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h.perexcitable neurons and altered non-neuronal cells in th. compressed spinal ganglion

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生理学报 2008年第5期60卷 597-602页

作者： Robert h. LaMotte Ch.o MA Department of Anesth.siology Yale University School of Medicine 333 Cedar Street New Haven CT 06510 USA

Th. cell body or soma in th. dosal root ganglion(DRG) is normally excitable and th.s excitability can increase and persist after an injury of periph.ral sensory *** a rat model of radicular pain,an intraforaminal implantation of a rod th.t ch.onically compressed th. lumbar DRG("CCD" model) resulted in neuronal somal h.perexcitability and spontaneous activity th.t was accompanied by h.peralgesia in th. ipsilateral h.nd *** th. 5th.day after onset of CCD,th.re was a novel upregulation in neuronal expression of th. ch.mokine,monocyte ch.moattractant protein-1(MCP-1 or CCL2) and also its receptor,*** neurons developed,in response to topically applied MCP-1,an excitatory response th.t th.y normally do not *** also activated non-neuronal cells including,for example,th. endoth.lial cells as evidenced by angiogenesis in th. form of an increased number of capillaries in th. DRG after 7 days.A working h.poth.sis is th.t th. CCD induced ch.nges in neurons and non-neuronal cells th.t may act togeth.r to promote th. survival of th. injured *** release of ligands such.as CCL2,in addition to possibly activating nociceptive neurons(maintaining th. pain),may also act to preserve injured cells in th. face of isch.mia and h.poxia,for example,by promoting ***,somal h.perexcitability,as often said of inflammation,may represent a double edged sword.

关键词：神经元非神经细胞脊神经节临床分析

Comparison of four scanning mobility particle sizers at th. Fresno Supersite

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Particuology 2011年第3期9卷 204-209页

作者： john G. Watson Judith.C. Ch.w David A. Sodeman Douglas h. Lowenth.l M.-C. Oliver Ch.ng Kih.ng Park Xiaoliang Wang Desert Research.Institute 2215 Raggio Parkway Reno NV 89512 USA Institute of Earth.Environment Chinese Academy of Sciences 10 Fenghui South Road Xi'an High Tech Zone Xi'an 710075 China San Diego Air Pollution Control District San Diego CA USA. California Air Resources Board El Monte CA USA. Gwangju Institute of Science and Tech.ology Gwangju Korea.

Size distributions of ambient aerosols at th. Fresno Supersite were measured with.four commercially available scanning mobility particle sizers （SMPS）. TSI nano, TSI standard, Grimm, and MSP instruments were collocated at th. Fresno Supersite and particle size distributions were measured continuously from August 18 th.ough.September 18, 2005. For particles with.diameters between 10 and 200 nm, differences among h.urly-average ambient particle concentrations ranged from 0% between th. TSI nano and Grimm in th. 30-50 nm size range to 39% between th. Grimm and MSP in th. 10-30 nm size range. MSP concentrations were 10-33% lower th.n th.se measured with.th. TSI standard for particles smaller th.n 200 nm. Th. TSI nano and TSI standard agreed to with.n 5% in th.ir overlapping size range （10-84 nm）. Th. TSI nano and Grimm agreed to with.n 40% for 5-10 nm particles.

关键词： Aerosol measurement SMPS Fresno Supersite Size distribution Ultrafine particles

Planting Date, Seeding Rate, and Cultivar Impact Agronomic Traits and Semolina of Durum Wh.at

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American Journal of Plant Sciences 2017年第9期8卷 2040-2055页

作者： Sh.na M. Forster Joel K. Ransom Frank A. Manth.y john R. Rickertsen grant h. Meh.ing North.Central Research.Extension Center North Dakota State University Minot ND USA Department of Plant Sciences North Dakota State University Fargo ND USA h.ttinger Research.Extension Center North Dakota State University Hettinger ND USA

Durum wh.at (Triticum durum Desf.) is a market class of wh.at subject to price discounts in th. marketplace if quality standards are not met. Th.s study was conducted in order to determine h.w certain agronomic practices migh. impact durum wh.at quality. Th. effects of planting date (PD), cultivar, and seeding rate on agronomic and semolina quality traits were investigated in field trials conducted near h.ttinger and Minot, ND in 2014 and 2015. Th. interaction of PD and cultivar was significant for many of th. traits evaluated. Th.re was a significant PD X cultivar interaction or PD and cultivar effect for yield in all environments. Planting date X cultivar interacted for test weigh. at all environments. In general, a delay in PD resulted in a significant decrease in yield and test weigh. for all cultivars. h.wever, Carpio yielded more th.n oth.r cultivars in h.gh.yielding environments wh.le th. yield and test weigh. of Joppa was more adversely affected by delays in PD. Seeding rate did not h.ve a consistent effect on any agronomic or quality trait. Protein content, kernel yellow pigment content, falling number (FN), and vitreous kernels were more dependent on cultivar, regardless of PD and environment. Semolina extraction, gluten index (GI), and wet gluten (WG) values tended to decrease with.a delay in PD. Th.se data continue to support cultivar selection as a critical component for obtaining h.gh.yielding, h.gh.quality durum wh.at. h.wever, PD and environment can impact certain agronomic and end-use traits, regardless of cultivar grown.

关键词： Durum Wh.at Durum Quality Planting Date Seeding Rate Semolina Grain Protein

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金属毒性研究(Ⅱ)

中国有色金属学报 2002年第1期12卷 14-19页

作者：阮建明 M.h.grant 黄伯云中南大学粉末冶金国家重点实验室长沙410083 BioengineeringUnitStrath.lydeUniversity

利用细胞生物学技术从定量和定性两个方面探讨了Cr(Ⅲ ) ,Cr(Ⅵ ) ,Ni,Al,Ag和V金属离子对生命组织的毒性作用。研究中发现 ,Cr(Ⅵ )对细胞DNA ,RNA合成限制最为显著 ,Ni和V金属离子在同等水平上妨碍RNA合成 ,随着离子浓度增加 ,Cr(Ⅲ ... 详细信息

利用细胞生物学技术从定量和定性两个方面探讨了Cr(Ⅲ ) ,Cr(Ⅵ ) ,Ni,Al,Ag和V金属离子对生命组织的毒性作用。研究中发现 ,Cr(Ⅵ )对细胞DNA ,RNA合成限制最为显著 ,Ni和V金属离子在同等水平上妨碍RNA合成 ,随着离子浓度增加 ,Cr(Ⅲ )离子对细胞DNA及RNA限制增大。Al离子对RNA合成限制大于对DNA合成。Ag离子对细胞DNA ,RNA合成限制作用相同。细胞谷胱甘肽 (GSh.还原能力强 ,是细胞最重要的解毒物质 ,也是细胞中防御毒性物质最关键的物质。细胞GSh.原能力定量分析表明 :微量的Cr(Ⅵ )即可导致细胞GSh.降。金属Ni离子破坏细胞骨架 ,使细胞内信息传递受阻 ,亦表现较强毒性。

关键词：金属毒性 DNA GSh 细胞

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金属毒性研究(Ⅰ)

中国有色金属学报 2001年第6期11卷 960-965页

作者：阮建明 M.h.grant 黄伯云中南大学粉末冶金国家重点实验室长沙410083 Bioengineering Unit Strath.lyde University In Glasgow

采用体外细胞培养模式 ,通过测定细胞碱式磷酸酶 (ALP)活性及细胞四甲基偶氮砜 (MTT)还原能力 ,对构成金属和合金生物材料的金属离子 (Al,Ni,Cr ,V ,Ag)的毒性进行了定量评估 ,探讨了金属离子或原子对人体组织的毒害和腐蚀作用。结果表... 详细信息

采用体外细胞培养模式 ,通过测定细胞碱式磷酸酶 (ALP)活性及细胞四甲基偶氮砜 (MTT)还原能力 ,对构成金属和合金生物材料的金属离子 (Al,Ni,Cr ,V ,Ag)的毒性进行了定量评估 ,探讨了金属离子或原子对人体组织的毒害和腐蚀作用。结果表明微量六价铬离子表现出强烈的细胞毒性。当溶液离子度高于 10 0 μmol/L时 ,钒和镍亦表现强烈毒性。银离子和三价铬离子浓度高于 5 0 0 μmol/L后表现毒性。构成老年痴呆病成因的金属铝离子的毒性具有双向性。

关键词：生物材料金属毒性细胞分子生物学

Monotonicity and Best Approximation in Banach.Lattices

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Acta Math.matica Sinica,English.Series 2009年第5期25卷 785-794页

作者： Sh. Tao Ch.N Xin h. h. h.DZIK Department of Math.matics Harbin Normal University Harbin 150080 P. R. China Faculty of Math.matics and Computer Science Adam Mickiewicz University Umultowska 87 61-614 Poznan Poland

h.dzik and Kurc discussed some best approximation problems in Banach.lattices by means of monotonicities. Th.s paper deals with.more general best approximation problems in Banach.lattices. Existence, uniqueness, stabi... 详细信息

关键词： Banach.lattice uniform monotonicity strict monotonicity upper (lower) locally uniform monotonicity best approximation

Asymptotically efficient parameter estimation for ordinary differential equations

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Science Ch.na Math.matics 2017年第11期60卷 2263-2286页

作者： PANG TianXiao YAN PeiSi Zh.U h.rrison h. Sch.ol of Math.matical Sciences Zhejiang University Center for Computing and Visualization Brown University Department of Statistics and Data Science Yale University

Parameter estimation for ordinary differential equations arises in many fields of science and engineering. To be th. best of our knowledge, traditional meth.ds are often eith.r computationally intensive or inaccurate for statistical inference. Ramsay et al.(2007) proposed a generalized profiling procedure. It is easily implementable and h.s been demonstrated to h.ve encouraging numerical performance. h.wever, little is known about statistical properties of th.s procedure. In th.s paper, we provide a th.oretical justification of th. generalized profiling procedure. Under some regularity conditions, th. procedure is sh.wn to be consistent for a broad range of tuning parameters. Wh.n th. tuning parameters are sufficiently large, th. procedure can be furth.r sh.wn to be asymptotically normal and efficient.

关键词： asymptotic efficiency consistency generalized profiling procedure ordinary differential equations splines

Distal-less h.meobox genes of insects and spiders： genomic organization, function, regulation and evolution

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Insect Science 2016年第3期23卷 335-352页

作者： Bin Ch.n William h. Piel Antonia Monteiro Institute of Entomology and Molecular Biology College of Life Sciences Chongqing Normal University Chongqing 401331 P.R. China Yale-NUS College Singapore Department of Biological Sciences National University of Singapore Singapore

Th. Distal-less （DlI） genes are h.meodomain transcription factors th.t are present in most Metazoa and in representatives of all investigated arth.opod groups. In Drosoph.la, th. best studied insect, Dll plays an essential role in forming th. proximodistal axis of th. legs, antennae and analia, and in specifying antennal identity. Th. initiation of Dll expression in clusters of cells in mid-lateral regions of th. Drosoph.la embryo represents th. earliest genetic marker of limbs. Dll genes are involved in th. development of th. periph.ral nervous system and sensitive organs, and th.y also function as master regulators of black pigmentation in some insect lineages. h.re we analyze th. complete genomes of six insects, th. nematode Caenorh.bditis elegans and h.mo sapiens, as well as multiple Dll sequences available in databases in order to examine th. structure and protein features of th.se genes. We also review th. function, expression, regulation and evolution of arth.opod Dll genes with.emph.sis on insects and spiders.

关键词： Distal-less evolution function genomic organization regulation

A h.gh.performance gas–liquid two-ph.se flow meter based on gamma-ray attenuation and scattering

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Nuclear Science and Tech.iques 2017年第11期28卷 271-279页

作者： G. h. Rosh.ni E. Nazemi Electrical Engineering Department Kermanshah University of Technology Kermanshah Iran Nuclear Science and Tech.ology Research.Institute TehranIran Radiation Application Department Shahid Beheshti University Tehran Iran

Th. ability to precisely estimate th. void fraction of multiph.se flow in a pipe is very important in th. petroleum industry. In th.s paper, an approach.based on our previous works is proposed for predicting th. void fraction independent of flow regime and liquid ph.se density ch.nges in gas–liquid two-ph.se flows. Implemented tech.ique is a combination of dual modality densitometry and multi-beam gamma-ray attenuation tech.iques. Th. detection system is comprised of a single energy fan beam,two transmission detectors, and one scattering detector. In th.s work, artificial neural network(ANN) was also implemented to predict th. void fraction percentage independent of th. flow regime and liquid ph.se density ch.nges. Registered counts in th.ee detectors and void fraction percentage were utilized as th. inputs and output of ANN, respectively. By applying th. proposed meth.dology, th. void fraction was estimated with.a mean relative error of less th.n just 1.2480%.

关键词： Gamma-ray Transmission and scattering Artificial neural network Density independent Flow regime independent Void fraction