavefish eyes [Current Zoology 59 （2）： 170-174, 2013].

关键词： Sinocyclocheilus Cavefish Eye Retina Opsin.

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A comprehensive framework for the delimitation of species within the Bemisia tabaci cryptic complex,a global pest-species group

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Insect Science 2025年第1期32卷 321-342页

作者： hua-Ling Wang Teng Lei Xiao-Wei Wang Stephen Cameron Jesús Navas-Castillo Yin-Quan Liu M.N.Maruthi Christopher A.Omongo hélène Delatte Kyeong-Yeoll Lee Renate Krause-Sakate James Ng Susan Seal Elvira Fiallo-Olivé Kathryn Bushley john Colvin Shu-Sheng Liu College of Forestry Hebei Agricultural UniversityBaodingHebei ProvinceChina The Ministry of Agriculture Key Laboratory of Molec ular Biology of Crop Pathogens and Insects Institute of Insect SciencesZhejiang UniversityHangzhouChina Natural Resources Institute University of GreenwichKentUK College of Life Sciences Taizhou UniversityTaizhouZhejiang ProvinceChina Department of Entomology Purdue UniversityWest LafayetteINUSA Instituto de hortofruticultura Subtropical y Mediterranea"La Mayora"(IhSMUMA-CsiC) Consejo Superior de Investigaciones CientificasMalagaSpain National Crops Resources Research Institute KampalaUganda CIRAD UMR PVBMT CIRADPole de Protection des PlantesSaint-PierreFrance School of Applied Biosciences Kyungpook National UniversityDaeguRepublic of Korea uNESP Faculdade de Ciencias AgronomicasBotucatuBrazil Department of Microbiology and Plant Pathology University of CaliforniaRiversideCA uSDA Agricultural Research Service 17123Emerging Pests and Pathogens Research UnitIthacaNYUSA

Identifying cryptic species poses a substantial challenge to both biologists and naturalists due to morphological *** tabaci is a cryptic species complex containing more than 44 putative species;several of which are currently among the world's most destructive crop *** and delimiting the evolution of this species complex has proved *** develop a comprehensive framework for species delimitation and identification,we evaluated the performance of distinct data sources both individually and in combination among numerous samples of the *** species complex acquired *** datasets include full mitogenomes,single-copy nuclear genes,restriction site-associated DNA sequencing,geographic range,host speciation,and reproductive compatibility ***,our well-supported topologies generated from three dense molecular markers highlighted the evolutionary divergence of species of the *** complex and suggested that the nuclear markers serve as a more accurate representation of *** species *** compatibility datasets facilitated the identification of at least 17 different cryptic species within our *** geographic range information provides a complementary assessment of species recognition,while the host range datasets provide low rate of delimiting *** further summarized different data performances in species classification when compared with reproductive compatibility,indicating that combination of mtCOI divergence,nuclear markers,geographic range provide a complementary assessment of species ***,we represent a model for understanding and untangling the cryptic species complexes based on the evidence from this study and previously published articles.

关键词： Bemisia tabaci cryptic species phylogenetics RAD-Seq reproductive compatibility whiteflies

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A seaweed-inspired separator for high performance Zn metal batteries:Boosting kinetics and confining side-reactions

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Journal of Energy Chemistry 2025年第2期101卷 191-200页

作者： Qianzhi Gou horan Luo Long Qu Feilin Yu Kaixin Wang Sida Zhang Ziga Luogu Ben Zhang Yujie Zheng Bingye Song john Wang Meng Li National Innovation Center for Industry-Education Integration of Energy Storage MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCQU-NUS Renewable Energy Materials & Devices Joint Laboratory College of Energy & Power Engineering Chongqing University School of Building Services Science and Engineering Xi'an University of Architecture and Technology School of Chemistry and Chemical Engineering Chongqing University of Science and Technology Southwest Technology and Engineering Research Institute National University of Singapore (Chongqing) Research Institute

Uncontrolled dendrite growth,sluggish reaction kinetics,and drastic side reactions on the anodeelectrolyte interface are the main obstacles that restrict the application prospect of aqueous zinc-ion *** glass fiber（GF） separator with chemical inertness is almost ineffective in restricting these ***,inspired by the ionic enrichment behavior of seaweed plants,a facile biomass species,anionic sodium alginate（SA）,is purposely decorated on the commercial GF separator to tackle these issues towards Zn *** from the abundant zincophilic functional groups and superior mechanical strength properties,the as-obtained SA@GF separator could act as ion pump to boost the Zn2+transference number（0.68）,reduce the de-solvation energy barrier of hydrated Zn2+,and eliminate the undesired concentration polarization effect,which are verified by experimental tests,theoretical calculations,and finite element simulation,*** on these efficient modulation mechanisms,the SA@GF separator can synchronously achieve well-aligned Zn deposition and the suppression of parasitic ***,the Zn‖Zn coin cell integrated with SA@GF separator could yield a prolonged calendar lifespan over 1230 h(1 mA cm-2and 1 mAh cm-2),exhibiting favorable competitiveness with previously reported separator modification ***,the Zn-MnO2full and pouch cell assembled with the SA@GF separator also delivered superior cycling stability and rate performance,further verifying its practical application *** work provides a new design philosophy to stabilize the Zn anode from the aspect of separator.

关键词： Aqueous zinc-ion batteries Dendrite-free Interfacial reaction kinetics Separator modification Sodium alginate

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Reverse-Time Prestack Depth Migration of GPR Data from Topography for Amplitude Reconstruction in Complex Environments

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Journal of Earth Science 2015年第6期26卷 791-798页

作者： john h.Bradford Center for Geophysical Investigation of the Shallow Subsurface Boise State University

With increased computational power, reverse-time prestack depth migration（RT-PSDM） has become a preferred imaging tool in seismic exploration, yet its use has remained relatively limited in ground-penetrating radar（GPR） applications. Complex topography alters the wavefield kinematics making for a challenging imaging problem. Model simulations show that topographic variation can substantially distort reflection amplitudes due to irregular wavefield spreading, attenuation anomalies due to irregular path lengths, and focusing and defocusing effects at the surface. The effects are magnified when the topographic variations are on the same order as the depth of investigation––a situation that is often encountered in GPR investigations. here, I use a full wave-equation RT-PSDM algorithm to image GPR data in the presence of large topographic variability relative to the depth of investigation. The source and receiver wavefields are propagated directly from the topographic surface and this approach inherently corrects for irregular kinematics, spreading and attenuation. The results show that when GPR data are acquired in areas of extreme topography, RT-PSDM can accurately reconstruct reflector geometry as well as reflection amplitude.

关键词： reverse-time prestack depth migration ground-penetrating radar topography wavefield reflector geometry reflection amplitude.

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Boosting corticospinal system synaptic plasticity to recover motor functions

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Neural Regeneration Research 2023年第10期18卷 2182-2183页

作者： Weiguo Song john h.Martin Feinstein Institutes for Medical Research ManhassetNYUSA Department of Molecular Cellularand Biomedical SciencesCenter for Discovery and Innovation Neuroscience Program Graduate Center of the City University of New YorkNew YorkNYUSA

An importa nt strategy to promote voluntary movements after motor system injury is to strengthen the connections between the motor cortex and muscles by taking advantage of the plasticity of the corticospinal motor *** neuromodulation approaches are directed to activate the spinal cord and peripheral axons to strengthen muscle *** discuss in this perspective that,the cortex and spinal cord should be ta rgeted together to enhance cortex-to-musclefunction(Amer and Martin,2022).

关键词： plasticity system activation

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Statistical testing and distribution for lead chloride toxicity

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Asian Journal of Andrology 2005年第1期7卷 107-108,页

作者： john h.Lange Envirosafe Training and Consultants P.O. Box 114022 Pittsburgh PA 15239 USA

Dear Sir, Graca et al.[1]provided an interesting investigationon the toxicity of lead chloride and sperm developmentin ***, I would like to make a comment onthe statistical analysis *** 1 and its resultsSuggest that a... 详细信息

关键词： Animals Biomedical Research Comparative Study Lead Male Mice Spermatogenesis

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Eyes and stroke:the visual aspects of cerebrovascular disease

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Stroke & Vascular Neurology 2017年第4期2卷 211-221页

作者： john h Pula Carlen A Yuen Department of Neurology NorthShore University HealthSystemChicagoIllinoisUSA Department of Neurology University of ChicagoChicagoIllinoisUSA

A large portion of the central nervous system is dedicated to vision and therefore strokes have a high likelihood of involving vision in some *** loss can be the most disabling residual effect after a cerebral *** vision problems can likewise be a harbinger of stroke and prompt evaluation after recognition of visual symptoms can prevent future vascular *** this review,we discuss the visual aspects of ***,anatomy and the vascular supply of the visual system are ***,the different stroke syndromes which involve vision are ***,topics involving the assessment,prognosis,treatment and therapeutic intervention of vision-specific stroke topics are reviewed.

关键词： anatomy ed. visual

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