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continued development of azithromycin as a neuroprotective therapeutic for the treatment of spinal cord injury and other neurological conditions

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Neural Regeneration Research 2021年第3期16卷 508-509页

作者： Timothy J.Kopper john c.gensel Spinal cord and Brain Injury Research center Department of PhysiologyUniversity of KentuckyLexingtonKYUSA

Spinal cord injury(ScI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain *** these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after ScI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.

关键词： protective injury therapeutic

Data and subject heterogeneity and data sharing:keys to translational success in spinal cord injury research?

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Neural Regeneration Research 2023年第8期18卷 1730-1731页

作者： Karim Fouad Olivia H.Wireman john c.gensel Faculty of Rehabilitation Medicine Department of Physical TherapyNeuroscience and Mental Health InstituteUniversity of AlbertaAlbertaCanada Spinal cord and Brain Injury Research center(ScoBIRc) Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA

Spinal cord injury(ScI)is a highly devastating and com plex inj u ry with many seconda ry *** a treatment for ScI has been a rollercoaster ride through exciting peaks and sobering *** a matter of fact,there are still ... 详细信息

关键词： damage treatment ScI

Impact of cOVID-19 pandemic on cardiovascular health in sedentary and athletes:consensus,uncertainties,and ways for mitigation

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Sports Medicine and Health Science 2024年第3期6卷 205-208页

作者： john c.Quindry Lei Xi School of Integrative Physiology and Athletic Training University of MontanaMissoulaMT59812USA Pauley Heart center Department of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA23298-0204USA

More than 4 years has elapsed since the World Health Organization(WHO)ofﬁcially announced the coronavirus disease 2019(cOVID-19)as a pandemic outbreak in March 11,*** the ongoing investigations and political debates upon the origin,exacerbation,resurgence,andﬁnal control of cOVID-19,medical and scientiﬁc consensus indicates that the now endemic cOVID-19 virus is one of the worst public health crises in our *** every person on earth has been directly or indirectly impacted by the adverse effects of the highly contagious viral pathogen-SARS-coV-2(severe acute respiratory syndrome coronavirus 2).Indeed,the population reach of the cOVID-19 infection includes governmental response measures(e.g.,lockdowns and social distancing,mandates for masks and face coverings,vaccines,etc.)that have restricted entrenched societal routines,personal mobility,and ***,the host of health problems linked to this viral infection linger to this day,with selective groups of people experiencing a higher risk for untoward medical outcomes and/or elevated levels of vulnerability to the post-acute sequelae of cOVID-19(***-cOVID).For example,a 2021 study by Logue et *** initial evidence that 10%–30%of individuals in United States may experience prolonged symptoms following SARS-coV-2 infection,including cardiovascular abnormalities.1 Similarly,a 2021 retrospective cohort study in England suggest that the incidence of major adverse cardiovascular events(*** failure,myocardial infarction,ischemic stroke.

关键词： cardiovascular routine Impact

Review of Networked Microgrid Protection:Architectures,challenges,Solutions,and Future Trends

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cSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： Jorge de la cruz Ying Wu john E.candelo-Becerra Juan c.Vasquez Josep M.Guerrero center for Research on Microgrids(cROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. center for Research on Microgrids at UPc(UPc cROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain IcREA Pg.Lluis Companys 2308010 BarcelonaSpain center for Research on Microgrids at AAU(AAU cROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

Assessment of clinical depression metrics in cardiac patients using the patient health Questionnaire-9 before and after phase-II cardiac rehabilitation

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Sports Medicine and Health Science 2024年第3期6卷 240-245页

作者： john c.Quindry Michael McNamara carrie Oser crystelle Fogle Integrative Physiology and Athletic Training University of MontanaMissoulaMTUSA St.Patrick's Hospital MissoulaMTUSA cardiovascular Health Program–Montana Department of Public Health and Human Services HelenaMTUSA

cardiovascular disease remains a leading cause of morbidity and mortality,a fact that is commonly associated with co-morbidities such as clinical *** phase II cardiac rehabilitation is an established intervention for those with cardiovascular disease,its effect on patients who also suffer from depression are under ***:To quantify Pre-and Post-cardiac rehabilitation questionnaire scores collected from a large patient data *** this investigation,27670 patients completed Patient Health Questionnaire-9 questionnaires both Pre-and Post-rehabilitation(averaging[28.08.7]phase II sessions).Findings reveal that questionnaire scores decreased by 40%–48%across all groups,a finding that was independent of assigned sex,race,and ***,when data were stratified for questionnaire scores that may indicate major and minor depressive disorder,phase II cardiac rehabilitation outcomes were lower by 61%and 49%*** all groups exhibited lower questionnaire scores following cardiac rehabilitation participation,numerical differences at Preand Post-rehabilitation time points indicate that males and White patients have more favorable *** latter observation,while not confirmed currently,appears to be linked to referral rates to phase II cardiac rehabilitation,which remain poor for females,racial and ethnic minorities.

关键词： clinical depression Exercise Psychological health

Boron neutron capture therapy of cancer:where do we stand now?

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cancer communications 2024年第8期44卷 889-892页

作者： Rolf F.Barth Gong Wu Maria da Graca H.Vicente john c Grecula Nilendu Gupta Department of Pathology The Ohio State UniversityColumbusOhioUSA Mass Spectrometry and Proteomics Facility The Ohio State UniversityColumbusOhioUSA Department of chemistry Louisiana State UniversityBaton RougeLouisianaUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA

1 INTRODUcTION,This is the third Editorial/commentary that one of us(***)has written relating to boron neutron capture therapy(BNcT)[1,2].For those readers who are unfamiliar with BNcT we would refer them to several recent comprehensive reviews[3–5].The second Editorial ended on a hopeful note that with the introduction of acceleratorbased neutron sources(ABNSs),BNcT would enter into the mainstream of radiation therapy[2].

关键词： boron 1,2 neutron

Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： carolina S.Ilkow john cameron Bell Ottawa Hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

Therapeutic implications of advanced age at time of spinal cord injury

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Neural Regeneration Research 2019年第11期14卷 1895-1896页

作者： Andrew N. Stewart john c. gensel Bei Zhang Spinal cord and Brain Injury Research center Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA college of Public Health Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina

A recent demographic shift towards increased age at time of spinal cord injury (ScI), as well as decreased functional recovery following ScI in older populations, create the need to investigate how age effects ScI pathology and repair (Scivoletto et al., 2003). While decreased neuroplasticity or physical strength with age may contribute to functional deficits, work from our lab and others have identified exacerbated acute inflammatory events as contributors to age-dependent secondary injury. Specifically, our recent paper identified that increased production of reactive oxygen species (ROS) from macrophage nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) with age exacerbates secondary injury after ScI (Zhang et al., 2019).

关键词： spinal cord injury nicotinamide adenine dinucleotide phosphate(NADPH) reactive oxygen species(ROS)

Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal cOVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter c Hayes john N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BAcKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(cOVID-19),while preexisting MASLD increases the risk of LI and the development of cOVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-coV-2)which causes cOVID-19,uses angiotensin-converting expression enzyme 2(AcE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic AcE2 levels are altered during progression of MASLD and in patients who died with severe *** AcE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe cOVID-19,using AcE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** AcE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,AcE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but AcE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry cOVID-19 cOVID-19-associated cholangiopathy